Novel triazines as potent and selective phosphodiesterase 10A inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 18, 2012, Pages 5876-5884

  Malamas, Michael S ^a   Stange, Hans ^b   Schindler, Rudolf ^b   Lankau, Hans Joachim ^b   Grunwald, Christian ^b   Langen, Barbara ^b   Egerland, Ute ^b   Hage, Thorsten ^b   Ni, Yike ^a   Erdei, James ^a   Fan, Kristi Yi ^a,d   Parris, Kevin ^a   Marquis, Karen L ^a   Grauer, Steve ^a   Brennan, Julie ^a   Navarra, Rachel ^a   Graf, Radka ^a   Harrison, Boyd L ^a   Robichaud, Albert ^a,c   Kronbach, Thomas ^b   Pangalos, Menelas N ^a,e   Brandon, Nicholas J ^a,e   Hoefgen, Norbert ^b   more..

^a PFIZER INC   (United States)

^b Biocrea   (Germany)

^c Sage Therapeutics Inc   (United States)

^d Vitae Pharmaceuticals   (United States)

^e ASTRAZENECA   (United Kingdom)

Author keywords

MK 801; PDE10A inhibitors; Schizophrenia; Triazines

Indexed keywords

CLOZAPINE; PHOSPHODIESTERASE; PHOSPHODIESTERASE 10A; PHOSPHODIESTERASE INHIBITOR; TRIAZINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DESIGN; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HYPERACTIVITY; IC 50; LIGAND BINDING; NONHUMAN; RAT; SNIFFING;

ADMINISTRATION, ORAL; ANIMALS; CRYSTALLOGRAPHY, X-RAY; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYPERKINESIS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

ANIMALIA;

EID: 84865487391     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.07.076     Document Type: Article

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