Bronchodilators accelerate the dynamics of muscle O2 delivery and utilisation during exercise in COPD

Thorax

Volumn 65, Issue 7, 2010, Pages 588-593

  Berton, Danilo C ^a   Barbosa, Priscila B ^a   Takara, Luciana S ^a   Chiappa, Gaspar R ^a   Siqueira, Ana Cristina B ^a   Bravo, Daniela M ^a   Ferreira, Leonardo F ^b   Neder, J Alberto ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRONCHODILATING AGENT; DEOXYHEMOGLOBIN; IPRATROPIUM BROMIDE PLUS SALBUTAMOL SULFATE; MYOGLOBIN; OXYGEN; PLACEBO; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; IPRATROPIUM BROMIDE; SALBUTAMOL;

AGED; ARTICLE; BICYCLE ERGOMETER; BICYCLE ERGOMETRY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ERGOMETER; ERGOMETRY; EXERCISE; EXERCISE TEST; FORCED EXPIRATORY VOLUME; HEART OUTPUT; HUMAN; HYPERINFLATION; HYPOXEMIA; IMPEDANCE CARDIOGRAPHY; LUNG FUNCTION; LUNG INFLATION; LUNG VOLUME; MALE; METERED DOSE INHALER; MICROVASCULARIZATION; NEAR INFRARED SPECTROSCOPY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKELETAL MUSCLE; STEADY STATE; VASTUS LATERALIS MUSCLE; BRAZIL; CROSSOVER PROCEDURE; LEG; METHODOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY; VITAL CAPACITY;

ADRENERGIC BETA-AGONISTS; AGED; ALBUTEROL; BRAZIL; BRONCHODILATOR AGENTS; CHOLINERGIC ANTAGONISTS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EXERCISE TEST; FORCED EXPIRATORY VOLUME; HUMANS; IPRATROPIUM; LEG; MALE; MIDDLE AGED; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; VITAL CAPACITY;

EID: 77955302878     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thx.2009.120857     Document Type: Article

References (34)

1. Aliverti A, Macklem PT. The major limitation to exercise performance in COPD is inadequate energy supply to the respiratory and locomotor muscles. J Appl Physiol 2008;105:749-51.
2. Debigaré R, Maltais F. The major limitation to exercise performance in COPD is lower limb muscle dysfunction. J Appl Physiol 2008;105:751-3.
3. O'Donnell DE, Webb KA. The major limitation to exercise performance in COPD is dynamic hyperinflation. J Appl Physiol 2008;105:753-7555.
4. Chiappa GR, Borghi-Silva A, Ferreira LF, et al. Kinetics of muscle deoxygenation are accelerated at the onset of heavy-intensity exercise in patients with COPD: relationship to central cardiovascular dynamics. J Appl Physiol 2008;104:1341-50.
5. Chiappa GR, Queiroga F Jr, Meda E, et al. Heliox improves oxygen delivery and utilization during dynamic exercise in patients with COPD. Am J Respir Crit Care Med 2009;179:1004-10.
6. Saito S, Miyamoto K, Nishimura M, et al. Effects of inhaled bronchodilators on pulmonary hemodynamics at rest and during exercise in patients with COPD. Chest 1999;115:376-82.
7. Hanania NA, Donohue JF. Pharmacologic interventions in chronic obstructive pulmonary disease: bronchodilators. Proc Am Thorac Soc 2007;4:526-34.
8. Neder JA, Andreoni S, Castelo-Filho A, et al. Reference values for lung function tests. I. Static volumes. Braz J Med Biol Res 1999;32:703-17.
9. Neder JA, Andreoni S, Peres C, et al. Reference values for lung function tests. III. Carbon monoxide diffusing capacity (transfer factor). Braz J Med Biol Res 1999;32:729-37.
10. O'Donnell DE, Lam M, Webb KA. Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;158:1557-65.
11. Poole DC, Behnke BJ, Padilla DJ. Dynamics of muscle microcirculatory oxygen exchange. Med Sci Sports Exerc 2005;37:1559-66.
12. 2 uptake and near-infrared spectroscopy. J Appl Physiol 2005;98:1820-8.
13. Charloux A, Lonsdorfer-Wolf E, Richard R, et al. A new impedance cardiograph device for the non-invasive evaluation of cardiac output at rest and during exercise: comparison with the "direct" Fick method. Eur J Appl Physiol 2000;82:313-20.
14. Bougault V, Lonsdorfer-Wolf E, Charloux A, et al. Does thoracic bioimpedance accurately determines cardiac output in COPD patients during maximal or intermittent exercise? Chest 2005;127:1122-31.
15. Kemps HM, Thijssen EJ, Schep G, et al. Evaluation of two methods for continuous cardiac output assessment during exercise in chronic heart failure patients. J Appl Physiol 2008;105:1822-9.
16. Whipp BJ, Ward SA, Lamarra N, et al. Parameters of ventilatory and gas exchange dynamics during exercise. J Appl Physiol 1982;52:1506-13.
17. Poole DC, Barstow TJ, McDonough P, et al. Control of oxygen uptake during exercise. Med Sci Sports Exerc 2008;40:462-74.
18. Borghi-Silva A, Oliveira CC, Carrascosa C, et al. Respiratory muscle unloading improves leg muscle oxygenation during exercise in patients with COPD. Thorax 2008;63:910-15.
19. Sperandio PA, Borghi-Silva A, Barroco A, et al. Microvascular oxygen delivery-to-utilization mismatch at the onset of heavy intensity exercise in optimally-treated patients with CHF. Am J Physiol Heart Circ Physiol 2009;297:H1720-8.
20. Neder JA, Nery LE, Castelo A, et al. Prediction of metabolic and cardiopulmonary responses to maximum cycle ergometry: a randomised study. Eur Respir J 1999;14:1304-13.
21. Pellegrino R, Viegi G, Brusasco V, et al. Interpretative strategies for lung function tests. Eur Respir J 2005;26:948-68.
22. 2 on-kinetics in isolated in situ canine muscle. J Appl Physiol 1998;85:1394-403.
23. 2 exchange. Respir Physiol Neurobiol 2005;147:91-103.
24. Saltin B. Exercise hyperaemia: magnitude and aspects on regulation in humans. J Physiol 2007;583:819-23.
25. Bauer TA, Reusch JE, Levi M, et al. Skeletal muscle deoxygenation after the onset of moderate exercise suggests slowed microvascular blood flow kinetics in type 2 diabetes. Diabetes Care 2007;30:2880-5.
26. Fagraeus L, Linnarsson D. Autonomic origin of heart rate fluctuations at the onset of muscular exercise. J Appl Physiol 1976;40:679-82.
27. Bleecker ER. Cholinergic and neurogenic mechanisms in obstructive airways disease. Am J Med 1986;81:93-102.
28. Tobin MJ, Hughes JA, Hutchison DC. Effects of ipratropium bromide and fenoterol aerosols on exercise tolerance. Eur J Respir Dis 1984;65:441-6.
29. Buda AJ, Pinsky MR, Ingels NB, et al. Effect of intrathoracic pressure on left ventricular performance. N Engl J Med 1979;301:453-9.
30. Laveneziana P, Palange P, Ora J, et al. Bronchodilator effect on ventilatory, pulmonary gas exchange, and heart rate kinetics during high-intensity exercise in COPD. Eur J Appl Physiol 2009;107:633-43.
31. Buckwalter JB, Clifford PS. Autonomic control of skeletal muscle blood flow at the onset of exercise. Am J Physiol Heart Circ Physiol 1999;277:H1872-7.
32. Casaburi R. Factors determining constant work rate exercise tolerance in COPD and their role in dictating the minimal clinically important difference in response to interventions. COPD 2005;2:131-6.
33. Saey D, Debigare R, LeBlanc P, et al. Contractile leg fatigue after cycle exercise: a factor limiting exercise in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003;15:425-30.
34. Pepin V, Saey D, Whittom F, et al. Walking versus cycling: sensitivity to bronchodilation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005;172:1517-22.