A novel algorithm for the diagnosis of celiac disease and a comprehensive review of celiac disease diagnostics

Clinical Reviews in Allergy and Immunology

Volumn 42, Issue 3, 2012, Pages 331-341

  Rozenberg, Orit ^a   Lerner, Aaron ^b,c   Pacht, Avi ^b   Grinberg, Maya ^a   Reginashvili, Dina ^a   Henig, Clara ^a   Barak, Mira ^a  

^a CLALIT HEALTH SERVICES   (Israel)

^b CARMEL MEDICAL CENTER   (Israel)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Antibodies; Celiac disease diagnosis; Deamidated gliadin; Intestinal histopathology; Tissue transglutaminase

Indexed keywords

ADOLESCENT; ADULT; ALGORITHM; BLOOD ANALYSIS; BLOOD SAMPLING; CELIAC DISEASE; CHILD; DIAGNOSTIC ACCURACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FALSE POSITIVE RESULT; FEMALE; HUMAN; HUMAN TISSUE; INFANT; INTESTINE BIOPSY; MAJOR CLINICAL STUDY; MALE; NEWBORN; OUTPATIENT CARE; PRESCHOOL CHILD; REVIEW; SCHOOL CHILD; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY;

ADOLESCENT; ADULT; ALGORITHMS; CELIAC DISEASE; CHILD; CHILD, PRESCHOOL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLIADIN; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INFANT; INFANT, NEWBORN; MALE; PREGNANCY; ROC CURVE; SENSITIVITY AND SPECIFICITY; TRANSGLUTAMINASES; YOUNG ADULT;

EID: 84865233579     PISSN: 10800549     EISSN: 15590267     Source Type: Journal    
DOI: 10.1007/s12016-010-8250-y     Document Type: Review

References (80)

1. Gasbarrini G, Malandrino N, Giorgio V, Fundaró C, Cammarota G, Merra G et al (2008) Celiac disease: What's new about it? Dig Dis 26:121-127
2. Green PH, Cellier C (2007) Celiac disease. N Engl J Med 357:1731-1743
3. Schuppan D, Hahn EG (2001) IgA anti-tissue transglutaminase: Setting the stage for coeliac disease screening. Eur J Gastroenterol Hepatol 13:635-637
4. Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO et al
5. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 3:797-801
6. Van de Wal Y, Kooy Y, van Veelen P, Pena S, Mearin L, Papadopoulos G et al (1998) Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T-cell reactivity. J Immunol 161:1585-1588
7. Armstrong MJ, Robins GG, Howdle PD (2009) Recent advances in coeliac disease. Curr Opin Gastroenterol 25:100-109
8. Mustalahti K, Catassi C, Reunanen A, Fabiani E, Heier M, McMillan S et al (2010) The prevalence of celiac disease in Europe: Results of a centralized, international mass screening project. Ann Med 42:587-595
9. Lerner A (2010) An additional piece in the Israeli celiac disease puzzle. Isr Med Assoc J 12:305-306
10. Shamir R, Lerner A, Shinar E, Lahat N, Sobel E, Bar-or R et al
11. The use of a single serological marker underestimates the prevalence of celiac disease in Israel: A study of blood donors. Am J Gastroenterol 97:2589-2594
12. Catassi C, Ratsch IM, Fabiani E, Rossini M, Bordicchia F, Candela F et al (1994) Coeliac disease in the year 2000: Exploring the iceberg. Lancet 343:200-203
13. Hadjivassiliou M, Sanders DS, Grünewald RA, Woodroofe N, Boscolo S, Aeschlimann D (2010) Gluten sensitivity: From gut to brain. Lancet Neurol 9:318-330
14. Roma E, Panayiotou J, Karantana H, Constantinidou C, Siakavellas SI, Krini M et al (2009) Changing pattern in the clinical presentation of pediatric celiac disease: A 30-year study. Digestion 80:185-191
15. Barker JM, Liu E (2008) Celiac disease: Pathophysiology, clinical manifestations, and associated autoimmune conditions. Adv Pediatr 55:349-365
16. Buzby M (2010) Celiac disease: The endocrine connection. J Pediatr Nurs 25:311-313
17. Godfrey JD, Brantner TL, Brinjikji W, Christensen KN, Brogan DL, Van Dyke CT et al (2010) Morbidity and mortality among older individuals with undiagnosed celiac disease. Gastroenterology 139:763-769
18. Fernández A, González L, de-la-Fuente J (2010) Coeliac disease: Clinical features in adult populations. Rev Esp Enferm Dig 102:466471
19. Korkut E, Bektas M, Oztas E, Kurt M, Cetinkaya H, Ozden A (2010) The prevalence of celiac disease in patients fulfilling Rome III criteria for irritable bowel syndrome. Eur J Intern Med 21:389-392
20. Zugna D, Richiardi L, Akre O, Stephansson O, Ludvigsson JF (2010) A nationwide population-based study to determine whether coeliac disease is associated with infertility. Gut 59:1471-1475
21. Gabrielli M, Candelli M, Franceschi F, Cremonini F, Nista EC, Santarelli L et al (2004) Primary autoimmune haemolytic anaemia and coeliac disease. Scand J Gastroenterol 39:605-606
22. Freeman HJ (2008) Neurological disorders in adult celiac disease. Can J Gastroenterol 22:909-911
23. Nachman F, Vázquez H, González A, Andrenacci P, Compagni L, Reyes H et al (2010) Gastroesophageal reflux symptoms in patients with celiac disease and the effects of a gluten-free diet. Clin Gastroenterol Hepatol (in press)
24. Fasano A, Araya M, Bhatnagar S, Cameron D, Catassi C, Dirks M et al (2008) Federation of International Societies of Pediatric Gastroenterology, Hepatology, and Nutrition consensus report on celiac disease. J Pediatr Gastroenterol Nutr 47:214-219
25. Koskinen O, Collin P, Lindfors K, Laurila K, Mäki M, Kaukinen K (2010) Usefulness of small-bowel mucosal transglutaminase-2 specific autoantibody deposits in the diagnosis and follow-up of celiac disease. J Clin Gastroenterol 44:483-488
26. Freeman HJ (2004) Adult celiac disease and the severe "flat" small bowel biopsy lesion. Dig Dis Sci 49:535-545
27. Vogelsang H, Häne lS, Steiner B, Oberhuber G (2001) Diagnostic duodenal bulb biopsy in celiac disease. Endoscopy 33:336-340
28. Bonamico M, Mariani P, Thanasi E, Ferri M, Nenna R, Tiberi C et al (2004) Patchy villous atrophy of duodenum in childhood celiac disease. J Pediatr Gastroenterol Nutr 38:204-207
29. Marsh MN (1992) Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to
30. the spectrum of gluten sensitivity ("celiac sprue"). Gastroenterology 102:330-354
31. Collin P, Kaukinen K, Vogelsang H, Korponay-Szabó I, Sommer R, Schreier E et al (2005) Antiendomysial and antihuman recombinant tissue transglutaminase antibodies in the diagnosis of celiac disease: A biopsy proven European multicentre study. Eur J Gastroenterol Hepatol 17:85-91
32. Collin P (1999) New diagnostic findings in celiac disease. Ann Med 31:399-405
33. Meuwisse GW (1970) Diagnostic criteria in coeliac disease. Acta Paediatr Scand 59:461
34. Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition. Arch Dis Child 65:909-911
35. Bürgin-Wolff A, Hernandez R, Just M, Signer E (1976) Immunofluorescent antibodies against gliadin: A screening test for coeliac disease. Helv Paediatr Acta 31:375-380
36. Savilahti E, Viander M, Perkkiö M, Vainio E, Kalimo K, Reunala T (1983) IgA antigliadin antibodies: A marker of mucosal damage in childhood coeliac disease. Lancet 1:320-322
37. Kumar V, Jain N, Lerner A, Beutner EH, Chorzelski TP, Lebenthal E (1986) Comparative studies of different gliadin preparations in detecting antigliadin antibodies. J Pediatr Gastroenterol Nutr 5:730-734
38. Hill ID (2005) What are the sensitivity and specificity of serologic tests for celiac disease? Do sensitivity and specificity vary in different populations? Gastroenterology 128:S25-S32
39. Burgin-Wolff A, Gaze H, Hadziselimovic F, Huber H, Lentze MJ, Nussle D et al (1991) Antigliadin and antiendomysium antibody determination for coeliac disease. Arch Dis Child 66:941-947
40. Chorzelski TP, Beutner EH, Sulej J, Tchorzewska H, Jablonska S, Kumar V et al (1984) IgA anti-endomysium antibody. A new immunological marker of dermatitis herpetiformis and coeliac disease. Br J Dermatol 111:395-402
41. Dieterich W, Laag E, Schöpper H, Volta U, Ferguson A, Gillett H et al (1998) Autoantibodies to tissue transglutaminase as predictors of celiac disease. Gastroenterology 115:1317-1321
42. Biagi F, Klersy C, Balduzzi D, Corazza GR (2010) Are we not over-estimating the prevalence of coeliac disease in the general population? Ann Med 42:557-561
43. Aleanzi M, Demonte AM, Esper C, Garcilazo S, Waggener M (2001) Celiac disease: Antibody recognition against native and selectively deamidated gliadin peptides. Clin Chem 47:2023-2028
44. Skovbjerg H, Koch C, Anthonsen D, Sjöström H (2004) Deamidation and cross-linking of gliadin peptides by transglutaminases and the relation to celiac disease. Biochim Biophys Acta 1690:220-230
45. Matthias T, Pfeiffer S, Selmi C, Gershwin ME (2010) Diagnostic challenges in celiac disease and the role of the tissue transglutaminase-neo-epitope. Clin Rev Allergy Immunol 38:298-301
46. Reeves GE, Squance ML, Duggan AE, Murugasu RR, Wilson RJ, Wong RC et al (2006) Diagnostic accuracy of coeliac serological tests: A prospective study. Eur J Gastroenterol Hepatol 18:493-501
47. Fasano A, Not T, Wang W, Uzzau S, Berti I, Tommasini A et al
48. Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet 355:1518-1519
49. Duerksen DR, Wilhelm-Boyles C, Veitch R, Kryszak D, Parry DM (2010) A comparison of antibody testing, permeability testing, and zonulin levels with small-bowel biopsy in celiac disease patients on a gluten-free diet. Dig Dis Sci 55:1026-1031
50. Vivas S, Ruiz de Morales JG, Riestra S, Arias L, Fuentes D, Alvarez N et al (2009) Duodenal biopsy may be avoided when high transglutaminase antibody titers are present. World J Gastroenterol 15:4775-4780
51. Sugai E, Nachman F, Váquez H, González A, Andrenacci P, Czech A et al (2010) Dynamics of celiac disease-specific serology after initiation of a gluten-free diet and use in the assessment of compliance with treatment. Dig Liver Dis 42:352-358
52. Carroccio A, Brusca I, Iacono G, Di Prima L, Teresa S, Pirrone G et al (2005) Anti-actin antibodies in celiac disease: Correlation with intestinal mucosal damage and comparison of ELISA with immunofluorescence assay. Clin Chem 51:917-920
53. Basso D, Guariso G, Fogar P, Meneghel A, Zambon CF, Navaglia F et al (2009) Antibodies against synthetic deamidated gliadin peptides for celiac disease diagnosis and follow-up in children. Clin Chem 55:150-157
54. James SP (2005) This month at the NIH: Final statement of NIH Consensus Conference on celiac disease. Gastroenterology 128:6
55. Kumar V, Jarzabek-Chorzelska M, Sulej J, Karnewska K, Farrell T, Jablonska S (2002) Celiac disease and immunoglobulin A deficiency: How effective are the serological methods of diagnosis? Clin Diagn Lab Immunol 9:1295-1300
56. Shamir R, Eliakim R, Lahat N, Sobe lE, Lerner A (2002) ELISA of anti-endomysial antibodies in the diagnosis of celiac disease: Comparison with immunofluorescence assay of anti-endomysial antibodies and tissue transglutaminase antibodies. Isr Med Assoc J 4:594-596
57. Broide E, Sandbank J, Scapa E, Kimchi NA, Shapiro M, Lerner A
58. The immunohistochemistry profile of lymphocytic gastritis in celiac disease and Helicobacter pylori infection: Interplay between infection and inflammation. Mediat Inflamm 2007:81838
59. Sugai E, Hwang HJ, Vázquez H, Smecuol E, Niveloni S, Mazure R et al (2010) New serology assays can detect gluten sensitivity among enteropathy patients seronegative for anti-tissue transglutaminase. Clin Chem 56:661-665
60. Jaskowski TD, Donaldson MR, Hull CM, Wilson AR, Hill HR, Zone JJ, Book LS (2010) Novel screening assay performance in pediatric celiac disease and adult dermatitis herpetiformis. J Pediatr Gastroenterol Nutr 51:19-23
61. Aberg AK, Olcén P (2009) Serologic screening for celiac disease in children: A comparison between established assays and tests with deamidated gliadin-derived peptides plus conjugates for both IgA and IgG antibodies. APMIS 117:808-813
62. Basso D, Guariso G, Fasolo M, Pittoni M, Schiavon S, Fogar P et al (2006) A new indirect chemiluminescent immunoassay to measure anti-tissue transglutaminase antibodies. J Pediatr Gastroenterol Nutr 43:613-618
63. Rostom A, Dubé C, Cranney A, Saloojee N, Sy R, Garritty C et al
64. The diagnostic accuracy of serologic tests for celiac disease: A systematic review. Gastroenterology 128:S38-S46
65. van der Windt DA, Jellema P, Mulder CJ, Kneepkens CM, van der Horst HE (2010) Diagnostic testing for celiac disease among
66. patients with abdominal symptoms: A systematic review. JAMA 303:1738-1746
67. Leffler DA, Schuppan D (2010) Update on serologic testing in celiac disease. Am J Gastroenterol 105:2520-2524
68. Kurppa K, Lindfors K, Collin P, Saavalainen P, Partanen J, Haimila K et al (2010) Antibodies against deamidated gliadin peptides in early-stage celiac disease. J Clin Gastroenterol (in press)
69. Tonutti E, Visentini D, Picierno A, Bizzaro N, Villalta D, Tozzoli R et al (2009) Diagnostic efficacy of the ELISA test for the detection of deamidated anti-gliadin peptide antibodies in the diagnosis and monitoring of celiac disease. J Clin Lab Anal 23:165-171
70. Volta U, Granito A, Parisi C, Fabbri A, Fiorini E, Piscaglia M et al (2010) Deamidated gliadin peptide antibodies as a routine test for celiac disease: A prospective analysis. J Clin Gastroenterol 44:186-190
71. Bansal AK, Lindemann MJ, Ramsperger V, Kumar V (2009) Celiac G+ antibody assay for the detection of autoantibodies in celiac disease. Ann NY Acad Sci 1173:36-40
72. Weir DC, Glickman JN, Roiff T, Valim C, Leichtner AM (2010) Variability of histopathological changes in childhood celiac disease. Am J Gastroenterol 105:207-212
73. Rashid M, MacDonald A (2009) Importance of duodenal bulb biopsies in children for diagnosis of celiac disease in clinical practice. BMC Gastroenterol 9:78
74. Walker MM, Murray JA, Ronkainen J, Aro P, Storskrubb T, D'Amato M et al (2010) Detection of celiac disease and lymphocytic enteropathy by parallel serology and histopathology in a population-based study. Gastroenterology 139:112-119
75. Elli l, Bonura A, Bardella MT (2009) Avoiding duodenal endoscopies in celiac disease: Are we going forward or looking to the past. Dig Liver Dis 42:154-155
76. Sugai E, Moreno ML, Hwang HJ, Cabanne A, Crivelli A, Nachman F et al (2010) Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable? World J Gastroenterol 16:3144-3152
77. Plenge RM (2008) Shared genetic risk factors for type 1 diabetes and celiac disease. N Engl J Med 359:2837-2838
78. Shaoul R, Lerner A (2007) Associated autoantibodies in celiac disease. Autoimmun Rev 6:559-565
79. Simell S, Hoppu S, Simell T, Ståhlberg MR, Viander M, Routi T et al (2010) Age at development of type 1 diabetes- and celiac disease-associated antibodies and clinical disease in genetically susceptible children observed from birth. Diab Care 33:774-779
80. Lerner A (2010) New therapeutic strategies for celiac disease. Autoimmun Rev 9:144-147