Poly(ethylene glycol) hydrogels formed by thiol-ene photopolymerization for enzyme-responsive protein delivery

Biomaterials

Volumn 30, Issue 30, 2009, Pages 6048-6054

  Aimetti, Alex A ^a   Machen, Alexandra J ^a   Anseth, Kristi S ^a,b  

^a UCB 450   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Drug delivery; Hydrogel; Inflammation; Photopolymerization

Indexed keywords

BIOMEDICAL APPLICATIONS; BOVINE SERUM ALBUMINS; CARBONIC ANHYDRASES; CELLULAR RESPONSE; CONCENTRATION OF; DEGRADABLE HYDROGEL; DEGRADATION KINETICS; DELIVERY SYSTEMS; ENVIRONMENTAL CONDITIONS; HUMAN NEUTROPHIL ELASTASE; INFLAMMATION; MASS LOSS; POLY(ETHYLENE GLYCOL); POLY(ETHYLENE GLYCOL) HYDROGEL; PROTEIN DELIVERY; PROTEIN RELEASE; PROTEIN THERAPEUTICS; SURFACE EROSION; THIOL-ENE PHOTOPOLYMERIZATION;

AMINES; BODY FLUIDS; DEGRADATION; DRUG DELIVERY; ENZYMES; ETHYLENE; ETHYLENE GLYCOL; GELATION; GELS; PATHOLOGY; PEPTIDES; PHOTOPOLYMERIZATION; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES;

HYDROGELS;

BOVINE SERUM ALBUMIN; CARBONATE DEHYDRATASE; LEUKOCYTE ELASTASE; LYSOZYME; MACROGOL; PEPTIDE; PROTEIN; THIOL DERIVATIVE; THIOL ENE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DEGRADATION; DRUG DELIVERY SYSTEM; HYDROGEL; INFLAMMATION; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN SECRETION;

ANIMALS; BIOCOMPATIBLE MATERIALS; CATTLE; DRUG DELIVERY SYSTEMS; ENZYMES; HUMANS; HYDROGELS; INFLAMMATION; KINETICS; LEUKOCYTE ELASTASE; LIGHT; MURAMIDASE; POLYETHYLENE GLYCOLS; PROTEINS; SERUM ALBUMIN; SULFHYDRYL COMPOUNDS; SURFACE PROPERTIES;

BOVINAE;

EID: 69249229499     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.07.043     Document Type: Article

References (38)

1. Burdick J.A., and Anseth K.S. Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering. Biomaterials 23 22 (2002) 4315-4323
2. Nguyen K.T., and West J.L. Photopolymerizable hydrogels for tissue engineering applications. Biomaterials 23 22 (2002) 4307-4314
3. Peppas N.A., Bures P., Leobandung W., and Ichikawa H. Hydrogels in pharmaceutical formulations. European Journal of Pharmaceutics and Biopharmaceutics 50 1 (2000) 27-46
4. Lin C.C., and Metters A.T. Hydrogels in controlled release formulations: network design and mathematical modeling. Advanced Drug Delivery Reviews 58 12-13 (2006) 1379-1408
5. Lu S.X., and Anseth K.S. Release behavior of high molecular weight solutes from poly(ethylene glycol)-based degradable networks. Macromolecules 33 7 (2000) 2509-2515
6. Bryant S.J., Bender R.J., Durand K.L., and Anseth K.S. Encapsulating chondrocytes in degrading PEG hydrogels with high modulus: engineering gel structural changes to facilitate cartilaginous tissue production. Biotechnology and Bioengineering 86 7 (2004) 747-755
7. Mellott M.B., Searcy K., and Pishko M.V. Release of protein from highly cross-linked hydrogels of poly(ethylene glycol) diacrylate fabricated by UV polymerization. Biomaterials 22 9 (2001) 929-941
8. Sawhney A.S., Pathak C.P., and Hubbell J.A. Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(alpha-hydroxy acid) diacrylate macromers. Macromolecules 26 4 (1993) 581-587
9. Bromberg L.E., and Ron E.S. Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery. Advanced Drug Delivery Reviews 31 3 (1998) 197-221
10. Qiu Y., and Park K. Environment-sensitive hydrogels for drug delivery. Advanced Drug Delivery Reviews 53 3 (2001) 321-339
11. Lutolf M.P., Lauer-Fields J.L., Schmoekel H.G., Metters A.T., Weber F.E., Fields G.B., et al. Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: engineering cell-invasion characteristics. Proceedings of the National Academy of Sciences of the United States of America 100 9 (2003) 5413-5418
12. Aimetti A.A., Tibbitt M.W., and Anseth K.S. Human neutrophil elastase responsive delivery from poly(ethylene glycol) hydrogels. Biomacromolecules 10 6 (2009) 1484-1489
13. Zisch A.H., Schenk U., Schense J.C., Sakiyama-Elbert S.E., and Hubbell J.A. Covalently conjugated VEGF-fibrin matrices for endothelialization. Journal of Controlled Release 72 1-3 (2001) 101-113
14. Sakiyama-Elbert S.E., Panitch A., and Hubbell J.A. Development of growth factor fusion proteins for cell-triggered drug delivery. FASEB Journal 15 7 (2001) 1300-1302
15. Mann B.K., Gobin A.S., Tsai A.T., Schmedlen R.H., and West J.L. Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering. Biomaterials 22 22 (2001) 3045-3051
16. Lin-Gibson S., Jones R.L., Washburn N.R., and Horkay F. Structure-property relationships of photopolymerizable poly(ethylene glycol) dimethacrylate hydrogels. Macromolecules 38 7 (2005) 2897-2902
17. Elbert D.L., Pratt A.B., Lutolf M.P., Halstenberg S., and Hubbell J.A. Protein delivery from materials formed by self-selective conjugate addition reactions. Journal of Controlled Release 76 1-2 (2001) 11-25
18. Lutolf M.P., Raeber G.P., Zisch A.H., Tirelli N., and Hubbell J.A. Cell-responsive synthetic hydrogels. Advanced Materials 15 11 (2003) 888
19. Fairbanks BD, M.P.; Halevi, A.E.; Nuttelman, C.R.; Bowman, C.N.; Anseth, K.S. A versatile synthetic extracellular matrix mimic via thiol-ene photopolymerization. Advanced Materials, in press, doi:10.1002/adma.200901808.
20. Cramer N.B., and Bowman C.N. Kinetics of thiol-ene and thiol-acrylate photopolymerizations with real-time fourier transform infrared. Journal of Polymer Science Part A Polymer Chemistry 39 19 (2001) 3311-3319
21. Tung C.Y.M., and Dynes P.J. Relationship between viscoelastic properties and gelation in thermosetting systems. Journal of Applied Polymer Science 27 2 (1982) 569-574
22. Quick D.J., Macdonald K.K., and Anseth K.S. Delivering DNA from photocrosslinked, surface eroding polyanhydrides. Journal of Controlled Release 97 2 (2004) 333-343
23. Hopfenberg H.B. Controlled release from erodible slabs, cylinders, and spheres. ACS Symposium Series 33 (1976) 26-32
24. Gopferich A., Karydas D., and Langer R. Predicting drug-release from cylindric polyanhydride matrix discs. European Journal of Pharmaceutics and Biopharmaceutics 41 2 (1995) 81-87
25. Muggli D.S., Burkoth A.K., and Anseth K.S. Crosslinked polyanhydrides for use in orthopedic applications: degradation behavior and mechanics. Journal of Biomedical Materials Research 46 2 (1999) 271-278
26. Burkoth A.K., and Anseth K.S. A review of photocrosslinked polyanhydrides: in situ forming degradable networks. Biomaterials 21 23 (2000) 2395-2404
27. Canal T., and Peppas N.A. Correlation between mesh size and equilibrium degree of swelling of polymeric networks. Journal of Biomedical Materials Research 23 10 (1989) 1183-1193
28. Lustig S.R., and Peppas N.A. Solute diffusion in swollen membranes. 9. scaling laws for solute diffusion in gels. Journal of Applied Polymer Science 36 4 (1988) 735-747
29. Anseth K.S., Bowman C.N., and BrannonPeppas L. Mechanical properties of hydrogels and their experimental determination. Biomaterials 17 17 (1996) 1647-1657
30. Lin C.C., Sawicki S.M., and Metters A.T. Free-radical-mediated protein inactivation and recovery during protein photoencapsulation. Biomacromolecules 9 1 (2008) 75-83
31. Lin C.C., and Metters A.T. Enhanced protein delivery from photopolymerized hydrogels using a pseudospecific metal chelating ligand. Pharmaceutical Research 23 3 (2006) 614-622
32. Bailon P., Palleroni A., Schaffer C.A., Spence C.L., Fung W.J., Porter J.E., et al. Rational design of a potent, long-lasting form of interferon: a 40 kDa branched polyethylene glycol-conjugated interferon alpha-2a for the treatment of hepatitis C. Bioconjugate Chem 12 2 (2001) 195-202
33. Diwan M., and Park T.G. Pegylation enhances protein stability during encapsulation in PLGA microspheres. Journal of Controlled Release 73 2-3 (2001) 233-244
34. Hinds K.D., and Kim S.W. Effects of PEG conjugation on insulin properties. Advanced Drug Delivery Reviews 54 4 (2002) 505-530
35. Hayashi T., Shimoyama Y., Kuwata K., and Era S. Investigation of slow dynamics of the sulfhydryl in the solution and gel states of bovine serum albumin: a vector electron paramagnetic resonance study. Japanese Journal of Physiology 49 1 (1999) 27-33
36. Koulmanda M., Bhasin M., Hoffman L., Fan Z.G., Qipo A.D., Shi H., et al. Curative and beta cell regenerative effects of alpha 1-antitrypsin treatment in autoimmune diabetic NOD mice. Proceedings of the National Academy of Sciences of the United States of America 105 42 (2008) 16242-16247
37. Choy E.H.S., and Panayi G.S. Mechanisms of disease: cytokine pathways and joint inflammation in rheumatoid arthritis. New England Journal of Medicine 344 12 (2001) 907-916
38. Schafer M., and Werner S. Cancer as an overhealing wound: an old hypothesis revisited. Nature Reviews Molecular Cell Biology 9 8 (2008) 628-638