Kinetic mechanism of human DNA ligase I reveals magnesium-dependent changes in the rate-limiting step that compromise ligation efficiency

Journal of Biological Chemistry

Volumn 286, Issue 26, 2011, Pages 23054-23062

  Taylor, Mark R ^a   Conrad, John A ^a   Wahl, Daniel ^a   O'Brien, Patrick J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACHILLES' HEEL; ADENYLYLATION; DNA LIGASES; DNA LIGATION; DNA REPLICATIONS; GENOMIC STABILITY; ION-DEPENDENCE; KINETIC MECHANISM; MAMMALIAN DNA; PHOSPHODIESTER BONDS; PRE-STEADY STATE; RATE LIMITING; RATE-LIMITING STEPS; REACTION COORDINATES; REACTION MECHANISM; REACTION STEPS; SATURATING CONCENTRATION; SINGLE-STRAND BREAKS; STEADY STATE; THERMODYNAMIC FRAMEWORK;

CATALYSIS; ENZYMES; KINETICS; MAGNESIUM; MAMMALS; METAL IONS; REACTION KINETICS;

DNA;

ADENOSINE TRIPHOSPHATE; MAGNESIUM ION; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE 1; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ADENYLATION; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CHEMICAL BOND; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; ENZYME BINDING; ENZYME MECHANISM; ENZYME SPECIFICITY; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STEADY STATE; THERMODYNAMICS;

ADENOSINE TRIPHOSPHATE; CATALYSIS; DNA; DNA BREAKS; DNA LIGASES; DNA REPAIR; DNA REPLICATION; HUMANS; KINETICS; MAGNESIUM;

MAMMALIA;

EID: 79959536186     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.248831     Document Type: Article

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