Markedly enhanced skeletal muscle transfection achieved by the ultrasound-targeted delivery of non-viral gene nanocarriers with microbubbles

Journal of Controlled Release

Volumn 162, Issue 2, 2012, Pages 414-421

  Burke, Caitlin W ^a   Suk, Jung Soo ^c   Kim, Anthony J ^c   Hsiang, Yu Han J ^a   Klibanov, Alexander L ^b   Hanes, Justin ^c   Price, Richard J ^a,b  

^a University of Virginia   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Microbubbles; Nanomedicine; Non viral gene delivery; Polyethylenimine; Skeletal muscle; Ultrasound

Indexed keywords

ACOUSTIC PRESSURES; AFTER-TREATMENT; BIOLUMINESCENT IMAGING; C57BL/6 MICE; CELLULAR UPTAKE; GENE CARRIER; HIND LIMBS; INTRAMUSCULAR INJECTIONS; LUCIFERASE ACTIVITIES; MICRO-BUBBLE; MICROBUBBLES; NAKED PLASMID DNA; NANOCARRIERS; NANOCOMPLEXES; NON-VIRAL GENE DELIVERY; NONVIRAL; POLYETHYLENIMINES; POST TREATMENT; PULSED ULTRASOUNDS; SECONDARY MECHANISMS; SKELETAL MUSCLE;

DNA; ENZYME ACTIVITY; GENE EXPRESSION; GENE TRANSFER; MEDICAL NANOTECHNOLOGY; MOLECULAR BIOLOGY; ULTRASONICS;

MUSCLE;

LUCIFERASE; MACROGOL; PLASMID DNA; POLYETHYLENEIMINE;

ANIMAL EXPERIMENT; ARTICLE; BIOLUMINESCENCE; CONTROLLED STUDY; ECHOGRAPHY; ENZYME ACTIVITY; GENE TARGETING; GENETIC TRANSFECTION; HINDLIMB; IMAGE ANALYSIS; MICROBUBBLE; MOUSE; NANOFABRICATION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PLASMID; PRIORITY JOURNAL; SKELETAL MUSCLE;

ANIMALS; DNA; GENETIC VECTORS; LUCIFERASES; MICE; MICE, INBRED C57BL; MICROBUBBLES; MUSCLE, SKELETAL; PLASMIDS; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; SERUM ALBUMIN; TRANSFECTION; ULTRASONICS;

EID: 84865341680     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.07.005     Document Type: Article

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