Role of MTL-1, MTL-2, and CDR-1 in mediating cadmiumsensitivity in Caenorhabditis elegans

Toxicological Sciences

Volumn 128, Issue 2, 2012, Pages 418-426

  Hall, Julie ^a   Haas, Kathryn L ^a   Freedman, Jonathan H ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Cadmium; Caenorhabditis elegans; Metallothionein; Phytochelatin.

Indexed keywords

CADMIUM; CADMIUM SPECIFIC RESPONSE 1 PROTEIN; METALLOPROTEIN; METALLOTHIONEIN I; METALLOTHIONEIN II; PHYTOCHELATIN; UNCLASSIFIED DRUG;

ARTICLE; CAENORHABDITIS ELEGANS; DETOXIFICATION; EMBRYO DEVELOPMENT; EMBRYOPATHY; ENVIRONMENTAL EXPOSURE; GENE DELETION; HEAVY METAL POISONING; HYPERSENSITIVITY; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION;

ANIMALS; CADMIUM; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CHROMATOGRAPHY, LIQUID; GENE KNOCKDOWN TECHNIQUES; GENES, LETHAL; HOT TEMPERATURE; MASS SPECTROMETRY; MUTATION;

EID: 84865382946     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs166     Document Type: Article

References (34)

1. Barsyte, D., Lovejoy, D. A., and Lithgow, G. J. (2001). Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans. FASEB J. 15, 627-634.
2. Beyersmann, D. and Hechtenberg, S. (1997). Cadmium, gene regulation, and cellular signalling in mammalian cells. Toxicol. Appl. Pharmacol. 144, 247-261.
3. Boyd, W. A., Smith, M. V., Kissling, G. E., and Freedman, J. H. (2010). Medium-and high-throughput screening of neurotoxicants using C. elegans. Neurotoxicol. Teratol. 32, 68-73.
4. Cardillo, G. (2006). Dunn's Test: A Procedure for Multiple, Non Parametric, Comparisons MATLAB Central, MathWorks, Natick, MA.
5. Cioci, L. K., Qiu, L., and Freedman, J. H. (2000). Transgenic strains of the nematode Caenorhabditis elegans as biomonitors of metal contamination. Environ. Toxicol. Chem. 19, 2122-2129.
6. Cui, Y., McBride, S. J., Boyd, W. A., Alper, S., and Freedman, J. H. (2007). Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity. Genome Biol. 8, R122.
7. Dong, J., Boyd, W. A., and Freedman, J. H. (2008). Molecular characterization of two homologs of the Caenorhabditis elegans cadmium-responsive gene cdr-1: cdr-4 and cdr-6. J. Mol. Biol. 376, 621-633.
8. Dong, J., Song, M. O., and Freedman, J. H. (2005). Identification and characterization of a family of Caenorhabditis elegans genes that is homologous to the cadmium-responsive gene cdr-1. Biochim. Biophys. Acta 1727, 16-26.
9. Freedman, J. H., Ciriolo, M. R., and Peisach, J. (1989). The role of glutathione in copper metabolism and toxicity. J. Biol. Chem. 264, 5598-5605.
10. Freedman, J. H., Slice, L. W., Dixon, D., Fire, A., and Rubin, C. S. (1993). The novel metallothionein genes of Caenorhabditis elegans. Structural organization and inducible, cell-specific expression. J. Biol. Chem. 268, 2554-2564.
11. Haq, F., Mahoney, M., and Koropatnick, J. (2003). Signaling events for metallothionein induction. Mutat. Res. 533, 211-226.
12. Hughes, S., and Stürzenbaum, S. R. (2007). Single and double metallothionein knockout in the nematode C. elegans reveals cadmium dependent and independent toxic effects on life history traits. Environ. Pollut. 145, 395-400.
13. Hughes, S. L., Bundy, J. G., Want, E. J., Kille, P., and Stürzenbaum, S. R. (2009). The metabolomic responses of Caenorhabditis elegans to cadmium are largely independent of metallothionein status, but dominated by changes in cystathionine and phytochelatins. J. Proteome Res. 8, 3512-3519.
14. Kang, Y. J., and Enger, M. D. (1988). Glutathione is involved in the early cadmium cytotoxic response in human lung carcinoma cells. Toxicology 48, 93-101.
15. Khanna, N., Cressman, C. P.,III, Tatara, C. P., and Williams, P. L. (1997). Tolerance of the nematode Caenorhabditis elegans to pH, salinity, and hardness in aquatic media. Arch. Environ. Contam. Toxicol. 32, 110-114.
16. Klaassen, C. D., Liu, J., and Choudhuri, S. (1999). Metallothionein: An intracellular protein to protect against cadmium toxicity. Annu. Rev. Pharmacol. Toxicol. 39, 267-294.
17. Lazo, J. S., Kondo, Y., Dellapiazza, D., Michalska, A. E., Choo, K. H., and Pitt, B. R. (1995). Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes. J. Biol. Chem. 270, 5506-5510.
18. Leung, M. C., Williams, P. L., Benedetto, A., Au, C., Helmcke, K. J., Aschner, M., and Meyer, J. N. (2008). Caenorhabditis elegans: An emerging model in biomedical and environmental toxicology. Toxicol. Sci. 106, 5-28.
19. Liao, V. H., Dong, J., and Freedman, J. H. (2002). Molecular characterization of a novel, cadmium-inducible gene from the nematode Caenorhabditis elegans. A new gene that contributes to the resistance to cadmium toxicity. J. Biol. Chem. 277, 42049-42059.
20. Liao, V. H., and Freedman, J. H. (1998). Cadmium-regulated genes from the nematode Caenorhabditis elegans. Identification and cloning of new cadmium-responsive genes by differential display. J. Biol. Chem. 273, 31962-31970.
21. Masters, B. A., Kelly, E. J., Quaife, C. J., Brinster, R. L., and Palmiter, R. D. (1994). Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc. Natl. Acad. Sci. U.S.A. 91, 584-588.
22. McCarter, J., Bartlett, B., Dang, T., and Schedl, T. (1999). On the control of oocyte meiotic maturation and ovulation in Caenorhabditis elegans. Dev. Biol. 205, 111-128.
23. Ochi, T., Otsuka, F., Takahashi, K., and Ohsawa, M. (1988). Glutathione and metallothioneins as cellular defense against cadmium toxicity in cultured Chinese hamster cells. Chem. Biol. Interact. 65, 1-14.
24. Olson, B. J., and Markwell, J. (2007). Assays for determination of protein concentration. Current Protocols in Protein Science 48, 3.4.1-3.4.29.
25. Popham, J. D., and Webster, J. M. (1979). Cadmium toxicity in the free-living nematode, Caenorhabditis elegans. Environ. Res. 20, 183-191.
26. Roh, J. Y., Lee, J., and Choi, J. (2006). Assessment of stress-related gene expression in the heavy metal-exposed nematode Caenorhabditis elegans: A potential biomarker for metal-induced toxicity monitoring and environmental risk assessment. Environ. Toxicol. Chem. 25, 2946-2956.
27. Singhal, R. K., Anderson, M. E., and Meister, A. (1987). Glutathione, a first line of defense against cadmium toxicity. FASEB J. 1, 220-223.
28. Sirover, M. A., and Loeb, L. A. (1976). Infidelity of DNA synthesis in vitro: Screening for potential metal mutagens or carcinogens. Science 194, 1434-1436.
29. Slice, L. W., Freedman, J. H., and Rubin, C. S. (1990). Purification, characterization, and cDNA cloning of a novel metallothionein-like, cadmium-binding protein from Caenorhabditis elegans. J. Biol. Chem. 265, 256-263.
30. Sulston, J., and Hodgkin, J. (1988). Methods. In The Nematode Caenorhabditis elegans (W. B. Wood, Ed.), pp. 587-606. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
31. Swain, S. C., Keusekotten, K., Baumeister, R., and Stürzenbaum, S. R. (2004). C. elegans metallothioneins: New insights into the phenotypic effects of cadmium toxicosis. J. Mol. Biol. 341, 951-959.
32. Vatamaniuk, O. K., Bucher, E. A., Ward, J. T., and Rea, P. A. (2001). A new pathway for heavy metal detoxification in animals. Phytochelatin synthase is required for cadmium tolerance in Caenorhabditis elegans. J. Biol. Chem. 276, 20817-20820.
33. Vatamaniuk, O. K., Bucher, E. A., Ward, J. T., and Rea, P. A. (2002). Worms take the 'phyto' out of 'phytochelatins'. Trends Biotechnol. 20, 61-64.
34. Williams, P. L., and Dusenbery, D. B. (1990). Aquatic toxicity testing using the nematode, Caenorhabditis elegans. Environ. Toxicol. Chem. 9, 1285-1290.