PH sensitive polyelectrolyte complex of O-carboxymethyl chitosan and poly (acrylic acid) cross-linked with calcium for sustained delivery of acid susceptible drugs

International Journal of Pharmaceutics

Volumn 436, Issue 1-2, 2012, Pages 418-425

  Gujarathi, Nayan A ^a   Rane, Bhushan R ^b   Patel, Jayvadan K ^c  

^a Jodhpur National University   (India)

^b NORTH MAHARASHTRA UNIVERSITY   (India)

^c NOOTAN PHARMACY COLLEGE   (India)

Author keywords

Carbopol; Ionic gelation method; Mucoadhesive; O Carboxymethyl chitosan; Polyelectrolyte complex; Rabeprazole sodium

Indexed keywords

CALCIUM ION; CARBOMER; CARBOXYLIC ACID; CHITOSAN DERIVATIVE; GLYCOPROTEIN; MUCIN; O CARBOXYMETHYL CHITOSAN; POLYACRYLIC ACID; POLYELECTROLYTE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL COMPOSITION; CROSS LINKING; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; FOURIER TRANSFORM INFRARED PHOTOACOUSTIC SPECTROSCOPY; GASTROINTESTINAL TRACT; HYDROGEL; HYDROGEN BOND; HYDROPHILICITY; IN VITRO STUDY; IONIZATION; MUCOADHESION; NANOENCAPSULATION; PH; PRIORITY JOURNAL; PROTON TRANSPORT; STATIC ELECTRICITY; SUSTAINED DRUG RELEASE; THERMOGRAPHY; VISCOSITY;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ACRYLIC RESINS; ANIMALS; CALCIUM; CALORIMETRY, DIFFERENTIAL SCANNING; CHITOSAN; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; HYDROGEN-ION CONCENTRATION; INTESTINAL MUCOSA; MALE; MUCINS; POLYVINYLS; RATS; RATS, WISTAR; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 84865293889     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.07.016     Document Type: Article

References (35)

1. U. Bertram, and R. Bodmeier In situ gelling, bioadhesive nasal inserts for extended drug delivery: in vitro characterization of a new nasal dosage form Eur. J. Pharm. Sci. 27 2006 62 71
2. G. Bonacucina, S. Martelli, and G.F. Palmieri Rheological, mucoadhesive and release properties of Carbopol gels in hydrophilic cosolvents Int. J. Pharm. 282 2004 115 130
3. V. Chavasit, C. Kienzle-Sterzer, and J. Antonio Torres Formation and characterization of an insoluble polyelectrolyte complex: chitosan-polyacrylic acid Polym. Bull. 19 1988 223 230
4. S.M. Cho, and H.K. Choi Preparation of mucoadhesive chitosan-poly (acrylic acid) microspheres by interpolymer complexation and solvent evaporation method II Arch. Pharm. Res. 28 2005 612 618
5. A. Dev, J.C. Mohan, V. Sreeja, H. Tamura, G.R. Patzke, F. Hussain, S. Weyeneth, S.V. Nair, and R. Jayakumar Novel carboxymethyl chitin nanoparticles for cancer drug delivery applications Carbohydr. Polym. 79 2010 1073 1079
6. S. Dhawan, A.K. Singla, and V.R. Sinha Evaluation of mucoadhesive properties of chitosan microspheres prepared by different methods AAPS PharmSciTech 5 2004 1 7
7. B.G. Ershov, and A. Henglein Time-resolved investigation of early processes in the reduction of Ag+ on polyacrylate in aqueous solution J. Phys. Chem. B 102 1998 10667 10671
8. N.A. Fefelova, Z. Nurkeeva, G. Mun, and V. Khutoryanskiy Mucoadhesive interactions of amphiphilic cationic copolymers based on [2-(methacryloyloxy) ethyl] trimethylammonium chloride Int. J. Pharm. 339 2007 25 32
9. R.D.A. Fernando, and P.C. Sergio Characteristics and properties of carboxymethyl chitosan related to the preparation conditions Carbohydr. Polym. 75 2004 214 221
10. L. Guo, G. Liu, R.Y. Hong, and H.Z. Li Preparation and characterization of chitosan poly (acrylic acid) magnetic microspheres Mar. Drugs 8 2010 2212 2222
11. P. He, S.S. Davis, and L. Illum In vitro evaluation of the mucoadhesive properties of chitosan microspheres Int. J. Pharm. 166 1998 75 88
12. C. Heitz, and J. Francois Poly (methacrylic acid)-copper ion interactions: phase diagrams: light and X-ray scattering Polymer 40 1999 3331 3344
13. R. Jayakumar, M. Prabaharan, S.V. Nair, S. Tokura, H. Tamura, and N. Selvamurugan Novel carboxymethyl derivatives of chitin and chitosan materials and their biomedical applications Prog. Mater. Sci. 55 2010 675 709
14. Y. Kawashima, H. Yamamoto, H. Takeuchi, and Y. Kuno Mucoadhesive dl-lactide/glycolide copolymer nanospheres coated with chitosan to improve oral delivery of elcatonin Pharm. Dev. Technol. 5 2000 77 85
15. T.A. Khan, K.K. Peh, and H.S. Chang Mechanical, bioadhesive strength and biological evaluations of chitosan films for wound dressing J. Pharm. Sci. 3 2000 303 311
16. V.V. Khutoryanskiy Hydrogen-bonded interpolymer complexes as materials for pharmaceutical applications Int. J. Pharm. 334 2007 15 26
17. F.S. Kittur, K.V. Harish Prashanth, K. Udaya Sankar, and R.N. Tharanathan Characterization of chitin, chitosan and their carboxymethyl derivatives by differential scanning calorimetry Carbohydr. Polym. 49 2002 185 193
18. C.F. Lee The effect of aqueous medium contains poly (acrylic acid) on the morphology of composite polymer particle produced by two stages soapless seeded emulsion polymerization Polymer 43 2002 5763 5769
19. Z. Liu, Y. Jiao, and Z. Zhang Calcium-carboxymethyl chitosan hydrogel beads for protein drug delivery system J. Appl. Polym. Sci. 103 2007 3164 3168
20. A. Ludwig The use of mucoadhesive polymers in ocular drug delivery Adv. Drug Deliv. Rev. 57 2005 1595 1639
21. K. Maculotti, I. Genta, P. Perugini, M. Imam, A. Bernkop-Schnurch, and F. Pavanetto Preparation and in vitro evaluation of thiolated chitosan microparticles J. Microencapsul. 22 2005 459 470
22. M.E. Mathew, J.C. Mohan, K. Manzoor, S.V. Nair, H. Tamura, and R. Jayakumar Folate conjugated carboxymethyl chitosan-manganese doped zinc sulphide nanoparticles for targeted drug delivery and imaging of cancer cells Carbohydr. Polym. 80 2010 442 448
23. Y. Meissner, N. Ubrich, F.E. Ghazouani, P. Maincent, and A. Lamprecht Low molecular weight heparin loaded pH-sensitive microparticles Int. J. Pharm. 335 2007 147 153
24. S.A. Mortazavi An in vitro assessment of mucus/mucoadhesive interactions Int. J. Pharm. 124 1995 173 182
25. J. Nunthanid, M. Laungtana-Anan, P. Sriamornsak, S. Limmatvapirat, S. Puttipipatkhachorn, L.Y. Lim, and E. Khor Characterization of chitosan acetate as a binder for sustained release tablets J. Control. Release 99 2004 15 26
26. S. Peng, and C. Wu Controllable interaction between cations and thermally sensitive poly (N-vinylcaprolactam-co-sodium acrylate) microgels in water Polymer 42 2001 6871 6876
27. D. Quong, R.J. Neufeld, B. Skjak, and D. Poncelet External versus internal source of calcium during the gelation of alginate beads for DNA encapsulation Biotechnol. Bioeng. 57 1998 438 446
28. L. Shargel, B.C. Andrew, and S. Wu-Pong Applied Biopharmaceutics and Pharmacokinetics 2005 McGraw-Hill New York, USA
29. J.J. Shieh, and R.Y.M. Huang Pervaporation with chitosan membranes II. Blend membranes of chitosan and polyacrylic acid and comparison of homogeneous and composite membrane based on polyelectrolyte complexes of chitosan and polyacrylic acid for the separation of ethanol-water mixtures J. Membr. Sci. 127 1997 185 202
30. A.K. Singla, M. Chawla, and A. Singh Potential applications of carbomer in oral mucoadhesive controlled drug delivery system: a review Drug Dev. Ind. Pharm. 26 2000 913 924
31. H. Takeuchi, Y. Matsui, H. Yamamoto, and Y. Kawashima Mucoadhesive properties of carbopol or chitosan-coated liposomes and their effectiveness in the oral administration of calcitonin to rats J. Control. Release 86 2003 235 242
32. H. Takeuchi, H. Yamamoto, and Y. Kawashima Mucoadhesive nanoparticulate systems for peptide drug delivery Adv. Drug Deliv. Rev. 47 2001 39 54
33. P.M. Torre, Y. Enobakhare, G. Torrado, and S. Torrado Release of amoxicillin from polyionic complexes of chitosan and poly (acrylic acid). Study of polymer/polymer and polymer/drug interactions within the network structure Biomaterials 24 2003 1499 1506
34. A. Wade Handbook of Pharmaceutical Excipients 1994 Pharmaceutical Press USA
35. H. Zhang, and J. Ruhe Swelling of poly (methacrylic acid) brushes: influence of monovalent salts in the environment Macromolecules 38 2005 4855 4860