Perturbation of Myelin basic protein (Mbp) splice variant expression in developing rat cerebellum following perinatal exposure to methylmercury

Toxicology Letters

Volumn 213, Issue 3, 2012, Pages 374-380

  Padhi, Bhaja K ^a   Pelletier, Guillaume ^a  

^a Health Canada   (Canada)

Author keywords

Alternative gene splicing; Cerebellum; Methylmercury; Myelin basic protein; Rat; Real time quantitative PCR

Indexed keywords

COMPLEMENTARY DNA; METHYLMERCURY; MYELIN BASIC PROTEIN; RNA;

ALTERNATIVE RNA SPLICING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CEREBELLUM; CONTROLLED STUDY; EXON; GENE EXPRESSION; MOUSE; MYELIN SHEATH; MYELINATION; NEUROTOXICITY; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PERINATAL PERIOD; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

AGE FACTORS; ANIMALS; CEREBELLUM; DOWN-REGULATION; EXONS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GESTATIONAL AGE; LACTATION; MALE; MATERNAL EXPOSURE; METHYLMERCURY COMPOUNDS; MYELIN BASIC PROTEINS; MYELIN SHEATH; OLIGODENDROGLIA; PREGNANCY; PROTEIN ISOFORMS; RATS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

RATTUS; VERTEBRATA;

EID: 84865324899     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.07.011     Document Type: Article

References (38)

1. Akiyama K., Ichinose S., Omori A., Sakurai Y., Asou H. Study of expression of myelin basic proteins (MBPs) in developing rat brain using a novel antibody reacting with four major isoforms of MBP. Journal of Neuroscience Research 2002, 68:19-28.
2. Boggs J.M. Myelin basic protein: a multifunctional protein. Cellular and Molecular Life Sciences 2006, 63:1945-1961.
3. Bradl M., Lassmann H. Oligodendrocytes: biology and pathology. Acta Neuropathologica 2010, 119:37-53.
4. Burbacher T.M., Rodier P.M., Weiss B. Methylmercury developmental neurotoxicity: a comparison of effects in humans and animals. Neurotoxicology and Teratology 1990, 12:191-202.
5. Campagnoni A.T., Verdi J.M., Verity A.N., Mur-Umarjee S., Byravan S. Posttranscriptional regulation of myelin protein gene expression. Annals of the New York Academy of Sciences 1991, 633:178-188.
6. Castoldi A.F., Onishchenko N., Johansson C., Coccini T., Roda E., Vahter M., Ceccatelli S., Manzo L. Neurodevelopmental toxicity of methylmercury: Laboratory animal data and their contribution to human risk assessment. Regulatory Toxicology and Pharmacology 2008, 51:215-229.
7. Castoldi A.F., Johansson C., Onishchenko N., Coccini T., Roda E., Vahter M., Ceccatelli S., Manzo Human developmental neurotoxicity of methylmercury: impact of variables and risk modifiers. Regulatory Toxicology and Pharmacology 2008, 51:201-214.
8. Deng W., Poretz R.D. Oligodendroglia in developmental neurotoxicity. Neurotoxicology 2003, 24:161-178.
9. Fahrion J.K., Komuro Y., Li Y., Ohno N., Littner Y., Raoult E., Galas L., Vaudry D., Komuro H. Rescue of neuronal migration deficits in a mouse model of fetal Minamata disease by increasing neuronal Ca2+ spike frequency. Proceedings of the National academy of Sciences of the United States of America 2012, 109:5057-5062.
10. Farina M., Rocha J.B., Aschner M. Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies. Life Sciences 2011, 89:555-563.
11. Fernandez M., Paradisi M., D'Intino G., Del V.G., Sivilia S., Giardino L., Calza L. A single prenatal exposure to the endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin alters developmental myelination and remyelination potential in the rat brain. Journal of Neurochemistry 2010, 115:897-909.
12. Fulton D., Paez P.M., Campagnoni A.T. The multiple roles of myelin protein genes during the development of the oligodendrocyte. American Society for Neurochemistry NEURO 2010, 2:e00027.
13. Garcia S.J., Seidler F.J., Slotkin T.A. Developmental neurotoxicity elicited by prenatal or postnatal chlorpyrifos exposure: effects on neurospecific proteins indicate changing vulnerabilities. Environmental Health Perspectives 2003, 111:297-303.
14. Guo L., Eviatar-Ribak T., Miskimins R. Sp1 phosphorylation is involved in myelin basic protein gene transcription. Journal of Neuroscience Research 2010, 88:3233-3242.
15. Harauz G., Libich D.S. The classic basic protein of myelin-conserved structural motifs and the dynamic molecular barcode involved in membrane adhesion and protein-protein interactions. Current Protein & Peptide Science 2009, 10:196-215.
16. Jacobs E.C., Pribyl T.M., Feng J.M., Kampf K., Spreur V., Campagnoni C., Colwell C.S., Reyes S.D., Martin M., Handley V., Hiltner T.D., Readhead C., Jacobs R.E., Messing A., Fisher R.S., Campagnoni A.T. Region-specific myelin pathology in mice lacking the golli products of the myelin basic protein gene. Journal of Neuroscience 2005, 25:7004-7013.
17. Jakovcevski I., Filipovic R., Mo Z., Rakic S., Zecevic N. Oligodendrocyte development and the onset of myelination in the human fetal brain. Frontiers in Neuroanatomy 2009, 3:5.
18. Kamholz J., de F.F., Puckett C., Lazzarini R. Identification of three forms of human myelin basic protein by cDNA cloning. Proceedings of the National academy of Sciences of the United States of America 1986, 83:4962-4966.
19. Keren H., Lev-Maor G., Ast G. Alternative splicing and evolution: diversification, exon definition and function. Nature Reviews Genetics 2010, 11:345-355.
20. Kobayashi K., Akune H., Sumida K., Saito K., Yoshioka T., Tsuji R. Perinatal exposure to PTU decreases expression of Arc, Homer 1 Egr 1 and Kcna 1 in the rat cerebral cortex and hippocampus. Brain Research 2009, 1264:24-32.
21. Lee P.R., Fields R.D. Regulation of myelin genes implicated in psychiatric disorders by functional activity in axons. Frontiers in Neuroanatomy 2009, 3:4.
22. Li Z., Dong T., Proschel C., Noble M. Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function. PLoS Biology 2007, 5:e35.
23. Lu Z., Ku L., Chen Y., Feng Y. Developmental abnormalities of myelin basic protein expression in fyn knock-out brain reveal a role of Fyn in posttranscriptional regulation. Journal of Biological Chemistry 2005, 280:389-395.
24. Murata K., Weihe P., Budtz-Jorgensen E., Jorgensen P.J., Grandjean P. Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercury. Journal of Pediatrics 2004, 144:177-183.
25. Nakajima K., Ikenaka K., Kagawa T., Aruga J., Nakao J., Nakahira K., Shiota C., Kim S.U., Mikoshiba K. Novel isoforms of mouse myelin basic protein predominantly expressed in embryonic stage. Journal of Neurochemistry 1993, 60:1554-1563.
26. Nakamura K., Houzawa U., Uemura T. Auditory brainstem responses in rats with methylmercury poisoning. Audiology Japan 1986, 29:445-446.
27. NRC (National Research Council) Toxicological Effects of Methylmercury 2000, National Academy Press, Washington, DC.
28. Nave K.A. Myelination and support of axonal integrity by glia. Nature 2010, 468:244-252.
29. Padhi B.K., Pelletier G., Williams A., Berndt-Weis L., Yauk C., Bowers W.J., Chu I. Gene expression profiling in rat cerebellum following in utero and lactational exposure to mixtures of methylmercury, polychlorinated biphenyls and organochlorine pesticides. Toxicology Letters 2008, 176:93-103.
30. Rice D., Barone S. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environmental Health Perspectives 2000, 108(Suppl. 3):511-533.
31. Sanchez E.S., Bigbee J.W., Fobbs W., Robinson S.E., Sato-Bigbee C. Opioid addiction and pregnancy: perinatal exposure to buprenorphine affects myelination in the developing brain. Glia 2008, 56:1017-1027.
32. Soazo M., Garcia G.B. Vanadium exposure through lactation produces behavioral alterations and CNS myelin deficit in neonatal rats. Neurotoxicology and Teratology 2007, 29:503-510.
33. Takahashi M., Negishi T., Imamura M., Sawano E., Kuroda Y., Yoshikawa Y., Tashiro T. Alterations in gene expression of glutamate receptors and exocytosis-related factors by a hydroxylated-polychlorinated biphenyl in the developing rat brain. Toxicology 2009, 257:17-24.
34. Vandesompele J., De P.K., Pattyn F., Poppe B., Van R.N., De P.A., Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biology 2002, 3. RESEARCH0034.
35. Veronesi B., Pringle J., Mezei C. Myelin basic protein-mRNA used to monitor trimethyltin neurotoxicity in rats. Toxicology and Applied Pharmacology 1991, 108:428-435.
36. Zarazua S., Rios R., Delgado J.M., Santoyo M.E., Ortiz-Perez D., Jimenez-Capdeville M.E. Decreased arginine methylation and myelin alterations in arsenic exposed rats. Neurotoxicology 2010, 31:94-100.
37. Zawia N.H., Harry G.J. Developmental exposure to lead interferes with glial and neuronal differential gene expression in the rat cerebellum. Toxicology and Applied Pharmacology 1996, 138:43-47.
38. Zoeller R.T., Butnariu O.V., Fletcher D.L., Riley E.P. Limited postnatal ethanol exposure permanently alters the expression of mRNAs encoding myelin basic protein and myelin-associated glycoprotein in cerebellum. Alcoholism: Clinical & Experimental Research 1994, 18:909-916.