Carcinoma of the collecting ducts of bellini and renal medullary carcinoma: Clinicopathologic analysis of 52 cases of rare aggressive subtypes of renal cell carcinoma with a focus on their interrelationship

American Journal of Surgical Pathology

Volumn 36, Issue 9, 2012, Pages 1265-1278

  Gupta, Ruta ^a   Billis, Athanase ^b   Shah, Rajal B ^c   Moch, Holger ^d   Osunkoya, Adeboye O ^e   Jochum, Wolfram ^f   Hes, Ondrej ^g   Bacchi, Carlos E ^h   De Castro, Marilia G ⁱ   Hansel, Donna E ^j   Zhou, Ming ^k   Vankalakunti, Mahesha ^a   Salles, Paulo G ^l   Cabrera, Rafael A ^m   Gown, Allen M ⁿ   Amin, Mahul B ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c MIRACA LIFE SCIENCES   (United States)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^g CHARLES UNIVERSITY   (Czech Republic)

^h Department of Pathology Consultoria em Patologia ^*  (Brazil)

ⁱ Santa Casa School of Medicine   (Brazil)

^j LERNER RESEARCH INSTITUTE   (United States)

^k NEW YORK UNIVERSITY   (United States)

^l Associação Mario Penna Hospital Luxemburgo   (Brazil)

^m INSTITUTO PORTUGUÊS DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL   (Portugal)

ⁿ PATH   (United States)

more..

Author keywords

BK polyoma virus; collecting duct carcinoma; histologic subtypes; immunohistochemistry; metastases; prognosis; renal allograft; renal cell carcinoma; renal medullary carcinoma; sickle cell trait

Indexed keywords

CYTOKERATIN 7; PLANT LECTIN; TUMOR MARKER; ULEX EUROPAEUS LECTINS;

ADOLESCENT; ADULT; AGED; CHILD; CLINICAL TRIAL; FEMALE; HUMAN; KIDNEY CARCINOMA; KIDNEY TUMOR; LYMPH NODE METASTASIS; MALE; MEDULLARY CARCINOMA; METABOLISM; METASTASIS; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; NEPHRECTOMY; PATHOLOGY; REVIEW; SURVIVAL RATE; UNITED STATES;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, MEDULLARY; CARCINOMA, RENAL CELL; CHILD; FEMALE; HUMANS; KERATIN-7; KIDNEY NEOPLASMS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEPHRECTOMY; PLANT LECTINS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; UNITED STATES; YOUNG ADULT;

EID: 84865485319     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3182635954     Document Type: Review

References (66)

1. Srigley JR, Moch H. Carcinoma of the collecting ducts of Bellini. In: Eble JN, Sauter G, Epstein JI, et al, eds. World Health Organization Classification of Tumors Pathology & Genetics: Tumors of the Urinary System and Male Genital Organs. Lyons: IARC; 2004:33-34.
2. Amin MB, Varma VD, Tickoo SK, et al. Collecting duct carcinoma of the kidney. Adv Anat Pathol. 1997;4:85-94.
3. Fleming S, Lewi HJ. Collecting duct carcinoma of the kidney. Histopathology. 1986;10:1131-1141. (Pubitemid 17205211)
4. Foot NC, Papanicolaou GN. Early renal cell carcinoma in situ: detected by means of fixed urinary sediment. J Am Med Assoc. 1949;139:356-358.
5. Srigley JR, Eble JN. Collecting duct carcinoma of kidney. Semin Diagn Pathol. 1998;15:54-67. (Pubitemid 28093788)
6. Avery RA, Harris JE, Davis CJ Jr, et al. Renal medullary carcinoma: clinical and therapeutic aspects of a newly described tumor. Cancer. 1996;78:128-132. (Pubitemid 26189912)
7. Milowsky MI, Rosmarin A, Tickoo SK, et al. Active chemotherapy for collecting duct carcinoma of the kidney: a case report and review of the literature. Cancer. 2002;94:111-116. (Pubitemid 34049048)
8. Oudard S, Banu E, Vieillefond A, et al. Prospective multicenter phase II study of gemcitabine plus platinum salt for metastatic collecting duct carcinoma: results of a GETUG (Groupe d'Etudes des Tumeurs Uro-Genitales) study. J Urol. 2007;177: 1698-1702. (Pubitemid 46560664)
9. Srigley JR, Delahunt B. Uncommon and recently described renal carcinomas. Mod Pathol. 2009;22(suppl 2):S2-S23.
10. Staehler M, Schoppler G, Haseke N, et al. Carcinoma of the collecting ducts of Bellini of the kidney: adjuvant chemotherapy followed by multikinase inhibition with sunitinib. Clin Genitourin Cancer. 2009;7: 58-61.
11. Wu ZS, Lee JH, Kwon JA, et al. Genetic alterations and chemosensitivity profile in newly established human renal collecting duct carcinoma cell lines. BJU Int. 2009;103:1721-1728.
12. Davis CJ Jr, Mostofi FK, Sesterhenn IA. Renal medullary carcinoma. The seventh sickle cell nephropathy. Am J Surg Pathol. 1995;19:1-11.
13. Eble JN. Renal medullary carcinoma: a distinct entity emerges from the confusion of "collecting duct carcinoma". Adv Anat Pathol. 1996;3:233-238.
14. Albadine R, Wang W, Brownlee NA, et al. Topoisomerase II alpha status in renal medullary carcinoma: immuno-expression and gene copy alterations of a potential target of therapy. J Urol. 2009;182: 735-740.
15. Rathmell WK, Monk JP. High-dose-intensity MVAC for advanced renal medullary carcinoma: report of three cases and literature review. Urology. 2008;72:659-663.
16. Schaeffer EM, Guzzo TJ, Furge KA, et al. Renal medullary carcinoma: molecular, pathological and clinical evidence for treatment with topoisomerase-inhibiting therapy. BJU Int. 2009;106:62-65.
17. Billis A. Renal medullary carcinoma: report of seven cases from Brazil. Int Braz J Urol. 2007;33:724-726.
18. Watanabe IC, Billis A, Guimaraes MS, et al. Renal medullary carcinoma: report of seven cases from Brazil. Mod Pathol. 2007; 20:914-920. (Pubitemid 47267828)
19. Davis CJ Jr. Renal medullary carcinoma. In: Eble JN, Sauter G, Epstein JI, et al, eds. World Health Organization Classification of Tumors Pathology & Genetics: Tumors of the Urinary System and Male Genital Organs. Lyons: IARC; 2004:35-36.
20. Amin MB, Tamboli P, Javidan J, et al. Prognostic impact of histologic subtyping of adult renal epithelial neoplasms: an experience of 405 cases. Am J Surg Pathol. 2002;26:281-291. (Pubitemid 34184451)
21. Downs TM, Schultzel M, Shi H, et al. Renal cell carcinoma: risk assessment and prognostic factors for newly diagnosed patients. Crit Rev Oncol Hematol. 2009;70:59-70.
22. Galfano A, Novara G, Iafrate M, et al. Mathematical models for prognostic prediction in patients with renal cell carcinoma. Urol Int. 2008;80:113-123. (Pubitemid 351440502)
23. Adsay NV, deRoux SJ, Sakr W, et al. Cancer as a marker of genetic medical disease: an unusual case of medullary carcinoma of the kidney. Am J Surg Pathol. 1998;22:260-264. (Pubitemid 28113390)
24. Baer SC, Ro JY, Ordonez NG, et al. Sarcomatoid collecting duct carcinoma: a clinicopathologic and immunohistochemical study of five cases. Hum Pathol. 1993;24:1017-1022. (Pubitemid 23281540)
25. Chao D, Zisman A, Pantuck AJ, et al. Collecting duct renal cell carcinoma: clinical study of a rare tumor. J Urol. 2002;167:71-74. (Pubitemid 34024502)
26. Dimopoulos MA, Logothetis CJ, Markowitz A, et al. Collecting duct carcinoma of the kidney. Br J Urol. 1993;71:388-391. (Pubitemid 23166055)
27. Hakimi AA, Koi PT, Milhoua PM, et al. Renal medullary carcinoma: the Bronx experience. Urology. 2007;70:878-882. (Pubitemid 350192580)
28. Kennedy SM, Merino MJ, Linehan WM, et al. Collecting duct carcinoma of the kidney. Hum Pathol. 1990;21:449-456. (Pubitemid 20141032)
29. Miyamoto H, Kuwamitsu O, Moriyama M, et al. Bellini duct carcinoma of the kidney. Urol Int. 1992;48:460-462.
30. O'Donnell PH, Jensen A, Posadas EM, et al. Renal medullary-like carcinoma in an adult without sickle cell hemoglobinopathy. Nat Rev Urol. 2010;7:110-114.
31. Peyromaure M, Thiounn N, Scotte F, et al. Collecting duct carcinoma of the kidney: a clinicopathological study of 9 cases. J Urol. 2003;170:1138-1140. (Pubitemid 37108097)
32. Selby DM, Simon C, Foley JP, et al. Renal medullary carcinoma: can early diagnosis lead to long-term survival? J Urol. 2000;163:1238. (Pubitemid 30169402)
33. SwartzMA, Karth J, Schneider DT, et al. Renal medullary carcinoma: clinical, pathologic, immunohistochemical, and genetic analysis with pathogenetic implications. Urology. 2002;60:1083-1089. (Pubitemid 35447572)
34. Weiss LM, Gelb AB, Medeiros LJ. Adult renal epithelial neoplasms. Am J Clin Pathol. 1995;103:624-635.
35. Wesche WA, Wilimas J, Khare V, et al. Renal medullary carcinoma: a potential sickle cell nephropathy of children and adolescents. Pediatr Pathol Lab Med. 1998;18:97-113. (Pubitemid 28168540)
36. Kausman JY, Somers GR, Francis DM, et al. Association of renal adenocarcinoma and BK virus nephropathy post transplantation. Pediatr Nephrol. 2004;19:459-462. (Pubitemid 38477415)
37. Kamranvar SA, Gruhne B, Szeles A, et al. Epstein-Barr virus promotes genomic instability in Burkitt's lymphoma. Oncogene. 2007;26:5115-5123. (Pubitemid 47206955)
38. Moscicki AB. HPV vaccines: today and in the future. J Adolesc Health. 2008;43:S26-S40.
39. O'Neil JD, Owen TJ, Wood VH, et al. Epstein-Barr virus-encoded EBNA1 modulates the AP-1 transcription factor pathway in nasopharyngeal carcinoma cells and enhances angiogenesis in vitro. J Gen Virol. 2008;89:2833-2842.
40. Emerson LL, Carney HM, Layfield LJ, et al. Collecting duct carcinoma arising in association with BK nephropathy post-transplantation in a pediatric patient. A case report with immunohistochemical and in situ hybridization study. Pediatr Transplant. 2008;12:600-605.
41. Vats A. BK virus and neoplasia: an emerging role. Pediatr Transplant. 2008;12:499-502.
42. Kalyanpur A, Schwartz DS, Fields JM, et al. Renal medulla carcinoma in a white adolescent. Am J Roentgenol. 1997;169:1037-1038. (Pubitemid 27406901)
43. Sathyamoorthy K, Teo A, AtallahM. Renal medullary carcinoma in a patient with sickle-cell disease. Nat Clin Pract Urol. 2006;3:279-283, quiz 289. (Pubitemid 43738870)
44. Ataga KI, Orringer EP. Renal abnormalities in sickle cell disease. Am J Hematol. 2000;63:205-211. (Pubitemid 30165408)
45. Jiang BH, Agani F, Passaniti A, et al. V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res. 1997;57:5328-5335. (Pubitemid 27516371)
46. Kobayashi N, Matsuzaki O, Shirai S, et al. Collecting duct carcinoma of the kidney: an immunohistochemical evaluation of the use of antibodies for differential diagnosis. Hum Pathol. 2008;39: 1350-1359.
47. Orsola A, Trias I, Raventos CX, et al. Renal collecting (Bellini) duct carcinoma displays similar characteristics to upper tract urothelial cell carcinoma. Urology. 2005;65:49-54. (Pubitemid 40169604)
48. Sibony M, Vieillefond A. Non clear cell renal cell carcinoma. 2008 update in renal tumor pathology. Ann Pathol. 2008;28:381-401.
49. Esheba GE, Longacre TA, Atkins KA, et al. Expression of the urothelial differentiation markers GATA3 and placental S100 (S100P) in female genital tract transitional cell proliferations. Am J Surg Pathol. 2009;33:347-353.
50. Higgins JP, Kaygusuz G, Wang L, et al. Placental S100 (S100P) and GATA3: markers for transitional epithelium and urothelial carcinoma discovered by complementary DNA microarray. Am J Surg Pathol. 2007;31:673-680. (Pubitemid 46684205)
51. Amin MB, Corless CL, Renshaw AA, et al. Papillary (chromophil) renal cell carcinoma: histomorphologic characteristics and evaluation of conventional pathologic prognostic parameters in 62 cases. Am J Surg Pathol. 1997;21:621-635. (Pubitemid 27265749)
52. Amin MB,MacLennan GT, Gupta R, et al. Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. Am J Surg Pathol. 2009; 33:384-392.
53. Albadine R, Schultz L, Illei P, et al. PAX8 (+)/p63 (-) immunostaining pattern in renal collecting duct carcinoma (CDC): a useful immunoprofile in the differential diagnosis of CDC versus urothelial carcinoma of upper urinary tract. Am J Surg Pathol. 2010;34:965-969.
54. Gupta R, Balzer B, Picken M, et al. Diagnostic implications of transcription factor Pax 2 protein and transmembrane enzyme complex carbonic anhydrase IX immunoreactivity in adult renal epithelial neoplasms. Am J Surg Pathol. 2009;33:241-247.
55. Gupta R, Paner GP, Amin MB. Neoplasms of the upper urinary tract: a review with focus on urothelial carcinoma of the pelvicalyceal system and aspects related to its diagnosis and reporting. Adv Anat Pathol. 2008;15:127-139. (Pubitemid 351591496)
56. Cheng JX, Tretiakova M, Gong C, et al. Renal medullary carcinoma: rhabdoid features and the absence of INI1 expression as markers of aggressive behavior. Mod Pathol. 2008;21:647-652. (Pubitemid 351744839)
57. Elwood H, Chaux A, Schultz L, et al. Immunohistochemical analysis of SMARCB1/INI-1 expression in collecting duct carcinoma. Urology. 2011;78:e471-e475.
58. Mejean A, Roupret M, Larousserie F, et al. Is there a place for radical nephrectomy in the presence of metastatic collecting duct (Bellini) carcinoma? J Urol. 2003;169:1287-1290. (Pubitemid 36323768)
59. Wright JL, Risk MC, Hotaling J, et al. Effect of collecting duct histology on renal cell cancer outcome. J Urol. 2009;182:2595-2599.
60. Polascik TJ, Cairns P, Epstein JI, et al. Distal nephron renal tumors: microsatellite allelotype. Cancer Res. 1996;56:1892-1895. (Pubitemid 26118228)
61. Schoenberg M, Cairns P, Brooks JD, et al. Frequent loss of chromosome arms 8p and 13q in collecting duct carcinoma (CDC) of the kidney. Genes Chromosomes Cancer. 1995;12:76-80.
62. Fuzesi L, Cober M, Mittermayer C. Collecting duct carcinoma: cytogenetic characterization. Histopathology. 1992;21:155-160.
63. Selli C, Amorosi A, Vona G, et al. Retrospective evaluation of c-erbB-2 oncogene amplification using competitive PCR in collecting duct carcinoma of the kidney. J Urol. 1997;158:245-247. (Pubitemid 27251634)
64. Yang XJ, Sugimura J, Tretiakova MS, et al. Gene expression profiling of renal medullary carcinoma: potential clinical relevance. Cancer. 2004;100:976-985. (Pubitemid 38222858)
65. Simpson L, He X, Pins M, et al. Renal medullary carcinoma and ABL gene amplification. J Urol. 2005;173:1883-1888. (Pubitemid 40675203)
66. Stahlschmidt J, Cullinane C, Roberts P, et al. Renal medullary carcinoma: prolonged remission with chemotherapy, immunohistochemical characterisation and evidence of bcr/abl rearrangement. Med Pediatr Oncol. 1999;33:551-557.