Comparative study of blood collection tubes and thromboplastin reagents for correction of INR discrepancies: A proposal for maximum allowable magnesium contamination in sodium citrate anticoagulant solutions

American Journal of Clinical Pathology

Volumn 138, Issue 2, 2012, Pages 248-254

  Van Den Besselaar, Anton M H P ^a   Van Zanten, Anton P ^b   Brantjes, Helen M ^c   Elisen, Marc G L M ^d,e   Van Der Meer, Felix J M ^a,f   Poland, Dennis C W ^b,g   Sturk, Augueste ^h   Leyte, Anja ^e   Castel, Ad ⁱ  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b SLOTERVAART HOSPITAL   (Netherlands)

^c BovenIJ Ziekenhuis   (Netherlands)

^d Medical Center Zuiderzee   (Netherlands)

^e Onze Lieve Vrouwe Gasthuis ^*  (Netherlands)

^f Thrombosis Service Leiden   (Netherlands)

^g Amsterdam Thrombosis Service   (Netherlands)

^h UNIVERSITY OF AMSTERDAM   (Netherlands)

ⁱ MEDICAL CENTER HAAGLANDEN   (Netherlands)

Author keywords

Anticoagulant; Blood collection tubes; Calibration; Contamination; International normalized ratio; Prothrombin time

Indexed keywords

ACENOCOUMAROL; CITRATE SODIUM; FRESH FROZEN PLASMA; MAGNESIUM; PHENPROCOUMON; THROMBOPLASTIN;

ANTICOAGULATION; ARTICLE; BLOOD SAMPLING; COMPARATIVE STUDY; CONTAINER; CONTAMINATION; HUMAN; INTERNATIONAL NORMALIZED RATIO; PRIORITY JOURNAL; PROTHROMBIN TIME;

ANTICOAGULANTS; BLOOD SPECIMEN COLLECTION; CALIBRATION; CITRATES; DRUG CONTAMINATION; HUMANS; INDICATORS AND REAGENTS; INTERNATIONAL NORMALIZED RATIO; MAGNESIUM; MEDICAL LABORATORY SCIENCE; NETHERLANDS; PROTHROMBIN TIME; SOLUTIONS; THROMBOPLASTIN; VITAMIN K;

EID: 84865420588     PISSN: 00029173     EISSN: 19437722     Source Type: Journal    
DOI: 10.1309/AJCPGSB5YPJRREEV     Document Type: Article

References (12)

1. WHO Expert Committee on Biological Standardization Guidelines for thromboplastins and plasma used to control oral anticoagulant therapy. WHO Technical Report Series no. 889 Geneva, Switzerland: World Health Organization; 1999:64-93.
2. Loeliger EA, Van Dijk-Wierda CA, van den Besselaar AMHP, et al. Anticoagulant control and the risk of bleeding. In: Meade TW, ed. Anticoagulants and Myocardial Infarction: A Reappraisal New York, NY: John Wiley & Sons; 1984:135-177.
3. Keeling D, Baglin T, Tait C, et al. Guidelines on oral anticoagulation with warfarin: fourth edition. Br J Haematol. 2011;154:311-224.
4. van den Besselaar AMHP, Barrowcliffe TW, Houbouyan-Reveillard LL, et al. Guidelines on preparation, certification, and use of certified plasmas for ISI calibration and INR determination. J Thromb Haemost 2004;2:1946-1953. (Pubitemid 40192748)
5. Clinical and Laboratory Standards Institute. Procedures for Validation of INR and Local Calibration of PT/INR Systems: Approved Guideline Wayne, PA: Clinical and Laboratory Standards Institute; 2005;25(23).
6. Bland JM, Altman DG. Comparing methods of measurement: why plotting difference against standard method is misleading. Lancet 1995;346:1085-1087.
7. Tomenson JA. A statistician's independent evaluation. In: van den Besselaar AMHP, Gralnick HR, Lewis SM, eds. Thromboplastin Calibration and Oral Anticoagulant Control Boston, MA: Martinus Nijhoff Publishers; 1984:87-108.
8. van den Besselaar AMHP, Witteveen E, Meeuwisse-Braun J, et al. The influence of exogenous magnesium chloride on the apparent INR determined with human, rabbit, and bovine thromboplastin reagents. Thromb Haemost 2003;89:43-47. (Pubitemid 36149791)
9. van den Besselaar AMHP. Magnesium and manganese ions accelerate tissue factor-induced coagulation independently of factor IX. Blood Coagul Fibrinolysis. 2002;13:19-23.
10. van den Besselaar AMHP, Hoekstra MMCL, Witteveen E, et al. Influence of blood collection systems on the prothrombin time and international sensitivity index determined with human and rabbit thromboplastin reagents. Am J Clin Pathol 2007;127:724-729.
11. van den Besselaar AMHP, Rutten WPF, Witteveen E. Effect of magnesium contamination in evacuated blood collection tubes on the prothrombin time test and ISI calibration using recombinant human thromboplastin and different types of coagulometer. Thromb Res. 2005;115:239-244. (Pubitemid 40029681)
12. Gogstad GO, Wadt J, Smith P, et al. Utility of a modified calibration model for reliable conversion of thromboplastin times to international normalized ratios. Thromb Haemost. 1986;56:178-182. (Pubitemid 17178794)