Evaluation of a common variant of the gene encoding clara Cell 10 kd Protein (CC10) as a candidate determinant for asthma severity and steroid responsiveness among chinese children

Journal of Asthma

Volumn 49, Issue 7, 2012, Pages 665-672

  Chen, Li Chen ^a   Tseng, Hsu Min ^b   Wu, Chia Jen ^b   Kuo, Ming Ling ^b   Wu, Cheng Jang ^b   Gao, Pei Song ^c   Yeh, Kuo Wei ^a   Yao, Tsung Chieh ^a   Lee, Wen I ^a   Ou, Liang Shiou ^a   Huang, Jing Long ^a   Huang, Shau Ku ^c,d  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

^d NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Acute exacerbation; Asthma; CC10; Gene polymorphism; Uteroglobin

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLARA CELL PROTEIN; DEXAMETHASONE; INTERLEUKIN 8; LUCIFERASE; METHACHOLINE; PREDNISOLONE; TERBUTALINE;

ALLELE; ARTICLE; ASTHMA; CASE CONTROL STUDY; CELL LINE; CHILD; CHINESE; CLARA CELL 10 KDA PROTEIN GENE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; COUGHING; DISEASE EXACERBATION; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; FORCED EXPIRATORY VOLUME; GENE; GENE ACTIVITY; GENE EXPRESSION; GENE FREQUENCY; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOTYPE; HUMAN; INHALATION TEST; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PROTEIN BLOOD LEVEL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SCHOOL CHILD; TRANSIENT TRANSFECTION; TREATMENT RESPONSE; WHEEZING; WILD TYPE;

ADRENAL CORTEX HORMONES; ASIAN CONTINENTAL ANCESTRY GROUP; ASTHMA; CHILD; CHILD, PRESCHOOL; FEMALE; GENOTYPE; HUMANS; MALE; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; UTEROGLOBIN;

EID: 84865320446     PISSN: 02770903     EISSN: 15324303     Source Type: Journal    
DOI: 10.3109/02770903.2012.697954     Document Type: Article

References (41)

1. Rabe K, Adachi M, Lai C, Soriano J, Vermeire P, Weiss K, Weiss S. Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J Allergy Clin Immunol 2004; 114:40-47. (Pubitemid 39022491)
2. Pearce N, Aït-Khaled N, Beasley R, Mallol J, Keil U, Mitchell E, Robertson C; and the ISAAC Phase Three Study Group. World-wide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2007; 62:758-766.
3. Tsuang HC, Su HJ, Kao FF, Shih HC. Effects of changing risk factors on increasing asthma prevalence in southern Taiwan. Paediatr Perinat Epidemiol 2003; 17:3-9. (Pubitemid 37128703)
4. Kao CC, Huang JL, Ou LS, See LC. The prevalence, severity and seasonal variations of asthma, rhinitis and eczema in Taiwanese schoolchildren. Pediatr Allergy Immunol 2005; 16:408-415.
5. Yan DC, Ou LS, Tsai TL, Wu WF, Huang JL. Prevalence and severity of symptoms of asthma, rhinitis, and eczema in 13-to 14-year-old children in Taipei, Taiwan. Ann Allergy Asthma Immunol 2005; 95:579-585.
6. Mukherjee AB, Zhang Z, Chilton BS. Uteroglobin: a steroid-inducible immunomodulatory protein that founded the Secretoglobin superfamily. Endocr Rev 2007; 28:707-725. (Pubitemid 350294292)
7. Shijubo N, Kawabata I, Sato N, Itoh Y. Clinical aspects of Clara cell 10-kDa protein/uteroglobin (secretoglobin 1A1). Curr Pharm Des 2003; 9:1139-1149. (Pubitemid 36443216)
8. Hayashida S, Harrod KS, Whitsett JA. Regulation and function of CCSP during pulmonary Pseudomonas aeruginosa infection in vivo. Am J Physiol Lung Cell Mol Physiol 2000; 279:452-459.
9. Chen LC, Zhang Z, Myers AC, Huang SK. Cutting edge: altered pulmonary eosinophilic inflammation in mice deficient for Clara cell secretory 10-kDa protein. J Immunol 2001; 340 (167): 3025-3028. (Pubitemid 32852537)
10. Mandal AK, Zhang Z, Ray R, Choi MS, Chowdhury B, Pattabiraman N, Mukherjee AB. Uteroglobin represses allergen-induced inflammatory response by blocking PGD2 receptor-mediated functions. J Exp Med 2004; 199:1317-1330. (Pubitemid 38685724)
11. Wang SZ, Rosenberger CL, Espindola TM, Barrett EG, Tesfaigzi Y, Bice DE, Harrod KS. CCSP modulates airway dysfunction and host responses in an Ova-challenged mouse model. Am J Physiol Lung Cell Mol Physiol 2001; 281:L1303-L1311.
12. Laing IA, Hermans C, Bernard A, Burton PR, Goldblatt J, Le Souef PN. Association between plasma CC16 levels, the A38G polymorphism, and asthma. Am J Respir Crit Care Med 2000; 16:124-127. (Pubitemid 30055913)
13. Candelaria PV, Backer V, Laing IA, Porsbjerg C, Nepper-Christensen S, de Klerk N, Goldblatt J, Le Souëf PN. Association between asthmarelated phenotypes and the CC16 A38G polymorphism in an unselected population of young adult Danes. Immunogenetics 2005; 57:25-32. (Pubitemid 40591244)
14. Gao PS, Mao XQ, Kawai M, Enomoto T, Sasaki S, Tanabe O, Yoshimura K, Shaldon SR, Dake Y, Kitano H, Coull P, Shirakawa T, Hopkin JM. Negative association between asthma and variants of CC16 (CC10) on chromosome 11q13 in British and Japanese populations. Hum Genet 1998; 103:57-59. (Pubitemid 28398386)
15. Mansur AH, Fryer AA, Hepple M, Strange RC, Spiteri MA. An association study between the Clara cell secretory protein CC16 A38G polymorphism and asthma phenotypes. Clin Exp Allergy 2002; 32:994-999. (Pubitemid 34779593)
16. Sharma S, Ghosh B. Association of an intragenic microsatellite marker in the CC16 gene with asthma in the Indian population. J Hum Genet 2004; 49:677-683.
17. Van Vyve T, Chanez P, Bernard A, Bousquet J, Godard P, Lauwerijs R, Sibille Y. Protein content in bronchoalveolar lavage fluid of patients with asthma and control subjects. J Allergy Clin Immunol 1995; 95:60-68.
18. Shijubo N, Itoh Y, Yamaguchi T, Sugaya F, Hirasawa M, Yamada T, Kawai T, Abe S. Serum levels of Clara cell 10-kDa protein are decreased in patients with asthma. Lung 1999; 177:45-52. (Pubitemid 29013440)
19. Yang KD, Ou CY, Chang JC, Chen RF, Liu CA, Liang HM, Hsu TY, Chen LC, Huang SK. Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism and concentration, but not allergy sensitization, in a perinatal cohort study. J Allergy Clin Immunol 2007; 120:842-848. (Pubitemid 47531851)
20. Benson M, Fransson M, Martinsson T, Naluai AT, Uddman R, Cardell LO. Inverse relation between nasal fluid Clara Cell Protein 16 levels and symptoms and signs of rhinitis in allergen-challenged patients with intermittent allergic rhinitis. Allergy 2007; 62:178-183. (Pubitemid 46090300)
21. Gioldassi XM, Papadimitriou H, Mikraki V, Karamanos NK. Clara cell secretory protein: determination of serum levels by an enzyme immunoassay and its importance as an indicator of bronchial asthma in children. J Pharm Biomed Anal 2004; 34:823-826. (Pubitemid 38264562)
22. Chen J, Lam S, Pilon A, McWilliams A, Macaulay C, Szabo E. Higher levels of the anti-inflammatory protein CC10 are associated with improvement in bronchial dysplasia and sputum cytometric assessment in individuals at high risk for lung cancer. Clin Cancer Res 2008; 14:1590-1597. (Pubitemid 351413944)
23. Broeckaert F, Arsalane K, Hermans C, Bergamaschi E, Brustolin A, Mutti A, Serum BA. Clara cell protein: a sensitive biomarker of increased lung epithelium permeability caused by ambient ozone. Environ Health Perspect 2000; 108:533-537. (Pubitemid 30453775)
24. Lakind JS, Holgate ST, Ownby DR, Mansur AH, Helms PJ, Pyatt D, Hays SM. A critical review of the use of Clara cell secretory protein (CC16) as a biomarker of acute or chronic pulmonary effects. Biomarkers 2007; 12:445-467. (Pubitemid 47304652)
25. Hallstrand TS, Fahy JV. Practical management of acute asthma in adults. Respir Care 2002; 47:171-182.
26. Robinson D, Hamid Q, Ying S, Bentley A, Assoufi B, Durham S. Prednisolone treatment in asthma is associatedwithmodulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression. Am Rev Respir Dis 1993; 148:401-406. (Pubitemid 23221585)
27. Schwiebert LM, Beck LA, Stellato C, Bickel CA, Bochner BS, Schleimer RP. Glucocorticosteroid inhibition of cytokine production relevance to anti-allergic actions. J Allergy Clin Immunol 1996; 97:143-152. (Pubitemid 26049495)
28. Goleva E, Li LB, Eves PT, Strand MJ, Martin RJ, Leung DY. Increased glucocorticoid receptor beta alters steroid response in glucocorticoidinsensitive asthma. Am J Respir Crit Care Med 2006; 173:607-616. (Pubitemid 43363801)
29. Berg T, Cassel TN, Schwarze PE, Nord M. Glucocorticoids regulate the CCSP and CYP2B1 promoters via C/EBPbeta and delta in lung cells. Biochem Biophys Res Commun 2002; 293:907-912.
30. Kim S, Shim JJ, Burgel PR, Ueki IF, Dao-Pick T, Tam DC, Nadel JA. IL- 13-induced Clara cell secretory protein expression in airway epithelium: role of EGFR signaling pathway. Am J Physiol Lung Cell Mol Physiol 2002; 283:L67-L75. (Pubitemid 34773421)
31. Yao TC, Kuo ML, See LC, Chen LC, Yan DC, Ou LS, Shaw CK, Huang JL. The RANTES promoter polymorphism: a genetic risk factor for nearfatal asthma in Chinese children. J Allergy Clin Immunol 2003; 111 (6): 1285-1292.
32. x on pulmonary function and methacholine and allergen bronchial sensitivities in asthmatic children. Arch Environ Health 1991; 46:296-299.
33. Tsaprouni LG, Ito K, Adcock IM, Punchard N. Suppression of lipopolysaccharide-and tumor necrosis factor-alpha-induced interleukin (IL)-8 expression by glucocorticoids involves changes in IL-8 promoter acetylation. Clin Exp Immunol 2007; 150:151-157. (Pubitemid 47383307)
34. Neale BM, Sham PC. The future of association studies: gene-based analysis and replication. Am J Hum Genet 2004; 75 (3): 353-362. (Pubitemid 39095812)
35. Zhu M, Zhao S. Candidate gene identification approach: progress and challenges. Int J Biol Sci 2007; 3 (7): 420-427. (Pubitemid 350132789)
36. Sengler C, Heinzmann A, Jerkic SP, Haider A, Sommerfeld C, Niggemann B, Lau S, Forster J, Schuster A, Kamin W, Bauer C, Laing I, LeSouef P, Wahn U, Deichmann K, Nickel R. Clara cell protein 16 (CC16) gene polymorphism influences the degree of airway responsiveness in asthmatic children. J Allergy Clin Immunol 2003; 111:515-519. (Pubitemid 36337871)
37. Boldt K, Rist W, Weiss SM, Weith A, Lenter MC. FPRL-1 induces modifications of migration-associated proteins in human neutrophils. Proteomics 2006; 6 (17): 4790-4799. (Pubitemid 44369058)
38. Hung CH, Chen LC, Zhang Z, Chowdhury B, Lee WL, Plunkett B, Chen CH, Myers AC, Huang SK. Regulation of TH2 responses by the pulmonary Clara cell secretory 10-kd protein. J Allergy Clin Immunol 2004; 114 (3): 664-670. (Pubitemid 39194945)
39. Snyder JC, Reynolds SD, Hollingsworth JW, Li Z, Kaminski N, Stripp BR. Clara cells attenuate the inflammatory response through regulation of macrophage behavior. Am J Respir Cell Mol Biol 2010; 42 (2): 161-171.
40. Martin AC, Laing IA, Khoo SK, Zhang G, Rueter K, Teoh L, Taheri S, Hayden CM, Geelhoed GC, Goldblatt J, LeSouëf PN. Acute asthma in children: Relationships among CD14 and CC16 genotypes, plasma levels, and severity. Am J Respir Crit Care Med 2006; 173:617-622. (Pubitemid 43363802)
41. Sawaya PL, Stripp BR, Whitsett JA, Luse DS. The lung-specific CC10 gene is regulated by transcription factors from the AP-1, octamer, and hepatocyte nuclear factor 3 families. Mol Cell Biol 1993; 13:3860-3871. (Pubitemid 23187614)