S1, a novel pan-BH3 mimetic, induces apoptosis in Mcl-1-overexpressing cells through bak

Journal of Pharmacological Sciences

Volumn 119, Issue 4, 2012, Pages 330-340

  Song, Ting ^a,b,c   Chang, Xilong ^c   Zhang, Zhichao ^a   Liu, Yubo ^c   Shen, Xiaoyun ^c  

^a School of Chemistry   (China)

^b PEKING UNIVERSITY   (China)

^c DALIAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Bak; Bax; Bcl 2 Mcl 1 dual inhibitor; BH3 mimetic; Mcl 1 dynamics

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; BH3 PROTEIN; BIM PROTEIN; CASPASE; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; PROTEASOME; PROTEIN BAK; PROTEIN BCL 2; PROTEIN MCL 1; SHORT HAIRPIN RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL ASSAY; CELL PROTECTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG MEGADOSE; DRUG PROTEIN BINDING; DRUG RESISTANCE; DRUG SENSITIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MALE; MOLECULAR INTERACTION; MONOTHERAPY; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN STABILITY; TUMOR XENOGRAFT;

EID: 84865422232     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.12103FP     Document Type: Article

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