An anxiogenic drug, FG 7142, induced an increase in mRNA of Btg2 and Adamts1 in the hippocampus of adult mice

Behavioral and Brain Functions

Volumn 8, Issue , 2012, Pages

  Kurumaji, Akeo ^a   Nishikawa, Toru ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Adamts1; Anxiety; Btg2; Dentate gyrus; Development; FG7142; Flumazenil; GABAA receptors; Hippocampus; RT PCR

Indexed keywords

ADAMTS1 PROTEIN; BTG2 PROTEIN; FLUMAZENIL; MEMBRANE PROTEIN; MESSENGER RNA; N METHYL BETA CARBOLINE 3 CARBOXAMIDE; RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DENTATE GYRUS; DRUG BINDING SITE; GABAERGIC SYSTEM; GENE EXPRESSION; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; TRANSCRIPTION REGULATION; UPREGULATION;

ADAM PROTEINS; ANIMALS; CARBOLINES; GABA ANTAGONISTS; GENE EXPRESSION; HIPPOCAMPUS; IMMEDIATE-EARLY PROTEINS; MALE; MICE; MICE, INBRED C57BL; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEINS;

EID: 84865200000     PISSN: None     EISSN: 17449081     Source Type: Journal    
DOI: 10.1186/1744-9081-8-43     Document Type: Article

References (47)

1. Dorow R, Horowski R, Paschelke G, Amin M, Braestrup C. Severe anxiety induced by FG7142, a Beta-carboline ligand for benzdiazepine receptors. Lancet. I 1983, 8:98-99.
2. Takamatsu H, Noda A, Kurumaji A, Murakami Y, Tatsumi M, Ichise R, Nishimura S. A PET study following treatment with a pharmacological stressor, FG7142, in conscious rhesus monkeys. Brain Res 2003, 2003(980):275-280.
3. Pellow S, File SE. Anxiolytic and anxiogeic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav 1986, 24:525-529. 10.1016/0091-3057(86)90552-6, 2871560.
4. Rodgers RJ, Cole JC, Aboualfa K, Stephenson LH. Ethopharmacological analysis of the effects of putative 'anxiogenic' agents in the mouse. Pharmacol Biochem Behav 1995, 52:805-813. 10.1016/0091-3057(95)00190-8, 8587923.
5. Evans AK, Lowry CA. Pharmacology of the ß-carboline FG7142, a partial inverse agonist at the benzodiazepine allosteric site of the GABAA receptor: neurochemical, neurophysiological, and behavioral effects. CNS drug Review 2007, 13:475-501.
6. Bradberry CW, Lory JD, Roth RH. The anxiogenic beta-carboline FG7142 selectively increases dopamine release in rat prefrontal cortex as measured by microdialysis. J Neurochem 1991, 56:748-752. 10.1111/j.1471-4159.1991.tb01987.x, 1993892.
7. Dazzi L, Seu E, Cherchi G, Biggio G. Inhibition of stress-induced dopamine output in the rat prefrontal cortex by chronic treatment with olanzapine. Biol Psychiatry 2004, 55:477-483. 10.1016/j.biopsych.2003.11.020, 15023575.
8. Nakane H, Shimizu N, Hori T. Stress-induced norepinephrine release in the rat prefrontal cortex measured by microdialysis. Am J Physiol 1994, 267:R1559-R1566.
9. Dazzi L, Seu E, Cherchi G, Biggio G. Antagonism of the stress-induced increases in cortical norepinephrine output by the selective norepinephrine reuptake inhibitor reboxetine. Eur J Pharmacol 2003, 476:55-61. 10.1016/S0014-2999(03)02130-7, 12969749.
10. Moghaddam B. Stress activation of glutamate neurotransmission in the prefrontal cortex: implication for dopamine-associated psychiatric disorders. Biol Psychiatry 2002, 51:775-787. 10.1016/S0006-3223(01)01362-2, 12007451.
11. Kovács KJ. c-Fos as a transcription factor: a stressful (re)view from a functional map. Neurochem Int 1998, 33:287-297. 10.1016/S0197-0186(98)00023-0, 9840219.
12. Senba E, Ueyama T. Stress-induced expression of immediate early gene in the brain and peripheral organs of the rat. Neurosci Res 1997, 29:183-207. 10.1016/S0168-0102(97)00095-3, 9436645.
13. Kurumaji A, Umino A, Tanami A, Ito A, Asakawa M, Nshikawa T. Distribution of anxiogenic-induced c-fos in the forebrain regions of developing rats. J Neural Transm 2003, 110:1161-1168. 10.1007/s00702-003-0023-9, 14523628.
14. Singewald N, Salchner P, Sharp T. Induction of c-fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs. Biol Psychiatry 2003, 53:275-283. 10.1016/S0006-3223(02)01574-3, 12586446.
15. Atack JR, Hutson PH, Collinson N, Marshall G, Bently G, Moyes C, Cook SM, Collins I, Wafford K, McKernan RM, Dawson GR. Anxiogenic properties of an inverse agonist selective for α3 subunit-containing GABAA receptors. Brit J Pharmacol 2005, 2005(144):357-366.
16. Kurumaji A, Ito T, Ishii S, Nishikawa T. Effects of FG7142 and immobilization stress on the gene expression in the neocortex of mice. Neurochemical Res 2008, 62:155-159.
17. Kurumaji A, Umino M, Nishikwa T. Effects of novelty stress on hippocampal gene expression, corticosterone and motor activity in mice. Neurochemical Res 2011, 71:161-167.
18. Squire LR. Memory and the hippocampus: a synthesis from findings with rats, and humans. Psychological Rev 1992, 99:195-231.
19. Makkar SR, Zang SQ, Cranney J. Behavioral and neural analysis of GABA in the acquisition, consolidation, reconsolidation, and extinction of fear memory. Neuropsychopharamacology 2010, 35:1625-1652.
20. Gage FH. Mammalian neural stem cells. Science 2000, 287:1433-1438. 10.1126/science.287.5457.1433, 10688783.
21. Deng W, Aimone JB, Gage FH. New neurons and new memories: how does adult hippocampus neurogenesis affect learning and memory?. Nat Rev Neurosci 2010, 11:339-350. 10.1038/nrn2822, 2886712, 20354534.
22. Rouault JP, Falette N, Guéhenneux F, Guillot C, Rimokh R, Wang Q, Berthet C, Moyret-Lalle C, Savatoe P, Pain B, Shaw P, Berger R, Samaru J, Maguad JP, Ozturk M, Samarut C, Puisieux A. Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. Nat Genet 1996, 14:482-486. 10.1038/ng1296-482, 8944033.
23. Guardavaccaro D, Corrente G, Covone F, Micheli L, D'Agnano I, Starace G, Caruso M, Tirone F. Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription. Mol Cell Biol 2000, 20:1797-1815. 10.1128/MCB.20.5.1797-1815.2000, 85361, 10669755.
24. Iacopetti P, Michelini M, Stuckmann I, Oback B, Aaku-Saraste E, Huttner WB. Expression of the antiproliferative gene TIS21 at the onset of neurogenesis identifies signal neuroepithelial cells that switch from proliferative to neuron-generating division. Proc Natl Acad Sci USA 1999, 96:4639-4644. 10.1073/pnas.96.8.4639, 16385, 10200315.
25. Haubensak W, Attardo A, Denk W, Huttner WB. Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis. Proc Natl Acad Sci USA 2004, 101:3196-3201. 10.1073/pnas.0308600100, 365766, 14963232.
26. Farioli-Vecchioli F, Saraulli D, Costanzi M, Leonardi L, Cina I, Micheli L, Nutini M, Longone P, Paul Oh S, Cestari V, Tirone F. Impaired terminal differentiation of hippocampal granule neurons and defective contextual memory in PC/Tis21 knockout mice. PLoS One 2009, 4:e8339. 10.1371/journal.pone.0008339, 2791842, 20020054.
27. Parker CC, Sokoloff G, Cheng R, Palmer AA. Genome-wide association for fear conditioning in an advanced intercross mouse line. Behavioral Genetics 2012, Epub ahead of print..
28. Kuno K, Kanada N, Nakajima E, Fujiki F, Ichimura F, Matsushima K. Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thombospondin motifs as an inflammation associated gene. J Biol Chem 1997, 272:556-562. 10.1074/jbc.272.1.556, 8995297.
29. Vázquez F, Hastings G, Ortega M-A, Lane TF, Oikemus S, Lombardo M, Iruela-Arispe ML. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. J Biol Chem 1999, 1999(274):23349-23357.
30. Apte SS. A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: function and mechanisms. J Biol Chem 2009, 284:31493-31497. 10.1074/jbc.R109.052340, 2797218, 19734141.
31. Wang L, Zhou C, Wang Z, Liu J, Jing Z, Zhang Z, Wang Y. Dynamic variation of genes profiles and pathways in the hippocampus of ischemic mice: a genomic study. Brain Res 2011, 2011(1372):13-21.
32. Cross AK, Haddock G, Stock CJ, Allan S, Surr J, Bunning RAD, Buttle DJ, Woodroofe MN. ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes. Brain Res 2006, 1088:19-30. 10.1016/j.brainres.2006.02.136, 16630594.
33. Tian YF, Zhang PB, Xiao XL, Zhang JS, Zhao JJ, Kang QY, Chen XL, Qui F, Liu Y. The quantification of ADAMTS expression in an animal model of cerebral ischemia using real-time PCR. Acta Anaesthesiol Scand 2007, 51:158-164. 10.1111/j.1399-6576.2006.01161.x, 17073862.
34. Castello R, Estelles A, Vazquez C, Falco C, Espana F, Almenar SM, Fuster C, Aznar J. Quantitative real-time reverse transcription-PCR assay for urokinase plasminogen activator, plasminogen activator inhibitor type 1, and tissue metalloproteinase inhibitor type 1 gene expressions in primary breast cancer. Clin Chem 2002, 48:1288-1295.
35. Thellin O, Zorzi W, Lakaye B, De Borman B, Coumans B, Hennen G, Grisar T, Igout A, Heinen E. Housekeeping genes as internal standards: use and limits. J Biotechnology 1999, 75:291-295.
36. Hoshino M, Sone M, Fukata M, Kuroda S, Kaibuchi K, Nabeshima Y, Hama C. Identifiction of the stef gene that encodes a novel guanine nucleotide exchange factor specific for Rac1. J Biol Chemistry 1999, 274:17837-17844.
37. Shimazu D, Yamamoto N, Umino A, Ishii S, Sakurai S, Nishikawa T. Inhibition of D-serine accumulation in the Xenopus oocyte by expression of the rat ortholog of human 3'-phosphoadenosine 5'-phosphosulfate transporter gene isolated from the neocortex as D-serine modulator-1. J Neurochemistry 2006, 96:30-42.
38. Kaneko K, Kurumaji A, Shibuya H, Nabeshima T, Toru M. The effects of single and repeated phencyclidine administration on [125I]iomazenil binding in the rat brain. Neurochem Int 1996, 29:279-287. 10.1016/0197-0186(96)00006-X, 8885287.
39. Sperk G, Schwarzer C, Tsunashima K, Fuchs K, Sieghart W. GABAA-receptor subunits in the rat hippocampus- I, Immunocytochemical distribution of thirteen subunits. Neuroscience 1997, 80:987-1000. 10.1016/S0306-4522(97)00146-2, 9284055.
40. Pieker S, Schwarzer C, Wieselthaler A, Sieghart W, Sperk G. GABAA receptors: immocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 2000, 101:815-850. 10.1016/S0306-4522(00)00442-5, 11113332.
41. Cazoniere D, Farioli-Vecchioli S, Conti F, Ciotti MT, Tata AM, Augusti-Tocco GG, Mattei E, Laksmana MK, Krizhanvsky V, Reeves SA, Giovanoni R, Castano F, Servadio A, Ben-Ari N, Tirone F. Dual control of neurogenesis by PC3 through cell cycle inhibition and induction of Math1. J Neurosci 2004, 24:3355-3369. 10.1523/JNEUROSCI.3860-03.2004, 15056715.
42. Calegari F, Hausensak W, Haffner C, Huttner WB. Selective lengthening of the cell cycle in the neurogenic subpopulation of neural progenitor cells during mouse brain development. J Neurosci 2005, 25:6533-6538. 10.1523/JNEUROSCI.0778-05.2005, 16014714.
43. Attardo A, Fabel K, Krebs J, Haubensak W, Huttner WB, Kempermann G. Tis21 expression marks not only population of neurogenic precursor cells but also new postmitotic neurons in adult hippocampal neurogeniseis. Cereb Cortex 2010, 20:304-314. 10.1093/cercor/bhp100, 2803732, 19482889.
44. Kajii Y, Muraoka S, Hiraoka S, Fujiyama K, Umino A, Nishikwa T. A developmentally regulated and psychostimulant-inducible novel rat gene mrt1 encoding PDZ-PX proteins isolated in the neocortex. Mol Psychiatry 2003, 8:434-444. 10.1038/sj.mp.4001258, 12740601.
45. Ito T, Hiraoka S, Kuroda Y, Ishii S, Umino A, Kashiwa A, Yamamoto N, Kurumaji A, Nishikawa T. Effects of schizophrenomimetics on the expression of the CCN1 (CYR61) gene encoding a matricellualr protein in the infant and adult neocortex of the mouse and rat. Int J Neuropsychopharmacol 2007, 10:717-725.
46. Takebayahsi H, Yamamoto N, Umino A, Nishikawa T. Developmentally regulated and thalamus-selective induction of leiomodin2 gene by a schizophrenomimetic, phencyclidine, in the rat. Int J Neuropsychopharmacol 2009, 12:1111-1126. 10.1017/S1461145709009997, 19254430.
47. Cherubini E, Gaiarsa J, Ben-Ari Y. GABA: an excitatory transmitter in early postnatal life. Trends Neurosci 1991, 14:515-519. 10.1016/0166-2236(91)90003-D, 1726341.