-
1
-
-
0031015833
-
Plasma renin activity: A risk factor for myocardial infarction in hypertensive patients
-
Aldeman MH, Ooi WI, Cohen H, et al. 1997. Plasma renin activity: a risk factor for myocardial infarction in hypertensive patients. Am J hypertens, 10:1-18.
-
(1997)
Am J hypertens
, vol.10
, pp. 1-18
-
-
Aldeman, M.H.1
Ooi, W.I.2
Cohen, H.3
-
2
-
-
39849089447
-
Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: A 6-month, randomized, double-blind trial
-
Andersen K, Weinberger MH, Egan B, et al. 2008. Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: a 6-month, randomized, double-blind trial. J Hypertens, 26:589-99.
-
(2008)
J Hypertens
, vol.26
, pp. 589-599
-
-
Andersen, K.1
Weinberger, M.H.2
Egan, B.3
-
3
-
-
9644287897
-
Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1-receptor antagonist valsartan on the angiotensin II-renin feedback interruption
-
Azizi M, Menrad J, Bissery A, et al. 2004. Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1-receptor antagonist valsartan on the angiotensin II-renin feedback interruption. J Am Soc Nephrol, 15:3126-33.
-
(2004)
J Am Soc Nephrol
, vol.15
, pp. 3126-3133
-
-
Azizi, M.1
Menrad, J.2
Bissery, A.3
-
4
-
-
33644789557
-
Renin inhibition with aliskiren: Where are we now and where are we going?
-
Azizi M, Webb R, Nussberger J, et al. 2006. Renin inhibition with aliskiren: where are we now and where are we going? J Hypertens, 24:243-56.
-
(2006)
J Hypertens
, vol.24
, pp. 243-256
-
-
Azizi, M.1
Webb, R.2
Nussberger, J.3
-
5
-
-
34548818515
-
Hormonal and hemodynamic effects of aliskiren and valsartan and their combination in sodium-replete normotensive individuals
-
Azizi M, Menrad J, Bissery A, et al. 2007. Hormonal and hemodynamic effects of aliskiren and valsartan and their combination in sodium-replete normotensive individuals. Clin J Am Soc Nephrol, 2:947-55.
-
(2007)
Clin J Am Soc Nephrol
, vol.2
, pp. 947-955
-
-
Azizi, M.1
Menrad, J.2
Bissery, A.3
-
6
-
-
0035144110
-
Plasma prorenin levels may predict persistent microalbuminuria in children with diabetes
-
Chiarelli F, Pomilio M, De Luca FA, et al. 2001. Plasma prorenin levels may predict persistent microalbuminuria in children with diabetes. Pediatr Nephrol, 16:116-20.
-
(2001)
Pediatr Nephrol
, vol.16
, pp. 116-120
-
-
Chiarelli, F.1
Pomilio, M.2
De Luca, F.A.3
-
7
-
-
0347423198
-
Seventh report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure
-
Chobanian AV, Bakris GL, Black HR, et al. 2003. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. Hypertension, 42:1206-52.
-
(2003)
Hypertension
, vol.42
, pp. 1206-1252
-
-
Chobanian, A.V.1
Bakris, G.L.2
Black, H.R.3
-
8
-
-
42549113198
-
Long-term safety, tolerability and efficacy of aliskiren in combination with valsartan in patients with hypertension: A 6-month interim analysis
-
Chrysant SG, Murray AV, Hoppe UC, et al. 2008. Long-term safety, tolerability and efficacy of aliskiren in combination with valsartan in patients with hypertension: a 6-month interim analysis. Curr Med Res Opin, 24:1039-47.
-
(2008)
Curr Med Res Opin
, vol.24
, pp. 1039-1047
-
-
Chrysant, S.G.1
Murray, A.V.2
Hoppe, U.C.3
-
9
-
-
0036863587
-
Success and predictors of blood pressure control in diverse North American settings: The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
-
Cushman WC, Ford CE, Cutler JA, et al. 2002. Success and predictors of blood pressure control in diverse North American settings: The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). J Clin Hyertens, 4:393-404.
-
(2002)
J Clin Hyertens
, vol.4
, pp. 393-404
-
-
Cushman, W.C.1
Ford, C.E.2
Cutler, J.A.3
-
10
-
-
36348998335
-
Aliskiren, a direct renin inhibitor, provides antihypertensive efficacy and excellent tolerability independent of age or gender in patients with hypertension
-
Dahlof B, Anderson DR, Arora V, et al. 2007. Aliskiren, a direct renin inhibitor, provides antihypertensive efficacy and excellent tolerability independent of age or gender in patients with hypertension. J Clin Hypertens, 9 (Suppl A):A157.
-
(2007)
J Clin Hypertens
, vol.9
, Issue.SUPPL. A
-
-
Dahlof, B.1
Anderson, D.R.2
Arora, V.3
-
11
-
-
15144347939
-
Determinant so finterindividual variation of renin and pro-renin concentrations: Evidence for a sexual dimorphism of (pro)renin levels in humans
-
Danser AH, Derkx FH, Schalekamp MA, et al. 1998. Determinant so finterindividual variation of renin and pro-renin concentrations: evidence for a sexual dimorphism of (pro)renin levels in humans. J Hypertens, 16:853-62.
-
(1998)
J Hypertens
, vol.16
, pp. 853-862
-
-
Danser, A.H.1
Derkx, F.H.2
Schalekamp, M.A.3
-
12
-
-
27444447364
-
Renin, pro-renin and the putative (pro)renin receptor
-
Danser AHJ, Deinum J. 2005. Renin, pro-renin and the putative (pro)renin receptor. Hypertension, 46:1069-76.
-
(2005)
Hypertension
, vol.46
, pp. 1069-1076
-
-
Danser, A.H.J.1
Deinum, J.2
-
14
-
-
4744348177
-
Effect of the oral renin inhibitor aliskiren on the pharmacokinetics and pharmacodynamics of a single dose of warfarin in health subjects
-
Dieterle W, Corynen S, Mann J. 2004. Effect of the oral renin inhibitor aliskiren on the pharmacokinetics and pharmacodynamics of a single dose of warfarin in health subjects. Br J Clin Pharmacol, 58:433-6.
-
(2004)
Br J Clin Pharmacol
, vol.58
, pp. 433-436
-
-
Dieterle, W.1
Corynen, S.2
Mann, J.3
-
15
-
-
33749850285
-
Aliskiren, the first in a new class of orally effective renin inhibitors, has no clinically significant interactions with digoxin in healthy volunteers
-
Dieterich H, Kemp C, Vaidyanathan S, et al. 2006. Aliskiren, the first in a new class of orally effective renin inhibitors, has no clinically significant interactions with digoxin in healthy volunteers. Clin Pharmacol Ther, 79:111-24.
-
(2006)
Clin Pharmacol Ther
, vol.79
, pp. 111-124
-
-
Dieterich, H.1
Kemp, C.2
Vaidyanathan, S.3
-
16
-
-
28044453329
-
Pharmacokinetic interactions of the oral renin inhibitor aliskiren with lovastatin, atenolol, celecoxib and cimetidine
-
Dieterle W, Corynen S, Vaidyanathan S, et al. 2005. Pharmacokinetic interactions of the oral renin inhibitor aliskiren with lovastatin, atenolol, celecoxib and cimetidine. Int J Clin Pharmacol Ther, 43:527-35.
-
(2005)
Int J Clin Pharmacol Ther
, vol.43
, pp. 527-535
-
-
Dieterle, W.1
Corynen, S.2
Vaidyanathan, S.3
-
17
-
-
36248931230
-
Antihypertensive efficacy of the oral direct renin inhibitor aliskiren as add-on therapy in patients not responding to amlodipine monotherapy
-
Drummond W, Munger MA, Essop MR, et al. 2007. Antihypertensive efficacy of the oral direct renin inhibitor aliskiren as add-on therapy in patients not responding to amlodipine monotherapy. J Clin Hypertens, 9:742-50.
-
(2007)
J Clin Hypertens
, vol.9
, pp. 742-750
-
-
Drummond, W.1
Munger, M.A.2
Essop, M.R.3
-
18
-
-
0035048905
-
Tissue angiotensin and pathophysiology of vascuklar disease, a unifying hypothesis
-
Dzau VJ. 2001. Tissue angiotensin and pathophysiology of vascuklar disease, a unifying hypothesis. Hypertension, 37:1047-52.
-
(2001)
Hypertension
, vol.37
, pp. 1047-1052
-
-
Dzau, V.J.1
-
19
-
-
46449118638
-
Effect of aliskiren on blood pressure, albuminuria, and(pro)renin receptor expression in diabetic TG(mRen-2) rats
-
Feldman DL, Jin L, Xuan H, et al. 2008. Effect of aliskiren on blood pressure, albuminuria, and(pro)renin receptor expression in diabetic TG(mRen-2) rats. Hypertension, 52:130-6.
-
(2008)
Hypertension
, vol.52
, pp. 130-136
-
-
Feldman, D.L.1
Jin, L.2
Xuan, H.3
-
21
-
-
47049093197
-
Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans
-
Fisher ND, Jan Danser AH, Nussberger J, et al. 2008. Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans. Circulation, 117:3199-205.
-
(2008)
Circulation
, vol.117
, pp. 3199-3205
-
-
Fisher, N.D.1
Jan Danser, A.H.2
Nussberger, J.3
-
22
-
-
0029957780
-
Angiotensin (1-7) inhibits vascular smooth muscle growth
-
Freeman EJ, Chisolm GM, Ferrario CM, et al. 1996. Angiotensin (1-7) inhibits vascular smooth muscle growth. Hypertension, 28:104-8.
-
(1996)
Hypertension
, vol.28
, pp. 104-108
-
-
Freeman, E.J.1
Chisolm, G.M.2
Ferrario, C.M.3
-
23
-
-
0026753520
-
Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensin genes
-
Ganten D, Wagner J, Zeh K et al. 1992. Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensin genes. Proc Natl Acad Sci USA, 89:7806-10.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 7806-7810
-
-
Ganten, D.1
Wagner, J.2
Zeh, K.3
-
24
-
-
14844363404
-
Aliksiren, a novel orally effective renin inhibitir, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients
-
Gradman AH, Schmieder RE, Lins RL, et al. 2005. Aliksiren, a novel orally effective renin inhibitir, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation, 111:102-8.
-
(2005)
Circulation
, vol.111
, pp. 102-108
-
-
Gradman, A.H.1
Schmieder, R.E.2
Lins, R.L.3
-
25
-
-
0031688757
-
Pathways of angiotensin II generation in intact human tissue: Evidence from comparative pharmacological interruption of the renin system
-
Hollenberg NK, Fisher ND, Price DA. 1998. Pathways of angiotensin II generation in intact human tissue: Evidence from comparative pharmacological interruption of the renin system. Hypertension, 32:387-92.
-
(1998)
Hypertension
, vol.32
, pp. 387-392
-
-
Hollenberg, N.K.1
Fisher, N.D.2
Price, D.A.3
-
26
-
-
0031935350
-
Vasodepressor actions of angiotensin (1-7) unmasked during combine treatment with lisinopril and losartan
-
Iyer SN, Chappell MC, Averill DB, et al. 1998. Vasodepressor actions of angiotensin (1-7) unmasked during combine treatment with lisinopril and losartan. Hypertension, 31:699-705.
-
(1998)
Hypertension
, vol.31
, pp. 699-705
-
-
Iyer, S.N.1
Chappell, M.C.2
Averill, D.B.3
-
27
-
-
34247867955
-
Direct renin inhibition with aliskiren in obese patients with arterial hypertension
-
Jordan J, Engeli S, Boye SW, et al. 2007. Direct renin inhibition with aliskiren in obese patients with arterial hypertension. Hypertension, 49:1047-55.
-
(2007)
Hypertension
, vol.49
, pp. 1047-1055
-
-
Jordan, J.1
Engeli, S.2
Boye, S.W.3
-
28
-
-
12344282783
-
Global burden of hypertension: Analysis of worldwide data
-
Kearney PM, Whelton M, Reynolds K, et al. 2005. Global burden of hypertension: analysis of worldwide data. Lancet, 365:217-23.
-
(2005)
Lancet
, vol.365
, pp. 217-223
-
-
Kearney, P.M.1
Whelton, M.2
Reynolds, K.3
-
29
-
-
34848907212
-
Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats
-
Kelly DJ, Zhang Y, Moe G, et al. 2007. Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats. Diabetologia, 50:2398-404.
-
(2007)
Diabetologia
, vol.50
, pp. 2398-2404
-
-
Kelly, D.J.1
Zhang, Y.2
Moe, G.3
-
30
-
-
0034100147
-
Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases
-
Kim S, Iwao H. 2000. Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases. Pharmacol Rev, 52:11-34.
-
(2000)
Pharmacol Rev
, vol.52
, pp. 11-34
-
-
Kim, S.1
Iwao, H.2
-
31
-
-
33846781398
-
Aliskiren, a novel oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in Japanese patients with hypertension
-
Kushiro T, Itakura H, Abo Y, et al. 2006. Aliskiren, a novel oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in Japanese patients with hypertension. Hypertens Res, 29:997-1005.
-
(2006)
Hypertens Res
, vol.29
, pp. 997-1005
-
-
Kushiro, T.1
Itakura, H.2
Abo, Y.3
-
32
-
-
0031034312
-
Angiotensin (1-7) augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide
-
Li P, Chappell MC, Ferrario CM, et al. 1997. Angiotensin (1-7) augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide. Hypertension, 29:394-400.
-
(1997)
Hypertension
, vol.29
, pp. 394-400
-
-
Li, P.1
Chappell, M.C.2
Ferrario, C.M.3
-
33
-
-
0021889169
-
Increased plasma inactive renin in diabetes mellitus a marker of microvascular complications
-
Luetscher JA, Kraemer FB, Wilson DM, et al. 1985. Increased plasma inactive renin in diabetes mellitus a marker of microvascular complications. N Engl J Med, 312:1412-17.
-
(1985)
N Engl J Med
, vol.312
, pp. 1412-1417
-
-
Luetscher, J.A.1
Kraemer, F.B.2
Wilson, D.M.3
-
34
-
-
0029974215
-
Effects of captopril related to increased levels of prostacyclin and angiotensin-(1-7) in essential hypertension
-
Luque M, Martin P, Martell N, et al. 1996. Effects of captopril related to increased levels of prostacyclin and angiotensin-(1-7) in essential hypertension. J Hypertens, 14:799-805.
-
(1996)
J Hypertens
, vol.14
, pp. 799-805
-
-
Luque, M.1
Martin, P.2
Martell, N.3
-
35
-
-
0028560423
-
Angiotensin (1-7) is an antagonist at the type 1 angiotensin II receptor
-
Mahon JM, Carr RD, Nicol AK, et al. 1994. Angiotensin (1-7) is an antagonist at the type 1 angiotensin II receptor. J Hypertens, 12:1377-81.
-
(1994)
J Hypertens
, vol.12
, pp. 1377-1381
-
-
Mahon, J.M.1
Carr, R.D.2
Nicol, A.K.3
-
36
-
-
0027461577
-
Single drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. The department of Veterans Affairs Cooperative Study Group on Antihypertensive agents
-
Materson BJ, Reda DJ, Cushman WC, et al. 1993. Single drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. The department of Veterans Affairs Cooperative Study Group on Antihypertensive agents. N Engl J Med, 328:914-21.
-
(1993)
N Engl J Med
, vol.328
, pp. 914-921
-
-
Materson, B.J.1
Reda, D.J.2
Cushman, W.C.3
-
37
-
-
34548442794
-
The difficult conception, birth and delivery of renin inhibitor: Controversies around aliskiren
-
Menard J, Aziz M. 2007. The difficult conception, birth and delivery of renin inhibitor: controversies around aliskiren. J Hypertens, 25:1775-82.
-
(2007)
J Hypertens
, vol.25
, pp. 1775-1782
-
-
Menard, J.1
Aziz, M.2
-
38
-
-
60249085515
-
-
Novartis Pharmaceuticals Corporation, US prescribing information. East Hanover, NJ
-
Novartis Pharmaceuticals Corporation. 2007. Tecturna® (aliskiren tablets): US prescribing information. East Hanover, NJ.
-
(2007)
Tecturna® (aliskiren tablets)
-
-
-
39
-
-
0036266596
-
Pivotal role of the renin/ pro-renin receptor in angiotensin II production and cellular responses to renin
-
Nguyen G, Delarue F, Burckle C, et al. 2002. Pivotal role of the renin/ pro-renin receptor in angiotensin II production and cellular responses to renin. J Clin Invest, 109:1417-27.
-
(2002)
J Clin Invest
, vol.109
, pp. 1417-1427
-
-
Nguyen, G.1
Delarue, F.2
Burckle, C.3
-
40
-
-
0036372173
-
Angiotensin II suppression in humans by the orally active renin inhibitor aliskiren (SPP100); Comparison with enalapril
-
Nussbeger J, Wuerzner G, Jensen C, et al. 2002. Angiotensin II suppression in humans by the orally active renin inhibitor aliskiren (SPP100); Comparison with enalapril. Hypertension, 39:E1-8.
-
(2002)
Hypertension
, vol.39
-
-
Nussbeger, J.1
Wuerzner, G.2
Jensen, C.3
-
41
-
-
42349086752
-
Renin inhibition by aliskiren prevents atherosclerosis progression: Comparison with irbesartan, atenolol, and amlodipine
-
Nussberger J, Aubert JF, Bouzourene K, et al. 2008. Renin inhibition by aliskiren prevents atherosclerosis progression: comparison with irbesartan, atenolol, and amlodipine. Hypertension, 51:1306-11.
-
(2008)
Hypertension
, vol.51
, pp. 1306-1311
-
-
Nussberger, J.1
Aubert, J.F.2
Bouzourene, K.3
-
42
-
-
33846421005
-
Aliskiren reduced blood pressure and suppress plasma renin activity in combination with a thiazide diuretic, an angiotensin converting enzyme inhibitor, or an angiotensin receptor blocker
-
O'Brien E, Barton J, Nussberger J, et al. 2007. Aliskiren reduced blood pressure and suppress plasma renin activity in combination with a thiazide diuretic, an angiotensin converting enzyme inhibitor, or an angiotensin receptor blocker. Hypertension, 49:276-84.
-
(2007)
Hypertension
, vol.49
, pp. 276-284
-
-
O'Brien, E.1
Barton, J.2
Nussberger, J.3
-
43
-
-
33947182655
-
Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and sustained 24-hour blood pressure control in patients with hypertension
-
Oh BH, Mitchell J, Herron JR, et al. 2007. Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and sustained 24-hour blood pressure control in patients with hypertension. J Am Coll Cardiol, 49:1157-63.
-
(2007)
J Am Coll Cardiol
, vol.49
, pp. 1157-1163
-
-
Oh, B.H.1
Mitchell, J.2
Herron, J.R.3
-
44
-
-
33847633400
-
Prevalence, awareness, treatment and control of hypertension among United States adults 1999-2004
-
Ong KL, Cheung BM, Man YB, et al. 2007. Prevalence, awareness, treatment and control of hypertension among United States adults 1999-2004. Hypertension, 49:69-75.
-
(2007)
Hypertension
, vol.49
, pp. 69-75
-
-
Ong, K.L.1
Cheung, B.M.2
Man, Y.B.3
-
45
-
-
0016261414
-
The renin angiotensin system
-
Oparil S, Haber E. 1974. The renin angiotensin system. N Engl J Med, 291:381-401.
-
(1974)
N Engl J Med
, vol.291
, pp. 381-401
-
-
Oparil, S.1
Haber, E.2
-
46
-
-
34447521458
-
Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: A randomized, double-blind trial
-
Oparil S, Yarows SA, Patel S, et al. 2007. Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomized, double-blind trial. Lancet, 370:221-9.
-
(2007)
Lancet
, vol.370
, pp. 221-229
-
-
Oparil, S.1
Yarows, S.A.2
Patel, S.3
-
47
-
-
44849114597
-
Aliskiren combined with losartan in type 2 diabetes and nephropathy
-
Parving HH, Persson F, Lewis JB, et al. 2008. Aliskiren combined with losartan in type 2 diabetes and nephropathy. N Engl J Med, 358:2433-46.
-
(2008)
N Engl J Med
, vol.358
, pp. 2433-2446
-
-
Parving, H.H.1
Persson, F.2
Lewis, J.B.3
-
48
-
-
0027534353
-
Levels of angiotensin and molecular biology of the tissue angiotensin systems
-
Philips MI, Speakman EA, Kimura B. 1993. Levels of angiotensin and molecular biology of the tissue angiotensin systems. Regul Pept, 43:1-20.
-
(1993)
Regul Pept
, vol.43
, pp. 1-20
-
-
Philips, M.I.1
Speakman, E.A.2
Kimura, B.3
-
49
-
-
25444454353
-
Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats
-
Pilz B, Shagdarsuren E, Wellner M, et al. 2005. Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats. Hypertension, 46:569-76.
-
(2005)
Hypertension
, vol.46
, pp. 569-576
-
-
Pilz, B.1
Shagdarsuren, E.2
Wellner, M.3
-
50
-
-
33845785350
-
Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan
-
Pool JL, Schmieder RE, Azizi M, et al. 2007. Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan. Am J Hypertens, 20:11-20.
-
(2007)
Am J Hypertens
, vol.20
, pp. 11-20
-
-
Pool, J.L.1
Schmieder, R.E.2
Azizi, M.3
-
51
-
-
33750266798
-
Pro-renin induces intracellular signaling in cardiomyocytes independently of angiotensin II
-
Sarris JJ, 't Hoen PAC, Garrelds IM, et al. 2006. Pro-renin induces intracellular signaling in cardiomyocytes independently of angiotensin II. Hypertension, 48:564-71.
-
(2006)
Hypertension
, vol.48
, pp. 564-571
-
-
Sarris, J.J.1
't Hoen, P.A.C.2
Garrelds, I.M.3
-
52
-
-
26244440599
-
Compliment activation in angiotensin II induced organdamge
-
Shagdarsuren E, Wellner M, Braesen JH, et al. 2005. Compliment activation in angiotensin II induced organdamge. Circ Res, 97:716-24.
-
(2005)
Circ Res
, vol.97
, pp. 716-724
-
-
Shagdarsuren, E.1
Wellner, M.2
Braesen, J.H.3
-
53
-
-
56749090710
-
Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren
-
Schefe JH, Neumann C, Goebel M, et al. 2008. Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren. J Hypertens, 26:1787-94.
-
(2008)
J Hypertens
, vol.26
, pp. 1787-1794
-
-
Schefe, J.H.1
Neumann, C.2
Goebel, M.3
-
54
-
-
34250353444
-
The potential role of pro-renin in diabetic nephropathy
-
Schmieder RE. 2007. The potential role of pro-renin in diabetic nephropathy. J Hypertens, 25:1323-6.
-
(2007)
J Hypertens
, vol.25
, pp. 1323-1326
-
-
Schmieder, R.E.1
-
55
-
-
34547867168
-
Aliskiren-based therapy lowers blood pressure more effectively than hydrochlorothiazide-based therapy in patients with hypertension
-
Schmieder RE, Philipp T, Guerediaga J, et al. 2007. Aliskiren-based therapy lowers blood pressure more effectively than hydrochlorothiazide-based therapy in patients with hypertension. J Clin Hypertens, 9(Suppl A):A182.
-
(2007)
J Clin Hypertens
, vol.9
, Issue.SUPPL. A
-
-
Schmieder, R.E.1
Philipp, T.2
Guerediaga, J.3
-
56
-
-
34247644329
-
Aliskiren, the first renin inhibitor for treating hypertension: Reactive renin secretion may limit its effectiveness
-
Sealey JE, Laragh JH. 2007. Aliskiren, the first renin inhibitor for treating hypertension: reactive renin secretion may limit its effectiveness. Am J Hypertens, 20:587-97.
-
(2007)
Am J Hypertens
, vol.20
, pp. 587-597
-
-
Sealey, J.E.1
Laragh, J.H.2
-
57
-
-
33947223136
-
Aliskiren, a novel renin inhibitor, is well tolerated and has sustained BP-lowering effects alone or in combination with HCTZ during long-term (52 weeks) treatment of hypertension
-
Sica D, Gradman A, Lederballe O, et al. 2006. Aliskiren, a novel renin inhibitor, is well tolerated and has sustained BP-lowering effects alone or in combination with HCTZ during long-term (52 weeks) treatment of hypertension. Eur Heart J, 27(Suppl):A797.
-
(2006)
Eur Heart J
, vol.27
, Issue.SUPPL.
-
-
Sica, D.1
Gradman, A.2
Lederballe, O.3
-
58
-
-
11244331346
-
Angiotensin subtype-2 receptors inhibit renin biosynthesis and angiotensin II formation
-
Siragy HM, Xue C, Abadir P, et al. 2005. Angiotensin subtype-2 receptors inhibit renin biosynthesis and angiotensin II formation. Hypertension, 45:133-7.
-
(2005)
Hypertension
, vol.45
, pp. 133-137
-
-
Siragy, H.M.1
Xue, C.2
Abadir, P.3
-
59
-
-
0034657439
-
Combination antihypertensive drugs: Recommendations for use
-
Skolnik NS, Beck JD, Clark M. 2000. Combination antihypertensive drugs: recommendations for use. Am Fam Physician, 61:3049-56.
-
(2000)
Am Fam Physician
, vol.61
, pp. 3049-3056
-
-
Skolnik, N.S.1
Beck, J.D.2
Clark, M.3
-
60
-
-
0031297091
-
Theodore Cooper Memorial Lecture. A mouse view of hypertension
-
Smithies O. 1997. Theodore Cooper Memorial Lecture. A mouse view of hypertension. Hypertension, 30:1318-24.
-
(1997)
Hypertension
, vol.30
, pp. 1318-1324
-
-
Smithies, O.1
-
61
-
-
0347479295
-
Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren
-
Stanton A, Jensen C, Nussberger J, O'Brien E.2003. Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren. Hypertension, 42:1137-43.
-
(2003)
Hypertension
, vol.42
, pp. 1137-1143
-
-
Stanton, A.1
Jensen, C.2
Nussberger, J.3
O'Brien, E.4
-
62
-
-
34548855067
-
A comparison of the tolerability of the direct renin inhibitor aliskiren and lisinopril in patients with severe hypertension
-
Strasser RH, Puig JG, Farsang C, et al. 2007. A comparison of the tolerability of the direct renin inhibitor aliskiren and lisinopril in patients with severe hypertension. J Hum Hypertens, 21:780-7.
-
(2007)
J Hum Hypertens
, vol.21
, pp. 780-787
-
-
Strasser, R.H.1
Puig, J.G.2
Farsang, C.3
-
63
-
-
34447272037
-
Regression of nephropathy developed in diabetes by (pro)renin receptor blockade
-
Takahashi H, Ichihara A, Kaneshiro Y, et al. 2007. Regression of nephropathy developed in diabetes by (pro)renin receptor blockade. J Am Soc Nephrol, 18:1989-92.
-
(2007)
J Am Soc Nephrol
, vol.18
, pp. 1989-1992
-
-
Takahashi, H.1
Ichihara, A.2
Kaneshiro, Y.3
-
64
-
-
0025598309
-
Identification of a highly specific chymase as the major angiotensin II forming enzyme in the human heart
-
Urata H, Kinoshita A, Misono KS, et al. 1990. Identification of a highly specific chymase as the major angiotensin II forming enzyme in the human heart. J Biol Chem, 265:22348-57.
-
(1990)
J Biol Chem
, vol.265
, pp. 22348-22357
-
-
Urata, H.1
Kinoshita, A.2
Misono, K.S.3
-
65
-
-
38649102508
-
Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension
-
Uresin Y, Taylor AA, Kilo C, et al. 2007. Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension. J Renin Angiotensin Aldosterone Syst, 8:190-8.
-
(2007)
J Renin Angiotensin Aldosterone Syst
, vol.8
, pp. 190-198
-
-
Uresin, Y.1
Taylor, A.A.2
Kilo, C.3
-
66
-
-
33749853955
-
Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers
-
Vaidyanathan S, Velencia J, Kemp C, et al. 2006. Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers. Int J Clin Pract, 60:1343-56.
-
(2006)
Int J Clin Pract
, vol.60
, pp. 1343-1356
-
-
Vaidyanathan, S.1
Velencia, J.2
Kemp, C.3
-
67
-
-
33947543780
-
Pharmacokinetics, safety and tolerability of the novel oral direct renin inhibitor aliskiren in elderly healthy subjects
-
Vaidyanathan S, Reynolds C, Yeh CM, et al. 2007. Pharmacokinetics, safety and tolerability of the novel oral direct renin inhibitor aliskiren in elderly healthy subjects. J Clin Pharmacol, 47:453-60.
-
(2007)
J Clin Pharmacol
, vol.47
, pp. 453-460
-
-
Vaidyanathan, S.1
Reynolds, C.2
Yeh, C.M.3
-
68
-
-
36949012071
-
Safety and efficacy of the oral direct renin inhibitor aliskiren in elderly patients with hypertension
-
Verdecchia P, Calvo C, Mockel V, et al. 2007. Safety and efficacy of the oral direct renin inhibitor aliskiren in elderly patients with hypertension. Blood Press, 16:381-91.
-
(2007)
Blood Press
, vol.16
, pp. 381-391
-
-
Verdecchia, P.1
Calvo, C.2
Mockel, V.3
-
69
-
-
33845366982
-
Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide
-
Villamil A, Chrysant SG, Calhoun D, et al. 2007. Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide. J Hypertens, 25:217-26.
-
(2007)
J Hypertens
, vol.25
, pp. 217-226
-
-
Villamil, A.1
Chrysant, S.G.2
Calhoun, D.3
-
70
-
-
2342558633
-
Combination therapy with ACE inhibitors/angiotensin II receptor antagonists and diuretic in hypertension
-
Waeber B. 2003. Combination therapy with ACE inhibitors/angiotensin II receptor antagonists and diuretic in hypertension. Expert Rev Cardiovascular Ther, 1: 43-50.
-
(2003)
Expert Rev Cardiovascular Ther
, vol.1
, pp. 43-50
-
-
Waeber, B.1
-
71
-
-
34547221695
-
Absorption, distribution, metabolism and elimination of the direct renin inhibitor aliskiren in healthy volunteers
-
Waldmeier FJ, Glaenzel U, Wirz B, et al. 2007. Absorption, distribution, metabolism and elimination of the direct renin inhibitor aliskiren in healthy volunteers. Drug Metab Dispos, 35:1418-28.
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1418-1428
-
-
Waldmeier, F.J.1
Glaenzel, U.2
Wirz, B.3
-
72
-
-
13144249129
-
Angiotensin II and the endothelium: Diverse signals and effects
-
Wantanabe T, Barker TA, Berk BC. 2005. Angiotensin II and the endothelium: diverse signals and effects. Hypertension, 45:163-9.
-
(2005)
Hypertension
, vol.45
, pp. 163-169
-
-
Wantanabe, T.1
Barker, T.A.2
Berk, B.C.3
-
73
-
-
34447621764
-
Antihypertensive efficacy, safety, and tolrability of the oral direct renin inhibitor aliskiren in patients with hypertension: A pooled analysis
-
Weir MR, Bush C, Anderson DR, et al. 2007. Antihypertensive efficacy, safety, and tolrability of the oral direct renin inhibitor aliskiren in patients with hypertension: a pooled analysis. J Am Soc Hypertens, 1:264-77.
-
(2007)
J Am Soc Hypertens
, vol.1
, pp. 264-277
-
-
Weir, M.R.1
Bush, C.2
Anderson, D.R.3
-
74
-
-
0035912127
-
Angiotensin II and the pathophysiology of cardiovascular remodeling
-
Williams B. 2001. Angiotensin II and the pathophysiology of cardiovascular remodeling. Am J Cardiol, 87:10C-17C.
-
(2001)
Am J Cardiol
, vol.87
-
-
Williams, B.1
-
75
-
-
50349091496
-
Effect of renin inhibition and AT1R blockade on myocardial remodeling in the transgenic Ren2 rat
-
Whaley-Connell A, Habibi J, Cooper SA, et al. 2008. Effect of renin inhibition and AT1R blockade on myocardial remodeling in the transgenic Ren2 rat. Am J Physiol Endocrinol Metab.
-
(2008)
Am J Physiol Endocrinol Metab
-
-
Whaley-Connell, A.1
Habibi, J.2
Cooper, S.A.3
-
76
-
-
9144248446
-
Hypertension treatment and control in five European countries, Canada and the United States
-
Wolf-Maier K, Cooper RS, Kramer H, et al. 2004. Hypertension treatment and control in five European countries, Canada and the United States. Hypertension, 43:10-7.
-
(2004)
Hypertension
, vol.43
, pp. 10-17
-
-
Wolf-Maier, K.1
Cooper, R.S.2
Kramer, H.3
-
77
-
-
0042661157
-
Structure based design of aliskiren, a novel orally effective renin inhibitor
-
Wood JM, Mailbaum J, Rahuel J, et al. 2003. Structure based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun, 308:698-705.
-
(2003)
Biochem Biophys Res Commun
, vol.308
, pp. 698-705
-
-
Wood, J.M.1
Mailbaum, J.2
Rahuel, J.3
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