Optimization of designed armadillo repeat proteins by molecular dynamics simulations and NMR spectroscopy

Protein Science

Volumn 21, Issue 9, 2012, Pages 1298-1314

  Alfarano, Pietro ^a   Varadamsetty, Gautham ^a   Ewald, Christina ^a   Parmeggiani, Fabio ^a   Pellarin, Riccardo ^a   Zerbe, Oliver ^a   Plückthun, Andreas ^a   Caflisch, Amedeo ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Implicit solvent; Protein design; Repeat protein; Structural biology

Indexed keywords

ARMADILLO DOMAIN PROTEIN; GLUTAMINE; KARYOPHERIN ALPHA; LYSINE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPUTER MODEL; ENTROPY; HETERONUCLEAR NUCLEAR MAGNETIC RESONANCE; MELTING POINT; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN STABILITY; STATIC ELECTRICITY; THERMOSTABILITY;

ANIMALS; ARMADILLO DOMAIN PROTEINS; MICE; MOLECULAR DYNAMICS SIMULATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; REPETITIVE SEQUENCES, AMINO ACID; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; THERMODYNAMICS;

EID: 84865441090     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2117     Document Type: Article

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