Linear and non-linear associations of symptom dimensions and cognitive function in first-onset psychosis

Schizophrenia Research

Volumn 140, Issue 1-3, 2012, Pages 221-231

  Kravariti, Eugenia ^a   Russo, Manuela ^a   Vassos, Evangelos ^a   Morgan, Kevin ^a,f   Fearon, Paul ^a,g   Zanelli, Jolanta W ^a   Demjaha, Arsime ^a   Lappin, Julia M ^a   Tsakanikos, Elias ^b,h   Dazzan, Paola ^a   Morgan, Craig ^a   Doody, Gillian A ^c   Harrison, Glynn ^d   Jones, Peter B ^e   Murray, Robin M ^a   Reichenberg, Abraham ^a  

^a SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f UNIVERSITY OF WESTMINSTER   (United Kingdom)

^g TRINITY COLLEGE DUBLIN   (Ireland)

^h UNIVERSITY OF ROEHAMPTON   (United Kingdom)

Author keywords

Affective; Cognition; First onset psychosis; Non affective; Population based; Symptom dimensions

Indexed keywords

ADOLESCENT; ADULT; AFFECTIVE PSYCHOSIS; ARTICLE; BRAIN DYSFUNCTION; CONTROLLED STUDY; DEPRESSION; DISEASE ASSOCIATION; DISORIENTATION; EXECUTIVE FUNCTION; FEMALE; HUMAN; INTELLIGENCE QUOTIENT; LEARNING CURVE; MAJOR CLINICAL STUDY; MALE; MANIC PSYCHOSIS; MENTAL PERFORMANCE; NEGATIVE SYNDROME; ONSET AGE; PERCEPTION DISORDER; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; PSYCHOSIS; SYMPTOMATOLOGY; VERBAL MEMORY; VISUAL MEMORY; WORKING MEMORY;

ADOLESCENT; ADULT; ASSOCIATION; COGNITION DISORDERS; COHORT STUDIES; COMMUNITY HEALTH PLANNING; FEMALE; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; NONLINEAR DYNAMICS; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTIC DISORDERS; SEX FACTORS; YOUNG ADULT;

EID: 84865315958     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2012.06.008     Document Type: Article

References (50)

1. Allardyce J., Suppes T., Van Os J. Dimensions and the psychosis phenotype. Int. J. Methods Psychiatr. Res. 2007, 16(S1):S34-S40.
2. Balanzá-Martínez V., Rubio C., Selva-Vera G., Martinez-Aran A., Sánchez-Moreno J., Salazar-Fraile J., Vieta E., Tabarés-Seisdedos R. Neurocognitive endophenotypes (Endophenocognitypes) from studies of relatives of bipolar disorder subjects: A systematic review. Special section: The European Workshop in Imagery and Cognition: Neurocognition and Visual Imagery. Neurosci. Biobehav. Rev. 2008, 32(8):1426-1438.
3. Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. B 1995, 57(1):289-300.
4. Bozikas V.P., Kosmidis M.H., Kioperlidou K., Karavatos A. Relationship between psychopathology and cognitive functioning in schizophrenia. Compr. Psychiatry 2004, 45(5):392-400.
5. Breakspear M. The nonlinear theory of schizophrenia. Aust. N. Z. J. Psychiatry 2006, 40(1):20-35.
6. Burdick K.E., Gunawardane N., Woodberry K., Malhotra A.K. The role of general intelligence as an intermediate phenotype for neuropsychiatric disorders. Cogn. Neuropsychiatry 2009, 14(4-5):299-311.
7. Cameron A.M., Oram J., Geffen G.M., Kavanagh D.J., McGrath J.J., Geffen L.B. Working memory correlates of three symptom clusters in schizophrenia. Psychiatry Res. 2002, 110(1):49-61.
8. Cannon M., Caspi A., Moffitt T.E., Harrington H., Taylor A., Murray R.M., Poulton R. Evidence for early-childhood, pan-developmental impairment specific to schizophreniform disorder: results from a longitudinal birth cohort. Arch. Gen. Psychiatry 2002, 59(5):449-456.
9. Curran-Everett D. Multiple comparisons: philosophies and illustrations. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2000, 279(1):R1-R8.
10. Demjaha A., Morgan K., Morgan C., Landau S., Dean K., Reichenberg A., Sham P., Fearon P., Hutchinson G., Jones P.B., Murray R.M., Dazzan P. Combining dimensional and categorical representation of psychosis: the way forward for DSM-V and ICD-11?. Psychol. Med. 2009, 39(12):1943-1955.
11. Dikeos D.G., Wickham H., McDonald C., Walshe M., Sigmundsson T., Bramon E., Grech A., Toulopoulou T., Murray R., Sham P.C. Distribution of symptom dimensions across Kraepelinian divisions. Br. J. Psychiatry 2006, 189(4):346-353.
12. Dixon T., Kravariti E., Frith C., Murray R.M., McGuire P.K. Effect of symptoms on executive function in bipolar illness. Psychol. Med. 2004, 34(5):811-821.
13. Dominguez M.G., Viechtbauer W., Simons C.J., van Os J., Krabbendam L. Are psychotic psychopathology and neurocognition orthogonal? A systematic review of their associations. Psychol. Bull. 2009, 135(1):157-171.
14. Fearon P., Kirkbride J.B., Morgan C., Dazzan P., Morgan K., Lloyd T., Hutchinson G., Tarrant J., Fung W.L., Holloway J., Mallett R., Harrison G., Leff J., Jones P.B., Murray R.M. Incidence of schizophrenia and other psychoses in ethnic minority groups: results from the MRC AESOP Study. Psychol. Med. 2006, 36(11):1541-1550.
15. Glahn D.C., Almasy L., Barguil M., Hare E., Peralta J.M., Kent J.W., Dassori A., Contreras J., Pacheco A., Lanzagorta N., Nicolini H., Raventos H., Escamilla M.A. Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families. Arch. Gen. Psychiatry 2010, 67(2):168-177.
16. Gold J.M., Carpenter C., Randolph C., Goldberg T.E., Weinberger D.R. Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia. Arch. Gen. Psychiatry 1997, 54(2):159-165.
17. Gottesman I.I., Gould T.D. The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry 2003, 160(4):636-645.
18. Heydebrand G., Weiser M., Rabinowitz J., Hoff A.L., DeLisi L.E., Csernansky J.G. Correlates of cognitive deficits in first episode schizophrenia. Schizophr. Res. 2004, 68(1):1-9.
19. Howard R., Rabins P.V., Mary V., Seeman M.V., Jeste D.V. Late-onset schizophrenia and very-late-onset schizophrenia-like psychosis: an international consensus. Am. J. Psychiatry 2000, 157(2):172-178. International Late-Onset Schizophrenia Group.
20. Jablensky A. Subtyping schizophrenia: implications for genetic research. Mol. Psychiatry 2006, 11(9):815-836.
21. Joyce E.M., Roiser J.P. Cognitive heterogeneity in schizophrenia. Curr. Opin. Psychiatry 2007, 20(3):268-272.
22. Kaymaz N., Van Os J. Murray et al. (2004) revisited: is bipolar disorder identical to schizophrenia without developmental impairment?. Acta Psychiatr. Scand. 2009, 120(4):249-252.
23. Koenen K.C., Moffitt T.E., Roberts A.L., Martin L.T., Kubzansky L., Harrington H., Poulton R., Caspi A. Childhood IQ and adult mental disorders: a test of the cognitive reserve hypothesis. Am. J. Psychiatry 2009, 166(1):50-57.
24. Kravariti E., Dixon T., Frith C., Murray R., McGuire P. Association of symptoms and executive function in schizophrenia and bipolar disorder. Schizophr. Res. 2005, 74(3):221-231.
25. Liddle P. The symptoms of chronic schizophrenia. A re-examination of the positive-negative dichotomy. Br. J. Psychiatry 1987, 151(2):145-151.
26. Lindenmayer J.P., Bossie C.A., Kujawa M., Zhu Y., Canuso C.M. Dimensions of psychosis in patients with bipolar mania as measured by the positive and negative syndrome scale. Psychopathology 2008, 41(4):264-270.
27. Ling X.B., Cohen H., Jin J., Lau I., Schilling J. FDR made easy in differential feature discovery and correlation analyses. Bioinformatics 2009, 25(11):1461-1462.
28. Lucas S., Fitzgerald D., Redoblado-Hodge M.A., Anderson J., Sanbrook M., Harris A., Brennan J. Neuropsychological correlates of symptom profiles in first episode schizophrenia. Schizophr. Res. 2004, 71(2-3):323-330.
29. MacCabe J.H., Lambe M.P., Cnattingius S., Sham P.C., David A.S., Reichenberg A., Murray R.M., Hultman C.M. Excellent school performance at age 16 and risk of adult bipolar disorder: national cohort study. Br. J. Psychiatry 2010, 196(2):109-115.
30. Mallett R. Sociodemographic Schedule 1997, Section of Social Psychiatry, Institute of Psychiatry, London.
31. Morgan C., Dazzan P., Morgan K., Jones P., Harrison G., Leff J., Murray R., Fearon P. First episode psychosis and ethnicity: initial findings from the AESOP study. World Psychiatry 2006, 5(1):40-46.
32. Murray R.M., Sham P., Van Os J., Zanelli J., Cannon M., McDonald C. A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder. Schizophr. Res. 2004, 71(2-3):405-416.
33. Peralta V., Cuesta M.J., Farre C. Factor structure of symptoms in functional psychoses. Biol. Psychiatry 1997, 42(9):806-815.
34. Raven J.C. Coloured Progressive Matrices. Sets A, AB, B 1995, Oxford Psychologists Press Ltd., Oxford.
35. Reitan R.M. Validity of the Trail Making Test as an indication of organic brain damage. Percept. Mot. Skills 1958, (8):271-276.
36. Simonsen C., Sundet K., Vaskinn A., Birkenaes A.B., Engh J.A., Faerden A., Jonsdottir H., Ringen P.A., Opjordsmoen S., Melle I., Friis S., Andreassen O.A. Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group. Schizophr. Bull. 2009, 37(1):73-83.
37. Smith M.J., Barch D.M., Csernansky J.G. Bridging the gap between schizophrenia and psychotic mood disorders: relating neurocognitive deficits to psychopathology. Schizophr. Res. 2009, 107(1):69-75.
38. Spreen O., Strauss E. A compendium of neuropsychological tests: administration, norms, and commentary 1991, Oxford University Press, New York.
39. Squires R.F., Saederup E. A review of evidence for GABergic predominance/glutamatergic deficit as a common etiological factor in both schizophrenia and affective psychoses: more support for a continuum hypothesis of "functional" psychosis. Neurochem. Res. 1991, 16(10):1099-1111.
40. StataCorp STATA v.10.0 for Windows 2007, Stata Corportation, College Station, Texas.
41. Storey J.D., Tibshirani R. Statistical significance for genomewide studies. Proc. Natl. Acad. Sci. U. S. A. 2003, 100(16):9440.
42. Strimmer K. A unified approach to false discovery rate estimation. BMC Bioinformatics 2008, 9:303.
43. Stroup T.S. Heterogeneity of treatment effects in schizophrenia. Am. J. Med. 2007, 120(4):S26-S31.
44. Van der Does A.J., Dingemans P.M., Linszen D.H., Nugter M.A., Scholte W.F. Symptom dimensions and cognitive and social functioning in recent-onset schizophrenia. Psychol. Med. 1993, 23(3):745-753.
45. Van Os J., Gilvarry C., Bale R., Van Horn E., Tattan T., White I., Murray R. A comparison of the utility of dimensional and categorical representations of psychosis. UK700 Group. Psychol. Med. 1999, 29(3):595-606.
46. Wechsler D. Wechsler Adult Intelligence Scale-Revised manual 1981, The Psychological Corporation, USA.
47. Wechsler D. Instruction Manual for the Wechsler Memory Scale Revised 1987, Psychological Corp., New York.
48. World Health Organization International statistical classification of diseases and related health problems: ICD-10 1992, World Health Organization, Geneva. 10th revision. ed.
49. World Health Organization SCAN (Schedules for Clinical Assessment in Neuropsychiatry) 1994, World Health Organization, Geneva.
50. Zanelli J., Reichenberg A., Morgan K., Fearon P., Kravariti E., Dazzan P., Morgan C., Zanelli C., Demjaha A., Jones P.B., Doody G.A., Kapur S., Murray R.M. Specific and generalized neuropsychological deficits: a comparison of patients with various first-episode psychosis presentations. Am. J. Psychiatry 2010, 167(1):78-85.