Gomisin J from Schisandra chinensis induces vascular relaxation via activation of endothelial nitric oxide synthase

Vascular Pharmacology

Volumn 57, Issue 2-4, 2012, Pages 124-130

  Park, Ji Young ^a   Choi, Young Whan ^b   Yun, Jung Wook ^a   Bae, Jin Ung ^a   Seo, Kyo Won ^a   Lee, Seung Jin ^a   Park, So Youn ^a   Kim, Chi Dae ^a  

^a Pusan National University School of Medicine   (South Korea)

^b Pusan National University   (South Korea)

Author keywords

Endothelium; ENOS; Gomisin J; Nitric oxide; Vasorelaxation

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GOMISIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SCHISANDRA CHINENSIS EXTRACT; SERINE;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CORONARY ARTERY; CYTOSOL; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SCHISANDRA CHINENSIS; THORACIC AORTA; VASODILATATION;

ANIMALS; AORTA, THORACIC; CALCIUM; CORONARY VESSELS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; LIGNANS; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; POLYCYCLIC COMPOUNDS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SCHISANDRA; TIME FACTORS; VASODILATION;

EID: 84865433417     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2012.06.002     Document Type: Article

References (28)

1. β. J. Biol. Chem. 2001, 276:24153-24159.
2. Chen S.Y., Li F. Tonics and astringents. Clinical Guide to Chinese Herbs and Formulae 1993, 75. Churchill Livingstone, London. F. Diebschlag (Ed.).
3. Choi Y.W., Takamatsu S., Khan S.I., Srinivas P.V., Ferreira D., Zhao J., Khan I.A. Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. J. Nat. Prod. 2006, 69:356-359.
4. Dimmeler S., Fleming I., Fisslthaler B., Hermann C., Busse R., Zeiher A.M. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999, 399:601-605.
5. Fleming I. Molecular mechanisms underlying the activation of eNOS. Pflugers Arch. 2010, 459:793-806.
6. Fleming I., Busse R. Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2003, 284:R1-R12.
7. Fleming I., Bauersachs J., Busse R. Calcium-dependent and calcium-independent activation of the endothelial NO synthase. J. Vasc. Res. 1997, 34:165-174.
8. Fleming I., Fisslthaler B., Dimmeler S., Kemp B.E., Busse R. Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity. Circ. Res. 2001, 88:E68-E75.
9. Fujita S., Roerig D.L., Bosnjak Z.J., Stowe D.F. Effects of vasodilators and perfusion pressure on coronary flow and simultaneous release of nitric oxide from guinea pig isolated hearts. Cardiovasc. Res. 1998, 38:655-667.
10. Haug L.S., Jensen V., Hvalby O., Walaas S.I., Ostvold A.C. Phosphorylation of the inositol 1,4,5-triphosphate receptor by cyclic nucleotide-dependent kinases in vitro and in rat cerebellar slices in situ. J. Biol. Chem. 1999, 274:7467-7473.
11. Herman A.G., Moncada S. Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis. Eur. Heart J. 2005, 26:1945-1955.
12. Huang T., Shen P., Shen Y. Preparative separation and purification of deoxyschisandrin and γ-schisandrin from Schisandra chinensis (Turcz.) Baill by high-speed counter-current chromatography. J. Chromatogr. A 2005, 1066:239-242.
13. Ikeya T., Taquchi H., Yosioka I., Kobayashi H. The constituents of Schisandra chinensis Baill. I. Isolation and structure determination of five new lignans, gomisin A, B, C, F and G, and the absolute structure of schizandrin. Chem. Pharm. Bull. 1979, 27:1383-1394.
14. Kojima H., Sakurai K., Kikuchi K., Kawahara S., Kirino Y., Nagoshi H., Hirata Y., Nagano T. Development of a fluorescent indicator for nitric oxide based on the fluorescein chromophore. Chem. Pharm. Bull. 1998, 46:373-375.
15. Landmesser U., Drexler H. The clinical significance of endothelial dysfunction. Curr. Opin. Cardiol. 2005, 20:547-551.
16. Lu Y., Chen D.F. Analysis of Schisandra chinensis and Schisandra sphenanthera. J. Chromatogr. A 2009, 1216:1980-1990.
17. Marin J., Rodriguez-Martinez M.A. Role of vascular nitric oxide in physiological and pathological conditions. Pharmacol. Ther. 1997, 75:111-134.
18. Michel T., Feron O. Nitric oxide synthases: which, where, how, and why?. J. Clin. Invest. 1997, 100:2146-2152.
19. Oh S.Y., Kim Y.H., Bae D.S., Um B.H., Pan C.H., Kim C.Y., Lee H.J., Lee J.K. Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis. Biosci. Biotechnol. Biochem. 2010, 74:285-291.
20. Omura M., Kobayashi S., Mizukami Y., Mogami K., Todoroki-Ikeda N., Miyake T., Matsuzaki M. Eicosapentaenoic acid (EPA) induces Ca(2+)-independent activation and translocation of endothelial nitric oxide synthase and endothelium-dependent vasorelaxation. FEBS Lett. 2001, 487:361-366.
21. Park J.Y., Lee S.J., Yun M.R., Seo K.W., Bae S.S., Park J.W., Lee Y.J., Shin W.J., Choi Y.W., Kim C.D. Gomisin A from Schisandra chinensis induces endothelium-dependent and direct relaxation in rat thoracic aorta. Planta Med. 2007, 73:1537-1542.
22. Park J.Y., Shin H.K., Lee Y.J., Choi Y.W., Bae S.S., Kim C.D. The mechanism of vasorelaxation induced by Schisandra chinensis extract in rat thoracic aorta. J. Ethnopharmacol. 2009, 121:69-73.
23. Park J.Y., Shin H.K., Choi Y.W., Lee Y.J., Bae B.B., Han J., Kim C.D. Gomisin A induces Ca2+-dependent activation of eNOS in human coronary artery endothelial cells. J. Ethnopharmacol. 2009, 125:291-296.
24. Peng H.L., Chen D.F., Lan H.X., Zhang X.M., Gu Z., Jiang M.H. Anti-lipid peroxidation of gomisin J on liver mitochondria and cultured myocardial cells. Zhongguo Yao Li Xue Bao 1996, 17:538-541.
25. Rapoport R.M., Murad F. Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ. Res. 1983, 52:352-357.
26. β. Nature 2000, 404:197-201.
27. Seok Y.M., Choi Y.W., Kim G.D., Kim H.Y., Takuwa Y., Kim I.K. Effects of gomisin A on vascular contraction in rat aortic rings. Naunyn Schmiedebergs Arch. Pharmacol. 2011, 383:45-56.
28. Yoshikawa A., Saito Y., Maruyama K. Lignan compounds and 4,4'-dihydroxybiphenyl protect C2C12 cells against damage from oxidative stress. Biochem. Biophys. Res. Commun. 2006, 344:394-399.