In vitro anti-metastatic activity of enterolactone, a mammalian lignan derived from flax lignan, and down-regulation of matrix metalloproteinases in MCF-7 and MDA MB 231 cell lines

Indian Journal of Cancer

Volumn 49, Issue 1, 2012, Pages 181-187

  Mali, A A ^a   Wagh, U V ^a   Hegde, M V ^a   Chandorkar, S S ^b   Surve, S V ^c   Patole, M V ^c  

^a Bharati Vidyapeeth   (India)

^b BHARATI VIDYAPEETH UNIVERSITY   (India)

^c NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

Actin cytoskeleton; enterolactone; matrix metalloproteinases

Indexed keywords

ENTEROLACTONE; GELATINASE A; GELATINASE B; LIGNAN; MATRIX METALLOPROTEINASE 14; STROMELYSIN 3;

ACTIN FILAMENT; ACTIN POLYMERIZATION; AGAR GEL ELECTROPHORESIS; ARTICLE; CELL ADHESION; CELL ASSAY; CELL INVASION; CELL LINE; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CELL STRAIN MCF 7; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; FILOPODIUM; FLAX; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; LAMELLIPODIUM; MATRIX METALLOPROTEINASE 11 GENE; MATRIX METALLOPROTEINASE 14 GENE; MATRIX METALLOPROTEINASE 2 GENE; MATRIX METALLOPROTEINASE 9 GENE; METASTASIS INHIBITION; MICROPHOTOGRAPHY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

4-BUTYROLACTONE; ACTIN CYTOSKELETON; BREAST NEOPLASMS; CELL ADHESION; CELL MOVEMENT; FEMALE; FLAX; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIGNANS; MATRIX METALLOPROTEINASES; MCF-7 CELLS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS;

EID: 84865247185     PISSN: 0019509X     EISSN: 19984774     Source Type: Journal    
DOI: 10.4103/0019-509X.98948     Document Type: Article

References (21)

1. Magee PJ, McGlynn H, Rowland IR. Differential effects of isoflavones and lignans on invasiveness of MDA-MB-231 breast cancer cells in vitro. Cancer Lett 2004;208:35-1. (Pubitemid 38501781)
2. Chen J, Thompson LU. Lignans and tamoxifen, alone or in combination, reduce human breast cancer cell adhesion, invasion and migration in vitro. Breast Cancer Res Treat 2003;80:163-70. (Pubitemid 36886504)
3. Pignatelli M, Stamp G. Integrins in tumour development and spread. Cancer Surv 1995;24:113-27.
4. Liotta LA, Tryggvason K, Garbisa S, Hart I, Foltz CM, Shafie S. Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature 1980;284:67-8. (Pubitemid 10098769)
5. Balduyck M, Zerimech F, Gouyer V, Lemaire R, Hemon B, Grard G, et al. Specific expression of matrix metalloproteinases 1, 3, 9 and 13 associated with invasiveness of breast cancer cells in vitro. Clin. Exp. Metastasis 2000;18:171-8. (Pubitemid 32165251)
6. Mitchison TJ, Cramer LP. Actin-Based Cell Motility and Cell Locomotion. Cell 1996;84:371-9. (Pubitemid 26058562)
7. Donaldson MS. Nutrition and cancer: A review of the evidence for an anti-cancer diet. Nutr J 2004;3:19.
8. Thompson LU. Flaxseed, lignans and cancer. In: Thompson LU, Cunnane SC, editors. Flaxseed in Human Nutrition. 2nd ed. Champaign: AOCS Press; 2003.
9. Thompson LU. Experimental studies on lignans and cancer. Baillieres Clin Endocrinol Metab 1998;12:691-705. (Pubitemid 29261278)
10. Chen J, Stavro PM, Thompson LU. Dietary flaxseed inhibits breast cancer growth and metastasis and downregulates expression of epidermal growth factor receptor and insulin-like growth factor. Nutr Cancer 2002;43:187-92. (Pubitemid 36134093)
11. Dabrosin C, Chen J, Wang L, Thompson LU. Flaxseed inhibits metastasis and decreases extracellular vascular endothelial growth factor in human breast cancer xenografts. Cancer Lett 2002;185:31-7. (Pubitemid 34876530)
12. Yan L, Yee JA, Li D, McGuire MH, Thompson LU. Dietary flaxseed supplementation and experimental metastasis of melanoma cells in mice. Cancer Lett 1998;124:181-6. (Pubitemid 28073685)
13. Lacroix M. Significance, detection and markers of disseminated breast cancer cells. Endocr Relat Cancer 2006;13:1033-67. (Pubitemid 46212562)
14. Li D, Yee JA, Thompson LU, Yan L. Dietary supplementation with secoisolariciresinol diglycoside (SDG) reduces experimental metastasis of melanoma cells in mice. Cancer Lett 1999;142:91-6. (Pubitemid 29281572)
15. Thompson LU, Rickard SE, Orcheson LJ, Seidl MM. Flaxseed and its lignan and oil components reduce mammary tumor growth at a late stage of carcinogenesis. Carcinogenesis 1996;17:1373-6. (Pubitemid 26197671)
16. Rickard SE, Yuan YV, Chen J, Thompson LU. Dose effects of flaxseed and its lignan on N-methyl-N-nitrosourea induced mammary tumorigenesis in rats. Nutr Cancer 1999;35:50-7.
17. Daisuke Y, Shusaku K, Tadaomi T. Regulation of cancer cell motility through actin reorganization. Cancer Sci 2005;96:379-86.
18. Stetler-Stevenson WG, Aznavoorian S, Liotta LA. Tumour cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol 1993;9:541-73.
19. Duffy MJ, Maguire TM, Hill A, McDermott E, O'Higgins N. Metalloproteinases: Role in breast carcinogenesis, invasion and metastasis. Breast Cancer Res 2000;2:252-7. (Pubitemid 32223594)
20. Grit K, Matthias R, Miriam T, Niels D, Karen SW, Roland L, et al. Stromelysin-3 over-expression enhances tumourigenesis in MCF-7 and MDA-MB-231 breast cancer cell lines: Involvement of the IGF-1 signalling pathway. BMC Cancer 2007;7:12.
21. Bernard T, Jacques B, Chang SW, Hélène L, Geneviève B, Caty B, et al. The influence of MMP-14, TIMP-2 and MMP-2 expression on breast cancer prognosis. Breast Cancer Res 2006;8:28.