The Hyaluronan Synthases

Chemistry and Biology of Hyaluronan

Volumn , Issue , 2004, Pages 553-567

  Weigel, Paul H ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BINDING SITES; CELL MEMBRANES; CHAINS; CYTOLOGY; ENZYMES; GLUCOSE; SUBSTRATES;

DISACCHARIDE UNITS; ENZYMATIC ACTIVITIES; EXTRACELLULAR MATRICES; GLYCOSYLTRANSFERASE ACTIVITY; HYALURONAN SYNTHASES; MEMBRANE-BOUND ENZYMES; N-ACETYLGLUCOSAMINE; UDP-GLUCURONIC ACID;

HYALURONIC ACID;

EID: 77957080643     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-008044382-9/50056-X     Document Type: Chapter

References (45)

1. Meyer K, Palmer JW The polysaccharide of the vitreous humor. J Biol Chem 1934, 107:629-634.
2. New Frontiers in Medical Sciences: Redefining Hyaluronan 2000, Elsevier, Amsterdam. G. Abatangelo, P.H. Weigel (Eds.).
3. DeAngelis PL, Papaconstantinou J, Weigel PH Isolation of a Streptococcus pyogenes gene locus that directs hyaluronan biosynthesis in acapsular mutants and in heterologous bacteria. J Biol Chem 1993, 268:14568-14571.
4. De Angelis PL, Papaconstantinou J, Weigel PH Molecular cloning, identification, and sequence of the hyaluronan synthase gene from Group A Streptococcus pyogenes. J Biol Chem 1993, 268:19181-19184.
5. Kumari K, Weigel PH Molecular cloning, expression, and characterization of the authentic hyaluronan synthase from Group C Streptococcus equisimilis. J Biol Chem 1997, 272:32539-32546.
6. DeAngelis PL, Jing W, Drake RR, Achyuthan AM Identification and molecular cloning of a unique hyaluronan synthase from Pasteurella multocida. J Biol Chem 1998, 273:8454-8458.
7. Ward PN, Field TR, Ditcham WG, Maguin E, Leigh JA Identification and disruption of two discrete loci encoding hyaluronic acid capsule biosynthesis genes hasA, hasB and hasC in Streptococcus uberis. Infect Immun 2001, 69:392-399.
8. Itano N, Kimata K Expression cloning and molecular characterization of hyaluronan synthase protein, a eukaryotic hyaluronan synthase. J Biol Chem 1996, 271:9875-9878.
9. Shyjan AM, Heldin P, Butcher EC, Yoshino T, Briskin MJ Functional cloning of the cDNA for a human hyaluronan synthase. J Biol Chem 1996, 271:23395-23399.
10. Spicer AP, Augustine ML, McDonald JA Molecular cloning and characterization of a putative mouse hyaluronan synthase. J Biol Chem 1996, 271:23400-23406.
11. Watanabe K, Yamaguchi Y Molecular identification of a putative human hyaluronan synthase. J Biol Chem 1996, 271:22945-22948.
12. Fulop C, Salustri A, Hascall VC Coding sequence of a hyaluronan synthase homologue expressed during expansion of the mouse cumulus-oocyte complex. Arch Biochem Biophys 1997, 37:261-266.
13. Spicer AP, Olson JS, McDonald JA Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase. J Biol Chem 1997, 272:8957-8961.
14. Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA Chromosomal localization of the human and mouse hyaluronan synthase genes. Genomics 1997, 41:493-497.
15. Spicer AP, McDonald JA Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family. J Biol Chem 1998, 273:1923-1932.
16. Yamada Y, Itano N, Zako M, Yoshida M, Lenas P, Niimi A, Ueda M, Kimata K The gene structure and promoter sequence of mouse hyaluronan synthase 1 (mHAS1). Biochem J 1998, 330:1223-1227.
17. DeAngelis PL, Jing W, Graves MV, Burbank DE, Van Etten JL Hyaluronan synthase of chlorella virus PBCV-1. Science 1997, 278:1800-1803.
18. Weigel PH, Hascall VC, Tammi M Hyaluronan synthases. J Biol Chem 1997, 272:13997-14000.
19. McDonald JA, Spicer A Science of Hyaluronan Today 1998, Chap. 7. http://www.glycoforum.gr.ip, V.C. Hascall, M. Yanagishita (Eds.).
20. DeAngelis PL Hyaluronan synthases: fascinating glycosyltransferases from vertebrates, bacterial pathogens, and algal viruses. Cell Mol Life Sci 1999, 56:670-682.
21. Itano N, Kimata K Mammalian hyaluronan synthases. IUBMB Life 2002, 54:195-199.
22. Weigel PH Functional characteristics and catalytic mechanisms of the bacterial hyaluronan synthases. IUBMB Life 2002, 54:201-211.
23. Slevin M, Kumar S, Gaffney J Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses. J Biol Chem 2002, 277:41046-41059.
24. Horton MR, Burdick MD, Strieter RM, Bao C, Noble PW Regulation of hyaluronan-induced chemokine gene expression by IL-10 and IFN-gamma in mouse macrophages. J Immunol 1998, 160:3032.
25. Wessels MR, Moses AE, Goldberg JB, Dicesare TJ Hyaluronic acid capsule is a virulence factor for mucoid Group A streptococci. Proc Natl Acad Sci USA 1991, 88:8317-8321.
26. Markovitz M, Cifonelli JA, Dorfman A The biosynthesis of hyaluronic acid by Group A Streptococcus. VI. Biosynthesis from uridine nucleotides in cell-free extracts. J Biol Chem 1959, 234:2343-2350.
27. Crater DL, van de Rijn I Hyaluronic acid synthesis operon (has) expression in Group A Streptococci. J Biol Chem 1995, 270:18452-18458.
28. Itano N, Sawai T, Yoshida M, Leans P, Yamada Y, Imagawa M, Shinomura T, Hamaguchi M, Yoshida Y, Ohnuki Y, Miyauchi S, Spicer AP, McDonald JA, Kimata K Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties. J Biol Chem 1999, 274:25085-25092.
29. Camenisch TD, Spicer AP, Brehm-Gibson T, Biesterfeldt J, Augustine ML, Calabro A, Kubalak S, Klewer SE, McDonald JA Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme. 2000. J Clin Investig 2000, 106:335-336.
30. McDonald JA, Camensich TD Hyaluronan: genetic insights into the complex biology of a simpel polysaccharide. Glycoconj J 2002, 19:331-339.
31. Heldermon CD, DeAngelis PL, Weigel PH Topological organization of the hyaluronan synthase from Streptococcus pyogenes. J Biol Chem 2001, 276:2037-2046.
32. Tlapak-Simmons VL, Kempner ES, Baggenstoss BA, Weigel PH The active streptococcal hyaluronan synthases (HASs) contain a single HA synthase monomer and multiple cardiolipin molecules. J Biol Chem 1998, 273:26100-26109.
33. Pummill PE, Kempner ES, DeAngelis PL Functional molecular mass of a vertebrate hyaluronan synthase as determined by radiation inactivation analysis. J Biol Chem 2001, 276:39832-39835.
34. Tlapak-Simmons VL, Baggenstoss BA, Clyne T, Weigel PH Purification and lipid dependence of the recombinant hyaluronan synthases from Streptococcus pyogenes and Streptococcus equisimilis. J Biol Chem 1999, 274:4239-4245.
35. Yoshida M, Itano N, Yamada Y, Kimata K In vitro synthesis of hyaluronan by a single protein derived from mouse HAS1 gene and characterization of amino acid residues essential for the activity. J Biol Chem 2000, 275:497-506.
36. DeAngelis PL, Weigel PH Immunochemical confirmation of the primary structure of streptococcal hyaluronan synthase and synthesis of high molecular weight product by the recombinant enzyme. Biochemistry 1994, 33:9033-9039.
37. Heldermon CD, Tlapkak-Simmons VL, Baggenstoss BA, Weigel PH Site directed mutation of conserved cysteine residues does not inactivate the Streptococcus pyogenes hyaluronan synthase. Glycobiology 2001, 11:1-8.
38. Kumari K, Tlapkak-Simmons VL, Baggenstoss BA, Weigel PH The streptococcal hyaluronan synthases are inhibited by sulfhydryl modifying reagents but conserved cysteine residues are not essential for enzyme function. J Biol Chem 2002, 277:13943-13951.
39. Tlapak-Simmons VL, Baggenstoss BA, Kumari K, Heldermon C, Weigel PH Kinetic characterization of the recombinant hyaluronan synthases from Streptococcus pyogenes and Streptococcus equisimilis. J Biol Chem 1999, 274:4246-4253.
40. Prehm P Synthesis of hyaluronate in differentiated teratocarcinoma cells: mechanism of chain growth. Biochem J 1983, 211:191-198.
41. Asplund T, Brinck J, Suzuki M, Briskin MJ, Heldin P Characterization of hyaluronan synthase from a human glioma cell line. Biochim Biophys Acta 1998, 1380:377-388.
42. Tlapak-Simmons VL, Weigel PH Hyaluronan synthesis by the purified Class I hyaluronan synthase from S. pyogenes and S. equisimilis occurs by addition to the reducing end. Glycobiology 2002, 2:708.
43. DeAngelis PL Molecular directionality of polysaccharide polymerization by the Pasteurella multocida hyaluronan synthase. J Biol Chem 1999, 274:26557-26562.
44. Widner W, Behr R, Tang M, Hue T, Sternberg D, Von Dollen S, Sloma A, DeAngelis PL, Weigel PH, Brown SH Hyaluronic acid production by recombinant Bacillus subtilis strains. Online proceedings of HA2003 meeting at Matrix Biology Institute website 2003.
45. Heldermon C, Kumari K, Tlapak-Simmons V, Weigel PH Streptococcal hyaluronan synthases and the synthesis of designer hyaluronan. New Frontiers in Medical Sciences: Redefining Hyaluronan 2000, 41-50. Elsevier, Amsterdam. G. Abatelangelo, P.H. Weigel (Eds.).