메뉴 건너뛰기




Volumn 12, Issue 9, 2012, Pages 717-728

Protease inhibitors for the treatment of chronic hepatitis C genotype-1 infection: The new standard of care

Author keywords

[No Author keywords available]

Indexed keywords

BOCEPREVIR; CALCIUM CHANNEL BLOCKING AGENT; CONTRACEPTIVE AGENT; CYTOCHROME P450 3A4; GLYCOPROTEIN P INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 28B; PEGINTERFERON ALPHA2A PLUS RIBAVIRIN; PEGINTERFERON ALPHA2B PLUS RIBAVIRIN; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; RNA POLYMERASE; TELAPREVIR;

EID: 84865291164     PISSN: 14733099     EISSN: 14744457     Source Type: Journal    
DOI: 10.1016/S1473-3099(12)70060-9     Document Type: Review
Times cited : (106)

References (80)
  • 1
    • 0036828784 scopus 로고    scopus 로고
    • The burden of hepatitis C in the United States
    • Kim WR The burden of hepatitis C in the United States. Hepatology 2002, 36(5 suppl 1):S30-S34.
    • (2002) Hepatology , vol.36 , Issue.5 SUPPL 1
    • Kim, W.R.1
  • 2
    • 0003171299 scopus 로고    scopus 로고
    • Report of a WHO consultation organized in collaboration with the Viral Hepatitis Prevention Board, Antwerp, Belgium
    • Global surveillance and control of hepatitis C
    • Report of a WHO consultation organized in collaboration with the Viral Hepatitis Prevention Board, Antwerp, Belgium. J Viral Hepat 1999, 6:35-47. Global surveillance and control of hepatitis C.
    • (1999) J Viral Hepat , vol.6 , pp. 35-47
  • 3
    • 68249154875 scopus 로고    scopus 로고
    • Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection
    • McHutchison JG, Lawitz EJ, Shiffman ML, et al. Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection. N Engl J Med 2009, 361:580-593.
    • (2009) N Engl J Med , vol.361 , pp. 580-593
    • McHutchison, J.G.1    Lawitz, E.J.2    Shiffman, M.L.3
  • 4
    • 23944476834 scopus 로고    scopus 로고
    • Unravelling hepatitis C virus replication from genome to function
    • Lindenback BD, Rice CM Unravelling hepatitis C virus replication from genome to function. Nature 2005, 436:933-938.
    • (2005) Nature , vol.436 , pp. 933-938
    • Lindenback, B.D.1    Rice, C.M.2
  • 5
    • 0037687422 scopus 로고    scopus 로고
    • Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease
    • Foy E, Li K, Wang C, et al. Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science 2003, 300:1145-1148.
    • (2003) Science , vol.300 , pp. 1145-1148
    • Foy, E.1    Li, K.2    Wang, C.3
  • 6
    • 84857797219 scopus 로고    scopus 로고
    • Hepatitis C virus non-structural 3/4A protein interferes with intrahepatic interferon-γ production
    • published online Aug 3, 2011.
    • Brenndorfer ED, Brass A, Soderholm J, et al. Hepatitis C virus non-structural 3/4A protein interferes with intrahepatic interferon-γ production. Gut 2011, published online Aug 3, 2011. 10.1136/gut.2010.232116.
    • (2011) Gut
    • Brenndorfer, E.D.1    Brass, A.2    Soderholm, J.3
  • 7
    • 0038343796 scopus 로고    scopus 로고
    • Product inhibition of the hepatitis C virus NS3 protease
    • Steinkuhler C, Biasiol G, Brunetti M, et al. Product inhibition of the hepatitis C virus NS3 protease. Biochemistry 1998, 37:8899-8905.
    • (1998) Biochemistry , vol.37 , pp. 8899-8905
    • Steinkuhler, C.1    Biasiol, G.2    Brunetti, M.3
  • 8
    • 79953173221 scopus 로고    scopus 로고
    • Boceprevir for untreated chronic HCV genotype 1 infection
    • Poordad F, McCone J, Bacon BR, et al. Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med 2011, 364:1195-1206.
    • (2011) N Engl J Med , vol.364 , pp. 1195-1206
    • Poordad, F.1    McCone, J.2    Bacon, B.R.3
  • 9
    • 79953176289 scopus 로고    scopus 로고
    • Boceprevir for previously treated chronic HCV genotype 1 infection
    • Bacon BR, Gordon Sc, Lawitz E, et al. Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med 2011, 364:1207-1217.
    • (2011) N Engl J Med , vol.364 , pp. 1207-1217
    • Bacon, B.R.1    Gordon, S.2    Lawitz, E.3
  • 10
    • 79959438789 scopus 로고    scopus 로고
    • Telaprevir for previously untreated chronic hepatitis C virus infection
    • Jacobson IM, McHutchison JG, Dusheiko G, et al. Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med 2011, 364:2405-2416.
    • (2011) N Engl J Med , vol.364 , pp. 2405-2416
    • Jacobson, I.M.1    McHutchison, J.G.2    Dusheiko, G.3
  • 11
    • 79959381354 scopus 로고    scopus 로고
    • Telaprevir for retreatment of HCV infection
    • Zeuzem S, Andreone P, Pol S, et al. Telaprevir for retreatment of HCV infection. N Engl J Med 2011, 364:2417-2428.
    • (2011) N Engl J Med , vol.364 , pp. 2417-2428
    • Zeuzem, S.1    Andreone, P.2    Pol, S.3
  • 13
    • 80052826527 scopus 로고    scopus 로고
    • Response-guided teleprevir combination treatment for hepatitis C virus infection
    • Sherman KE, Flamm SL, Afdhal NH, et al. Response-guided teleprevir combination treatment for hepatitis C virus infection. N Engl J Med 2011, 365:1014-1024.
    • (2011) N Engl J Med , vol.365 , pp. 1014-1024
    • Sherman, K.E.1    Flamm, S.L.2    Afdhal, N.H.3
  • 14
    • 79960729857 scopus 로고    scopus 로고
    • Subanalyses of the telaprevir lead-in arm in the REALIZE study: response at week 4 is not a substitute for prior null response categorization
    • Foster GR, Zeuzem S, Andreone P, et al. Subanalyses of the telaprevir lead-in arm in the REALIZE study: response at week 4 is not a substitute for prior null response categorization. J Hepatol 2011, 54(1 suppl):8.
    • (2011) J Hepatol , vol.54 , Issue.1 SUPPL. , pp. 8
    • Foster, G.R.1    Zeuzem, S.2    Andreone, P.3
  • 15
    • 84865280937 scopus 로고    scopus 로고
    • FDA, (accessed Nov 15, 2011).
    • Boceprevir FDA, (accessed Nov 15, 2011). http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/AntiviralDrugsAdvisoryCommittee/UCM254079.pdf.
    • Boceprevir
  • 16
    • 77956268467 scopus 로고    scopus 로고
    • Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial
    • Kwo PY, Lawitz EJ, McCone J, et al. Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial. Lancet 2010, 376:705-716.
    • (2010) Lancet , vol.376 , pp. 705-716
    • Kwo, P.Y.1    Lawitz, E.J.2    McCone, J.3
  • 17
    • 79952364110 scopus 로고    scopus 로고
    • Evaluation of early null response to pegylated interferon and ribavirin as a predictor of therapeutic nonresponse in patients undergoing treatment for chronic hepatitis C
    • Reau N, Satoskar R, Te H, et al. Evaluation of early null response to pegylated interferon and ribavirin as a predictor of therapeutic nonresponse in patients undergoing treatment for chronic hepatitis C. Am J Gastroenterol 2011, 106:452-458.
    • (2011) Am J Gastroenterol , Issue.106 , pp. 452-458
    • Reau, N.1    Satoskar, R.2    Te, H.3
  • 18
    • 80053339008 scopus 로고    scopus 로고
    • An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guidelines by the American Association for the Study of Liver Diseases
    • Ghany MG, Nelson DR, Strader DB, Thomas DL, Seef LB An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guidelines by the American Association for the Study of Liver Diseases. Hepatology 2011, 54:1433-1444.
    • (2011) Hepatology , vol.54 , pp. 1433-1444
    • Ghany, M.G.1    Nelson, D.R.2    Strader, D.B.3    Thomas, D.L.4    Seef, L.B.5
  • 19
    • 84865302885 scopus 로고    scopus 로고
    • (accessed Nov 15, 2011).
    • Victrelis package insert (accessed Nov 15, 2011). http://www.merck.com/product/usa/pi_circulars/v/victrelis/victrelis_pi.pdf.
    • Victrelis package insert
  • 20
    • 80052869823 scopus 로고    scopus 로고
    • (accessed Nov 15, 2011).
    • Incivek package insert (accessed Nov 15, 2011). http://pi.vrtx.com/files/uspi_telaprevir.pdf.
    • Incivek package insert
  • 22
    • 77950817619 scopus 로고    scopus 로고
    • Telaprevir for previously treated chronic HCV infection
    • McHutchison JG, Manns MP, Muir AJ, et al. Telaprevir for previously treated chronic HCV infection. N Engl J Med 2010, 363:1292-1303.
    • (2010) N Engl J Med , vol.363 , pp. 1292-1303
    • McHutchison, J.G.1    Manns, M.P.2    Muir, A.J.3
  • 23
    • 78649951984 scopus 로고    scopus 로고
    • SVR with telaprevir, peginterferon alfa-2a and ribavirin in HCV patients with well-characterized prior null response, partial response, viral breakthrough or relapse after PR
    • Berg T, McHutchison JG, Adda F, et al. SVR with telaprevir, peginterferon alfa-2a and ribavirin in HCV patients with well-characterized prior null response, partial response, viral breakthrough or relapse after PR. J Hepatol 2010, 52(1 suppl):4.
    • (2010) J Hepatol , vol.52 , Issue.1 SUPPL. , pp. 4
    • Berg, T.1    McHutchison, J.G.2    Adda, F.3
  • 24
    • 79251554986 scopus 로고    scopus 로고
    • Telaprevir is effective given every 8 or 12 hours with ribavirin and peginterferon alfa-2a or -2b to patients with chronic hepatitis C
    • Marcellin P, Forns X, Goeser T, et al. Telaprevir is effective given every 8 or 12 hours with ribavirin and peginterferon alfa-2a or -2b to patients with chronic hepatitis C. Gastroenterology 2011, 140:459-468.
    • (2011) Gastroenterology , Issue.140 , pp. 459-468
    • Marcellin, P.1    Forns, X.2    Goeser, T.3
  • 25
    • 84865308669 scopus 로고    scopus 로고
    • VX-950-C211-a dosing regimen study (twice daily versus every 8 hours) of telaprevir in treatment-naive patients with genotype 1 chronic hepatitis C virus infection. July 21, (accessed Dec 2, 2011)
    • VX-950-C211-a dosing regimen study (twice daily versus every 8 hours) of telaprevir in treatment-naive patients with genotype 1 chronic hepatitis C virus infection. July 21, 2011. (accessed Dec 2, 2011). http://clinicaltrials.gov/ct2/show/NCT01241760?term=optimize+hepatitis+c&rank=6.
    • (2011)
  • 26
    • 79958816097 scopus 로고    scopus 로고
    • Rapid virologic response across genotypes in patients with chronic hepatitis C virus infection
    • Fried MW, Hadziyannis SJ, Shiffman ML, Messinger D, Zeuzem S Rapid virologic response across genotypes in patients with chronic hepatitis C virus infection. J Hepatol 2011, 55:69-75.
    • (2011) J Hepatol , vol.55 , pp. 69-75
    • Fried, M.W.1    Hadziyannis, S.J.2    Shiffman, M.L.3    Messinger, D.4    Zeuzem, S.5
  • 27
    • 79960453276 scopus 로고    scopus 로고
    • EASL clinical practice guidelines: management of hepatitis C virus infection
    • European Association for the Study of the Liver
    • EASL clinical practice guidelines: management of hepatitis C virus infection. J Hepatol 2011, 55:245-264. European Association for the Study of the Liver.
    • (2011) J Hepatol , vol.55 , pp. 245-264
  • 29
    • 79960206940 scopus 로고    scopus 로고
    • Boceprevir for chronic HCV genotype 1 infection
    • Limaye AR, Draganov PV, Cabrera R Boceprevir for chronic HCV genotype 1 infection. N Engl J Med 2011, 365:176-178.
    • (2011) N Engl J Med , vol.365 , pp. 176-178
    • Limaye, A.R.1    Draganov, P.V.2    Cabrera, R.3
  • 30
    • 33846246344 scopus 로고    scopus 로고
    • Impact of ribavirin dose reductions in hepatitis C virus genotype 1 patients completing peginterferon alfa-2-a/ribavirin treatment
    • Reddy KR, Shiffman ML, Morgan TR, et al. Impact of ribavirin dose reductions in hepatitis C virus genotype 1 patients completing peginterferon alfa-2-a/ribavirin treatment. Clin Gastroenterol Hepatol 2007, 5:124-129.
    • (2007) Clin Gastroenterol Hepatol , vol.5 , pp. 124-129
    • Reddy, K.R.1    Shiffman, M.L.2    Morgan, T.R.3
  • 31
    • 84865293864 scopus 로고    scopus 로고
    • Anemia had no effect on efficacy outcomes in treatment-naïve patients who received telaprevir-based regimens in the ADVANCE and ILLUMINATE phase 3 studies
    • Digestive Disease Week; Chicago, Illinois; May 7-10
    • Poordad F, Sulkowski MS, Reddy R, et al. Anemia had no effect on efficacy outcomes in treatment-naïve patients who received telaprevir-based regimens in the ADVANCE and ILLUMINATE phase 3 studies. Digestive Disease Week; Chicago, Illinois; May 7-10, 2011. 626.
    • (2011) , pp. 626
    • Poordad, F.1    Sulkowski, M.S.2    Reddy, R.3
  • 32
    • 84885740898 scopus 로고    scopus 로고
    • A randomized trial comparing ribavirin dose reduction versus erythropoietin for anemia management in previously untreated patients with chronic hepatitis C receiving boceprevir plus peginterferon/ribavirin
    • Spain; April 18-22
    • Poordad FF, Lawitz EJ, Reddy KR, et al. A randomized trial comparing ribavirin dose reduction versus erythropoietin for anemia management in previously untreated patients with chronic hepatitis C receiving boceprevir plus peginterferon/ribavirin. 47th Annual Meeting of the European Association for the Study of the Liver; Barcelona, Spain; April 18-22, 2012. 1419.
    • (2012) 47th Annual Meeting of the European Association for the Study of the Liver; Barcelona , pp. 1419
    • Poordad, F.F.1    Lawitz, E.J.2    Reddy, K.R.3
  • 33
    • 65449171953 scopus 로고    scopus 로고
    • Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
    • Hezode C, Forestier N, Dusheiko G, et al. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N Engl J Med 2009, 360:1839-1850.
    • (2009) N Engl J Med , vol.360 , pp. 1839-1850
    • Hezode, C.1    Forestier, N.2    Dusheiko, G.3
  • 34
    • 80052116134 scopus 로고    scopus 로고
    • Telaprevir alone or with peginterferon and ribavirin reduces HCV RNA in patients with chronic genotype 2 but not genotype 3 infections
    • Foster GR, Hezode C, Bronowicki JP, et al. Telaprevir alone or with peginterferon and ribavirin reduces HCV RNA in patients with chronic genotype 2 but not genotype 3 infections. Gastroenterology 2011, 141:881-889.
    • (2011) Gastroenterology , Issue.141 , pp. 881-889
    • Foster, G.R.1    Hezode, C.2    Bronowicki, J.P.3
  • 35
    • 79953733509 scopus 로고    scopus 로고
    • Genotype differences in susceptibility and resistance development of hepatitis C virus to protease inhibitors telaprevir (VX-950) and danoprevir (ITMN-191)
    • Imhof I, Simmonds P Genotype differences in susceptibility and resistance development of hepatitis C virus to protease inhibitors telaprevir (VX-950) and danoprevir (ITMN-191). Hepatology 2011, 53:1090-1099.
    • (2011) Hepatology , vol.53 , pp. 1090-1099
    • Imhof, I.1    Simmonds, P.2
  • 36
    • 80052123459 scopus 로고    scopus 로고
    • Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a and 6a NS3/4A protease recombinant viruses
    • Gottwein JM, Scheel TK, Jensen TB, Ghanem L, Bukh J Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a and 6a NS3/4A protease recombinant viruses. Gastroenterology 2011, 141:1067-1079.
    • (2011) Gastroenterology , vol.141 , pp. 1067-1079
    • Gottwein, J.M.1    Scheel, T.K.2    Jensen, T.B.3    Ghanem, L.4    Bukh, J.5
  • 37
    • 34247594930 scopus 로고    scopus 로고
    • Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir
    • Sarrazin C, Kieffer TL, Bartels D, et al. Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir. Gastroenterology 2007, 132:1767-1777.
    • (2007) Gastroenterology , vol.132 , pp. 1767-1777
    • Sarrazin, C.1    Kieffer, T.L.2    Bartels, D.3
  • 38
    • 37849032050 scopus 로고    scopus 로고
    • Phenotypic characterization of resistant val36 variants of hepatitis C virus NS3-4A serine protease
    • Zhou Y, Bartels D, Hanzelka B, et al. Phenotypic characterization of resistant val36 variants of hepatitis C virus NS3-4A serine protease. Antimicrob Chemother 2008, 52:110-120.
    • (2008) Antimicrob Chemother , vol.52 , pp. 110-120
    • Zhou, Y.1    Bartels, D.2    Hanzelka, B.3
  • 39
    • 84865293865 scopus 로고    scopus 로고
    • Telaprevir in combination with peginterferon alfa-2a/ribavirin in HCV/HIV co-infected patients: SVR12 interim analysis
    • 19th Conference on Retroviruses and Opportunistic Infections; Seattle, WA, USA; March 5-8, Seattle Washington. 46
    • Dieterich DT, Soriano V, Sherman KE, et al. Telaprevir in combination with peginterferon alfa-2a/ribavirin in HCV/HIV co-infected patients: SVR12 interim analysis. 19th Conference on Retroviruses and Opportunistic Infections; Seattle, WA, USA; March 5-8, 2012 Seattle Washington. 46.
    • (2012)
    • Dieterich, D.T.1    Soriano, V.2    Sherman, K.E.3
  • 40
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge D, Fellay J, Thompson AJ, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009, 461:399-401.
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.1    Fellay, J.2    Thompson, A.J.3
  • 41
    • 70349533037 scopus 로고    scopus 로고
    • Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
    • Tanaka Y, Nishida N, Sugiyama M, et al. Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet 2009, 41:1105-1109.
    • (2009) Nat Genet , vol.41 , pp. 1105-1109
    • Tanaka, Y.1    Nishida, N.2    Sugiyama, M.3
  • 42
    • 70349548852 scopus 로고    scopus 로고
    • IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    • Suppiah V, Moldovan M, Ahlenstiel G, et al. IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet 2009, 41:1100-1104.
    • (2009) Nat Genet , vol.41 , pp. 1100-1104
    • Suppiah, V.1    Moldovan, M.2    Ahlenstiel, G.3
  • 43
    • 77953881002 scopus 로고    scopus 로고
    • Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
    • Thompson AJ, Muir AJ, Sulkowski MS, et al. Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus. Gastroenterology 2010, 139:120-129.
    • (2010) Gastroenterology , vol.139 , pp. 120-129
    • Thompson, A.J.1    Muir, A.J.2    Sulkowski, M.S.3
  • 44
    • 84865288648 scopus 로고    scopus 로고
    • Telaprevir substantially improved SVR rates across all IL28B genotypes in the ADVANCE trial
    • 46th annual meeting of the European Association for the Study of the Liver; Berlin, Germany; March 30-April 3
    • Jacobson IM, Catlett I, Marcellin P, et al. Telaprevir substantially improved SVR rates across all IL28B genotypes in the ADVANCE trial. 46th annual meeting of the European Association for the Study of the Liver; Berlin, Germany; March 30-April 3, 2011. 1369.
    • (2011) , pp. 1369
    • Jacobson, I.M.1    Catlett, I.2    Marcellin, P.3
  • 45
    • 84865308666 scopus 로고    scopus 로고
    • Similar SVR rates in IL28B CC, CT or TT prior relapser, partial- or null-responder patients treated with telaprevir/peginterferon/ribavirin: retrospective analysis of the REALIZE study
    • 46th annual meeting of the European Association for the Study of the Liver; Berlin, Germany; March 30-April 3
    • Pol S, Aerssens J, Zeuzem S, et al. Similar SVR rates in IL28B CC, CT or TT prior relapser, partial- or null-responder patients treated with telaprevir/peginterferon/ribavirin: retrospective analysis of the REALIZE study. 46th annual meeting of the European Association for the Study of the Liver; Berlin, Germany; March 30-April 3, 2011.
    • (2011)
    • Pol, S.1    Aerssens, J.2    Zeuzem, S.3
  • 46
    • 84865293863 scopus 로고    scopus 로고
    • IL28B polymorphism predicts virologic response in patients with hepatitis C genotype 1 treated with boceprevir (BOC) combination therapy
    • 46th annual meeting of the European Association for the Study of the Liver; Berlin, Germany; March 30-April 3
    • Poordad F, Bronowicki JP, Gordon SC, et al. IL28B polymorphism predicts virologic response in patients with hepatitis C genotype 1 treated with boceprevir (BOC) combination therapy. 46th annual meeting of the European Association for the Study of the Liver; Berlin, Germany; March 30-April 3, 2011. 12.
    • (2011) , pp. 12
    • Poordad, F.1    Bronowicki, J.P.2    Gordon, S.C.3
  • 47
    • 0034646996 scopus 로고    scopus 로고
    • The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies
    • Farci P, Shimoda A, Coiana A, et al. The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies. Science 2000, 288:339-344.
    • (2000) Science , vol.288 , pp. 339-344
    • Farci, P.1    Shimoda, A.2    Coiana, A.3
  • 48
    • 0033920795 scopus 로고    scopus 로고
    • Replication of hepatitis C virus
    • Bartenschlager R, Lohmann V Replication of hepatitis C virus. J Gen Virol 2000, 81:1631-1648.
    • (2000) J Gen Virol , vol.81 , pp. 1631-1648
    • Bartenschlager, R.1    Lohmann, V.2
  • 49
    • 73149113353 scopus 로고    scopus 로고
    • Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients
    • Susser S, Welsch C, Wang Y, et al. Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients. Hepatology 2009, 50:1709-1718.
    • (2009) Hepatology , vol.50 , pp. 1709-1718
    • Susser, S.1    Welsch, C.2    Wang, Y.3
  • 50
    • 58149388300 scopus 로고    scopus 로고
    • Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve protease inhibitors
    • Kuntzen T, Timm J, Berical A, et al. Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve protease inhibitors. Hepatology 2008, 48:1769-1778.
    • (2008) Hepatology , vol.48 , pp. 1769-1778
    • Kuntzen, T.1    Timm, J.2    Berical, A.3
  • 51
    • 65449157987 scopus 로고    scopus 로고
    • Hepatitis C virus drug resistance and immune-driven adaptations: relevance to new antiviral therapy
    • Gaudieri S, Rauch A, Pfafferott K, et al. Hepatitis C virus drug resistance and immune-driven adaptations: relevance to new antiviral therapy. Hepatology 2009, 49:1069-1082.
    • (2009) Hepatology , vol.49 , pp. 1069-1082
    • Gaudieri, S.1    Rauch, A.2    Pfafferott, K.3
  • 52
    • 46249102168 scopus 로고    scopus 로고
    • Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus
    • Welsch C, Domingues FS, Susser S, et al. Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus. Genome Biol 2008, 9:R16.
    • (2008) Genome Biol , vol.9
    • Welsch, C.1    Domingues, F.S.2    Susser, S.3
  • 53
    • 34247565001 scopus 로고    scopus 로고
    • Antiviral activity of telaprevir (VX-950) and peginterferon alfa-2a in patients with hepatitis C
    • Fosterier N, Reesink HW, Weegink CJ, et al. Antiviral activity of telaprevir (VX-950) and peginterferon alfa-2a in patients with hepatitis C. Hepatology 2007, 46:640-648.
    • (2007) Hepatology , vol.46 , pp. 640-648
    • Fosterier, N.1    Reesink, H.W.2    Weegink, C.J.3
  • 54
    • 33749360242 scopus 로고    scopus 로고
    • Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a phase 1b, placebo-controlled, randomized study
    • Reesnink HW, Zeuzem S, Weegink CJ, et al. Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a phase 1b, placebo-controlled, randomized study. Gastroenterology 2006, 131:997-1002.
    • (2006) Gastroenterology , vol.131 , pp. 997-1002
    • Reesnink, H.W.1    Zeuzem, S.2    Weegink, C.J.3
  • 55
    • 46149127335 scopus 로고    scopus 로고
    • Antiviral effects and safety of telaprevir, peginterferon alfa-2a and ribavirin for 28 days in hepatitis C patients
    • Lawitz E, Rodriguez-Torres M, Muir AJ, et al. Antiviral effects and safety of telaprevir, peginterferon alfa-2a and ribavirin for 28 days in hepatitis C patients. J Hepatol 2008, 49:163-169.
    • (2008) J Hepatol , vol.49 , pp. 163-169
    • Lawitz, E.1    Rodriguez-Torres, M.2    Muir, A.J.3
  • 56
    • 34548758435 scopus 로고    scopus 로고
    • Telaprevir and pegylated interferon-alpha-2a inhibits wild-type and resistant genotype 1 hepatitis C virus replications in patients
    • Kieffer TL, Sarazin C, Miller JS, et al. Telaprevir and pegylated interferon-alpha-2a inhibits wild-type and resistant genotype 1 hepatitis C virus replications in patients. Hepatology 2007, 46:631-639.
    • (2007) Hepatology , vol.46 , pp. 631-639
    • Kieffer, T.L.1    Sarazin, C.2    Miller, J.S.3
  • 57
    • 79955103901 scopus 로고    scopus 로고
    • Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus
    • Pawlotsky JM Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus. Hepatology 2011, 53:1742-1751.
    • (2011) Hepatology , vol.53 , pp. 1742-1751
    • Pawlotsky, J.M.1
  • 58
    • 79955667562 scopus 로고    scopus 로고
    • Frequencies of resistance-associated amino acid variants following combination treatment with boceprevir plus pegIntron/ribavirin in patients with chronic hepatitis C, genotype 1
    • Vierling JM, Kwo PY, Lawitz E, et al. Frequencies of resistance-associated amino acid variants following combination treatment with boceprevir plus pegIntron/ribavirin in patients with chronic hepatitis C, genotype 1. Hepatology 2010, 52:702A.
    • (2010) Hepatology , vol.52
    • Vierling, J.M.1    Kwo, P.Y.2    Lawitz, E.3
  • 59
    • 79951630741 scopus 로고    scopus 로고
    • Long-term follow-up of patients with chronic hepatitis C treated with telaprevir in combination with peginterferon alfa-2a and ribavirin: interim analysis of the EXTEND study
    • Zeuzem S, Sulkowski MS, Zoulim F, et al. Long-term follow-up of patients with chronic hepatitis C treated with telaprevir in combination with peginterferon alfa-2a and ribavirin: interim analysis of the EXTEND study. Hepatology 2010, 52(4 suppl):227.
    • (2010) Hepatology , vol.52 , Issue.4 SUPPL. , pp. 227
    • Zeuzem, S.1    Sulkowski, M.S.2    Zoulim, F.3
  • 60
    • 73149113990 scopus 로고    scopus 로고
    • Public health impact of antiviral therapy for hepatitis C in the United States
    • Volk ML, Tocco R, Saini S, Lok AS Public health impact of antiviral therapy for hepatitis C in the United States. Hepatology 2009, 50:1750-1755.
    • (2009) Hepatology , vol.50 , pp. 1750-1755
    • Volk, M.L.1    Tocco, R.2    Saini, S.3    Lok, A.S.4
  • 61
    • 79953741413 scopus 로고    scopus 로고
    • Sustained virologic response to antiviral therapy for chronic hepatitis C virus infection: a cure and so much more
    • Pearlman BL, Traub N Sustained virologic response to antiviral therapy for chronic hepatitis C virus infection: a cure and so much more. Clin Infect Dis 2011, 52:889-900.
    • (2011) Clin Infect Dis , vol.52 , pp. 889-900
    • Pearlman, B.L.1    Traub, N.2
  • 62
    • 77349095969 scopus 로고    scopus 로고
    • A sustained virologic response is associated with reduced liver-related morbidity and mortality in patients with hepatitis C virus
    • Singal AG, Volk ML, Jensen D, DiBisceglie AM, Schoenfeld PS A sustained virologic response is associated with reduced liver-related morbidity and mortality in patients with hepatitis C virus. Clin Gastroenterol Hepatol 2010, 8:280-288.
    • (2010) Clin Gastroenterol Hepatol , vol.8 , pp. 280-288
    • Singal, A.G.1    Volk, M.L.2    Jensen, D.3    DiBisceglie, A.M.4    Schoenfeld, P.S.5
  • 63
    • 75149163334 scopus 로고    scopus 로고
    • Aging of hepatitis c-infected persons in the United States: a multiple cohort model of HCV prevalence and disease progression
    • Davis GL, Alter MJ, El-Serag H, Poynard T, Jennings LW Aging of hepatitis c-infected persons in the United States: a multiple cohort model of HCV prevalence and disease progression. Gastroenterology 2010, 138:513-521.
    • (2010) Gastroenterology , vol.138 , pp. 513-521
    • Davis, G.L.1    Alter, M.J.2    El-Serag, H.3    Poynard, T.4    Jennings, L.W.5
  • 64
    • 84865297890 scopus 로고    scopus 로고
    • Comparative effectiveness of antiviral therapy for prior null responders in the era of first generation protease inhibitors
    • Kim WR, Gross JB, Poterucha JJ Comparative effectiveness of antiviral therapy for prior null responders in the era of first generation protease inhibitors. Hepatology 2011, 54(4 suppl):932.
    • (2011) Hepatology , vol.54 , Issue.4 SUPPL. , pp. 932
    • Kim, W.R.1    Gross, J.B.2    Poterucha, J.J.3
  • 65
    • 81155132075 scopus 로고    scopus 로고
    • Treatment of chronic hepatitis C: the new standard of care for the future
    • Chan J Treatment of chronic hepatitis C: the new standard of care for the future. Formulary 2011, 46:314-336.
    • (2011) Formulary , vol.46 , pp. 314-336
    • Chan, J.1
  • 66
    • 84867267852 scopus 로고    scopus 로고
    • Cost-effectiveness of boceprevir based regimens in previously untreated adult subjects with chronic hepatitis C genotype 1
    • Ferrante SA, Chhatwal J, Elbasha E, et al. Cost-effectiveness of boceprevir based regimens in previously untreated adult subjects with chronic hepatitis C genotype 1. Hepatology 2011, 54(4 suppl):929.
    • (2011) Hepatology , vol.54 , Issue.4 SUPPL. , pp. 929
    • Ferrante, S.A.1    Chhatwal, J.2    Elbasha, E.3
  • 67
    • 84867277602 scopus 로고    scopus 로고
    • Cost-effectiveness of boceprevir use in patients with chronic hepatitis C genotype-1 who failed prior treatment with peginterferon/ribavirin
    • Chhatwal J, Ferrante SA, Dasbach EJ, et al. Cost-effectiveness of boceprevir use in patients with chronic hepatitis C genotype-1 who failed prior treatment with peginterferon/ribavirin. Hepatology 2011, 54(4 suppl):940.
    • (2011) Hepatology , vol.54 , Issue.4 SUPPL. , pp. 940
    • Chhatwal, J.1    Ferrante, S.A.2    Dasbach, E.J.3
  • 68
    • 84876194024 scopus 로고    scopus 로고
    • Projections using decision-analytic modeling of long-term clinical value of telaprevir for the treatment of HCV patients who had failed prior peginterferon/ribavirin treatment
    • Deniz B, Brogan A, Miller JD, Talbird SE, Thompson JR Projections using decision-analytic modeling of long-term clinical value of telaprevir for the treatment of HCV patients who had failed prior peginterferon/ribavirin treatment. Hepatology 2011, 54(4 suppl):943.
    • (2011) Hepatology , vol.54 , Issue.4 SUPPL. , pp. 943
    • Deniz, B.1    Brogan, A.2    Miller, J.D.3    Talbird, S.E.4    Thompson, J.R.5
  • 72
    • 84863676547 scopus 로고    scopus 로고
    • Safety and antiviral activity of MK-5172, a next generation inhibitor with a broad HCV genotypic activity spectrum and potent activity against known resistance mutants, in genotype 1 and 3 hepatitis C-infected patients
    • Petry As, Fraser IP, O'Mara E, et al. Safety and antiviral activity of MK-5172, a next generation inhibitor with a broad HCV genotypic activity spectrum and potent activity against known resistance mutants, in genotype 1 and 3 hepatitis C-infected patients. Hepatology 2011, 54(4 suppl):346.
    • (2011) Hepatology , vol.54 , Issue.4 SUPPL. , pp. 346
    • Petry, A.1    Fraser, I.P.2    O'Mara, E.3
  • 73
    • 79960453114 scopus 로고    scopus 로고
    • First SVR data with the nucleoside analogue polymerase inhibitor mericitabine (RG7128) combined with peginterferon/ribavirin in treatment-naïve HCV G1/4 patients: interim analysis from the JUMP-C trial
    • Pockros P, Jensen D, Tsai N, et al. First SVR data with the nucleoside analogue polymerase inhibitor mericitabine (RG7128) combined with peginterferon/ribavirin in treatment-naïve HCV G1/4 patients: interim analysis from the JUMP-C trial. J Hepatol 2011, 54(1 suppl):1359.
    • (2011) J Hepatol , vol.54 , Issue.1 SUPPL. , pp. 1359
    • Pockros, P.1    Jensen, D.2    Tsai, N.3
  • 74
    • 81155127803 scopus 로고    scopus 로고
    • First report of SVR-12 for a NS5a replication complex inhibitor or BMS-790052 in combination with PEG-IFN a-2a and RBV: phase 2a trial in treatment-naïve HCV-genotype-1 subjects
    • Pol S, Ghalib RH, Rustgi VK, et al. First report of SVR-12 for a NS5a replication complex inhibitor or BMS-790052 in combination with PEG-IFN a-2a and RBV: phase 2a trial in treatment-naïve HCV-genotype-1 subjects. J Hepatol 2011, 54(1 suppl):1373.
    • (2011) J Hepatol , vol.54 , Issue.1 SUPPL. , pp. 1373
    • Pol, S.1    Ghalib, R.H.2    Rustgi, V.K.3
  • 75
    • 78049527728 scopus 로고    scopus 로고
    • Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomized, double-blind, placebo-controlled, dose-escalation trial
    • Gane EJ, Roberts SK, Stedman CA, et al. Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomized, double-blind, placebo-controlled, dose-escalation trial. Lancet 2010, 376:1467-1475.
    • (2010) Lancet , vol.376 , pp. 1467-1475
    • Gane, E.J.1    Roberts, S.K.2    Stedman, C.A.3
  • 76
    • 79954911259 scopus 로고    scopus 로고
    • Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice
    • Ohara E, Hiraga N, Imamura M, et al. Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice. J Hepatol 2011, 54:872-878.
    • (2011) J Hepatol , vol.54 , pp. 872-878
    • Ohara, E.1    Hiraga, N.2    Imamura, M.3
  • 77
    • 84865308664 scopus 로고    scopus 로고
    • SVR4 and SVR12 with an interferon-free regimen of BI 201335 and BI 207127, +/- ribavirin, in treatment-naive patients with chronic genotype-1 HCV infection: interim results of SOUND-C2
    • 47th Annual Meeting of the European Association for the Study of the Liver; Barcelona, Spain; April 18-22
    • Zeuzem S, Soriano V, Asselah T, et al. SVR4 and SVR12 with an interferon-free regimen of BI 201335 and BI 207127, +/- ribavirin, in treatment-naive patients with chronic genotype-1 HCV infection: interim results of SOUND-C2. 47th Annual Meeting of the European Association for the Study of the Liver; Barcelona, Spain; April 18-22, 2012. 101.
    • (2012) , pp. 101
    • Zeuzem, S.1    Soriano, V.2    Asselah, T.3
  • 78
    • 84856159009 scopus 로고    scopus 로고
    • Preliminary study of two antiviral agents for hepatitis C genotype 1
    • Lok AS, Gardiner DF, Lawitz E, et al. Preliminary study of two antiviral agents for hepatitis C genotype 1. N Engl J Med 2012, 366:216-224.
    • (2012) N Engl J Med , vol.366 , pp. 216-224
    • Lok, A.S.1    Gardiner, D.F.2    Lawitz, E.3
  • 79
    • 84865283475 scopus 로고    scopus 로고
    • 12-week interferon-free regimen of ABT-450/ritonavir+ABT-333+ribavirin achieved SVR12 in more than 90% of treatment-naive HCV genotype-1-infected subjects and 47% of previous non-responders
    • 47th Annual Meeting of the European Association for the Study of the Liver; Barcelona, Spain;
    • Poordad F, Lawitz E, Kowdley KV, et al. 12-week interferon-free regimen of ABT-450/ritonavir+ABT-333+ribavirin achieved SVR12 in more than 90% of treatment-naive HCV genotype-1-infected subjects and 47% of previous non-responders. 47th Annual Meeting of the European Association for the Study of the Liver; Barcelona, Spain; April 18-22, 2012. 1399.
    • Poordad, F.1    Lawitz, E.2    Kowdley, K.V.3
  • 80
    • 84857395452 scopus 로고    scopus 로고
    • Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders
    • Chayama K, Takashashi S, Kawakami Y, et al. Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders. Hepatology 2012, 55:742-748.
    • (2012) Hepatology , vol.55 , pp. 742-748
    • Chayama, K.1    Takashashi, S.2    Kawakami, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.