The antiepileptic drug valproic acid restores T cell homeostasis and ameliorates pathogenesis of experimental autoimmune encephalomyelitis

Journal of Biological Chemistry

Volumn 287, Issue 34, 2012, Pages 28656-28665

  Lv, Jie ^a,b   Du, Changsheng ^a   Wei, Wei ^a,b   Wu, Zhiying ^c   Zhao, Guixian ^c   Li, Zhenxin ^c   Xie, Xin ^a,b  

^a TONGJI UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIEPILEPTIC DRUGS; AUTOIMMUNE DISEASE; CLINICAL USE; EFFECTIVE THERAPY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; HUMAN SUBJECTS; IMMUNE CELLS; MOUSE MODELS; MULTIPLE SCLEROSIS; SPINAL CORDS; T CELLS; VALPROIC ACID;

ASPECT RATIO; CELL DEATH; DISEASE CONTROL;

PHYSIOLOGY;

CASPASE 3; CASPASE 8; VALPROIC ACID;

ADULT; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; DEMYELINATING DISEASE; DRUG EFFECT; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; IMMUNOREGULATION; LEUKOCYTE MOTILITY; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; MULTIPLE SCLEROSIS; MYELITIS; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTICONVULSANTS; CASPASE 3; CASPASE 8; DRUG EVALUATION, PRECLINICAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; HOMEOSTASIS; HUMANS; MALE; MICE; MULTIPLE SCLEROSIS; T-LYMPHOCYTES; VALPROIC ACID;

EID: 84865207720     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.356584     Document Type: Article

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