Kinetic analysis of DNA strand joining by Chlorella virus DNA ligase and the role of nucleotidyltransferase motif VI in ligase adenylylation

Journal of Biological Chemistry

Volumn 287, Issue 34, 2012, Pages 28609-28618

  Samai, Poulami ^a   Shuman, Stewart ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLYLATION; BURST KINETICS; C TERMINUS; DNA LIGASES; DNA STRANDS; INSTRUCTIVE MODELS; KINETIC ANALYSIS; MECHANISTIC STUDIES; MRNA CAPPING; PHOSPHODIESTERS; POLYNUCLEOTIDES; PRE-STEADY STATE; RATE LIMITING;

CARBOXYLATION; CATALYSIS; CHEMICAL ANALYSIS; ENZYMES; ESTERS; FUNCTIONAL GROUPS; KINETICS; PH; PHOSPHORUS; PROTONATION; RATE CONSTANTS; VIRUSES;

DNA;

DIVALENT CATION; MAGNESIUM ION; MESSENGER RNA; NUCLEOTIDYLTRANSFERASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; VIRUS ENZYME;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ADENYLATION; AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA DETERMINATION; DNA STRAND; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; MISSENSE MUTATION; MUTATION RATE; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTON TRANSPORT; STRUCTURE ANALYSIS;

AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; CATALYSIS; CHLORELLA; DNA LIGASES; DNA, VIRAL; HYDROGEN-ION CONCENTRATION; KINETICS; MUTATION, MISSENSE; PLANT VIRUSES; VIRAL PROTEINS;

EID: 84865208997     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.380428     Document Type: Article

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