The reference dose for subchronic exposure of pigs to cadmium leading to early renal damage by benchmark dose method

Toxicological Sciences

Volumn 128, Issue 2, 2012, Pages 524-531

  Wu, Xiaosheng ^a,b   Wei, Shuai ^a   Wei, Yimin ^a   Guo, Boli ^a   Yang, Mingqi ^b   Zhao, Duoyong ^a   Liu, Xiaoling ^a   Cai, Xianfeng ^a  

^a AGRO ENVIRONMENTAL PROTECTION INSTITUTE   (China)

^b NORTHWEST A F UNIVERSITY   (China)

Author keywords

Benchmark dose; Biomarkers; Cadmium; Renal dysfunction; Subchronic exposure

Indexed keywords

ALPHA 1 MICROGLOBULIN; BETA 2 MICROGLOBULIN; CADMIUM; CALCIUM CHLORIDE; METALLOTHIONEIN; N ACETYL BETA GLUCOSAMINIDASE; RETINOL BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CHRONICITY; CONTROLLED STUDY; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; HEALTH HAZARD; KIDNEY DYSFUNCTION; NEPHROTOXICITY; NONHUMAN; QUALITY CONTROL; REFERENCE VALUE; SWINE; URINE LEVEL; WEIGHT GAIN;

ACETYLGLUCOSAMINIDASE; ALPHA-GLOBULINS; ANIMALS; BETA 2-MICROGLOBULIN; CADMIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; KIDNEY; RETINOL-BINDING PROTEINS; SWINE;

EID: 84865389276     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs173     Document Type: Article

References (37)

1. Åkesson, A., Lundh, T., Vahter, M., Bjellerup, P., Lidfeldt, J., Nerbrand, C., Samsioe, G., Stromberg, U., and Skerfving, S. (2005). Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure. Environ. Health Perspect. 113, 1627-1631.
2. Amzal, B., Julin, B., Vahter, M., Wolk, A., Johanson, G., and Åkesson, A. (2009). Population toxicokinetic modeling of cadmium for health risk assessment. Environ. Health Perspect. 117, 1293-1301.
3. Aoyagi, T., Hayakawa, K., Miyaji, K., Ishikawa, H., and Hata, M. (2003). Cadmium nephrotoxicity and evacuation from the body in a rat modeled subchronic intoxication. Int. J. Urol. 10, 332-338.
4. Bernard, A., Roels, H., Buchet, J. P., Cardenas, A., and Lauwerys, R. (1992). Cadmium and health: The Belgian experience. IARC Sci. Publ. 118, 15-33.
5. Brzoska, M. M., Kaminski, M., Supermak-Bobko, D., Zwierz, K., and Moniuszko-Jakoniuk, J. (2003). Changes in the structure and function of the kidney of rats chronically exposure to cadmium. Arch. Toxicol. 77, 344-352.
6. Chen, L., Jin, T. Y., Huang, B., Nordberg, G., and Nordberg, M. (2006). Critical exposure level of cadmium for elevated urinary metallothionein-An occupational population study in China. Toxicol. Appl. Pharmacol. 215, 93-99.
7. Crump, K. S. (1984). A new method for determining allowable daily intakes. Fundam. Appl. Toxicol. 4, 854-871.
8. EFSA (2009). Scientific opinion of the panel on contaminants in the food chain on a request from the European Commission on cadmium in food. EFSAJ 980, 1-139.
9. EFSA (2009). Scientific opinion, use of the benchmark dose approach in risk assessment, and guidance of the scientific commitee. EFSAJ 1150, 1-72.
10. Eugenio, F. B. (2008). Are more restrictive food cadmium standards justifiable health safety measures or opportunistic barriers to trade? An answer from economics and public health. Sci. Total Environ. 389, 1-9.
11. Feng, S. T., Chu, W. J., and Wang, Y. C. (1999). China Wuzhishan Pig (in Chinese). China Agricultural Science and Technology Press, Beijing, China, pp. 30-50.
12. Hogevorst, J., Plusquin, M., Vangronsveld, J., Nawrot, T., Cuypers, A., Van H. E., Roels,H. A., Carleer, R., and Staessen, J. A. (2006). House dust as possible route of environmental exposure to cadmium and lead in the adult general population. Environ. Res. 5, 9-17.
13. Hong, F., Jin, T. Y., and Zhang, A. (2004). Risk assessment on renal dysfunction caused by co-exposure to arsenic and cadmium using benchmark dose calculation in a Chinese population. BioMetals 17, 573-580.
14. Järup, L. (2003). Hazards of heavy metal contamination. Br. Med. Bull. 68, 167-182.
15. Järup, L., and Åkesson, A. (2009). Current status of cadmium as an environmental health problem. Toxicol. Appl. Pharmacol. 238, 201-208.
16. Järup, L., Berglund, M., Elinder, C. G., Nordberg, G., and Vahter, M. (1998). Health effects of cadmium exposure-A review of the literature and a risk estimate. Scand. J. Work Environ. Health 24(suppl 1), 1-51.
17. Järup, L., Persson, B., and Elinder, C. G. (1995). Decreased glomerular filtration rate in cadmium exposed solderers. Occup. Environ. Med. 52, 818-822.
18. Jin, T. Y., Wu, X., Tang, Y., Nordberg, M., Bermard, A., Ye, T., Kong, Q., Lundstrom, N. G., and Nordberg, G. F. (2004). Environmental epidemiological study and estimation of benchmark dose for renal dysfunction in a cadmium-polluted area in China. BioMetals 17, 525-530.
19. Klaassen, C. D. (2001). Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th ed., McGraw-Hill, New York. pp. 822-826.
20. Lauwerys, R. R., Bernard, A., and Roels, H. A. (1994). Cadmium: Exposure markers aspredictors of nephrotoxic effects. Clin. Chem. 40, 1391-1394.
21. Liu, Y., Liu, J., Habeenbu, S. M., Waalkes, M. P., and Klaassen, C. D. (2000). Metallothionein-I/II null mice are sensitive to chronic oral cadmium-induced nephrotoxicity. Toxicol. Sci. 57, 167-176.
22. Min, F. G., Wang, X. L., Yuan, W., Zhang, Y., Pan, J. C., and Wang, J. (2008). Determination of some blood physiological and biochemical parameters in Wuzhishan mini-pigs of closed colony. Acta Laboratorium Animalis Scientia Sinica, 5, 373-379 (in Chinese).
23. Nomiyama, K., Nomiyama, H., and Nomura, Y. (1979). Effect of dietary cadmium on rhesus monkeys. Environ. Health Perspect. 28, 223-243.
24. Nordberg, G. F., Nogawa, K., Nordberg, M., and Friberg, M. (2007). Cadmium. In Handbook on the Toxicology of Metals (G. F. Nordberg, B. A. Fowler, M. Nordberg, and L. T. Friberg, Eds.), 3rd ed., pp. 446-486. Academic Press/ Elsevier, Amsterdam and Boston.
25. Nordberg, M., and Nordberg, G. F. (2000). Toxicological aspects of metallothionein. Cell. Mol. Biol. 46, 451-463.
26. Satarug, S., Baker, J. R., Urbenjapol, S., Haswell-Elkins, M., Williams, D. J., and Moore, M. R. (2003). A global perspective on cadmium pollution and toxicity in non-occupationally exposed population. Toxicol. Lett. 137, 65-83.
27. Satarug, S., and Moore, M. R. (2004). Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke. Environ. Health Perspect. 112, 1099-1103.
28. Soisungwan, S., Jason, R. B., Supanee, U., Melissa, H. E., Paul, E. B., David, J. W., and Michael, R. M. (2003). A global perspective on cadmium pollution and toxicity in non-occupationally exposed population. Toxicol. Lett. 137, 65-83.
29. Staessen, J. A., Lauwerys, R. R., Ide, G., Roels, H. A., Vyncke, G., and Amery, A. (1994). Renal function and historical environmental cadmium pollution from zinc smelters. Lancet 343, 1523-1527.
30. Suwazono, Y., Sand, S., Vahter, M., Filipsson, A. F., Skerfving, S., Lidfeldt, J., and Åkesson, A. (2006). Benchmark dose for cadmium-induced renal effects in humans. Environ. Health Perspect. 114, 1072-1076.
31. Suwazono, Y., Uetani, M., Åkesson, A., and Vahter, M. (2010). Recent applications of benchmark dose method for estimation of reference cadmium exposure for renal effects in man. Toxicol. Lett. 198, 40-43.
32. Thijssen, S., Maringwa, J., Faes, C., Lambrichts, I., and Kerkhove, E. V. (2007). Chronic exposure of mice to environmentally relevant, low doses of cadmium leads to early renal damage, not predicted by blood or urine cadmium levels. Toxicology 229, 145-156.
33. Thomas, L. D. K., Hodgson, S., Nieuwenhuijsen, M., and Jarup, L. (2009). Early kidney damage in a population exposured to cadmium and other heavy metals. Environ. Health Perspect. 117, 181-184.
34. U.S. EPA (1995). The Use of the Benchmark Dose (BMD) Approach in Health Risk Assessment. Final report. Risk Assessment Forum, U.S. Environmental Protection Agency, Washington, DC.
35. WHO (1996). Guidelines for Drinking-Water Quality, Health Criteria and Other Supporting Information, 2nd ed., Vol. 2, pp. 195-201. WHO/WSH/03 .047/80.
36. WHO (2000). Cadmium: Air Quality Guidelines, 2nd ed. Chapter 6.3. WHO, Regional Office for Europe, Gopenhagen, Denmark.
37. WHO/IPCS (1992). Cadmium. Environmental Health Criteria Document 134, pp. 1-280.