Simultaneous determination and pharmacokinetic study of six flavonoids from Fructus Sophorae extract in rat plasma by LC-MS/MS

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 904, Issue , 2012, Pages 59-64

  Chang, Lu ^a   Ren, Yanping ^a   Cao, Liang ^a   Sun, Yingguang ^a   Sun, Qian ^a   Sheng, Ning ^a   Yuan, Lin ^a   Zhi, Xuran ^a   Zhang, Lantong ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Flavonoids; Fructus sophorae; LC MS MS; MRM; Pharmacokinetics

Indexed keywords

CHROMATOGRAPHIC SEPARATIONS; CLINICAL APPLICATION; FRUCTUS SOPHORAE; GENISTEIN; GENISTIN; INTERNAL STANDARDS; ION PAIRS; IONIZATION MODES; KAEMPFEROL; LC-MS/MS; LINEAR GRADIENT ELUTION; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID-LIQUID EXTRACTION; MATRIX EFFECTS; MRM; MULTIPLE REACTION MONITORING; ORAL ADMINISTRATION; PHARMACOKINETIC STUDIES; PLASMA SAMPLES; RAT PLASMA; RUNTIMES; SIMULTANEOUS DETERMINATIONS;

ALCOHOLS; BODY FLUIDS; ELECTROSPRAY IONIZATION; FATTY ACIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PHENOLS;

FLAVONOIDS;

FLAVONOID; GENISTEIN; GENISTIN; KAEMPFEROL; PLANT EXTRACT; QUERCETIN; RUTOSIDE; SOPHORA JAPONICA EXTRACT; SOPHORICOSIDE; SULFAMETHOXAZOLE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; ELECTROSPRAY; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MASS SPECTROMETER; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; RAT; SOPHORA JAPONICA; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION STUDY;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, LIQUID; DRUGS, CHINESE HERBAL; FABACEAE; FLAVONOIDS; LINEAR MODELS; MALE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 84865355011     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.07.015     Document Type: Article

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