Inhibitory effect of BMP-2 on the proliferation of breast cancer cells

Molecular Medicine Reports

Volumn 6, Issue 3, 2012, Pages 615-620

  Chen, Anan ^a   Wang, Dingding ^b   Liu, Xueting ^a   He, Shuilian ^a   Yu, Zhihong ^a   Wang, Ju ^a  

^a JINAN UNIVERSITY   (China)

^b GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bone morphogenetic protein 2; Breast cancer; Proliferation

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; CASPASE 3; PROTEIN P21;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER STAGING; CELL CYCLE G1 PHASE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR XENOGRAFT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE I; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; BREAST NEOPLASMS; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; MICE; MICE, NUDE; SMAD4 PROTEIN; TRANSPLANTATION, HETEROLOGOUS;

EID: 84865187839     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.962     Document Type: Article

References (28)

1. Wozney JM, Rosen V, Celeste AJ, et al: Novel regulators of bone formation: molecular clones and activities. Science 242: 1528-1534, 1988. (Pubitemid 19023695)
2. Hogan BL: Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev 10: 1580-1594, 1996.
3. Reddi AH: Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nat Biotechnol 16: 247-252, 1998.
4. Hoodless PA, Haerry T, Abdollah S, et al: MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell 85: 489-500, 1996. (Pubitemid 26157188)
5. Nohe A, Hassel S, Ehrlich M, et al: The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways. J Biol Chem 277: 5330-5338, 2002. (Pubitemid 34968578)
6. Liu F, Ventura F, Doody J and Massague J: Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol Cell Biol 15: 3479-3486, 1995.
7. Nohno T, Ishikawa T, Saito T, et al: Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors. J Biol Chem 270: 22522-22526, 1995.
8. Rosenzweig BL, Imamura T, Okadome T, et al: Cloning and characterization of a human type II receptor for bone morphogenetic proteins. Proc Natl Acad Sci USA 92: 7632-7636, 1995.
9. Massague J and Chen YG: Controlling TGF-beta signaling. Genes Dev 14: 627-644, 2000.
10. Attisano L and Wrana JL: Smads as transcriptional co-modulators. Curr Opin Cell Biol 12: 235-243, 2000. (Pubitemid 30142572)
11. Kimura N, Matsuo R, Shibuya H, Nakashima K and Taga T: BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. J Biol Chem 275: 17647-17652, 2000. (Pubitemid 30430812)
12. Lee KS, Hong SH and Bae SC: Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein. Oncogene 21: 7156-7163, 2002.
13. Guicheux J, Lemonnier J, Ghayor C, Suzuki A, Palmer G and Caverzasio J: Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation. J Bone Miner Res 18: 2060-2068, 2003. (Pubitemid 37377457)
14. Johnsen IK, Kappler R, Auernhammer CJ and Beuschlein F: Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis. Cancer Res 69: 5784-5792, 2009.
15. Ghosh Choudhury G, Kim YS, Simon M, et al: Bone morphogenetic protein 2 inhibits platelet-derived growth factor-induced c-fos gene transcription and DNA synthesis in mesangial cells. Involvement of mitogen-activated protein kinase. J Biol Chem 274: 10897-10902, 1999.
16. Wong GA, Tang V, El-Sabeawy F and Weiss RH: BMP-2 inhibits proliferation of human aortic smooth muscle cells via p21Cip1/ Waf1. Am J Physiol Endocrinol Metab 284: E972-E979, 2003. (Pubitemid 36444033)
17. Reinholz MM, Iturria SJ, Ingle JN and Roche PC: Differential gene expression of TGF-beta family members and osteopontin in breast tumor tissue: analysis by real-time quantitative PCR. Breast Cancer Res Treat 74: 255-269, 2002. (Pubitemid 34848353)
18. Alarmo EL and Kallioniemi A: Bone morphogenetic proteins in breast cancer: dual role in tumourigenesis? Endocr Relat Cancer 17: R123-R139, 2010.
19. Ghosh-Choudhury N, Ghosh-Choudhury G, Celeste A, et al: Bone morphogenetic protein-2 induces cyclin kinase inhibitor p21 and hypophosphorylation of retinoblastoma protein in estradiol-treated MCF-7 human breast cancer cells. Biochim Biophys Acta 1497: 186-196, 2000. (Pubitemid 30618830)
20. Ghosh-Choudhury N, Woodruff K, Qi W, Celeste A, Abboud SL and Ghosh Choudhury G: Bone morphogenetic protein-2 blocks MDA MB 231 human breast cancer cell proliferation by inhibiting cyclin-dependent kinase-mediated retinoblastoma protein phosphorylation. Biochem Biophys Res Commun 272: 705-711, 2000. (Pubitemid 30420703)
21. Raida M, Clement JH, Ameri K, Han C, Leek RD and Harris AL: Expression of bone morphogenetic protein 2 in breast cancer cells inhibits hypoxic cell death. Int J Oncol 26: 1465-1470, 2005.
22. Steinert S, Kroll TC, Taubert I, et al: Differential expression of cancer-related genes by single and permanent exposure to bone morphogenetic protein 2. J Cancer Res Clin Oncol 134: 1237-1245, 2008.
23. Pouliot F, Blais A and Labrie C: Overexpression of a dominant negative type II bone morphogenetic protein receptor inhibits the growth of human breast cancer cells. Cancer Res 63: 277-281, 2003. (Pubitemid 36152479)
24. Alarmo EL, Parssinen J, Ketolainen JM, Savinainen K, Karhu R and Kallioniemi A: BMP7 influences proliferation, migration, and invasion of breast cancer cells. Cancer Lett 275: 35-43, 2009.
25. Kim M and Choe S: BMPs and their clinical potentials. BMB Rep 44: 619-634, 2011.
26. Harper JW, Adami GR, Wei N, Keyomarsi K and Elledge SJ: The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75: 805-816, 1993. (Pubitemid 23346377)
27. Fong S, Itahana Y, Sumida T, et al: Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis. Proc Natl Acad Sci USA 100: 13543-13548, 2003. (Pubitemid 37444778)
28. Clement JH, Marr N, Meissner A, et al: Bone morphogenetic protein 2 (BMP-2) induces sequential changes of Id gene expression in the breast cancer cell line MCF-7. J Cancer Res Clin Oncol 126: 271-279, 2000. (Pubitemid 30246248)