Brain transcriptional responses to high-fat diet in acads-deficient mice reveal energy sensing pathways

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Kruger, Claudia ^a   Kumar, K Ganesh ^a,c   Mynatt, Randall L ^a   Volaufova, Julia ^b   Richards, Brenda K ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c Taconic Farms Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLCARNITINE; ADENYLATE KINASE; BUTYRYL COENZYME A DEHYDROGENASE; SHORT CHAIN FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; BRAIN TISSUE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME REGULATION; FOOD INTAKE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENOTYPE; HYPOTHALAMUS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LIPID BLOOD LEVEL; LIPID DIET; LOW FAT DIET; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; PROTEIN ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ACYL-COA DEHYDROGENASE; ADENOSINE TRIPHOSPHATE; ANIMALS; BRAIN; DIET, HIGH-FAT; FATTY ACIDS; HYPOTHALAMUS; MALE; MICE; MICE, MUTANT STRAINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84865176465     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041709     Document Type: Article

References (37)

1. Scharrer E, Langhans W, (1986) Control of food intake by fatty acid oxidation. Am J Physiol Regul Integr Comp Physiol 250: R1003-6.
2. Blouet C, Schwartz GJ, (2010) Hypothalamic nutrient sensing in the control of energy homeostasis. Behav Brain Res 209: 1-12.
3. Wolfgang MJ, Lane MD, (2006) Control of energy homeostasis: Role of enzymes and intermediates of fatty acid metabolism in the central nervous system. Annu Rev Nutr 26: 23-44.
4. Schreurs M, Kuipers F, van der Leij FR, (2010) Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndrome. Obes Rev 11: 380-8.
5. Hinsdale ME, Kelly CL, Wood PA, (1993) Null allele at Bcd-1 locus in BALB/cByJ mice is due to a deletion in the short-chain acyl-CoA dehydrogenase gene and results in missplicing of mRNA. Genomics 16: 605-611.
6. Schiffer SP, Prochazka M, Jezyk PF, Roderick TH, Yudkoff M, et al. (1989) Organic aciduria and butyryl CoA dehydrogenase deficiency in BALB/cByJ mice. Biochem Genet 27: 47-58.
7. Wood PA, Amendt BA, Rhead WJ, Millington DS, Inoue F, et al. (1989) Short-chain acyl-coenzyme A dehydrogenase deficiency in mice. Pediatr Res 25: 38-43.
8. Smith Richards BK, Belton BN, York B, Volaufova J, (2004) Mice bearing Acads mutation display altered postingestive but not 5-s orosensory response to dietary fat. Am J Physiol Regul Integr Comp Physiol 286: R311-319.
9. Tafti M, Petit B, Chollet D, Neidhart E, de Bilbao F, et al. (2003) Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep. Nat Genet 34: 320-325.
10. Reue K, Cohen RD, (1996) Acads gene deletion in BALB/cByJ mouse strain occurred after 1981 and is not present in BALB/cByJ-fld mutant mice. Mamm Genome 7: 694-695.
11. Amendt BA, Freneaux E, Reece C, Wood PA, Rhead WJ, (1992) Short-chain acyl-coenzyme A dehydrogenase activity, antigen, and biosynthesis are absent in the BALB/cByJ mouse. Pediatr Res 31: 552-556.
12. Kelly CL, Wood PA, (1996) Cloning and characterization of the mouse short-chain acyl-CoA dehydrogenase gene. Mamm Genome 7: 262-264.
13. Wood PA, Kelly-Kurtz CL, Hinsdale ME, Hamm DA, Rhead WJ, (1999) Lessons learned from the mouse model of short-chain acyl-CoA dehydrogenase deficiency. Adv Exp Med Biol 466: 395-402.
14. Bolstad BM, Irizarry RA, Astrand M, Speed TP, (2003) A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19: 185-93.
15. Benjamini Y, Hochberg Y, (1995) Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. Journal of the Royal Statistical Society, Series B (Methodological) 57: 289-300.
16. Abramoff MD, Magalhaes PJ, Ram SJ, (2004) Image processing with ImageJ. Biophotonics International 11: 36-42.
17. Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S, (2009) AMPK in the brain: its roles in energy balance and neuroprotection. J Neurochem 109 Suppl 1: 17-23.
18. Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, et al. (2004) AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428: 569-574.
19. Martin TL, Alquier T, Asakura K, Furukawa N, Preitner F, et al. (2006) Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle. J Biol Chem 281: 18933-18941.
20. Abbott CR, Rossi M, Wren AM, Murphy KG, Kennedy AR, et al. (2001) Evidence of an orexigenic role for cocaine- and amphetamine-regulated transcript after administration into discrete hypothalamic nuclei. Endocrinol 142: 3457-63.
21. Smith KL, Gardiner JV, Ward HL, Kong WM, Murphy KG, et al. (2008) Overexpression of CART in the PVN increases food intake and weight gain in rats. Obesity 16: 2239-44.
22. Hou J, Zheng DZ, Zhou JY, Zhou SW, (2010) Orexigenic effect of cocaine-and amphetamine-regulated transcript (CART) after in jection into hypothalamic nuclei in streptozotocin-diabetic rats. Clin Exp Pharmacol Physiol 37: 989-95.
23. Asnicar MA, Smith DP, Yang DD, Heiman ML, Fox N, et al. (2001) Absence of cocaine- and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet. Endocrinol 142: 4394-400.
24. Altarejos JY, Montminy M, (2011) CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nat Rev Mol Cell Biol 12: 141-151.
25. Iijima K, Zhao L, Shenton C, Iijima-Ando K, (2009) Regulation of energy stores and feeding by neuronal and peripheral CREB activity in Drosophila. PLoS One 4: e8498.
26. Ziotopoulou M, Mantzoros CS, Hileman SM, Flier JS, (2000) Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice. Am J Phyisol Endocrinol Metab 279: E838-845.
27. Qureshi IA, Ratnakumari L, Michalak A, Giguere R, Cyr D, et al. (1993) A profile of cerebral and hepatic carnitine, ammonia, and energy metabolism in a model of organic aciduria: BALB/cByJ mouse with short-chain acyl-CoA dehydrogenase deficiency. Biochem Med Metab Biol 50: 145-158.
28. Wahbe VG, Balfour WM, Samson FE, (1961) A comparative study on vertebrate brain mitochondria. Comp Biochem Physiol 3: 199-205.
29. Lopaschuk GD, Ussher JR, Jaswal JS, (2010) Targeting intermediary metabolism in the hypothalamus as a mechanism to regulate appetite. Pharmacol Rev 62: 237-264.
30. Owen OE, Morgan AP, Hemp HG, Sullivan JM, Herrara MG, et al. (1967) Brain metabolism during fasting. J Clin Invest 46: 1589-95.
31. Spitzer JJ, (1973) CNS and fatty acid metabolism. Physiologist 16: 55-68.
32. Reichmann H, Maltese WA, DeVivo DC, (1988) Enzymes of fatty acid beta-oxidation in developing brain. J Neurochem 51: 339-44.
33. Tyni T, Paetau A, Strauss AW, Middleton B, Kivela T, (2004) Mitochondrial fatty acid b-oxidation in the human eye and brain: Implications for the retinopathy of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. Pediatr Res 56: 744-50.
34. He M, Peic Z, Mohsena AW, Watkins P, Murdoch G, et al. (2011) Identification and characterization of new long chain acyl-CoA dehydrogenases. Mol Genet Metab 102: 418-29.
35. Schwartz MW, Seeley RJ, Woods SC, Weigle DS, Campfield LA, et al. (1997) Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46: 2119-23.
36. Young PT (1967) Palatability: the hedonic response to foodstuffs. In: Code CF, Editor. Handbook of Physiology Sec 6: Alimentary canal Vol. 1 Control of Food and Water Intake. Washington, D.C.: Am Physiol Society.
37. Hardie DG, Scott JW, Pan DA, Hudson ER, (2003) Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett 546: 113-20.