Limited cleavage of tau with matrix-metalloproteinase MMP-9, but not MMP-3, enhances tau oligomer formation

Experimental Neurology

Volumn 237, Issue 2, 2012, Pages 470-476

  Nubling G ^a,b   Levin, J ^a,b   Bader, B ^a,b   Israel, L ^b   Botzel K ^a   Lorenzl, S ^a   Giese, A ^b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Aggregation; Alzheimer's disease; Fluorescence correlation spectroscopy; Limited cleavage; Mass spectrometry; Matrix metalloproteinase; Neurodegeneration; Oligomer; Tau; Tauopathy

Indexed keywords

GELATINASE B; OLIGOMER; PROTEINASE K; STROMELYSIN; TAU PROTEIN; TRYPSIN;

ARTICLE; CONTROLLED STUDY; FLUORESCENCE CORRELATION SPECTROSCOPY; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CLEAVAGE; PROTEIN DEGRADATION;

HUMANS; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 9; NEURODEGENERATIVE DISEASES; PEPTIDE FRAGMENTS; PROTEOLYSIS; SPECTROMETRY, FLUORESCENCE; TAU PROTEINS;

EID: 84865306278     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.07.018     Document Type: Article

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