Minocycline reduces articular cartilage damage following osteochondral injury

Knee

Volumn 19, Issue 5, 2012, Pages 680-683

  Yamamoto, Akira ^a   Warren, Adam P ^a   Kim, Hubert T ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Chondrocyte; Minocycline; Osteochondral injury; Tetracycline

Indexed keywords

MINOCYCLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ARTICULAR CARTILAGE; BONE INJURY; CARTILAGE CELL; CARTILAGE INJURY; CHONDROPROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; EXPERIMENTAL RABBIT; FEMUR CONDYLE; HISTOPATHOLOGY; NONHUMAN; OSTEOCHONDRAL INJURY; PRIORITY JOURNAL; SHORT COURSE THERAPY; TISSUE INJURY; TISSUE REPAIR;

ANIMALS; ANTI-BACTERIAL AGENTS; APOPTOSIS; CARTILAGE, ARTICULAR; CHONDROCYTES; DISEASE MODELS, ANIMAL; FEMUR; KNEE INJURIES; MALE; MINOCYCLINE; RABBITS;

EID: 84865369360     PISSN: 09680160     EISSN: 18735800     Source Type: Journal    
DOI: 10.1016/j.knee.2011.12.007     Document Type: Article

References (19)

1. Anderson D.D., Chubinskaya S., Guilak F., Martin J.A., Oegema T.R., Olson S.A., et al. Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention. J Orthop Res 2011, 29(6):802-809.
2. Chu C.R., Beynnon B.D., Buckwalter J.A., Garrett W.E., Katz J.N., Rodeo S.A., et al. Closing the gap between bench and bedside research for early arthritis therapies (EARTH): report from the AOSSM/NIH U-13 Post-Joint Injury Osteoarthritis Conference II. Am J Sports Med 2011, 39(7):1569-1578.
3. Kim H.T., Lo M.Y., Pillarisetty R. Chondrocyte apoptosis following intra-articular fracture in humans. Osteoarthritis Cartilage 2002, 10(9):747-749.
4. Murray M.M., Zurakowski D., Vrahas M.S. The death of articular chondrocytes after intra-articular fracture in humans. J Trauma 2004, 56(1):128-131.
5. McKinley T.O., Borrelli J., D'Lima D.D., Furman B.D., Giannoudis P.V. Basic science of intra-articular fractures and posttraumatic osteoarthritis. J Orthop Trauma 2010, 24(9):567-570.
6. Lo M.Y., Kim H.T. Chondrocyte apoptosis induced by collagen degradation: inhibition by caspase inhibitors and IGF-1. J Orthop Res 2004, 22:140-144.
7. Costouros J.G., Dang A.C., Kim H.T. Inhibition of chondrocyte apoptosis in vivo following osteochondral injury. Osteoarthritis Cartilage 2003, 11:756-759.
8. Dang A.C., Warren A., Kim H.T. Beneficial effects of intra-articular caspase inhibition therapy following osteochondral injury. Osteoarthritis Cartilage 2006, 14(6):526-532.
9. D'Lima D., Hermida J., Hashimoto S., Colwell C., Lotz M. Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis. Arthritis Rheum 2006, 54(6):1814-1821.
10. Kim H.S., Suh Y.H. Minocycline and neurodegenerative diseases. Behav Brain Res 2009, 196(2):168-179.
11. Elewa H.F., Hilali H., Hess D.C., Machado L.S., Fagan S.C. Minocycline for short-term neuroprotection. Pharmacotherapy 2006, 26(4):515-521.
12. Dang A.C., Kim H.T. Chondrocyte programmed cell death following simulated intra-articular fracture: a comparison of detection methods. Clin Orthop Relat Res 2009, 467(7):1877-1884.
13. Pineda S., Pollack A., Stevenson S., Goldberg V., Caplan A. A semiquantitative scale for histologic grading of articular cartilage repair. Acta Anat (Basel) 1992, 143(4):335-340.
14. O'Driscoll S.W., Keeley F.W., Salter R.B. The chondrogenic potential of free autogenous periosteal grafts for biological resurfacing of major full-thickness defects in joint surfaces under the influence of continuous passive motion. An experimental investigation in the rabbit. J Bone Joint Surg Am 1986, 68(7):1017-1035.
15. Costouros J.G., Dang A.C., Kim H.T. Comparison of chondrocyte apoptosis in vivo and in vitro following acute osteochondral injury. J Orthop Res 2004, 22:678-683.
16. Arvin K.L., Han B.H., Du J., Lin S.-Z., Paul S.M., Holtzman D.M. Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury. Ann Neurol 2004, 52:54-61.
17. Pelletier J.P., Jovanovic D.V., Lascau-Coman V., Fernandes J.C., Manning P.T., Connor J.R., et al. Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: possible link with the reduction in chondrocyte apoptosis and caspase 3 level. Arthritis Rheum 2000, 43:1290-1299.
18. Wang J., Wei Q., Wang C.Y., Hill W.D., Hess D.C., Dong Z. Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. J Biol Chem 2004, 279:19948-19954.
19. Nuesch E., Rutjes A.W., Trelle S., Reichenbach S., Juni P. Doxycycline for osteoarthritis of the knee or hip. Cochrane Database Syst Rev 2009, (4):CD007323.