Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signaling

Cellular Signalling

Volumn 24, Issue 11, 2012, Pages 2095-2101

  Brauer, Helena ^a   Strauss, Julia ^a   Wegner, Wiebke ^a   Müller Tidow, Carsten ^b   Horstmann, Martin ^a   Jücker, Manfred ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Acute myeloid leukemia; Inositol 5 phosphatase; SH2 domain; SHIP1

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE SHP 1;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; GENE LOCATION; HUMAN; HUMAN CELL; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MISSENSE MUTATION; MUTATIONAL ANALYSIS; MUTATOR GENE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN TYROSINE PHOSPHATASE SHP 1 GENE; SIGNAL TRANSDUCTION;

DNA MUTATIONAL ANALYSIS; GRB2 ADAPTOR PROTEIN; HUMANS; JURKAT CELLS; LEUKEMIA, MYELOID, ACUTE; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS;

EID: 84865323036     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2012.07.017     Document Type: Article

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