Loss of pulsatile insulin secretion: A factor in the pathogenesis of type 2 diabetes?

Diabetes

Volumn 61, Issue 9, 2012, Pages 2228-2229

  Wahren, John ^a   Kallas, Åsa ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; SOMATOSTATIN;

HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NOTE; PANCREAS DISEASE; PANCREAS ISLET BETA CELL; PANCREAS ISLET BETA CELL FAILURE; PATHOGENESIS; PRIORITY JOURNAL;

ANIMALS; DIABETES MELLITUS, TYPE 2; INSULIN; LIVER; MALE;

EID: 84865455703     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-0664     Document Type: Note

References (16)

1. Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell 2012;148:852-871
2. Leahy JL, Hirsch IB, Peterson KA, Schneider D. Targeting beta-cell function early in the course of therapy for type 2 diabetes mellitus. J Clin Endocrinol Metab 2010;95:4206-4216
3. Schofield CJ, Sutherland C. Disordered insulin secretion in the development of insulin resistance and type 2 diabetes. Diabet Med. 24 March 2012 [Epub ahead of print]
4. Pørksen N, Munn S, Steers J, Vore S, Veldhuis J, Butler P. Pulsatile insulin secretion accounts for 70% of total insulin secretion during fasting. Am J Physiol 1995;269:E478-E488
5. Hellman B, Salehi A, Gylfe E, Dansk H, Grapengiesser E. Glucose generates coincident insulin and somatostatin pulses and antisynchronous glucagon pulses from human pancreatic islets. Endocrinology 2009;150:5334-5340
6. Song SH, McIntyre SS, Shah H, Veldhuis JD, Hayes PC, Butler PC. Direct measurement of pulsatile insulin secretion from the portal vein in human subjects. J Clin Endocrinol Metab 2000;85:4491-4499 (Pubitemid 32157623)
7. Gylfe E, Grapengiesser E, Hellman B. Propagation of cytoplasmic Ca2+ oscillations in clusters of pancreatic beta-cells exposed to glucose. Cell Calcium 1991;12:229-240
8. Ahrén B. Autonomic regulation of islet hormone secretion-implications for health and disease. Diabetologia 2000;43:393-410 (Pubitemid 30237947)
9. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Betacell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003;52:102-110 (Pubitemid 36042113)
10. Stapelfeldt W, Bender H, Schusdziarra V, Pfeiffer EF. Effect of continuous and oscillatory portal vein insulin infusion upon glucose-induced insulin release in rats. Res Exp Med (Berl) 1984;184:67-71 (Pubitemid 14147582)
11. Temple RC, Carrington CA, Luzio SD, et al. Insulin deficiency in noninsulin-dependent diabetes. Lancet 1989;1:293-295
12. Gual P, Le Marchand-Brustel Y, Tanti JF. Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 2005;87:99-109 (Pubitemid 40298772)
13. Matveyenko AV, Liuwantara D, Gurlo T, et al. Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling. Diabetes 2012;61:2269-2279
14. Rosengren AH, Jokubka R, Tojjar D, et al. Overexpression of alpha2Aadrenergic receptors contributes to type 2 diabetes. Science 2010;327:217-220
15. O'Rahilly S, Turner RC, Matthews DR. Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes. N Engl J Med 1988;318:1225-1230
16. Mirbolooki MR, Taylor GE, Knutzen VK, Scharp DW, Willcourt R, Lakey JR. Pulsatile intravenous insulin therapy: the best practice to reverse diabetes complications? Med Hypotheses 2009;73:363-369