Addition of tiotropium to formoterol improves inspiratory muscle strength after exercise in COPD

Respiratory Medicine

Volumn 106, Issue 10, 2012, Pages 1404-1412

  Canto, Nivea D ^a   Ribeiro, Jorge P ^b,c   Neder, J Alberto ^d   Chiappa, Gaspar R ^b  

^a UNIVERSITY OF SOUTHERN SANTA CATARINA   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Constant work test; Inspiratory muscle strength; Oxygen; Respiratory muscles

Indexed keywords

FLUIR; FORMOTEROL FUMARATE; PLACEBO; TIOTROPIUM BROMIDE; UNCLASSIFIED DRUG;

ADULT; ARTERIAL GAS; ARTICLE; BREATHING MUSCLE; CARDIOPULMONARY EXERCISE TEST; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; EXERCISE TOLERANCE; FEMALE; HUMAN; KINETICS; LUNG FUNCTION TEST; MALE; MAXIMAL INSPIRATORY PRESSURE; MUSCLE FUNCTION; MUSCLE STRENGTH; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT PARAMETERS; WORKLOAD;

ADMINISTRATION, INHALATION; BRONCHODILATOR AGENTS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; ETHANOLAMINES; EXERCISE; HUMANS; MIDDLE AGED; MUSCLE STRENGTH; OXYGEN CONSUMPTION; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY FUNCTION TESTS; RESPIRATORY MUSCLES; SCOPOLAMINE DERIVATIVES;

EID: 84865201428     PISSN: 09546111     EISSN: 15323064     Source Type: Journal    
DOI: 10.1016/j.rmed.2012.05.012     Document Type: Article

References (47)

1. D.C. Berton, M. Reis, and A.C. Siqueira Effects of tiotropium and formoterol on dynamic hyperinflation and exercise endurance in COPD Respir Med 104 9 2010 1288 1296
2. D.E. O'Donnell Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease Proc Am Thorac Soc 3 2 2006 180 184
3. T. Okamoto, H. Kanazawa, K. Hirata, and J. Yoshikawa Evaluation of oxygen uptake kinetics and oxygen kinetics of peripheral skeletal muscle during recovery from exercise in patients with chronic obstructive pulmonary disease Clin Physiol Funct Imaging 23 5 2003 257 262 (Pubitemid 37161551)
4. J.A. Neder On the issue of exercise normalcy Eur Respir J 34 1 2009 286 287 author reply 287-288
5. J.A. Neder The major limitation to exercise performance in COPD is inadequate energy supply to the respiratory and locomotor muscles vs. lower limb muscle dysfunction vs. dynamic hyperinflation. Interpretation of exercise intolerance in COPD requires an integrated, multisystemic approach J Appl Physiol 105 2 2008 758 759
6. D.M. Mancini, D. Henson, J. LaManca, and S. Levine Respiratory muscle function and dyspnea in patients with chronic congestive heart failure Circulation 86 3 1992 909 918
7. H. van der Vaart, D.S. Postma, R. Grevink, W. Roemer, and N. Ten Hacken Bronchodilation improves endurance but not muscular efficiency in chronic obstructive pulmonary disease Int J Chron Obstruct Pulmon Dis 6 2011 229 235
8. D.E. O'Donnell, N. Voduc, M. Fitzpatrick, and K.A. Webb Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary disease Eur Respir J 24 1 2004 86 94 (Pubitemid 39029073)
9. F. Maltais, A. Hamilton, and D. Marciniuk Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD Chest 128 3 2005 1168 1178 (Pubitemid 41324392)
10. D.D. Briggs Jr., H. Covelli, R. Lapidus, S. Bhattycharya, S. Kesten, and C. Cassino Improved daytime spirometric efficacy of tiotropium compared with salmeterol in patients with COPD Pulm Pharmacol Ther 18 6 2005 397 404 (Pubitemid 41354265)
11. V. Brusasco, R. Hodder, M. Miravitlles, L. Korducki, L. Towse, and S. Kesten Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD Thorax 58 5 2003 399 404 (Pubitemid 36560942)
12. C. Vogelmeier, B. Hederer, and T. Glaab Tiotropium versus salmeterol for the prevention of exacerbations of COPD N Engl J Med 364 12 2011 1093 1103
13. P. Weiner, R. Magadle, N. Berar-Yanay, A. Davidovich, and M. Weiner The cumulative effect of long-acting bronchodilators, exercise, and inspiratory muscle training on the perception of dyspnea in patients with advanced COPD Chest 118 3 2000 672 678
14. L.M. Fabbri, and S.S. Hurd Global Strategy for the diagnosis, Management and prevention of COPD: 2003 update Eur Respir J 22 1 2003 1 2 (Pubitemid 36896461)
15. J.A. Neder, S. Andreoni, A. Castelo-Filho, and L.E. Nery Reference values for lung function tests. I. Static volumes Braz J Med Biol Res 32 6 1999 703 717 (Pubitemid 129539335)
16. J.A. Neder, S. Andreoni, C. Peres, and L.E. Nery Reference values for lung function tests. III. Carbon monoxide diffusing capacity (transfer factor) Braz J Med Biol Res 32 6 1999 729 737 (Pubitemid 129539337)
17. D.C. Berton, P.B. Barbosa, and L.S. Takara Bronchodilators accelerate the dynamics of muscle O2 delivery and utilisation during exercise in COPD Thorax 65 7 2010 588 593
18. P. Dall'Ago, G.R. Chiappa, H. Guths, R. Stein, and J.P. Ribeiro Inspiratory muscle training in patients with heart failure and inspiratory muscle weakness: a randomized trial J Am Coll Cardiol 47 4 2006 757 763 (Pubitemid 43243097)
19. ATS/ERS Statement on respiratory muscle testing Am J Respir Crit Care Med 166 4 2002 518 624
20. J.A. Neder, L.E. Nery, and A. Castelo Prediction of metabolic and cardiopulmonary responses to maximum cycle ergometry: a randomised study Eur Respir J 14 6 1999 1304 1313 (Pubitemid 30019525)
21. A.L. Hamilton, K.J. Killian, E. Summers, and N.L. Jones Muscle strength, symptom intensity, and exercise capacity in patients with cardiorespiratory disorders Am J Respir Crit Care Med 152 6 Pt 1 1995 2021 2031
22. G.R. Chiappa, A. Borghi-Silva, and L.F. Ferreira Kinetics of muscle deoxygenation are accelerated at the onset of heavy-intensity exercise in patients with COPD: relationship to central cardiovascular dynamics J Appl Physiol 104 5 2008 1341 1350
23. D.E. O'Donnell, T. Fluge, and F. Gerken Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD Eur Respir J 23 6 2004 832 840 (Pubitemid 38807355)
24. J.A. Neder, J.P. Fuld, and T. Overend Effects of formoterol on exercise tolerance in severely disabled patients with COPD Respir Med 101 10 2007 2056 2064 (Pubitemid 47324257)
25. C.B. Cooper Airflow obstruction and exercise Respir Med 103 3 2009 325 334
26. G.R. Chiappa, F. Queiroga Jr., and E. Meda Heliox improves oxygen delivery and utilization during dynamic exercise in patients with chronic obstructive pulmonary disease Am J Respir Crit Care Med 179 11 2009 1004 1010
27. D. Linnarsson Dynamics of pulmonary gas exchange and heart rate changes at start and end of exercise Acta Physiol Scand Suppl 415 1974 1 68
28. F. Ozyener, H.B. Rossiter, S.A. Ward, and B.J. Whipp Influence of exercise intensity on the on- and off-transient kinetics of pulmonary oxygen uptake in humans J Physiol 533 Pt 3 2001 891 902 (Pubitemid 32600542)
29. G.R. Chiappa, B.T. Roseguini, and P.J. Vieira Inspiratory muscle training improves blood flow to resting and exercising limbs in patients with chronic heart failure J Am Coll Cardiol 51 17 2008 1663 1671 (Pubitemid 351626410)
30. J.P. Ribeiro, G.R. Chiappa, J.A. Neder, and L. Frankenstein Respiratory muscle function and exercise intolerance in heart failure Curr Heart Fail Rep 6 2 2009 95 101
31. R. Gosselink, J. De Vos, S.P. van den Heuvel, J. Segers, M. Decramer, and G. Kwakkel Impact of inspiratory muscle training in patients with COPD: what is the evidence? Eur Respir J 37 2 2011 416 425
32. W.D. Man, N. Mustfa, and D. Nikoletou Effect of salmeterol on respiratory muscle activity during exercise in poorly reversible COPD Thorax 59 6 2004 471 476 (Pubitemid 38797518)
33. M. Aubier, N. Viires, D. Murciano, G. Medrano, Y. Lecocguic, and R. Pariente Effects and mechanism of action of terbutaline on diaphragmatic contractility and fatigue J Appl Physiol 56 4 1984 922 929 (Pubitemid 14142849)
34. A. Grassino, M.D. Goldman, J. Mead, and T.A. Sears Mechanics of the human diaphragm during voluntary contraction: statics J Appl Physiol 44 6 1978 829 839 (Pubitemid 9158224)
35. M.J. Kendall, N.W. Clark, C.A. Haffner, J. Kong, and B.A. Hughes Investigation of the effects of beta-2 stimulation on free fatty acids in man J Clin Pharm Ther 16 1 1991 31 40
36. K. Collomp, B. Panse, R. Candau, A.M. Lecoq, and J. De Ceaurriz Beta-2 agonists and exercise performance in humans Sci Sport 25 6 2010 281 290
37. D.E. O'Donnell, A.L. Hamilton, and K.A. Webb Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD J Appl Physiol 101 4 2006 1025 1035 (Pubitemid 44497544)
38. S. Nanas, J. Nanas, and C. Kassiotis Respiratory muscles performance is related to oxygen kinetics during maximal exercise and early recovery in patients with congestive heart failure Circulation 100 5 1999 503 508 (Pubitemid 29360159)
39. M.I. Polkey, D. Kyroussis, C.H. Hamnegard, G.H. Mills, M. Green, and J. Moxham Diaphragm strength in chronic obstructive pulmonary disease Am J Respir Crit Care Med 154 5 1996 1310 1317 (Pubitemid 26391174)
40. S.Z. Newell, D.K. McKenzie, and S.C. Gandevia Inspiratory and skeletal muscle strength and endurance and diaphragmatic activation in patients with chronic airflow limitation Thorax 44 11 1989 903 912 (Pubitemid 19281531)
41. Q. Hamid, J. Shannon, and J. Martin Physiologic basis of respiratory disease 2005 BC Decker, Inc
42. D.E. O'Donnell, and K.A. Webb Exertional breathlessness in patients with chronic airflow limitation. The role of lung hyperinflation Am Rev Respir Dis 148 5 1993 1351 1357 (Pubitemid 23326038)
43. A.L. Albuquerque, L.E. Nery, and D.S. Villaca Inspiratory fraction and exercise impairment in COPD patients GOLD stages II-III Eur Respir J 28 5 2006 939 944 (Pubitemid 46331962)
44. R. Casaburi Skeletal muscle function in COPD Chest 117 5 Suppl. 1 2000 267S 271S (Pubitemid 30326985)
45. F. Maltais, P. LeBlanc, J. Jobin, and R. Casaburi Peripheral muscle dysfunction in chronic obstructive pulmonary disease Clin Chest Med 21 4 2000 665 677 (Pubitemid 32057585)
46. T. Troosters, I. Weisman, F. Dobbels, N. Giardino, and S.R. Valluri Assessing the impact of tiotropium on lung function and Physical activity in GOLD Stage II COPD patients who are Naive to Maintenance respiratory therapy: a study protocol Open Respir Med J 5 2011 1 9
47. N. Ambrosino, K. Foglio, G. Balzano, P.L. Paggiaro, P. Lessi, and S. Kesten Tiotropium and exercise training in COPD patients: effects on dyspnea and exercise tolerance Int J Chron Obstruct Pulmon Dis 3 4 2008 771 780