Unilesional follicular mycosis fungoides: Report of two cases with progression to tumor stage and review of the literature

Journal of Cutaneous Pathology

Volumn 39, Issue 9, 2012, Pages 853-860

  Kempf, Werner ^a   Kazakov, Dmitry V ^b   Schermesser, Martin ^c   Buechner, Stanislav A ^d   Parmentier, Laurent ^e   Wysocki, Anja ^f   Palmedo, Gabriele ^g   Häusermann, Peter ^e  

^a Histologische Diagnostik   (Switzerland)

^b CHARLES UNIVERSITY   (Czech Republic)

^c Dermatology Practice   (Switzerland)

^d Histologische Diagnostik and Dermatology Practice   (Switzerland)

^e UNIVERSITY OF BERN   (Switzerland)

^f Kantonsspital Lucerne ^*  (Switzerland)

^g Dermatopathologische Gemeinschaftspraxis   (Germany)

Author keywords

cutaneous lymphoma; dermatopathology; mycosis fungoides

Indexed keywords

CANCER STAGING; CASE REPORT; CELL TRANSFORMATION; CLASSIFICATION; DIFFERENTIAL DIAGNOSIS; FACE TUMOR; FEMALE; HUMAN; MALE; MIDDLE AGED; MYCOSIS FUNGOIDES; PATHOLOGY; REVIEW; SKIN TUMOR;

CELL TRANSFORMATION, NEOPLASTIC; DIAGNOSIS, DIFFERENTIAL; FACIAL NEOPLASMS; FEMALE; HUMANS; MALE; MIDDLE AGED; MYCOSIS FUNGOIDES; NEOPLASM STAGING; SKIN NEOPLASMS;

EID: 84865363424     PISSN: 03036987     EISSN: 16000560     Source Type: Journal    
DOI: 10.1111/j.1600-0560.2012.01965.x     Document Type: Article

References (65)

1. Willemze R, Jaffe ES, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas. Blood 2005; 105: 3768.
2. Burg G, Kempf W, Cozzio A, et al. WHO/EORTC classification of cutaneous lymphomas 2005: histological and molecular aspects. J Cutan Pathol 2005; 32: 647.
3. LeBoit PE,. Variants of mycosis fungoides and related cutaneous T-cell lymphomas. Semin Diagn Pathol 1991; 8: 73.
4. Shapiro PE, Pinto FJ,. The histologic spectrum of mycosis fungoides/Sezary syndrome (cutaneous T-cell lymphoma). A review of 222 biopsies, including newly described patterns and the earliest pathologic changes. Am J Surg Pathol 1994; 18: 645.
5. Kazakov DV, Burg G, Kempf W,. Clinicopathological spectrum of mycosis fungoides. J Eur Acad Dermatol Venereol 2004; 18: 397.
6. Kodama K, Fink-Puches R, Massone C, Kerl H, Cerroni L,. Papular mycosis fungoides: a new clinical variant of early mycosis fungoides. J Am Acad Dermatol 2005; 52: 694.
7. Martorell-Calatayud A, Botella-Estrada R, Sanmartin-Jimenez O, Requena C, Guillen-Barona C, Sangueza OP,. Papular mycosis fungoides: two new cases of a recently described clinicopathological variant of early mycosis fungoides. J Cutan Pathol 2010; 37: 330.
8. Hodak E, Phenig E, Amichai B, et al. Unilesional mycosis fungoides: a study of seven cases. Dermatology 2000; 201: 300.
9. Hess Schmid M, Dummer R, Kempf W, Hilty N, Burg G,. Mycosis fungoides with mucinosis follicularis in childhood. Dermatology 1999; 198: 284.
10. Cerroni L, Fink-Puches R, El-Shabrawi-Caelen L, Soyer HP, LeBoit PE, Kerl H,. Solitary skin lesions with histopathologic features of early mycosis fungoides. Am J Dermatopathol 1999; 21: 518.
11. Oliver GF, Winkelmann RK,. Unilesional mycosis fungoides: a distinct entity. J Am Acad Dermatol 1989; 20: 63.
12. Cerroni L, Fink-Puches R, Back B, Kerl H,. Follicular mucinosis: a critical reappraisal of clinicopathologic features and association with mycosis fungoides and Sezary syndrome. Arch Dermatol 2002; 138: 182.
13. Gerami P, Rosen S, Kuzel T, Boone SL, Guitart J,. Folliculotropic mycosis fungoides: an aggressive variant of cutaneous T-cell lymphoma. Arch Dermatol 2008; 144: 738.
14. Bonta MD, Tannous ZS, Demierre MF, Gonzalez E, Harris NL, Duncan LM,. Rapidly progressing mycosis fungoides presenting as follicular mucinosis. J Am Acad Dermatol 2000; 43: 635.
15. Gerami P, Guitart J,. The spectrum of histopathologic and immunohistochemical findings in folliculotropic mycosis fungoides. Am J Surg Pathol 2007; 31: 1430.
16. Hodak E, David M,. Follicular mycosis fungoides. J Cutan Pathol 2002; 29: 625.
17. Flaig MJ, Cerroni L, Schuhmann K, et al. Follicular mycosis fungoides. A histopathologic analysis of nine cases. J Cutan Pathol 2001; 28: 525.
18. Cerroni L, Kerl H,. Primary follicular mucinosis and association with mycosis fungoides and other cutaneous T-cell lymphomas. J Am Acad Dermatol 2004; 51: 146 author reply 147-148.
19. van Doorn R, Scheffer E, Willemze R,. Follicular mycosis fungoides, a distinct disease entity with or without associated follicular mucinosis: a clinicopathologic and follow-up study of 51 patients. Arch Dermatol 2002; 138: 191.
20. Lehman JS, Cook-Norris RH, Weed BR, et al. Folliculotropic mycosis fungoides: single-center study and systematic review. Arch Dermatol 2010; 146: 607.
21. Vergier B, Beylot-Barry M, Beylot C, et al. Pilotropic cutaneous T-cell lymphoma without mucinosis. A variant of mycosis fungoides? French Study Group of Cutaneous Lymphomas. Arch Dermatol 1996; 132: 683.
22. Pereyo NG, Requena L, Galloway J, Sangueza OP,. Follicular mycosis fungoides: a clinicohistopathologic study. J Am Acad Dermatol 1997; 36: 563.
23. Gibson LE, Muller SA, Leiferman KM, Peters MS,. Follicular mucinosis: clinical and histopathologic study. J Am Acad Dermatol 1989; 20: 441.
24. Mehregan DA, Gibson LE, Muller SA,. Follicular mucinosis: histopathologic review of 33 cases. Mayo Clin Proc 1991; 66: 387.
25. Campanati A, Giangiacomi M, Goteri G, Penna L, Turtu S, Offidani AM,. A case of follicular mycosis fungoides with follicular mucinosis: a rare association. Am J Dermatopathol 2002; 24: 423.
26. Wittenberg GP, Gibson LE, Pittelkow MR, el-Azhary RA,. Follicular mucinosis presenting as an acneiform eruption: report of four cases. J Am Acad Dermatol 1998; 38: 849.
27. Kim R, Winkelmann RK,. Follicular mucinosis (alopecia mucinosa). Arch Dermatol 1962; 85: 490.
28. Goldenhersh MA, Zlotogorski A, Rosenmann E,. Follicular mycosis fungoides. Am J Dermatopathol 1994; 16: 52.
29. Wilkinson JD, Black MM, Chu A,. Follicular mucinosis associated with mycosis fungoides presenting with gross cystic changes on the face. Clin Exp Dermatol 1982; 7: 333.
30. Burns MK, Chan LS, Cooper KD,. Woringer-Kolopp disease (localized pagetoid reticulosis) or unilesional mycosis fungoides? An analysis of eight cases with benign disease. Arch Dermatol 1995; 131: 325.
31. Rongioletti F, De Lucchi S, Meyes D, et al. Follicular mucinosis: a clinicopathologic, histochemical, immunohistochemical and molecular study comparing the primary benign form and the mycosis fungoides-associated follicular mucinosis. J Cutan Pathol 2010; 37: 15.
32. Muniesa C, Estrach T, Pujol RM, et al. Folliculotropic mycosis fungoides: clinicopathological features and outcome in a series of 20 cases. J Am Acad Dermatol 2010; 62: 418.
33. Ohtani T, Kikuchi K, Koizumi H, Kunii T, Aiba S,. A case of CD30+ large-cell transformation in a patient with unilesional patch-stage mycosis fungoides. Int J Dermatol 2009; 48: 623.
34. Kneba M, Bolz I, Linke B, Bertram J, Rothaupt D, Hiddemann W,. Characterization of clone-specific rearrangement T-cell receptor gamma-chain genes in lymphomas and leukemias by the polymerase chain reaction and DNA sequencing. Blood 1994; 84: 574.
35. Gerami P, Guitart J,. Basaloid folliculolymphoid hyperplasia: a distinctive finding in follicular mycosis fungoides. J Cutan Pathol 2007; 34 (Suppl. 1): 29.
36. Jacobs MA, Kocher W, Murphy GF,. Combined folliculotropic/syringotropic cutaneous T-cell lymphoma without epidermal involvement: report of 2 cases and pathogenic implications. Hum Pathol 2003; 34: 1216.
37. Berger TG, Goette DK,. Eccrine proliferation with follicular mucinosis. J Cutan Pathol 1987; 14: 188.
38. Charles J, Lantuejoul S, Reymond JL, Cuchet E, Wechsler J, Beani JC,. Syringotropic and pilotropic cutaneous T-cell lymphoma without follicular mucinosis. Ann Dermatol Venereol 2007; 134: 155.
39. Tannous Z, Baldassano MF, Li VW, Kvedar J, Duncan LM,. Syringolymphoid hyperplasia and follicular mucinosis in a patient with cutaneous T-cell lymphoma. J Am Acad Dermatol 1999; 41: 303.
40. Pileri A, Facchetti F, Rutten A, et al. Syringotropic mycosis fungoides: a rare variant of the disease with peculiar clinicopathologic features. Am J Surg Pathol 2011; 35: 100.
41. Yost JM, Do TT, Kovalszki K, Su L, Anderson TF, Gudjonsson JE,. Two cases of syringotropic cutaneous T-cell lymphoma and review of the literature. J Am Acad Dermatol 2009; 61: 133.
42. Hobbs JL, Chaffins ML, Douglass MC,. Syringolymphoid hyperplasia with alopecia: two case reports and review of the literature. J Am Acad Dermatol 2003; 49: 1177.
43. Burg G, Schmockel C,. Syringolymphoid hyperplasia with alopecia - a syringotropic cutaneous T-cell lymphoma? Dermatology 1992; 184: 306.
44. Thein M, Ravat F, Orchard G, Calonje E, Russell-Jones R,. Syringotropic cutaneous T-cell lymphoma: an immunophenotypic and genotypic study of five cases. Br J Dermatol 2004; 151: 216.
45. Kempf W, Ostheeren-Michaelis S, Paulli M, et al. Granulomatous mycosis fungoides and granulomatous slack skin: a multicenter study of the Cutaneous Lymphoma Histopathology Task Force Group of the European Organization For Research and Treatment of Cancer (EORTC). Arch Dermatol 2008; 144: 1609.
46. Apisarnthanarax N, Ha CS, Duvic M,. Mycosis fungoides with follicular mucinosis displaying aggressive tumor-stage transformation: successful treatment using radiation therapy plus oral bexarotene combination therapy. Am J Clin Dermatol 2003; 4: 429.
47. Gilliam AC, Lessin SR, Wilson DM, Salhany KE,. Folliculotropic mycosis fungoides with large-cell transformation presenting as dissecting cellulitis of the scalp. J Cutan Pathol 1997; 24: 169.
48. Klemke CD, Dippel E, Assaf C, et al. Follicular mycosis fungoides. Br J Dermatol 1999; 141: 137.
49. Ishibashi M, Ohshima K, Chen KR,. Folliculotropic mycosis fungoides with eosinophilia and CD30+ large-cell transformation: a case with a fatal outcome presenting with multifocal lesions and leonine facies. Clin Exp Dermatol 2010; 35: e133.
50. Mitteldorf C, Stadler R, Bertsch HP, Neumann C,. Folliculotropic mycosis fungoides with CD30+ large-cell transformation in a young woman: beneficial effect of bexarotene. Br J Dermatol 2007; 156: 584.
51. Kempf W,. CD30+ lymphoproliferative disorders: histopathology, differential diagnosis, new variants, and simulators. J Cutan Pathol 2006; 33 (Suppl. 1): 58.
52. Agar N, Whittaker SJ,. Folliculotropic mycosis fungoides (stage IIA) progressing to Sezary syndrome: a case report. Br J Dermatol 2008; 159: 1197.
53. van der Putte SC, Toonstra J, van Wichen DF,. B cells and plasma cells in mycosis fungoides. A study including cases with B cell follicle formation or a monotypical plasma cell component. Am J Dermatopathol 1989; 11: 509.
54. Fontaine J, Heimann M, Day MJ,. Canine cutaneous epitheliotropic T-cell lymphoma: a review of 30 cases. Vet Dermatol 2010; 21: 267.
55. Arai E, Okubo H, Tsuchida T, Kitamura K, Katayama I,. Pseudolymphomatous folliculitis: a clinicopathologic study of 15 cases of cutaneous pseudolymphoma with follicular invasion. Am J Surg Pathol 1999; 23: 1313.
56. Kazakov DV, Belousova IE, Kacerovska D, et al. Hyperplasia of hair follicles and other adnexal structures in cutaneous lymphoproliferative disorders: a study of 53 cases, including so-called pseudolymphomatous folliculitis and overt lymphomas. Am J Surg Pathol 2008; 32: 1468.
57. Pierard GE, Ackerman AB, Lapiere CM,. Follicular lymphomatoid papulosis. Am J Dermatopathol 1980; 2: 173.
58. Requena L, Sanchez M, Coca S, Sanchez Yus E,. Follicular lymphomatoid papulosis. Am J Dermatopathol 1990; 12: 67.
59. Kato N, Matsue K,. Follicular lymphomatoid papulosis. Am J Dermatopathol 1997; 19: 189.
60. Kossard S, Weller P,. Pseudotumorous folliculotropic mycosis fungoides. Am J Dermatopathol 2005; 27: 224.
61. Magro CM, Crowson AN,. Folliculotropic T-cell lymphocytosis as a distinct form of pilotropic T-cell dyscrasia. Am J Clin Pathol 2011; 135: 221.
62. Riley JL,. PD-1 signaling in primary T cells. Immunol Rev 2009; 229: 114.
63. Roncador G, Garcia Verdes-Montenegro JF, Tedoldi S, et al. Expression of two markers of germinal center T cells (SAP and PD-1) in angioimmunoblastic T-cell lymphoma. Haematologica 2007; 92: 1059.
64. Wada DA, Wilcox RA, Harrington SM, Kwon ED, Ansell SM, Comfere NI,. Programmed death 1 is expressed in cutaneous infiltrates of mycosis fungoides and Sezary syndrome. Am J Hematol 2011; 86: 325.
65. Cetinozman F, Jansen PM, Willemze R,. Expression of programmed death-1 in primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoma, cutaneous pseudo-T-cell lymphoma, and other types of cutaneous T-cell lymphoma. Am J Surg Pathol 2012; 36: 109.