Syringotropic mycosis fungoides: A rare variant of the disease with peculiar clinicopathologic features

American Journal of Surgical Pathology

Volumn 35, Issue 1, 2011, Pages 100-109

  Pileri, Alessandro ^a,b   Facchetti, Fabio ^c   Rütten, Arno ^d   Zumiani, Giuseppe ^e   Boi, Sebastiana ^e   Fink Puches, Regina ^a   Cerroni, Lorenzo ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c University Spedali Civili of Brescia   (Italy)

^d Dermatopathologische Gemeinschaftspraxis   (Germany)

^e SANTA CHIARA HOSPITAL   (Italy)

Author keywords

cutaneous T cell lymphoma; folliculotropic mycosis fungoides; mycosis fungoides; pilotropic mycosis fungoides; syringolymphoid hyperplasia with alopecia; syringotropic mycosis fungoides

Indexed keywords

TUMOR MARKER;

ADULT; AGED; ARTICLE; BIOPSY; CHEMISTRY; CLASSIFICATION; FEMALE; HAIR FOLLICLE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METAPLASIA; MIDDLE AGED; MYCOSIS FUNGOIDES; PATHOLOGY; PROGNOSIS; SKIN; SKIN TUMOR; SWEAT GLAND; T LYMPHOCYTE; TIME;

ADULT; AGED; AGED, 80 AND OVER; BIOPSY; ECCRINE GLANDS; FEMALE; HAIR FOLLICLE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; METAPLASIA; MIDDLE AGED; MYCOSIS FUNGOIDES; PROGNOSIS; SKIN; SKIN NEOPLASMS; T-LYMPHOCYTES; TIME FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 78650898566     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3182036ce7     Document Type: Article

References (33)

1. Burg G, Schmöckel C. Syringolymphoid hyperplasia with alopecia- A syringotropic cutaneous T-cell lymphoma? Dermatology. 1992;184:306-307.
2. Cerroni L, Gatter K, Kerl H. Skin Lymphoma: the Illustrated Guide. 3rd ed. Oxford: Wiley-Blackwell; 2009.
3. Charles J, Lantuejoul S, Reymond JL, et al. Mycosis fongöde syringotrope et pilotrope sans mucinose folliculaire. Ann Dermatol Venereol. 2007;134:155-159.
4. Dubin DB, Hurowitz JC, Brettler D, et al. Adnexotropic T-cell lymphoma presenting with generalized anhidrosis, progressive alopecia, pruritus, and Sjögren's syndrome. J Am Acad Dermatol. 1998;38:493-497.
5. Fink-Puches R, Zenahlik P, Bäck B, et al. Primary cutaneous lymphomas: applicability of current classification schemes (European Organization for Research and Treatment of Cancer, World Health Organization) based on clinicopathologic features observed in a large group of patients. Blood. 2002;99:800-805.
6. Garcovich A, Garcovich S, Massi G. An unusual variant of granulomatous adnexotropic cutaneous T-cell lymphoma. Br J Dermatol. 2003;148:363-365.
7. Gerami P, Guitart J. The spectrum of histopathologic and immunohistochemical findings in folliculotropic mycosis fungoides. Am J Surg Pathol. 2007;31:1430-1438.
8. Haller A, Elzubi E, Petzelbauer P. Localized syringolymphoid hyperplasia with alopecia and anhidrosis. J Am Acad Dermatol. 2001;45:127-130.
9. Hitchcock MG, Burchette JL Jr, Olsen EA, et al. Eccrine gland infiltration by mycosis fungoides. Am J Dermatopathol. 1996;18:447-453.
10. Hobbs JL, Chaffins ML, Douglass MC. Syringolymphoid hyperplasia with alopecia: two case reports and review of the literature. J Am Acad Dermatol. 2003;49:1177-1180.
11. Huang CL, Kuo TT, Chan HL. Acquired generalized hypohidrosis/ anhidrosis with subclinical Sjogren's syndrome: report of a case with diffuse syringolymphoid hyperplasia and lymphocytic sialadenitis. J Am Acad Dermatol. 1996;35:350-352.
12. Jacob R, Scala M, Fung MA. A case of syringotropic cutaneous T-cell lymphoma treated with local radiotherapy. J Am Acad Dermatol. 2009;60:152-154.
13. Jacobs MA, Kocher W, Murphy GF. Combined folliculotropic/ syringotropic cutaneous T-cell lymphoma without epidermal involvement: report of 2 cases and pathogenic implications. Hum Pathol. 2003;34:1216-1220.
14. Kazakov DV, Belousova IE, Kacerovska D, et al. Hyperplasia of hair follicles and other adnexal structures in cutaneous lymphoproliferative disorders: a study of 53 cases, including so-called pseudolymphomatous folliculitis and overt lymphomas. Am J Surg Pathol. 2008;32:1468-1478.
15. Kossard S, Weller P. Pseudotumorous folliculotropic mycosis fungoides. Am J Dermatopathol. 2005;27:224-227.
16. Lehman JS, Cook-Norris RH, Weed BR, et al. Folliculotropic mycosis fungoides: single-center study and systematic review. Arch Dermatol. 2010;146:607-613.
17. Mac Donald DM. Lymphomatoid granulomatosis. Proc R Soc Med. 1975;68:452-453.
18. Mac Donald DM, Sarkany I. Lymphomatoid granulomatosis. Clin Exp Dermatol. 1976;1:163-173.
19. Ralfkiaer E, Cerroni L, Sander CA, et al. Mycosis fungoides. In: Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue. 4th ed. Lyon: IARC Press; 2008:296-298.
20. Rongioletti F, Smoller B. The histologic value of adnexal (eccrine gland and follicle) infiltration in mycosis fungoides. J Cut Pathol. 2000;27:406-409.
21. Sarkany I. Patchy alopecia, anhidrosis, eccrine gland wall hypertrophy and vasculitis. Proc R Soc Med. 1969;62:157-159.
22. Steigleder GK, Bauermeister-Jasso K. Lymphomatoide Granulomatose mit "Epithelinseln". Z Hautkr. 1981;56:851-861.
23. Tannous Z, Baldassano MF, Li VW, et al. Syringolymphoid hyperplasia and follicular mucinosis in a patient with cutaneous T-cell lymphoma. J Am Acad Dermatol. 1999;41:303-308.
24. Thein M, Ravat F, Orchard G, et al. Syringotropic cutaneous T-cell lymphoma: an immunophenotypic and genotypic study of five cases. Br J Dermatol. 2004;151:216-226.
25. Tomaszewski MM, Lupton GP, Krishnan J, et al. Syringolymphoid hyperplasia with alopecia: a case report. J Cutan Pathol. 1994; 21:520-526.
26. Vakilzadeh F, Bröcker EB. Syringolymphoid hyperplasia with alopecia. Br J Dermatol. 1984;110:95-101.
27. Van Dongen JJM, Langerak AW, Brüggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 2003;17:2257-2317.
28. van Doorn R, Scheffer E, Willemze R. Follicular mycosis fungoides, a distinct disease entity with or without associated follicular mucinosis. Arch Dermatol. 2002;138:191-198.
29. Venturini A, Zane C, Rodella R, et al. Syringotropic cutaneous T cell lymphoma treated with PUVA therapy. Eur J Dermatol. 2005;15:262-264.
30. Weng AA, Howatson SR, Goodlad JR, et al. Erythrodermic syringotropic cutaneous T-cell lymphoma. Br J Dermatol. 2003; 148:349-352.
31. Willemze R, Jaffe ES, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas. Blood. 2005;105:3768-3785.
32. Yost JM, Do TT, Kovalszki K, et al. Two cases of syringotropic cutaneous T-cell lymphoma and review of the literature. J Am Acad Dermatol. 2009;61:133-138.
33. Zelger B, Sepp N, Weyrer K, et al. Syringotropic cutaneous T-cell lymphoma: a variant of mycosis fungoides? Br J Dermatol. 1994;130:765-769.