Size and dynamics of mucosal and peripheral IL-17A+ T-cell pools in pediatric age, and their disturbance in celiac disease

Mucosal Immunology

Volumn 5, Issue 5, 2012, Pages 513-523

  La Scaleia, R ^a,b   Barba, M ^a   Di Nardo, G ^b   Bonamico, M ^b   Oliva, S ^b   Nenna, R ^b   Valitutti, F ^b   Mennini, M ^b   Barbato, M ^b   Montuori, M ^b   Porzia, A ^a   Petrarca, L ^b   Battella, S ^a   Cucchiara, S ^b   Piccoli, M ^a   Santoni, A ^b,c   Mainiero, F ^a   Palmieri, G ^a,b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 17; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE;

ADULT; AGE; ARTICLE; CD4+ T LYMPHOCYTE; CELIAC DISEASE; CELL ASSAY; CHILD; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE SEVERITY; DOWN REGULATION; DUODENUM BIOPSY; FEMALE; HUMAN; HUMAN TISSUE; INFANT; INTRAEPITHELIAL LYMPHOCYTE; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SCHOOL CHILD; STOMACH MUCOSA LESION; T LYMPHOCYTE; UPREGULATION;

EID: 84865361878     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2012.26     Document Type: Article

References (49)

1. Garrett, W. S., Gordon, J. I. & Glimcher, L. H. Homeostasis and infl ammation in the intestine. Cell 140, 859-870 (2010
2. Hooper, L. V. & Macpherson, A. J. Immune adaptations that maintain homeostasis with the intestinal microbiota. Nature Rev. Immunol. 10, 159-169 (2010
3. Cerf-Bensussan, N. & Gaboriau-Routhiau, V. The immune system and the gut microbiota: friends or foes? Nat. Rev. Immunol. 10, 735-744 (2010
4. Lee, Y. K. & Mazmanian, S. K. Has the microbiota played a critical role in the evolution of the adaptive immune system? Science 330, 1768-1773 (2010
5. Eberl, G. & Lochner, M. The development of intestinal lymphoid tissues at the interface of self and microbiota. Mucosal Immunol. 2, 478-485 (2009
6. Selby, W. S., Janossy, G., Bofi ll, M. & Jewell, D. P. Lymphocyte subpopulations in the human small intestine. The fi ndings in normal mucosa and in the mucosa of patients with adult celiac disease. Clin. Exp. Immunol. 52, 219-228 (1983
7. Brandtzaeg, P. et al. Immunobiology and immunopathology of human gut mucosa: humoral immunity and intraepithelial lymphocytes. Gastroenterology 97, 1562-1584 (1989
8. Leon, F. Flow cytometry of intestinal intraepithelial lymphocytes in celiac disease. J. Immunol. Methods 363, 177-186 (2011
9. Jarry, A., Cerf-Bensussan, N., Brousse, N., Selz, F. & Guy-Grand, D. Subsets of CD3+ (T cell receptor alpha/beta or gamma/delta) and CD3-lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood. Eur. J. Immunol. 20, 1097-1103 (1990
10. Sheridan, B. S. & Lefrançois, L. Intraepithelial lymphocytes: to serve and protect. Curr. Gastroenterol. Rep. 12, 513-521 (2010
11. Jabri, B. & Ebert, E. Human CD8+ intraepithelial lymphocytes: A unique model to study the regulation of effector cytotoxic T lymphocytes in tissue. Immunol. Rev. 215, 202-214 (2007
12. Meresse, B. & Cerf-Bensussan, N. Innate T cell responses in human gut. Semin. Immunol. 21, 121-129 (2009
13. Shibahara, T. et al. Alteration of intestinal epithelial function by intraepithelial lymphocyte homing. J. Gastroenterol. 40, 878-886 (2005
14. Bhagat, G. et al. Small intestinal CD8+TCRgammadelta+NKG2A+intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease. J. Clin. Invest. 118, 281-293 (2008
15. Le ó n, F., S á nchez, L., Camarero, C. & Roy, G. Cytokine production by intestinal intraepithelial lymphocyte subsets in celiac disease. Dig. Dis. Sci. 50, 593-600 (2005
16. Cheroutre, H., Lambolez, F. & Mucida, D. The light and dark sides of intestinal intraepithelial lymphocytes. Nat. Rev. Immunol. 11, 445-456 (2011
17. Korn, T., Bettelli, E., Oukka, M. & Kuchroo, V. K. IL-17 and Th17 Cells. Annu. Rev. Immunol. 27, 485-517 (2009
18. O'Connor, W. Jr, Zenewicz, L. A. & Flavell, R. A. The dual nature of T(H)17 cells: shifting the focus to function. Nat. Immunol. 11, 471-476 (2010
19. Mucida, D. & Salek-Ardakani, S. Regulation of TH17 cells in the mucosal surfaces. J. Allergy Clin. Immunol. 123, 997-1003 (2009
20. Cua, D. J. & Tato, C. M. Innate IL-17-producing cells: The sentinels of the immune system. Nat. Rev. Immunol. 10, 479-489 (2010
21. Shrikant, P. A. et al. Regulating functional cell fates in CD8 T cells. Immunol. Res. 46, 12-22 (2010
22. Maggi, L. et al. CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC. Eur J Immunol. 40, 2174-2181 (2010
23. Annunziato, F. et al. Phenotypic and functional features of human Th17 cells. J. Exp. Med. 204, 1849-1861 (2007
24. Kleinschek, M. A. et al. Circulating and gut-resident human Th17 cells express CD161 and promote intestinal infl ammation. J. Exp. Med. 206, 525-534 (2009
25. Kondo, T., Takata, H., Matsuki, F. & Takiguchi, M. Cutting edge: Phenotypic characterization and differentiation of human CD8+ T cells producing IL-17. J. Immunol. 182, 1794-1798 (2009
26. Chen, Z. & O'Shea, J. J. Regulation of IL-17 production in human lymphocytes. Cytokine 41, 71-78 (2008
27. Peck, A. & Mellins, E. D. Plasticity of T-cell phenotype and function: The T helper Type 17 example. Immunology 129, 147-153 (2010
28. Di Sabatino, A. & Corazza, G. R. Coeliac disease. Lancet 373, 1480-1493 (2009
29. Abadie, V., Sollid, L. M., Barreiro, L. B. & Jabri, B. Integration of genetic and immunological insights into a model of celiac disease pathogenesis. Annu. Rev. Immunol. 29, 493-525 (2011
30. Fasano, A. Zonulin and its regulation of intestinal barrier function: The biological door to infl ammation, autoimmunity, and cancer. Physiol. Rev. 91, 151-175 (2011
31. Jabri, B. & Sollid, L. M. Tissue-mediated control of immunopathology in coeliac disease. Nat. Rev. Immunol. 9, 858-870 (2009
32. Gianfrani, C., Auricchio, S. & Troncone, R. Adaptive and innate immune responses in celiac disease. Immunol. Lett. 99, 141-145 (2005
33. Freedman, A. R., Macartney, J. C., Nelufer, J. M. & Ciclitira, P. J. Timing of infi ltration of T lymphocytes induced by gluten into the small intestine in coeliac disease. J. Clin. Pathol. 40, 741-745 (1987
34. Eiras, P., Rold á n, E., Camarero, C., Olivares, F., Bootello, A. & Roy, G. Flow cytometry description of a novel CD3-/CD7+ intraepithelial lymphocyte subset in human duodenal biopsies: potential diagnostic value in coeliac disease. Cytometry 34, 95-102 (1998
35. Meresse, B. et al. Reprogramming of CTLs into natural killer-like cells in celiac disease. J. Exp. Med. 203, 1343-1355 (2006
36. Jenkins, D., Goodall, A. & Scott, B. B. T-lymphocyte populations in normal and coeliac small intestinal mucosa defi ned by monoclonal antibodies. Gut 27, 1330-1337 (1986
37. Spencer, J., MacDonald, T. T., Diss, T. C., Walker-Smith, J. A., Ciclitira, P. J. & Isaacson, P. G. Changes in intraepithelial lymphocyte subpopulations in coeliac disease and enteropathy associated T cell lymphoma (malignant histiocytosis of the intestine). Gut 30, 339-346 (1989
38. Spencer, J., Isaacson, P. G., Diss, T. C. & MacDonald, T. T. Expression of disulfi de-linked and non-disulfi de-linked forms of the T cell receptor gamma/delta heterodimer in human intestinal intraepithelial lymphocytes. Eur. J. Immunol. 19, 1335-1338 (1989
39. Halstensen, T. S., Scott, H. & Brandtzaeg, P. Intraepithelial T cells of the TcR gamma/delta+ CD8-and V delta 1/J delta 1+ phenotypes are increased in coeliac disease. Scand. J. Immunol. 30, 665-672 (1989
40. Monteleone, I. et al. Characterization of IL-17A producing cells in celiac disease mucosa. J. Immunol. 184, 2211-2218 (2010
41. Fern á ndez, S. et al. Characterization of gliadin-specifi c Th17 cells from the mucosa of celiac disease patients. Am. J. Gastroenterol. 106, 528-538 (2011
42. Bodd, M. et al. HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22. Mucosal Immunol. 3, 594-601 (2010
43. Russell, G. J. et al. p126 (CDw101): A costimulatory molecule preferentially expressed on mucosal T lymphocytes. J. Immunol. 157, 3366-3374 (1996
44. Castellanos-Rubio, A., Santin, I., Irastorza, I., Casta ñ o, L., Carlos Vitoria, J. & Ramon Bilbao, J. TH17 (and TH1) signatures of intestinal biopsies of CD patients in response to gliadin. Autoimmunity 42, 69-73 (2009
45. Sapone, A. et al. Differential mucosal IL-17 expression in two gliadininduced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. Int. Arch. Allergy Immunol. 152, 75-80 (2010
46. Tjellstr ö m, B. et al. Gut microfl ora associated characteristics in children with celiac disease. Am. J. Gastroenterol. 100, 2784-2788 (2005
47. Hill, ID. et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J. Pediatr. Gastroenterol. Nutr. 40, 1-19 (2005
48. Marsh, M. N. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (' celiac sprue '). Gastroenterology 102, 330-354 (1992
49. Li, M. et al. A report on the International Transglutaminase Autoantibody Workshop for Celiac Disease. Am. J. Gastroenterol. 104, 154-163 (2009