Mechanisms underlining gender differences in Phenylephrine contraction of normoglycaemic and short-term Streptozotocin-induced diabetic WKY rat aorta

Vascular Pharmacology

Volumn 57, Issue 2-4, 2012, Pages 81-90

  Aloysius, U I ^a,c   Achike, F I ^b,c   Mustafa, M R ^c  

^a UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^b INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

^c UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Diabetes; Endothelium; Gender; Nitric oxide; Oestradiol; Phenylephrine; Prostaglandins

Indexed keywords

ACETYLCHOLINE; CYCLIC GMP; ESTRADIOL; INDOMETACIN; METHYLENE BLUE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PHENYLEPHRINE; PROSTACYCLIN; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; THROMBOXANE A2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; STREPTOZOCIN DIABETES; VASOCONSTRICTION; VASODILATATION; WISTAR KYOTO RAT;

ACETYLCHOLINE; ANIMALS; AORTA, THORACIC; DIABETES MELLITUS, EXPERIMENTAL; EPOPROSTENOL; ESTRADIOL; FEMALE; INDOMETHACIN; MALE; MUSCLE CONTRACTION; PHENYLEPHRINE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, INBRED WKY; SEX FACTORS; STREPTOZOCIN; VASOCONSTRICTOR AGENTS;

EID: 84865424248     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2011.11.009     Document Type: Article

References (42)

1. 1-adrenoceptor stimulation in the absence and presence of extracellular calcium. J. Cardiovasc. Pharmacol. 1990, 16(2):239-248.
2. Ajay M., Achike F.I., Mustafa A.M., Mustafa M.R. Effect of quercetin on altered vascular reactivity in aortas isolated from STZ-induced diabetic rats. Diabetes Res. Clin. Pract. 2006, 73:1-7.
3. Ajay M., Achike F.I., Mustafa A.M., Mustafa M.R. Quercetin, a flavonoid antioxidant, modulates endothelium-derived nitric oxide bioavailability in diabetic rat aortas. Nitric Oxide 2007, 16:442-447.
4. Alosachie I., Godfraind T. The modulatory role of vascular endothelium in the interaction of agonists and antagonists with alpha-adrenoceptors in the rat aorta. Br. J. Pharmacol. 1988, 95(2):619-629.
5. Barrett-Conner E.L., Cohn B.A., Wingard D.L., Edelstein S.L. Why is diabetes mellitus a stronger risk factor for a fatal ischemic heart disease in women than in men?. J. Am. Med. Assoc. 1991, 265:627-631.
6. Bell R.H., Hye R.J. Animal models of diabetes mellitus: physiology and pathology. J. Surg. Res. 1983, 35:433-460.
7. Binko J., Majweski H. 17β-oestradiol reduces vasoconstriction in endothelium-denuded rat aortas through inducible NOS. Am. J. Physiol. Heart Circ. Physiol. 1998, 274:853-859.
8. Bolego C., Cignarella A., Zancan V., Pinna C., Zanardo R., Puglisi L. Diabetes abolishes the vascular protective effects of estrogen in female rats. Life Sci. 1999, 64:741-749.
9. Browne D.L., Meekings D.R., Allard S., Munday L.J., Shaw K.M., Cumming M.H. Vasodilator prostanoids compensate for attenuated nitric oxide mediated vasodilatation in type 1 diabetes. Br. J. Diab. Vasc. Dis. 2007, 7:288.
10. Chang K.S., Stevens W.C. Endothelium-dependent increase in vascular sensitivity to Phenylephrine in long-term Streptozotocin diabetic rat aorta. Br. J. Pharmacol. 1992, 107:983-990.
11. Chin L.C., Achike F.I., Mustafa M.R. Hydrogen peroxide modulates Angiotensin II-induced contraction of mesenteric arteries from Streptozotocin-induced diabetic rats. Vasc. Pharmacol. 2007, 46:223-228.
12. Csanyi G., Lepran L., Flesch T., Telegdy G., Gyula S., Mezei Z. Lack of endothelium-derived hyperpolarizing factor (EDHF) up-regulation in endothelial dysfunction in aorta in diabetic rats. Pharmacol. Rep. 2007, 59:447-455.
13. 1-agonist-induced vasoconstriction in diabetes. J. Surg. Res. 1997, 70:119-123.
14. Hayashi T., Fukuto J.M., Ignarro L.J., Chaudhuri G. Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis. Proc. Natl. Acad. Sci. 1992, 89:11259-11263.
15. Head R.J., Longhurst P.A., Panek R.L., Stitzel R.E. A contrasting effect of the diabetic state upon the contractile responses of aortic preparations from the rat and rabbit. Br. J. Pharmacol. 1987, 91(2):275-286.
16. Kauser K., Rubanyi G.M. Gender difference in bioassayable endothelium-derived nitric oxide from isolated rat aortae. Am. J. Physiol. 1994, 267:H2311-H2317.
17. Kim N.N., Stankovic M., Cushman T.T., Goldstein I., Munarriz R., Traish A.M. Streptozotocin-induced diabetes in the rat is associated with changes in vaginal hemodynamics, morphology and biochemical markers. BMC Physiol. 2006, 6:4.
18. Lam J.Y.T., Chesebro J.H., Badimon L., Fuster V. Exogenous prostacyclin decreases vasoconstriction but not platelet thrombus deposition after arterial injury. J. Am. Coll. Cardiol. 1993, 21:488-492.
19. Li Z., Krause D.N., Doolen S., Duckles S.P. Ovariectomy eliminates sex differences in rat tail artery response to adrenergic nerve stimulation. Am. J. Physiol. Heart Circ. Physiol. 1997, 272:1819-1825.
20. Maggi A., Cignarella A., Brusadelli A., Bolego C., Pinna C., Puglisi L. Diabetes undermines estrogen control of inducible nitric oxide synthase function in rat aortic smooth muscle cells through overexpression of estrogen receptor-β. Circulation 2003, 108:211-217.
21. Mendelssohn M.E., Karas R.H. Mechanisms of disease: the protective effects of estrogen on the cardiovascular system. N. Engl. J. Med. 1999, 340:1801-1811.
22. Miller V.M., Vanhoutte P.M. 17β-Estradiol augments endothelium-dependent contractions to arachidonic acid in rabbit aorta. Am. J. Physiol. 1990, 258:R1502-R1507. (Regulatory Integrative Comp. Physiol.).
23. Misurski D.A., Hopfner R.L., Gopalakrishnan V. Attenuated agonist evoked vasoconstrictor responses in the perfused mesenteric vascular bed of Streptozotocin diabetic rats. Exp. Biol. Med. 2001, 226:940-946.
24. Mulhern M., Docherty J.R. Effects of experimental diabetes on the responsiveness of rat aorta. Br. J. Pharmacol. 1989, 97:1007-1012.
25. Muscara M.N., McKnight W., Asfaha S., Wallace J.L. Wound collagen deposition in rats: effects of an NO-NSAID and a selective COX-2 inhibitor. Br. J. Pharmacol. 2000, 129:681-686.
26. Myers T.O., Messina E.J. Depressed arteriolar responsiveness to norepinephrine in Streptozotocin-induced diabetes in the rat. Prostaglandins 1996, 52:415-430.
27. Nadarali E.K., Smith S.L., Dolye P.J., Williams G. Vasorelaxant effects of oestradiols on guinea pigs: a role for gender differences. Eur. J. Clin. Investig. 2001, 31:215-220.
28. Orshal J.M., Khalil R.K. Gender, sex hormones, and vascular tone. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004, 286:233-249.
29. Pieper G.M. Review of alterations in endothelial nitric oxide production in diabetes: protective role of arginine on endothelial dysfunction. Hypertension 1998, 31:1047-1069.
30. Pieper G.M. Enhanced, unaltered and impaired nitric oxide-mediated endothelium-dependent relaxation in experimental diabetes mellitus: importance of disease duration. Diabetologia 1999, 42:204-213.
31. Pinna C., Cignarella A., Zanardo R., Bolego C., Puglisi L. Gender differences and antioxidant treatment affect aortic reactivity in short-term diabetic rats. Eur. J. Pharmacol. 2001, 431:71-79.
32. Robert R., Chagneau-Derrode C., Carretier M., Mauco G., Silvain C. Gender differences in vascular reactivity of aortas from rats with and without portal hypertension. J. Gastroenterol. Hepatol. 2005, 20(6):890-894.
33. Rolland P.H., Jouve R., Pellegrin E., Mercier C., Serradimigni A. Alteration in prostacyclin and prostaglandin E2 production: correlation with changes in human aortic atherosclerotic disease. Arteriosclerosis 1984, 4:70-78.
34. Sanchez A., Gomez M.J., Dorantes A.L., Rosales J.L., Pastelín G., Diaz V., Posadas F., Escalante B. The effect of ovariectomy on depressed contractions to Phenylephrine and KCl and increased relaxation to Acetylcholine in isolated aortic rings of female compared to male rabbits. Br. J. Pharmacol. 1996, 118(8):2017-2022.
35. Sanz E., Fernandez N., Monge L., Martinez M.A., Climent B., Dieguez G., Villalon A.L. Effects of diabetes on the vascular response to nitric oxide and constrictor prostanoids: gender and regional differences. Life Sci. 2003, 72:1537-1547.
36. Stallone J.N., Crofton J.T., Share L. Sexual dimorphism in vasopressin-induced contraction of rat aorta. Am. J. Physiol. Heart Circ. Physiol. 1991, 260:453-458.
37. Stampfer M.J., Colditz G.A. Estrogen replacement therapy and coronary heart disease: a quantitative assessment of the epidemiologic evidence. Prev. Med. 1991, 20:47-63.
38. Teoh H., Quan A., Leung S.W.S., Man R.Y.K. Differential effects of 17β-estradiol and testosterone on the contractile responses of porcine coronary arteries. Br. J. Pharmacol. 2000, 129:1301-1308.
39. Tep-Areenan P., Kendall D.A., Randall M.D. Vasorelaxation to 17β-oestradiol in aortic rings from male and female rats. Eur. J. Pharmacol. 2003, 476:139-149.
40. Thomas G., Ito K., Zikic E., Bhatti T., Han C., Ramwell P. Specific inhibition of the contraction of the rat aorta by 17β-estradiol. J. Pharmacol. Exp. Ther. 1995, 273:1544-1550.
41. Wallace J.L., Chapman K., McKnight W. Limited anti-inflammatory efficacy of cyclo-oxygenase-2 inhibition in carrageenan-airpouch inflammation. Br. J. Pharmacol. 1999, 126:1200-1204.
42. Yamamoto Y., Kamiya K., Terao S. Modeling of human Thromboxane A2 receptor and analysis of the receptor-ligand interaction. J. Med. Chem. 1993, 36:820-825.