메뉴 건너뛰기




Volumn 77, Issue 11, 2012, Pages 1050-1060

Development of a GC/C/IRMS method - Confirmation of a novel steroid profiling approach in doping control

Author keywords

Alternative steroid profiling; Doping control; Isotope ratio; Mass spectrometry; Method validation

Indexed keywords

5BETA ANDROSTANE 3ALPHA,17BETA DIOL; ANDROSTANEDIOL; ANDROSTANOLONE; ANDROSTERONE; CARBON; CARBON 13; ETIOCHOLANOLONE; PRASTERONE; PREGNANEDIOL; STEROID; TESTOCAPS; TESTOSTERONE; TESTOSTERONE UNDECANOATE; UNCLASSIFIED DRUG;

EID: 84865461826     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2012.05.009     Document Type: Article
Times cited : (22)

References (41)
  • 1
    • 0038342935 scopus 로고    scopus 로고
    • Anabolic steroids in sport: Biochemical, clinical and analytical perspectives
    • A.T. Kicman, and D.B. Gower Anabolic steroids in sport: biochemical, clinical and analytical perspectives Ann Clin Biochem 40 2003 321 356
    • (2003) Ann Clin Biochem , vol.40 , pp. 321-356
    • Kicman, A.T.1    Gower, D.B.2
  • 3
    • 77955842529 scopus 로고    scopus 로고
    • Australian Crime Commision, Canberra
    • Illicit Drug Data Report 2007-08. Australian Crime Commision, Canberra; 2009.
    • (2009) Illicit Drug Data Report 2007-08
  • 4
    • 44349157577 scopus 로고    scopus 로고
    • Pharmacology of anabolic steroids
    • A.T. Kicman Pharmacology of anabolic steroids Br J Pharmacol 154 2008 502 521
    • (2008) Br J Pharmacol , vol.154 , pp. 502-521
    • Kicman, A.T.1
  • 5
    • 78650632932 scopus 로고    scopus 로고
    • WADA reported by accredited laboratories. LaboStatistics: 2008
    • WADA. Adverse analytical findings and atypical findings, reported by accredited laboratories. LaboStatistics: 2008, 2008.
    • (2008) Adverse Analytical Findings and Atypical Findings
  • 6
    • 0024602910 scopus 로고
    • Studies on anabolic-steroids 1. Integrated methodological approach to the gas chromatographic-mass spectrometric analysis of anabolic-steroid metabolites in urine
    • R. Masse, C. Ayotte, and R. Dugal Studies on anabolic-steroids 1. Integrated methodological approach to the gas chromatographic-mass spectrometric analysis of anabolic-steroid metabolites in urine J Chromatogr-Biomed 489 1989 23 50
    • (1989) J Chromatogr-Biomed , vol.489 , pp. 23-50
    • Masse, R.1    Ayotte, C.2    Dugal, R.3
  • 7
    • 0029987681 scopus 로고    scopus 로고
    • Metabolism of anabolic androgenic steroids
    • W. Schanzer Metabolism of anabolic androgenic steroids Clin Chem 42 1996 1001 1020
    • (1996) Clin Chem , vol.42 , pp. 1001-1020
    • Schanzer, W.1
  • 8
    • 0023053503 scopus 로고
    • Profiling steroid-hormones and urinary steroids
    • C.H.L. Shackleton Profiling steroid-hormones and urinary steroids J Chromatogr 379 1986 91 156
    • (1986) J Chromatogr , vol.379 , pp. 91-156
    • Shackleton, C.H.L.1
  • 9
    • 33750032249 scopus 로고    scopus 로고
    • Metabolism and excretion of anabolic steroids in doping control - New steroids and new insights
    • P. Van Eenoo, and F.T. Delbeke Metabolism and excretion of anabolic steroids in doping control - new steroids and new insights J Steroid Biochem Mol Biol 101 2006 161 178
    • (2006) J Steroid Biochem Mol Biol , vol.101 , pp. 161-178
    • Van Eenoo, P.1    Delbeke, F.T.2
  • 10
    • 77955417836 scopus 로고    scopus 로고
    • Detection of the misuse of steroids in doping control
    • M.K. Parr, and W. Schänzer Detection of the misuse of steroids in doping control J Steroid Biochem Mol Biol 121 2009 528 537
    • (2009) J Steroid Biochem Mol Biol , vol.121 , pp. 528-537
    • Parr, M.K.1    Schänzer, W.2
  • 11
    • 56749156282 scopus 로고    scopus 로고
    • Validation of an extended method for the detection of the misuse of endogenous steroids in sports, including new hydroxylated metabolites
    • P. Van Renterghem, P. Van Eenoo, W. Van Thuyne, H. Geyer, W. Schänzer, and F.T. Delbeke Validation of an extended method for the detection of the misuse of endogenous steroids in sports, including new hydroxylated metabolites J Chromatogr B 876 2008 225 235
    • (2008) J Chromatogr B , vol.876 , pp. 225-235
    • Van Renterghem, P.1    Van Eenoo, P.2    Van Thuyne, W.3    Geyer, H.4    Schänzer, W.5    Delbeke, F.T.6
  • 12
    • 0032947661 scopus 로고    scopus 로고
    • Applied gas chromatography coupled to isotope ratio mass spectrometry
    • W. Meier-Augenstein Applied gas chromatography coupled to isotope ratio mass spectrometry J Chromatogr A 842 1999 351 371
    • (1999) J Chromatogr A , vol.842 , pp. 351-371
    • Meier-Augenstein, W.1
  • 13
    • 47749087836 scopus 로고    scopus 로고
    • The application of carbon isotope ratio mass spectrometry to doping control
    • A.T. Cawley, and U. Flenker The application of carbon isotope ratio mass spectrometry to doping control J Mass Spectrom 43 2008 854 864
    • (2008) J Mass Spectrom , vol.43 , pp. 854-864
    • Cawley, A.T.1    Flenker, U.2
  • 14
    • 79960562136 scopus 로고    scopus 로고
    • Recent developments in the use of isotope ratio mass spectrometry in sports drug testing
    • T. Piper, C. Emery, and M. Saugy Recent developments in the use of isotope ratio mass spectrometry in sports drug testing Anal Bioanal Chem 401 2011 433 447
    • (2011) Anal Bioanal Chem , vol.401 , pp. 433-447
    • Piper, T.1    Emery, C.2    Saugy, M.3
  • 16
    • 0034746535 scopus 로고    scopus 로고
    • C-13/C-12 isotope ratio MS analysis of testosterone, in chemicals and pharmaceutical preparations
    • J. Segura, X. de la Torre, J.C. Gonzalez, S. Pichini, and J.A. Pascual C-13/C-12 isotope ratio MS analysis of testosterone, in chemicals and pharmaceutical preparations J Pharmaceut Biomed 24 2001 645 650
    • (2001) J Pharmaceut Biomed , vol.24 , pp. 645-650
    • Segura, J.1    De La Torre, X.2    Gonzalez, J.C.3    Pichini, S.4    Pascual, J.A.5
  • 17
    • 0032760434 scopus 로고    scopus 로고
    • Analysis of exogenous dehydroepiandrosterone excretion in urine by gas chromatography/combustion/isotope ratio mass spectrometry
    • M. Ueki, and M. Okano Analysis of exogenous dehydroepiandrosterone excretion in urine by gas chromatography/combustion/isotope ratio mass spectrometry Rapid Commun Mass Sp 13 1999 2237 2243
    • (1999) Rapid Commun Mass Sp , vol.13 , pp. 2237-2243
    • Ueki, M.1    Okano, M.2
  • 18
    • 0030934910 scopus 로고    scopus 로고
    • Confirming testosterone administration by isotope ratio mass spectrometric analysis of urinary androstanediols
    • C.H.L. Shackleton, A. Phillips, T. Chang, and Y. Li Confirming testosterone administration by isotope ratio mass spectrometric analysis of urinary androstanediols Steroids 62 1997 379 387
    • (1997) Steroids , vol.62 , pp. 379-387
    • Shackleton, C.H.L.1    Phillips, A.2    Chang, T.3    Li, Y.4
  • 19
    • 0032949912 scopus 로고    scopus 로고
    • Screening urine for exogenous testosterone by isotope ratio mass spectrometric analysis of preganediol two rostanediols
    • R. Aguilera, D.H. Catlin, M. Becchi, A. Phillips, C. Wang, R.S. Swerdloff, H.G. Pope, and C.K. Hatton Screening urine for exogenous testosterone by isotope ratio mass spectrometric analysis of preganediol two rostanediols J Chromatogr B 727 1999 95 105
    • (1999) J Chromatogr B , vol.727 , pp. 95-105
    • Aguilera, R.1    Catlin, D.H.2    Becchi, M.3    Phillips, A.4    Wang, C.5    Swerdloff, R.S.6    Pope, H.G.7    Hatton, C.K.8
  • 20
    • 47349109119 scopus 로고    scopus 로고
    • Determination of 13C/12C ratios of endogenous urinary steroids: Method validation, reference population and application to doping control purposes
    • T. Piper, U. Mareck, H. Geyer, U. Flenker, M. Thevis, P. Platen, and W. Schänzer Determination of 13C/12C ratios of endogenous urinary steroids: method validation, reference population and application to doping control purposes Rapid Commun Mass Spectrom 22 2008 2161 2175
    • (2008) Rapid Commun Mass Spectrom , vol.22 , pp. 2161-2175
    • Piper, T.1    Mareck, U.2    Geyer, H.3    Flenker, U.4    Thevis, M.5    Platen, P.6    Schänzer, W.7
  • 21
    • 61349177869 scopus 로고    scopus 로고
    • Carbon isotope ratio ([delta]13C) values of urinary steroids for doping control in sport
    • A.T. Cawley, G.J. Trout, R. Kazlauskas, C.J. Howe, and A.V. George Carbon isotope ratio ([delta]13C) values of urinary steroids for doping control in sport Steroids 74 2009 379 392
    • (2009) Steroids , vol.74 , pp. 379-392
    • Cawley, A.T.1    Trout, G.J.2    Kazlauskas, R.3    Howe, C.J.4    George, A.V.5
  • 22
    • 39449140045 scopus 로고    scopus 로고
    • Delta-13 values of endogenous urinary steroids
    • U. Flenker, U. Güntner, and W. Schänzer Delta-13 values of endogenous urinary steroids Steroids 73 2008 408 416
    • (2008) Steroids , vol.73 , pp. 408-416
    • Flenker, U.1    Güntner, U.2    Schänzer, W.3
  • 23
    • 84865521271 scopus 로고    scopus 로고
    • WADA epitestosterone, T/E ratio and other endogenous steroids. Technical document TD2004EAAS
    • WADA. Reporting and evaluation Guidance for testosterone, epitestosterone, T/E ratio and other endogenous steroids. Technical document TD2004EAAS; 2004.
    • (2004) Reporting and Evaluation Guidance for Testosterone
  • 25
    • 61349184438 scopus 로고    scopus 로고
    • Steroid isotopic standards for gas chromatography-combustion isotope ratio mass spectrometry (GCC-IRMS)
    • Y. Zhang, H.J. Tobias, and J.T. Brenna Steroid isotopic standards for gas chromatography-combustion isotope ratio mass spectrometry (GCC-IRMS) Steroids 74 2009 369 378
    • (2009) Steroids , vol.74 , pp. 369-378
    • Zhang, Y.1    Tobias, H.J.2    Brenna, J.T.3
  • 27
    • 77957289290 scopus 로고    scopus 로고
    • Population based evaluation of a multi-parametric steroid profiling on administered prohormones in single low dose
    • P. Van Renterghem, P. Van Eenoo, and F.T. Delbeke Population based evaluation of a multi-parametric steroid profiling on administered prohormones in single low dose Steroids 75 2010 1047 1057
    • (2010) Steroids , vol.75 , pp. 1047-1057
    • Van Renterghem, P.1    Van Eenoo, P.2    Delbeke, F.T.3
  • 28
    • 77953441311 scopus 로고    scopus 로고
    • Determination of 13C/12C ratios of urinary epitestosterone and its main metabolites 5α- and 5β-androstane-3α, 17α-diol
    • T. Piper, P. Riemann, G. Opfermann, U. Mareck, H. Geyer, G. Vajiala, U. Flenker, and W. Schänzer Determination of 13C/12C ratios of urinary epitestosterone and its main metabolites 5α- and 5β-androstane- 3α, 17α-diol Drug Test Anal 1 2009 576 586
    • (2009) Drug Test Anal , vol.1 , pp. 576-586
    • Piper, T.1    Riemann, P.2    Opfermann, G.3    Mareck, U.4    Geyer, H.5    Vajiala, G.6    Flenker, U.7    Schänzer, W.8
  • 29
    • 78650669390 scopus 로고    scopus 로고
    • Subject-based steroid profiling and the determination of novel biomarkers for DHT and DHEA misuse in sports
    • P. Van Renterghem, P. Van Eenoo, P.E. Sottas, M. Saugy, and F.T. Delbeke Subject-based steroid profiling and the determination of novel biomarkers for DHT and DHEA misuse in sports Drug Test Anal 2 2010 582 588
    • (2010) Drug Test Anal , vol.2 , pp. 582-588
    • Van Renterghem, P.1    Van Eenoo, P.2    Sottas, P.E.3    Saugy, M.4    Delbeke, F.T.5
  • 30
    • 79958839781 scopus 로고    scopus 로고
    • A pilot study on subject-based comprehensive steroid profiling: Novel biomarkers to detect testosterone misuse in sports
    • P. Van Renterghem, P. Van Eenoo, P.-E. Sottas, M. Saugy, and F.T. Delbeke A pilot study on subject-based comprehensive steroid profiling: novel biomarkers to detect testosterone misuse in sports Clin Endocrinol 75 2011 134 140
    • (2011) Clin Endocrinol , vol.75 , pp. 134-140
    • Van Renterghem, P.1    Van Eenoo, P.2    Sottas, P.-E.3    Saugy, M.4    Delbeke, F.T.5
  • 33
    • 41149087196 scopus 로고    scopus 로고
    • Detection of dehydroepiandrosterone misuse by means of gas chromatography-combustion-isotope ratio mass spectrometry
    • U. Mareck, H. Geyer, U. Flenker, T. Piper, M. Thevis, and W. Schänzer Detection of dehydroepiandrosterone misuse by means of gas chromatography-combustion-isotope ratio mass spectrometry Eur J Mass Spectrom 13 2007 419 426
    • (2007) Eur J Mass Spectrom , vol.13 , pp. 419-426
    • Mareck, U.1    Geyer, H.2    Flenker, U.3    Piper, T.4    Thevis, M.5    Schänzer, W.6
  • 34
    • 67650170341 scopus 로고    scopus 로고
    • Validation and performance comparison of two carbon isotope ratio methods to control the misuse of androgens in humans
    • C. Saudan, C. Emery, F.O. Marclay, E. Strahm, P. Mangin, and M. Saugy Validation and performance comparison of two carbon isotope ratio methods to control the misuse of androgens in humans J Chromatogr B 877 2009 2321 2329
    • (2009) J Chromatogr B , vol.877 , pp. 2321-2329
    • Saudan, C.1    Emery, C.2    Marclay, F.O.3    Strahm, E.4    Mangin, P.5    Saugy, M.6
  • 35
    • 0001059923 scopus 로고    scopus 로고
    • Kinetic isotope effects during metabolism of 4-ene-steroids
    • Schänzer W, Geyer H, Gotzmann A, Mareck-Engelke U, editor Cologne, Sport & Buch Strauss
    • Flenker U, Schänzer W. Kinetic isotope effects during metabolism of 4-ene-steroids. In: Schänzer W, Geyer H, Gotzmann A, Mareck-Engelke U, editor. Proceedings of the 19th cologne workshop on dope analysis, Cologne, Sport & Buch Strauss; 2001.
    • (2001) Proceedings of the 19th Cologne Workshop on Dope Analysis
    • Flenker, U.1    Schänzer, W.2
  • 36
    • 12844272116 scopus 로고    scopus 로고
    • Isotopic fractionation of endogenous anabolic androgenic steroids and its relationship to doping control in sports
    • A.T. Cawley, R. Kazlauskas, G. Trout, J.H. Rogerson, and A.V. George Isotopic fractionation of endogenous anabolic androgenic steroids and its relationship to doping control in sports J Chromatogr Sci 43 2005 32 38
    • (2005) J Chromatogr Sci , vol.43 , pp. 32-38
    • Cawley, A.T.1    Kazlauskas, R.2    Trout, G.3    Rogerson, J.H.4    George, A.V.5
  • 37
    • 73449147864 scopus 로고    scopus 로고
    • 13C/12C Ratios of endogenous urinary steroids investigated for doping control purposes
    • T. Piper, U. Flenker, U. Mareck, and W. Schänzer 13C/12C Ratios of endogenous urinary steroids investigated for doping control purposes Drug Test Anal 1 2009 65 72
    • (2009) Drug Test Anal , vol.1 , pp. 65-72
    • Piper, T.1    Flenker, U.2    Mareck, U.3    Schänzer, W.4
  • 39
    • 0342673228 scopus 로고    scopus 로고
    • Effect of dehydroepiandrosterone on urinary steroids
    • R. Kazlauskas Effect of dehydroepiandrosterone on urinary steroids W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck-Engelke, Proceedings of the 15th cologne workshop on dope analysis 1998 Sport & Buch Strauβ Cologne 83 89
    • (1998) Proceedings of the 15th Cologne Workshop on Dope Analysis , pp. 83-89
    • Kazlauskas, R.1
  • 40
    • 78649407597 scopus 로고    scopus 로고
    • Determination of 13C/12C ratios of endogenous urinary steroids excreted as sulpho conjugates
    • T. Piper, G. Opfermann, M. Thevis, and W. Schänzer Determination of 13C/12C ratios of endogenous urinary steroids excreted as sulpho conjugates Rapid Commun Mass Spectrom 24 2010 3171 3181
    • (2010) Rapid Commun Mass Spectrom , vol.24 , pp. 3171-3181
    • Piper, T.1    Opfermann, G.2    Thevis, M.3    Schänzer, W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.