Reduced triglyceride secretion in response to an acute dietary fat challenge in obese compared to lean mice

Frontiers in Physiology

Volumn 3 FEB, Issue , 2012, Pages

  Uchida, Aki ^a,b   Whitsitt, Mary C ^b   Eustaquio, Trisha ^c,d   Slipchenko, Mikhail N ^c   Leary, James F ^c,d,e   Cheng, Ji Xin ^a,c   Buhman, Kimberly K ^a,b  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c PURDUE UNIVERSITY   (United States)

^d Purdue University   (United States)

^e PURDUE UNIVERSITY   (United States)

Author keywords

Chylomicrons; Cytoplasmic lipid droplets; Dietary fat absorption; Obesity; Triglyceride

Indexed keywords

EID: 84865271055     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2012.00026     Document Type: Article

References (45)

1. Asakawa, A., Inui, A., Ueno, N., Makino, S., Uemoto, M., Fujino, M. A., and Kasuga, M. (2003). Ob/ob mice as a model of delayed gastric emptying. J. Diabetes Complicat. 17, 27-28.
2. Astrup, A., Buemann, B., Western, P., Toubro, S., Raben, A., and Christensen, N. J. (1994). Obesity as an adaptation to high-fat diet - evidence form a cross-sectional study. Am. J. Clin. Nutr. 59, 350-355.
3. Black, B. L., Croom, J., Eisen, E. J., Petro, A. E., Edwards, C. L., and Surwit, R. S. (1998). Differential effects of fat and sucrose on body composition in A/J and C57BL/6 mice. Metab. Clin. Exp. 47, 1354-1359.
4. Blackburn, P., Lamarche, B., Couillard, C., Pascot, A., Bergeron, N., Prud'homme, D., Tremblay, A., Bergeron, J., Lemieux, I., and Despres, J. P. (2003). Postprandial hyperlipidemia: another correlate of the "hypertriglyceridemic waist" phenotype in men. Atherosclerosis 171, 327-336.
5. Buettner, R., Schoelmerich, J., and Bollheimer, L. C. (2007). High-fat diets: modeling the metabolic disorders of human obesity in rodents. Obesity 15, 798-808.
6. Buhman, K. K., Smith, S. J., Stone, S. J., Repa, J. J., Wong, J. S., Knapp, F. F., Burri, B. J., Hamilton, R. L., Abumrad, N. A., and Farese, R. V. (2002). DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis. J. Biol. Chem. 277, 25474-25479.
7. de Vogel-van den Bosch, H. M., Bunger, M., De Groot, P. J., BoschVermeulen, H., Hooiveld, G., and Muller, M. (2008a). PPARalphamediated effects of dietary lipids on intestinal barrier gene expression. BMC Genomics 9, 231. doi:10.1186/1471-2164-9-231
8. de Vogel-van den Bosch, H. M., De Wit, N. J. W., Hooiveld, G. J. E. J., Vermeulen, H., Van Der Veen, J. N., Houten, S. M., Kuipers, F., Muller, M., and Van Der Meer, R. (2008b). A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 294, G1171-G1180.
9. de Wit, N. J., Bosch-Vermeulen, H., De Groot, P. J., Hooiveld, G. J., Bromhaar, M. M. G., Jansen, J., Muller, M., and Van Der Meer, R. (2008). The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice. BMC Med. Genomics 1, 14. doi:10.1186/1755-8794-1-14
10. Douglass, J. D., Storch, J., Malik, N., Chon, S.-H., Zhou, Y. X., Wells, K., Joseph, L. B., and Choi, A. (2012). Intestinal mucosal triacylglycerol accumulation secondary to decreased lipid secretion in obese and high fat-fed mice. Front. Physiol. 3:25. doi:10.3389/fphys.2012.00025
11. Dubois, C., Beaumier, G., Juhel, C., Armand, M., Portugal, H., Pauli, A. M., Borel, P., Latge, C., and Lairon, D. (1998). Effects of graded amounts (0-50 g) of dietary fat on postprandial lipemia and lipoproteins in normolipidemic adults. Am. J. Clin. Nutr. 67, 31-38.
12. Fraser, R., Cliff, W. J., and Courtice, F. C. (1968). Effect of dietary load on size and composition of chylomicrons in thoracic duct lymph. Q. J. Exp. Physiol. Cogn. Med. Sci. 53, 390-398.
13. Frayn, K. N. (2002). Insulin resistance, impaired postprandial lipid metabolism and abdominal obesity. A deadly triad. Med. Princ. Pract. 11(Suppl. 2), 31-40.
14. Friedman, J. (2002). Diabetes - fat in all the wrong places. Nature 415, 268-269.
15. Haidari, M., Leung, N., Mahbub, F., Uffelman, K. D., Kohen-Avramoglu, R., Lewis, G. F., and Adeli, K. (2002). Fasting and postprandial overproduction of intestinally derived lipoproteins in an animal model of insulin resistance - evidence that chronic fructose feeding in the hamster is accompanied by enhanced intestinal de novo lipogenesis and ApoB48-containing lipoprotein overproduction. J. Biol. Chem. 277, 31646-31655.
16. Haluzik, M., Colombo, C., Gavrilova, O., Chua, S., Wolf, N., Chen, M., Stannard, B., Dietz, K. R., Le Roith, D., and Reitman, M. L. (2004). Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. Endocrinology 145, 3258-3264.
17. Hultin, M., Mullertz, A., Zundel, M. A., Olivecrona, G., Hansen, T. T., Deckelbaum, R. J., Carpentier, Y. A., and Olivecrona, T. (1994). Metabolism of emulsions containing medium-chain and longchain triglycerides or interesterified triglycerides. J. Lipid Res. 35, 1850-1860.
18. Kane, J. P., Hardman, D. A., and Paulus, H. E. (1980). Heterogeneity of apolipoprotein B - isolation of a new species from human chylomicrons. Proc. Natl. Acad. Sci. U.S.A. 77, 2465-2469.
19. Kimura, R., Takahashi, N., Murota, K., Yamada, Y., Niiya, S., Kanzaki, N., Murakami, Y., Moriyama, T., Goto, T., and Kawada, T. (2011). Activation of peroxisome proliferator-activated receptor-alpha (PPAR alpha) suppresses postprandial lipidemia through fatty acid oxidation in enterocytes. Biochem. Biophys. Res. Commun. 410, 1-6.
20. Kondo, H., Minegishi, Y., Komine, Y., Mori, T., Matsumoto, I., Abe, K., Tokimitsu, I., Hase, T., and Murase, T. (2006). Differential regulation of intestinal lipid metabolism-related genes in obesity-resistant A/J vs. obesity-prone C57BL/6J mice. Am. J. Physiol. Endocrinol. Metab. 291, E1092-E1099.
21. Lee, B., Fast, A. M., Zhu, J., Chen, J. X., and Buhman, K. K. (2010). Intestine specific expression of acyl CoA:diacylgylcerol acyltransferase 1 (DGAT1) reverses resistance to dietinduced hepatic steatosis and obesity in Dgat1-/mice. J. Lipid Res. 51, 1770-1780.
22. Lee, B., Zhu, J. B., Wolins, N. E., Cheng, J. X., and Buhman, K. K. (2009). Differential association of adipophilin and TIP47 proteins with cytoplasmic lipid droplets in mouse enterocytes during dietary fat absorption. Biochim. Biophys. Acta 1791, 1173-1180.
23. Lin, X., Yue, P., Chen, Z. J., and Schonfeld, G. (2005). Hepatic triglyceride contents are genetically determined in mice: results of a strain survey. Am. J. Physiol. Gastrointest. Liver Physiol. 288, G1179-G1189.
24. Mansbach, C. M., and Gorelick, F. (2007). Development and physiological regulation of intestinal lipid absorption. II. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons. Am.J.Physiol. Gastrointest. Liver Physiol. 293, G645-G650.
25. Martins, I. J., Mortimer, B. C., Miller, J., and Redgrave, T. G. (1996). Effects of particle size and number on the plasma clearance of chylomicrons and remnants. J. Lipid Res. 37, 2696-2705.
26. Okawa, M., Fujii, K., Ohbuchi, K., Okumoto, M., Aragane, K., Sato, H., Tamai, Y., Seo, T., Itoh, Y., and Yoshimoto, R. (2009). Role of MGAT2 and DGAT1 in the release of gut peptides after triglyceride ingestion. Biochem. Biophys. Res. Commun. 390, 377-381.
27. Patsch, J. R., Miesenbock, G., Hopferwieser, T., Muhlberger, V., Knapp, E., Dunn, J. K., Gotto, A. M., and Patsch, W. (1992). Relation of triglyceridemetabolism and coronary-artery disease - studies in the postprandial state. Arterioscler. Thromb. 12, 1336-1345.
28. Petit, V., Arnould, L., Martin, P., Monnot, M. C., Pineau, T., Besnard, P., and Niot, I. (2007). Chronic highfat diet affects intestinal fat absorption and postprandial triglyceride levels in the mouse. J. Lipid Res. 48, 278-287.
29. Prentice, A. M., Sonko, B. J., Murgatroyd, P. R., and Goldberg, G. R. (1994). Obesity as an adaptation to a high-fat diet. Am. J. Clin. Nutr. 60, 640-641.
30. Rensen, P. C. N., Herijgers, N., Netscher, M. H., Meskers, S. C. J., Vaneck, M., and Vanberkel, T. J. C. (1997). Particle size determines the specificity of apolipoprotein Econtaining triglyceride-rich emulsions for the LDL receptor versus hepatic remnant receptor in vivo. J. Lipid Res. 38, 1070-1084.
31. Sakurai, T., Trirongjitmoah, S., Nishibata, Y., Namita, T., Tsuji, M., Hui, S.P., Jin, S., Shimizu, K., and Chiba, H. (2010). Measurement of lipoprotein particle sizes using dynamic light scattering. Ann. Clin. Biochem. 47, 476-481.
32. Schaffer, J. E. (2003). Lipotoxicity: when tissues overeat. Curr. Opin. Lipidol. 14, 281-287.
33. Smith, S. J., Cases, S., Jensen, D. R., Chen, H. C., Sande, E., Tow, B., Sanan, D. A., Raber, J., Eckel, R. H., and Farese, R. V. (2000). Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat. Genet. 25, 87-90.
34. Soriguer, F., Garcia-Serrano, S., Garrido-Sanchez, L., GutierrezRepiso, C., Rojo-Martinez, G., Garcia-Escobar, E., Garcia-Arnes, J., Gallego-Perales, J. L., Delgado, V., and Garcia-Fuentes, E. (2010). Jejunal wall triglyceride concentration of morbidly obese persons is lower in those with type 2 diabetes mellitus. J. Lipid Res. 51, 3516-3523.
35. Uchida, A., Slipchenko, M. N., Cheng, J. X., and Buhman, K. K. (2011). Fenofibrate, a peroxisome proliferator-activated receptor α agonist, alters triglyceride metabolism in enterocytes of mice. Biochim. Biophys. Acta 1811, 170-176.
36. Uiterwaal, C., Grobbee, D. E., Witteman, J. C. M., Vanstiphout, W., Krauss, X. H., Havekes, L. M., Debruijn, A. M., Vantol, A., and Hofman, A. (1994). Postprandial triglyceride response in young-adult men and familial risk for coronary atherosclerosis. Ann. Intern. Med. 121, 576-583.
37. Unger, R. H. (2002). Lipotoxic diseases. Annu.Rev.Med.53, 319-336.
38. Verhulst, P. J., Lintermans, A., Janssen, S., Loeckx, D., Himmelreich, U., Buyse, J., Tack, J., and Depoortere, I. (2011). GPR39, a receptor of the ghrelin receptor family, plays a role in the regulation of glucose homeostasis in a mouse model of early onset diet-induced obesity. J. Neuroendocrinol. 23, 490-500.
39. Werner, A., Havinga, R., Perton, F., Kuipers, F., and Verkade, H. J. (2006). Lymphatic chylomicron size is inversely related to biliary phospholipid secretion in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 290, G1177-G1185.
40. Yen, C.-L. E., Cheong, M.-L., Grueter, C., Zhou, P., Moriwaki, J., Wong, J. S., Hubbard, B., Marmor, S., and Farese, R. V. (2009a). Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding. Nat. Med. 15, 442-446.
41. Yen, C. L. E., Cheong, M. L., Grueter, C., Zhou, P., Moriwaki, J., Wong, J. S., Hubbard, B., Marmor, S., and Farese, R. V. (2009b). Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding. Nat. Med. 15, 442-446.
42. Zhu, J. B., Lee, B. G., Buhman, K. K., and Cheng, J. X. (2009). A dynamic, cytoplasmic triacylglycerol pool in enterocytes revealed by ex vivo and in vivo coherent anti-stokes Raman scattering imaging. J. Lipid Res. 50, 1080-1089.
43. Zilversmit, D. B. (1967). Formation and transport of chylomicrons. Fed. Proc. 26, 1599-1605.
44. Zilversmit, D. B. (1979). Atherogenesis - postprandial phenomenon. Circulation 60, 473-485.
45. Zoltowska, M., Ziv, E., Delvin, E., Sinnett, D., Kalman, R., Garofalo, C., Seidman, E., and Levy, E. (2003). Cellular aspects of intestinal lipoprotein assembly in Psammomys obesus - a model of insulin resistance and type 2 diabetes. Diabetes 52, 2539-2545.