Plasma BDNF and PDGF-AA levels are associated with high TCD velocity and stroke in children with sickle cell anemia

Cytokine

Volumn 60, Issue 1, 2012, Pages 302-308

  Hyacinth, Hyacinth I ^a   Gee, Beatrice E ^a   Adamkiewicz, Thomas V ^a   Adams, Robert J ^b   Kutlar, Abdullah ^c   Stiles, Jonathan K ^a   Hibbert, Jacqueline M ^a  

^a MOREHOUSE SCHOOL OF MEDICINE   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Biomarkers; Cerebral ischemia; Sickle cell anemia; Stroke; Trans cranial Doppler

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; PLATELET DERIVED GROWTH FACTOR AA; PLATELET DERIVED GROWTH FACTOR AB; PLATELET DERIVED GROWTH FACTOR BB;

ADOLESCENT; ARTICLE; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOPPLER ECHOGRAPHY; FEMALE; HUMAN; MALE; PREDICTIVE VALUE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RECEIVER OPERATING CHARACTERISTIC; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; SICKLE CELL ANEMIA;

ANALYSIS OF VARIANCE; ANEMIA, SICKLE CELL; BIOLOGICAL MARKERS; BLOOD FLOW VELOCITY; BRAIN-DERIVED NEUROTROPHIC FACTOR; CEREBROVASCULAR CIRCULATION; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; CYTOKINES; FEMALE; HUMANS; MALE; PLATELET-DERIVED GROWTH FACTOR; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS C-SIS; STROKE; ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL;

EID: 84865416509     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2012.05.017     Document Type: Article

References (45)

1. Pauling L., Itano H.A., Singer S.J., Wells I.C. Sickle cell anemia, a molecular disease. Science 1949, 110:543-548.
2. Aster J.C. Disease of organs systems: red blood cells and bleeding disorders - sickle cell disease. Robins and Cotran's pathologic basis of disease 2005, 628-632. Elselvier Saunders, Philadelphia. 7 Ed. K. Vinay, N. Fausto, A.K. Abbas (Eds.).
3. Woods D.H. Cerebrovascular complications of sickle cell anemia. Stroke 1978, 9:73-75.
4. Ohene-Frempong K., Weiner S.J., Sleeper L.A., et al. Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood 1998, 91:288-294.
5. Merkel K., Ginsberg P., Parker J., Post M. Cerebrovascular disease in sickle cell anemia: a clinical, pathological and radiological correlation. Stroke 1978, 9:45-52.
6. Bridgers W.H. Cerebral vascular disease accompanying sickle cell anemia. Am J Pathol 1939, 15:353-365.
7. Boros L., Thomas C., Weiner W.J. Large cerebral vessel disease in sickle cell anaemia. J Neurol, Neurosurg Psychiatry 1976, 39:1236-1239.
8. Yalçin H., Melek I., Okuyucu E., et al. Sickle cell disease with regional silent cerebral infarction detected by SPECT. Clin Nucl Med 2007, 32:842-843.
9. DeBaun M.R., Schatz J., Siegel M.J., et al. Cognitive screening examinations for silent cerebral infarcts in sickle cell disease. Neurology 1998, 50:1678-1682.
10. Schatz J., Brown R.T., Pascual J.M., Hsu L., DeBaun M.R. Poor school and cognitive functioning with silent cerebral infarcts and sickle cell disease. Neurology 2001, 56:1109-1111.
11. Bruce N., Pope D., Stanistreet D.L. Prevention strategies and evaluation of screening. Quantitative methods for health research: a practical interactive guide to epidemiology and statistics 2008, 433-470. John Wiley & Sons, Chichester. N. Bruce, D. Pope, D.L. Stanistreet (Eds.).
12. Wiznitzer M., Ruggieri P.M., Masaryk T.J., Ross J.S., Modic M.T., Berman B. Diagnosis of cerebrovascular disease in sickle cell anemia by magnetic resonance angiography. J Pediatr 1990, 117:551-555.
13. Adams R.J., McKie V.C., Hsu L., et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med 1998, 399:5-11.
14. Asare K., Gee B.E., Stiles J.K., et al. Plasma interleukin-1β concentration is associated with stroke in sickle cell disease. Cytokine 2010, 49:39-44.
15. Heldin C.H. Structural and functional studies on platelet derived growth factor. EMBO J 1992, 11:4251-4259.
16. Lindholm D., Dechant G., Heisenberg C.-P., Thoenen H. Brain derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate-induced neurotoxicity. Eur J Neurosci 1993, 5:1455-1464.
17. Schabitz W.-R., Sommer C., Zoder W., et al. Intravenous brain derived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia. Stroke 2000, 31:2212-2217.
18. Ernfors P., Ibáñez C.F., Ebendal T., Olson L., Persson H. Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain. Proc Natl Acad Sci 1990, 87:5454-5458.
19. Hohn A., Leibrock J., Bailey K., Barde Y.-A. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature 1990, 344:339-341.
20. Isackson P.J., Huntsman M.M., Murray K.D., Gall C.M. BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF. Neuron 1991, 6:937-948.
21. Bovolenta R., Zucchini S., Paradiso B., et al. Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures. J Neuroinflamm 2010, 7:81.
22. Schabitz W.-R., Schwab S., Spranger M., Hacke W. Intraventricular brain derived neurotrophic factor size after focal cerebral ischemia in rats. J Cereb Blood Flow Metab 1997, 17:500-506.
23. Hart C.E., Bailey M., Curtis D.A., et al. Purification of PDGF-AB and PDGF-BB from human platelet extracts and identification of all three PDGF dimers in human platelets. Biochemistry 1990, 29:166-172.
24. Inaba T., Shimano H., Gotoda T., et al. Expression of platelet derived growth factor β receptor on human monocyte-derived macrophages and effects of platelet derived growth factor BB dimer on the cellular function. J Biol Chem 1993, 268:24353-24360.
25. Tanizawa S., Ueda M., Van Der Loos C.M., Van Der Wal A.C., Becker A.E. Expression of platelet derived growth factor B chain and β receptor in human coronary arteries after percutaneous transluminal coronary angioplasty: an immunohistochemical study. Heart 1996, 75:549-556.
26. Elaine W.R. PDGF and cardiovascular disease. Cytokine Growth Factor Rev 2004, 15:237-254.
27. Mondy J.S., Lindner V., Miyashiro J.K., Berk B.C., Dean R.H., Geary R.L. Platelet derived growth factor ligand and receptor expression in response to altered blood flow in vivo. Circ Res 1997, 81:320-327.
28. Niu X., Nouraie M., Campbell A., et al. Angiogenic and inflammatory markers of cardiopulmonary changes in children and adolescents with sickle cell disease. PLoS One 2009, 11:e7956.
29. Sachinidis A., Locher R., Hoppe J., Vetter W. The platelet derived growth factor isomers, PDGF-AA, PDGF-AB and PDGF-BB, induce contraction of vascular smooth muscle cells by different intracellular mechanisms. FEBS Lett 1990, 275:95-98.
30. Raghupathy R., Manwani D., Little J.A. Iron overload in sickle cell disease. Adv Hematol 2010, 1-9.
31. Stroobant N., Vingerhoets G. Transcranial Doppler ultrasonography monitoring of cerebral hemodynamics during performance of cognitive tasks: a review. Neuropsychol Rev 2000, 10:213-231.
32. Ferrer I., Krupinski J., Goutan E., Martí E., Ambrosio S., Arenas E. Brain derived neurotrophic factor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat. Acta Neuropathol 2001, 101:229-238.
33. Yamashita K., Wiessner C., Lindholm D., Thoenen H., Hossmann K.A. Post-occlusion treatment with BDNF reduces infarct size in a model of permanent occlusion of the middle cerebral artery in rat. Metab Brain Dis 1997, 12:271-280.
34. Santhanam A.V.R., Smith L.A., Katusic Z.S. Brain derived neurotrophic factor stimulates production of prostacyclin in cerebral arteries. Stroke 2010, 41:350-356.
35. Kauer-Sant'Anna M., Kapczinski F., Andreazza A.C., et al. Brain-derived neurotrophic factor and inflammatory markers in subjects with early vs. late-stage bipolar disorder. Int J Neuropsychopharmacol 2009, 12:447-458.
36. Bilbo S.D., Barrientos R.M., Eads A.S., et al. Early-life infection leads to altered BDNF and IL-1β mRNA expression in rat hippocampus following learning in adulthood. Brain Behav Immun 2008, 22:451-455.
37. Makar T.K., Trisler D., Sura K.T., Sultana S., Patel N., Bever C.T. Brain derived neurotrophic factor treatment reduces inflammation and apoptosis in experimental allergic encephalomyelitis. J Neurol Sci 2008, 270:70-76.
38. Jiang Y., Wei N., Lu T., Zhu J., Xu G., Liu X. Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats. Neuroscience 2011, 172:398-405.
39. Hibbert J.M., Hsu L.L., Bhathena S.J., et al. Proinflammatory cytokines and the hypermetabolism of children with sickle cell disease. Exp Biol Med 2005, 230:68-74.
40. Hebbel R.P., Osarogiagbon R., Kaul D. The endothelial biology of sickle cell disease: inflammation and chronic vasculopathy. Microcirculation 2004, 11:129-151.
41. Hannink M., Donoghue D.J. Structure and function of platelet derived growth factor and related proteins. Biochim Biophy Acta 1989, 989:1-10.
42. Prohovnik I., Hurlet-Jensen A., Adams R.J., De Vivo D., Pavlakis S.G. Hemodynamic etiology of elevated flow velocity and stroke in sickle-cell disease. J Cereb Blood Flow Metab 2009, 29:803-810.
43. Nahavandi M., Tavakkoli F., Hasan S.P., Wyche M.Q., Castro O. Cerebral oximetry in subjects with sickle cell disease. Eur J Clin Invest 2004, 34:143-148.
44. Khachigian L.M., Anderson K.R., Halnon N.J., Gimbrone M.A., Resnick N., Collins T. Egr-1 is activated in endothelial cells exposed to fluid shear stress and interacts with a novel shear-stress-response element in the PDGF A-Chain promoter. Arterioscler Thromb Vasc Biol 1997, 17:2280-2286.
45. Bos R., Van Diest P.J., De Jong J.S., Van Der Groep P., Van Der Valk P., Van Der Wall E. Hypoxia-inducible factor-1α is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer. Histopathology 2005, 46:31-36.