메뉴 건너뛰기




Volumn 10, Issue 6, 2012, Pages 713-725

The evolving landscape of RAAS inhibition: From ACE inhibitors to ARBs, to DRIs andbeyond

Author keywords

(pro)renin receptor; ACE inhibitor; angiotensin receptor blocker; direct renin inhibitor; plasma renin activity

Indexed keywords

ALBUMIN; ALISKIREN; AMLODIPINE; ANGIOTENSIN RECEPTOR ANTAGONIST; ATENOLOL; BRADYKININ; BRAIN NATRIURETIC PEPTIDE; CANDESARTAN; CAPTOPRIL; CREATININE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; HYDROCHLOROTHIAZIDE; IRBESARTAN; LISINOPRIL; LOSARTAN; PLACEBO; RAMIPRIL; RENIN INHIBITOR; SPIRONOLACTONE; TELMISARTAN; VALSARTAN;

EID: 84865259797     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/erc.12.63     Document Type: Review
Times cited : (11)

References (53)
  • 2
    • 36248931664 scopus 로고    scopus 로고
    • The renin-angiotensin aldosterone system: Pathophysiological role and pharmacologic inhibition
    • Atlas SA. The renin-angiotensin aldosterone system: pathophysiological role and pharmacologic inhibition. J. Manag. Care Pharm. 13(8 Suppl. B), 9-20 (2007).
    • (2007) J. Manag. Care Pharm. , vol.13 , Issue.8 SUPPL. B , pp. 9-20
    • Atlas, S.A.1
  • 3
    • 85024286205 scopus 로고
    • Studies on experimental hypertension: I. The production of persistent elevation of systolic blood pressure by means of renal ischemia
    • Goldblatt H, Lynch J, Hanzal RF, Summerville WW. Studies on experimental hypertension: I. The production of persistent elevation of systolic blood pressure by means of renal ischemia. J. Exp. Med. 59(3), 347-379 (1934).
    • (1934) J. Exp. Med. , vol.59 , Issue.3 , pp. 347-379
    • Goldblatt, H.1    Lynch, J.2    Hanzal, R.F.3    Summerville, W.W.4
  • 4
    • 0035048905 scopus 로고    scopus 로고
    • Theodore Cooper lecture: Tissue angiotensin and pathobiology of vascular disease: A unifying hypothesis
    • Dzau VJ. Theodore Cooper lecture: tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis. Hypertension 37(4), 1047-1052 (2001).
    • (2001) Hypertension , vol.37 , Issue.4 , pp. 1047-1052
    • Dzau, V.J.1
  • 5
    • 60249094363 scopus 로고    scopus 로고
    • Renin inhibition with aliskiren in hypertension: Focus on aliskiren/hydrochlorothiazide combination therapy
    • Sureshkumar KK. Renin inhibition with aliskiren in hypertension: focus on aliskiren/hydrochlorothiazide combination therapy. Vasc. Health Risk Manag. 4(6), 1205-1220 (2008).
    • (2008) Vasc. Health Risk Manag. , vol.4 , Issue.6 , pp. 1205-1220
    • Sureshkumar, K.K.1
  • 6
    • 0034688194 scopus 로고    scopus 로고
    • Effects of an angiotensin converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. Heart Outcomes Prevention Evaluation Study Investigators
    • Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G. Effects of an angiotensin converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. Heart Outcomes Prevention Evaluation Study Investigators. N. Engl. J. Med. 342, 145-153 (2000).
    • (2000) N. Engl. J. Med. , vol.342 , pp. 145-153
    • Yusuf, S.1    Sleight, P.2    Pogue, J.3    Bosch, J.4    Davies, R.5    Dagenais, G.6
  • 7
    • 0026785561 scopus 로고
    • Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions
    • SOLVD Investigators
    • SOLVD Investigators. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N. Engl. J. Med. 327, 685-691 (1992).
    • (1992) N. Engl. J. Med. , vol.327 , pp. 685-691
  • 8
    • 0027423378 scopus 로고
    • Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure
    • The Acute Infarction Ramipril Efficacy (AIRE) Study Investigators
    • The Acute Infarction Ramipril Efficacy (AIRE) Study Investigators. Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. Lancet 342, 821-828 (1993).
    • (1993) Lancet , vol.342 , pp. 821-828
  • 9
    • 9044239676 scopus 로고
    • A clinical trial of the angiotensin converting-enzyme inhibitor trandolapril in patients with left ventricular dysfunction after myocardial infarction. Trandolapril Cardiac Evaluation (TRACE) Study Group
    • Køber L, Torp-Pedersen C, Carlsen JE et al. A clinical trial of the angiotensin converting-enzyme inhibitor trandolapril in patients with left ventricular dysfunction after myocardial infarction. Trandolapril Cardiac Evaluation (TRACE) Study Group. N. Engl. J. Med. 333(25), 1670-1676 (1995).
    • (1995) N. Engl. J. Med. , vol.333 , Issue.25 , pp. 1670-1676
    • Køber, L.1    Torp-Pedersen, C.2    Carlsen, J.E.3
  • 10
    • 0028063782 scopus 로고
    • Effects of captopril on ischemic events after myocardial infarction. Results of the Survival and Ventricular Enlargement trial. SAVE Investigators
    • Rutherford JD, Pfeffer MA, Moyé LA et al. Effects of captopril on ischemic events after myocardial infarction. Results of the Survival and Ventricular Enlargement trial. SAVE Investigators. Circulation 90(4), 1731-1738 (1994).
    • (1994) Circulation , vol.90 , Issue.4 , pp. 1731-1738
    • Rutherford, J.D.1    Pfeffer, M.A.2    Moyé, L.A.3
  • 11
    • 0042330455 scopus 로고    scopus 로고
    • Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: Randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study)
    • European Trial on Reduction of Cardiac Events with Perindopril in Stable Coronary Artery Disease Investigators.
    • Fox KM; European Trial on Reduction of Cardiac Events with Perindopril in Stable Coronary Artery Disease Investigators. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet 362(9386), 782-788 (2003).
    • (2003) Lancet , vol.362 , Issue.9386 , pp. 782-788
    • Fox, K.M.1
  • 12
    • 44849114597 scopus 로고    scopus 로고
    • Aliskiren combined with losartan in Type 2 diabetes and nephropathy
    • AVOID Study Investigators.
    • Parving HH, Persson F, Lewis JB, Lewis EJ, Hollenberg NK; AVOID Study Investigators. Aliskiren combined with losartan in Type 2 diabetes and nephropathy. N. Engl. J. Med. 358(23), 2433-2446 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , Issue.23 , pp. 2433-2446
    • Parving, H.H.1    Persson, F.2    Lewis, J.B.3    Lewis, E.J.4    Hollenberg, N.K.5
  • 13
    • 0035922441 scopus 로고    scopus 로고
    • Effects of losartan on renal and cardiovascular outcomes in patients with Type 2 diabetes and nephropathy
    • RENAAL Study Investigators
    • Brenner BM, Cooper ME, de Zeeuw D et al.; RENAAL Study Investigators. Effects of losartan on renal and cardiovascular outcomes in patients with Type 2 diabetes and nephropathy. N. Engl. J. Med. 345(12), 861-869 (2001).
    • (2001) N. Engl. J. Med. , vol.345 , Issue.12 , pp. 861-869
    • Brenner, B.M.1    Cooper, M.E.2    De Zeeuw, D.3
  • 14
    • 0035922447 scopus 로고    scopus 로고
    • Renoprotective effect of the angiotensin receptor antagonist irbesartan in patients with nephropathy due to Type 2 diabetes
    • Collaborative Study Group
    • Lewis EJ, Hunsicker LG, Clarke WR et al.; Collaborative Study Group. Renoprotective effect of the angiotensin receptor antagonist irbesartan in patients with nephropathy due to Type 2 diabetes. N. Engl. J. Med. 345(12), 851-860 (2001).
    • (2001) N. Engl. J. Med. , vol.345 , Issue.12 , pp. 851-860
    • Lewis, E.J.1    Hunsicker, L.G.2    Clarke, W.R.3
  • 15
    • 79751531393 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2011 update: A report from the American Heart Association
    • American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • Roger VL, Go AS, Lloyd-Jones DM et al.; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2011 update: a report from the American Heart Association. Circulation 123(4), e18-e209 (2011).
    • (2011) Circulation , vol.123 , Issue.4
    • Roger, V.L.1    Go, A.S.2    Lloyd-Jones, D.M.3
  • 16
    • 0036266596 scopus 로고    scopus 로고
    • Pivotal role of the renin/prorenin receptor in Ang II production and cellular responses to renin
    • Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD. Pivotal role of the renin/prorenin receptor in Ang II production and cellular responses to renin. J. Clin. Invest. 109(11), 1417-1427 (2002).
    • (2002) J. Clin. Invest. , vol.109 , Issue.11 , pp. 1417-1427
    • Nguyen, G.1    Delarue, F.2    Burcklé, C.3    Bouzhir, L.4    Giller, T.5    Sraer, J.D.6
  • 17
    • 62949127898 scopus 로고    scopus 로고
    • The sweeter side of ACE2: Physiological evidence for a role in diabetes
    • Bindom SM, Lazartigues E. The sweeter side of ACE2: physiological evidence for a role in diabetes. Mol. Cell. Endocrinol. 302(2), 193-202 (2009).
    • (2009) Mol. Cell. Endocrinol. , vol.302 , Issue.2 , pp. 193-202
    • Bindom, S.M.1    Lazartigues, E.2
  • 18
    • 0031688757 scopus 로고    scopus 로고
    • Pathways for Ang II generation in intact human tissue: Evidence from comparative pharmacological interruption of the renin system
    • Hollenberg NK, Fisher ND, Price DA. Pathways for Ang II generation in intact human tissue: evidence from comparative pharmacological interruption of the renin system. Hypertension 32(3), 387-392 (1998).
    • (1998) Hypertension , vol.32 , Issue.3 , pp. 387-392
    • Hollenberg, N.K.1    Fisher, N.D.2    Price, D.A.3
  • 19
    • 13144249129 scopus 로고    scopus 로고
    • Ang II and the endothelium: Diverse signals and effects
    • Watanabe T, Barker TA, Berk BC. Ang II and the endothelium: diverse signals and effects. Hypertension 45(2), 163-169 (2005).
    • (2005) Hypertension , vol.45 , Issue.2 , pp. 163-169
    • Watanabe, T.1    Barker, T.A.2    Berk, B.C.3
  • 20
    • 73849100324 scopus 로고    scopus 로고
    • Ablation of Ang IV receptor attenuates hypofibrinolysis via PAI-1 downregulation and reduces occlusive arterial thrombosis
    • Numaguchi Y, Ishii M, Kubota R et al. Ablation of Ang IV receptor attenuates hypofibrinolysis via PAI-1 downregulation and reduces occlusive arterial thrombosis. Arterioscler. Thromb. Vasc. Biol. 29(12), 2102-2108 (2009).
    • (2009) Arterioscler. Thromb. Vasc. Biol. , vol.29 , Issue.12 , pp. 2102-2108
    • Numaguchi, Y.1    Ishii, M.2    Kubota, R.3
  • 21
    • 0034721906 scopus 로고    scopus 로고
    • Human homolog of ang converting enzyme. Cloning and functional expression as captopril insensitive carboxypeptidase
    • Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G, Turner AJ. Human homolog of ang converting enzyme. Cloning and functional expression as captopril insensitive carboxypeptidase. J. Biol. Chem. 275, 33238-33243 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 33238-33243
    • Tipnis, S.R.1    Hooper, N.M.2    Hyde, R.3    Karran, E.4    Christie, G.5    Turner, A.J.6
  • 22
    • 33750722109 scopus 로고    scopus 로고
    • Glomerular localization and expression of angiotensin converting enzyme 2 and angiotensin converting enzyme: Implications for albuminuria in diabetes
    • Ye M, Wysocki J, William J, Soler MJ, Cokic I, Batlle D. Glomerular localization and expression of angiotensin converting enzyme 2 and angiotensin converting enzyme: implications for albuminuria in diabetes. J. Am. Soc. Nephrol. 17(11), 3067-3075 (2006).
    • (2006) J. Am. Soc. Nephrol. , vol.17 , Issue.11 , pp. 3067-3075
    • Ye, M.1    Wysocki, J.2    William, J.3    Soler, M.J.4    Cokic, I.5    Batlle, D.6
  • 23
    • 0036372173 scopus 로고    scopus 로고
    • Ang II suppression in humans by the orally active renin inhibitor aliskiren (SPP100): Comparison with enalapril
    • Nussberger J, Wuerzner G, Jensen C, Brunner HR. Ang II suppression in humans by the orally active renin inhibitor aliskiren (SPP100): comparison with enalapril. Hypertension 39(1), E1-E8 (2002).
    • (2002) Hypertension , vol.39 , Issue.1
    • Nussberger, J.1    Wuerzner, G.2    Jensen, C.3    Brunner, H.R.4
  • 24
    • 77957695178 scopus 로고    scopus 로고
    • Aliskiren binds to renin and prorenin bound to (pro)renin receptor in vitro
    • Biswas KB, Nabi AH, Arai Y et al. Aliskiren binds to renin and prorenin bound to (pro)renin receptor in vitro. Hypertens. Res. 33(10), 1053-1059 (2010).
    • (2010) Hypertens. Res. , vol.33 , Issue.10 , pp. 1053-1059
    • Biswas, K.B.1    Nabi, A.H.2    Arai, Y.3
  • 25
    • 56749090710 scopus 로고    scopus 로고
    • Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren
    • Schefe JH, Neumann C, Goebel M et al. Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren. J. Hypertens. 26(9), 1787-1794 (2008).
    • (2008) J. Hypertens. , vol.26 , Issue.9 , pp. 1787-1794
    • Schefe, J.H.1    Neumann, C.2    Goebel, M.3
  • 26
    • 46449118638 scopus 로고    scopus 로고
    • Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats
    • Feldman DL, Jin L, Xuan H et al. Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats. Hypertension 52(1), 130-136 (2008).
    • (2008) Hypertension , vol.52 , Issue.1 , pp. 130-136
    • Feldman, D.L.1    Jin, L.2    Xuan, H.3
  • 27
    • 0023266532 scopus 로고
    • Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)
    • CONSENSUS Trial Study Group
    • CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N. Engl. J. Med. 316, 1429-1435 (1987).
    • (1987) N. Engl. J. Med. , vol.316 , pp. 1429-1435
  • 28
    • 0026786643 scopus 로고
    • Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators
    • Pfeffer MA, Braunwald E, Moyé LA et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. N. Engl. J. Med. 327(10), 669-677 (1992).
    • (1992) N. Engl. J. Med. , vol.327 , Issue.10 , pp. 669-677
    • Pfeffer, M.A.1    Braunwald, E.2    Moyé, L.A.3
  • 29
    • 0027517659 scopus 로고
    • The effect of angiotensin convertingenzyme inhibition on diabetic nephropathy. The Collaborative Study Group
    • Lewis EJ, Hunsicker LG, Bain RP, Rohde RD. The effect of angiotensin convertingenzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N. Engl. J. Med. 329(20), 1456-1462 (1993).
    • (1993) N. Engl. J. Med. , vol.329 , Issue.20 , pp. 1456-1462
    • Lewis, E.J.1    Hunsicker, L.G.2    Bain, R.P.3    Rohde, R.D.4
  • 30
    • 17044440752 scopus 로고    scopus 로고
    • Comparative effects of ramipril on ambulatory and office blood pressures: A HOPE Substudy
    • Svensson P, de Faire U, Sleight P, Yusuf S, Ostergren J. Comparative effects of ramipril on ambulatory and office blood pressures: a HOPE Substudy. Hypertension 38(6), E28-E32 (2001).
    • (2001) Hypertension , vol.38 , Issue.6
    • Svensson, P.1    De Faire, U.2    Sleight, P.3    Yusuf, S.4    Ostergren, J.5
  • 31
    • 0033995775 scopus 로고    scopus 로고
    • Maximally recommended doses of angiotensin converting enzyme (ACE) inhibitors do not completely prevent ACE-mediated formation of Ang II in chronic heart failure
    • Jorde UP, Ennezat PV, Lisker J et al. Maximally recommended doses of angiotensin converting enzyme (ACE) inhibitors do not completely prevent ACE-mediated formation of Ang II in chronic heart failure. Circulation 101(8), 844-846 (2000).
    • (2000) Circulation , vol.101 , Issue.8 , pp. 844-846
    • Jorde, U.P.1    Ennezat, P.V.2    Lisker, J.3
  • 32
    • 0035818884 scopus 로고    scopus 로고
    • A randomized trial of the angiotensin receptor blocker valsartan in chronic heart failure
    • Valsartan Heart Failure Trial Investigators
    • Cohn JN, Tognoni G; Valsartan Heart Failure Trial Investigators. A randomized trial of the angiotensin receptor blocker valsartan in chronic heart failure. N. Engl. J. Med. 345(23), 1667-1675 (2001).
    • (2001) N. Engl. J. Med. , vol.345 , Issue.23 , pp. 1667-1675
    • Cohn, J.N.1    Tognoni, G.2
  • 33
    • 53049109468 scopus 로고    scopus 로고
    • Effects of the angiotensin receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin converting enzyme inhibitors: A randomised controlled trial
    • Telmisartan Randomised Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease (TRANSCEND) Investigators
    • Yusuf S, Teo K, Anderson C et al.; Telmisartan Randomised Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease (TRANSCEND) Investigators. Effects of the angiotensin receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin converting enzyme inhibitors: a randomised controlled trial. Lancet 372(9644), 1174-1183 (2008).
    • (2008) Lancet , vol.372 , Issue.9644 , pp. 1174-1183
    • Yusuf, S.1    Teo, K.2    Anderson, C.3
  • 34
    • 0037160968 scopus 로고    scopus 로고
    • Cardiovascular morbidity and mortality in the Losartan Intervention for Endpoint Reduction in Hypertension study (LIFE): A randomised trial against atenolol
    • LIFE Study Group
    • Dahlöf B, Devereux RB, Kjeldsen SE et al.; LIFE Study Group. Cardiovascular morbidity and mortality in the Losartan Intervention for Endpoint Reduction in Hypertension study (LIFE): a randomised trial against atenolol. Lancet 359(9311), 995-1003 (2002).
    • (2002) Lancet , vol.359 , Issue.9311 , pp. 995-1003
    • Dahlöf, B.1    Devereux, R.B.2    Kjeldsen, S.E.3
  • 35
    • 0041909380 scopus 로고    scopus 로고
    • Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin converting-enzyme inhibitors: The CHARM-Alternative trial
    • CHARM Investigators and Committees
    • Granger CB, McMurray JJ, Yusuf S et al.; CHARM Investigators and Committees. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin converting-enzyme inhibitors: the CHARM-Alternative trial. Lancet 362(9386), 772-776 (2003).
    • (2003) Lancet , vol.362 , Issue.9386 , pp. 772-776
    • Granger, C.B.1    McMurray, J.J.2    Yusuf, S.3
  • 36
    • 74949138493 scopus 로고    scopus 로고
    • Evaluation of the dose-response relationship of aliskiren, a direct renin inhibitor, in an 8-week, multicenter, randomized, double-blind, parallel-group, placebo-controlled study in adult patients with stage 1 or 2 essential hypertension
    • Puig JG, Schunkert H, Taylor AA, Boye S, Jin J, Keefe DL. Evaluation of the dose-response relationship of aliskiren, a direct renin inhibitor, in an 8-week, multicenter, randomized, double-blind, parallel-group, placebo-controlled study in adult patients with stage 1 or 2 essential hypertension. Clin. Ther. 31(12), 2839-2850 (2009).
    • (2009) Clin. Ther. , vol.31 , Issue.12 , pp. 2839-2850
    • Puig, J.G.1    Schunkert, H.2    Taylor, A.A.3    Boye, S.4    Jin, J.5    Keefe, D.L.6
  • 37
    • 60549087324 scopus 로고    scopus 로고
    • Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: A 12-month randomized, double-blind comparator trial with hydrochlorothiazide
    • Schmieder RE, Philipp T, Guerediaga J et al. Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: a 12-month randomized, double-blind comparator trial with hydrochlorothiazide. Circulation 119(3), 417-425 (2009).
    • (2009) Circulation , vol.119 , Issue.3 , pp. 417-425
    • Schmieder, R.E.1    Philipp, T.2    Guerediaga, J.3
  • 38
    • 61349170589 scopus 로고    scopus 로고
    • Effect of the direct renin inhibitor aliskiren, the angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy
    • Aliskiren in Left Ventricular Hypertrophy (ALLAY) Trial Investigators
    • Solomon SD, Appelbaum E, Manning WJ et al.; Aliskiren in Left Ventricular Hypertrophy (ALLAY) Trial Investigators. Effect of the direct renin inhibitor aliskiren, the angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy. Circulation 119(4), 530-537 (2009).
    • (2009) Circulation , vol.119 , Issue.4 , pp. 530-537
    • Solomon, S.D.1    Appelbaum, E.2    Manning, W.J.3
  • 39
    • 79955463305 scopus 로고    scopus 로고
    • Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction
    • Aliskiren Study in Post-MI Patients to Reduce Remodeling (ASPIRE) Investigators
    • Solomon SD, Shin SH, Shah A et al.; Aliskiren Study in Post-MI Patients to Reduce Remodeling (ASPIRE) Investigators. Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction. Eur. Heart J. 32(10), 1227-1234 (2011).
    • (2011) Eur. Heart J. , vol.32 , Issue.10 , pp. 1227-1234
    • Solomon, S.D.1    Shin, S.H.2    Shah, A.3
  • 40
    • 79958249630 scopus 로고    scopus 로고
    • Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure
    • Aliskiren Observation of Heart Failure Treatment (ALOFT) Investigators
    • McMurray JJ, Pitt B, Latini R et al.; Aliskiren Observation of Heart Failure Treatment (ALOFT) Investigators. Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure. Circ. Heart Fail. 1(1), 17-24 (2008).
    • (2008) Circ. Heart Fail. , vol.1 , Issue.1 , pp. 17-24
    • McMurray, J.J.1    Pitt, B.2    Latini, R.3
  • 41
    • 77249160552 scopus 로고    scopus 로고
    • Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors
    • Pimenta E, Oparil S. Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors. Vasc. Health Risk Manag. 5(1), 453-463 (2009).
    • (2009) Vasc. Health Risk Manag. , vol.5 , Issue.1 , pp. 453-463
    • Pimenta, E.1    Oparil, S.2
  • 42
    • 0242490542 scopus 로고    scopus 로고
    • Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both
    • Valsartan in Acute Myocardial Infarction Trial Investigators
    • Pfeffer MA, McMurray JJ, Velazquez EJ et al.; Valsartan in Acute Myocardial Infarction Trial Investigators. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N. Engl. J. Med. 349(20), 1893-1906 (2003).
    • (2003) N. Engl. J. Med. , vol.349 , Issue.20 , pp. 1893-1906
    • Pfeffer, M.A.1    McMurray, J.J.2    Velazquez, E.J.3
  • 43
    • 0041408235 scopus 로고    scopus 로고
    • Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin converting-enzyme inhibitors: The CHARM-Added trial
    • CHARM Investigators and Committees
    • McMurray JJ, Ostergren J, Swedberg K et al.; CHARM Investigators and Committees. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin converting-enzyme inhibitors: the CHARM-Added trial. Lancet 362(9386), 767-771 (2003).
    • (2003) Lancet , vol.362 , Issue.9386 , pp. 767-771
    • McMurray, J.J.1    Ostergren, J.2    Swedberg, K.3
  • 44
    • 42049107348 scopus 로고    scopus 로고
    • Telmisartan, ramipril, or both in patients at high risk for vascular events
    • ONTARGET Investigators
    • Yusuf S, Teo KK, Pogue J et al.; ONTARGET Investigators. Telmisartan, ramipril, or both in patients at high risk for vascular events. N. Engl. J. Med. 358(15), 1547-1559 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , Issue.15 , pp. 1547-1559
    • Yusuf, S.1    Teo, K.K.2    Pogue, J.3
  • 45
    • 65249182083 scopus 로고    scopus 로고
    • Aliskiren trial in Type 2 diabetes using cardio-renal endpoints (ALTITUDE): Rationale and study design
    • Parving HH, Brenner BM, McMurray JJ et al. Aliskiren trial in Type 2 diabetes using cardio-renal endpoints (ALTITUDE): rationale and study design. Nephrol. Dial. Transplant. 24(5), 1663-1671 (2009).
    • (2009) Nephrol. Dial. Transplant. , vol.24 , Issue.5 , pp. 1663-1671
    • Parving, H.H.1    Brenner, B.M.2    McMurray, J.J.3
  • 46
    • 0038460302 scopus 로고    scopus 로고
    • The seventh report of the joint national committee on prevention detection evaluation and treatment of high blood pressure: The JNC 7 report
    • National Heart Lung and Blood Institute Joint National Committee on Prevention Detection Evaluation and Treatment of High Blood Pressure; National High Blood Pressure Education Program Coordinating Committee
    • Chobanian AV, Bakris GL, Black HR et al.; National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; National High Blood Pressure Education Program Coordinating Committee. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 289(19), 2560-2572 (2003).
    • (2003) JAMA , vol.289 , Issue.19 , pp. 2560-2572
    • Chobanian, A.V.1    Bakris, G.L.2    Black, H.R.3
  • 47
    • 0344373794 scopus 로고    scopus 로고
    • Major outcomes in high-risk hypertensive patients randomized to angiotensin converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
    • The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group.
    • The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin converting enzyme inhibitor or calcium channel blocker vs diuretic: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 288, 2981-2997 (2002).
    • (2002) JAMA , vol.288 , pp. 2981-2997
  • 48
    • 38349042145 scopus 로고    scopus 로고
    • Effects of the Ang II receptor blockers telmisartan versus valsartan in combination with hydrochlorothiazide: A large, confirmatory trial
    • White WB, Murwin D, Chrysant SG, Koval SE, Davidai G, Guthrie R. Effects of the Ang II receptor blockers telmisartan versus valsartan in combination with hydrochlorothiazide: a large, confirmatory trial. Blood Press. Monit. 13(1), 21-27 (2008).
    • (2008) Blood Press. Monit. , vol.13 , Issue.1 , pp. 21-27
    • White, W.B.1    Murwin, D.2    Chrysant, S.G.3    Koval, S.E.4    Davidai, G.5    Guthrie, R.6
  • 49
    • 29144442424 scopus 로고    scopus 로고
    • Comparison of fixed-dose combinations of telmisartan/hydrochlorothiazide 40/12.5 mg and 80/12.5 mg and a fixed-dose combination of losartan/ hydrochlorothiazide 50/12.5 mg in mild to moderate essential hypertension: Pooled analysis of two multicenter, prospective, randomized, open-label, blinded-end point (PROBE) trials
    • Lacourcière Y, Neutel JM, Schumacher H. Comparison of fixed-dose combinations of telmisartan/hydrochlorothiazide 40/12.5 mg and 80/12.5 mg and a fixed-dose combination of losartan/hydrochlorothiazide 50/12.5 mg in mild to moderate essential hypertension: pooled analysis of two multicenter, prospective, randomized, open-label, blinded-end point (PROBE) trials. Clin. Ther. 27(11), 1795-1805 (2005).
    • (2005) Clin. Ther. , vol.27 , Issue.11 , pp. 1795-1805
    • Lacourcière, Y.1    Neutel, J.M.2    Schumacher, H.3
  • 50
    • 34948883404 scopus 로고    scopus 로고
    • Amlodipine and valsartan combined and as monotherapy in stage 2 elderly, and black hypertensive patients: Subgroup analyses of randomized, placebo-controlled studies
    • Smith TR, Philipp T, Vaisse B et al. Amlodipine and valsartan combined and as monotherapy in stage 2, elderly, and black hypertensive patients: subgroup analyses of randomized, placebo-controlled studies. J. Clin. Hypertens. (Greenwich). 9(5), 355-364 (2007).
    • (2007) J. Clin. Hypertens. (Greenwich). , vol.9 , Issue.5 , pp. 355-364
    • Smith, T.R.1    Philipp, T.2    Vaisse, B.3
  • 51
    • 24644443331 scopus 로고    scopus 로고
    • Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): A multicentre randomised controlled trial
    • ASCOT Investigators
    • Dahlöf B, Sever PS, Poulter NR et al.; ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 366(9489), 895-906 (2005).
    • (2005) Lancet , vol.366 , Issue.9489 , pp. 895-906
    • Dahlöf, B.1    Sever, P.S.2    Poulter, N.R.3
  • 52
    • 57349138291 scopus 로고    scopus 로고
    • Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients
    • ACCOMPLISH Trial Investigators
    • Jamerson K, Weber MA, Bakris GL et al.; ACCOMPLISH Trial Investigators. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N. Engl. J. Med. 359(23), 2417-2428 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , Issue.23 , pp. 2417-2428
    • Jamerson, K.1    Weber, M.A.2    Bakris, G.L.3
  • 53
    • 0037431774 scopus 로고    scopus 로고
    • Combination treatment of Ang-II receptor blocker and angiotensin converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): A randomised controlled trial
    • Nakao N, Yoshimura A, Morita H, Takada M, Kayano T, Ideura T. Combination treatment of Ang-II receptor blocker and angiotensin converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial. Lancet 361(9352), 117-124 (2003).
    • (2003) Lancet , vol.361 , Issue.9352 , pp. 117-124
    • Nakao, N.1    Yoshimura, A.2    Morita, H.3    Takada, M.4    Kayano, T.5    Ideura, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.