Sp1 phosphorylation is involved in myelin basic protein gene transcription

Journal of Neuroscience Research

Volumn 88, Issue 15, 2010, Pages 3233-3242

  Guo, Lili ^a   Eviatar Ribak, Tamar ^a   Miskimins, Robin ^a  

^a UNIVERSITY OF SOUTH DAKOTA   (United States)

Author keywords

Differentiation; Gene expression; Myelin basic protein; Oligodendrocyte; Signal transduction

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; MYELIN BASIC PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; GENE MUTATION; GENETIC TRANSCRIPTION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; STEM CELL;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; MYELIN BASIC PROTEINS; OLIGODENDROGLIA; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN KINASE C; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC;

EID: 78649416523     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22486     Document Type: Article

References (45)

1. Apt D, Watts RM, Suske G, Bernard HU. 1996. High Sp1/Sp3 ratios in epithelial cells during epithelial differentiation and cellular transformation correlate with the activation of the HPV-16 promoter. Virology 224:281-291.
2. - oligo-dendrocyte progenitor development in response to the phorbol ester TPA. J Neurosci Res 34:113-128.
3. Baron W, de Vries EJ, de Vries H, Hoekstra D. 1999. Protein kinase C prevents oligodendrocyte differentiation: modulation of actin cytoskeleton and cognate polarized membrane traffic. J Neurobiol 41:385-398.
4. Baron W, Metz B, Bansal R, Hoekstra D, de Vries H. 2000. PDGF and FGF-2 signaling in oligodendrocyte progenitor cells: regulation of proliferation and differentiation by multiple intracellular signaling pathways. Mol Cell Neurosci 15:314-329.
5. Berti-Mattera LN, Larocca JN, Pelligrino de Iraldi A, Pasquini JM, Soto EF. 1984. Isolation of oligodendroglial cells from young and adult whole rat brains using an in situ generated Percoll gradient. Neurochem Int 6:41-50.
6. Bhat NR. 1991. Phosphorylation of MARCKS (80-kDa) protein, a major substrate for protein kinase C in oligodendroglial progenitors. J Neurosci Res 30:447-454.
7. Bhat NR, Zhang P, Bhat AN. 1995. The expression of myristoylated alanine-rich C-kinase substrate in oligodendrocytes is developmentally regulated. Dev Neurosci 17:256-263.
8. Castagna M, Takai Y, Kaibuchi K, Sano K, Kikkawa U, Nishizuka Y. 1982. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J Biol Chem 257: 7847-7851.
9. Fabbro D, Mazurek N, Borner C, Conscience JF, Erne P. 1988. Role of protein kinase C (PKC) in short-and long-term cellular responses: inhibition of agonist-mediated calcium transients and down-regulation of PKC. J Cardiovasc Pharmacol 12(Suppl 5):S73-S79.
10. Fojas de Borja P, Collins NK, Du P, Azizkhan-Clifford J, Mudryj M. 2001. Cyclin A-CDK phosphorylates Sp1 and enhances Sp1-mediated transcription. EMBO J 20:5737-5747.
11. Gottlieb TM, Jackson SP. 1993. The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72: 131-142.
12. Haidweger E, Novy M, Rotheneder H. 2001. Modulation of Sp1 activity by a cyclin A/CDK complex. J Mol Biol 306:201-212.
13. Henson J, Saffer J, Furneaux H. 1992. The transcription factor Sp1 binds to the JC virus promoter and is selectively expressed in glial cells in human brain. Ann Neurol 32:72-77.
14. Leggett RW, Armstrong SA, Barry D, Mueller CR. 1995. Sp1 is phosphorylated and its DNA binding activity down-regulated upon terminal differentiation of the liver. J Biol Chem 270:25879-25884.
15. Liao M, Zhang Y, Dufau ML. 2008. Protein kinase Calpha-induced derepression of the human luteinizing hormone receptor gene transcription through ERK-mediated release of HDAC1/Sin3A repressor complex from Sp1 sites. Mol Endocrinol 22:1449-1463.
16. McCarthy KD, de Vellis J. 1980. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 85: 890-902.
17. Milanini-Mongiat J, Pouyssegur J, Pages G. 2002. Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription. J Biol Chem 277:20631-20639.
18. Miskimins R, Srinivasan R, Marin-Husstege M, Miskimins WK, Casaccia-Bonnefil P. 2002. p27(Kip1) enhances myelin basic protein gene promoter activity. J Neurosci Res 67:100-105.
19. Narayanan SP, Flores AI, Wang F, Macklin WB. 2009. Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination. J Neurosci 29:6860-6870.
20. Olofsson BA, Kelly CM, Kim J, Hornsby SM, Azizkhan-Clifford J. 2007. Phosphorylation of Sp1 in response to DNA damage by ataxia telangiectasia-mutated kinase. Mol Cancer Res 5:1319-1330.
21. Paez PM, Garcia CI, Pasquini JM. 2006. Expression of myelin basic protein in two oligodendroglial cell lines is modulated by apotransferrin through different transcription factors. J Neurosci Res 83:606-618.
22. Pfeiffer SE, Warrington AE, Bansal R. 1993. The oligodendrocyte and its many cellular processes. Trends Cell Biol 3:191-197.
23. Pouly S, Storch MK, Matthieu JM, Lassmann H, Monnet-Tschudi F, Honegger P. 1997. Demyelination induced by protein kinase C-activating tumor promoters in aggregating brain cell cultures. J Neurosci Res 49:121-132.
24. Rohlff C, Ahmad S, Borellini F, Lei J, Glazer RI. 1997. Modulation of transcription factor Sp1 by cAMP-dependent protein kinase. J Biol Chem 272:21137-21141.
25. Saffer JD, Jackson SP, Annarella MB. 1991. Developmental expression of Sp1 in the mouse. Mol Cell Biol 11:2189-2199.
26. Sato-Bigbee C, DeVries GH. 1996. Treatment of oligodendrocytes with antisense deoxyoligonucleotide directed against CREB mRNA: effect on the cyclic AMP-dependent induction of myelin basic protein expression. J Neurosci Res 46:98-107.
27. Sato-Bigbee C, Yu RK. 1993. Presence of cyclic AMP response element-binding protein in oligodendrocytes. J Neurochem 60:2106- 2110.
28. Sato-Bigbee C, Chan EL, Yu RK. 1994. Oligodendroglial cyclic AMP response element-binding protein: a member of the CREB family of transcription factors. J Neurosci Res 38:621-628.
29. Shiga H, Asou H, Ito E. 2005a. Advancement of differentiation of oligodendrocyte progenitor cells by a cascade including protein kinase A and cyclic AMP-response element binding protein. Neurosci Res 53:436- 441.
30. Shiga H, Yamane Y, Kubo M, Sakurai Y, Asou H, Ito E. 2005b. Differentiation of immature oligodendrocytes is regulated by phosphorylation of cyclic AMP-response element binding protein by a protein kinase C signaling cascade. J Neurosci Res 80:767-776.
31. Solomon SS, Majumdar G, Martinez-Hernandez A, Raghow R. 2008. A critical role of Sp1 transcription factor in regulating gene expression in response to insulin and other hormones. Life Sci 83:305-312.
32. Stariha RL, Kim SU. 2001a. Mitogen-activated protein kinase signalling in oligodendrocytes: a comparison of primary cultures and CG-4. Int J Dev Neurosci 19:427-437.
33. Stariha RL, Kim SU. 2001b. Protein kinase C and mitogen-activated protein kinase signalling in oligodendrocytes. Microsc Res Techniq 52: 680-688.
34. Stariha RL, Kikuchi S, Siow YL, Pelech SL, Kim M, Kim SU. 1997. Role of extracellular signal-regulated protein kinases 1 and 2 in oligo-dendroglial process extension. J Neurochem 68:945-953.
35. Tamura T, Miura M, Ikenaka K, Mikoshiba K. 1988. Analysis of transcription control elements of the mouse myelin basic protein gene in HeLa cell extracts: demonstration of a strong NFI-binding motif in the upstream region. Nucleic Acids Res 16:11441-11459.
36. Tan NY, Khachigian LM. 2009. Sp1 phosphorylation and its regulation of gene transcription. Mol Cell Biol 29:2483-2488.
37. Tan NY, Midgley VC, Kavurma MM, Santiago FS, Luo X, Peden R, Fahmy RG, Berndt MC, Molloy MP, Khachigian LM. 2008. Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1. Circ Res 102:e38-e51.
38. Teutsch I, Weible A, Siess M. 1987. Differential inotropic and chronotropic effects of various protein kinase C activators on isolated guinea pig atria. Eur J Pharmacol 144:363-367.
39. Tretiakova A, Steplewski A, Johnson EM, Khalili K, Amini S. 1999. Regulation of myelin basic protein gene transcription by Sp1 and Puralpha: evidence for association of Sp1 and Puralpha in brain. J Cell Physiol 181:160-168.
40. Wei Q, Miskimins WK, Miskimins R. 2003. The Sp1 family of transcription factors is involved in p27(Kip1)-mediated activation of myelin basic protein gene expression. Mol Cell Biol 23:4035-4045.
41. Wei Q, Miskimins WK, Miskimins R. 2004. Sox10 acts as a tissue-specific transcription factor enhancing activation of the myelin basic protein gene promoter by p27Kip1 and Sp1. J Neurosci Res 78:796-802.
42. Wei Q, Miskimins WK, Miskimins R. 2005. Stage-specific expression of myelin basic protein in oligodendrocytes involves Nkx2.2-mediated repression that is relieved by the Sp1 transcription factor. J Biol Chem 280:16284-16294.
43. Wierstra I. 2008. Sp1: Emerging roles-beyond constitutive activation of TATA-less housekeeping genes. Biochem Biophys Res Commun 372: 1-13.
44. Yang H, Sun X, Wang Z, Ning G, Zhang F, Kong J, Lu L, Reinach PS. 2003. EGF stimulates growth by enhancing capacitative calcium entry in corneal epithelial cells. J Membr Biol 194:47-58.
45. You HL, Eng HL, Hsu SF, Chen CM, Ye TC, Liao WT, Huang MY, Baer R, Cheng JT. 2007. A PKC-Sp1 signaling pathway induces early differentiation of human keratinocytes through up-regulation of TSG101. Cell Signal 19:1201-1211.