Influence of polymer architecture on antigens camouflage, CD47 protection and complement mediated lysis of surface grafted red blood cells

Biomaterials

Volumn 33, Issue 31, 2012, Pages 7871-7883

  Chapanian, Rafi ^a   Constantinescu, Iren ^a   Rossi, Nicholas A A ^a   Medvedev, Nadia ^a,b   Brooks, Donald E ^a   Scott, Mark D ^a   Kizhakkedathu, Jayachandran N ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b ST PAUL S HOSPITAL   (Canada)

Author keywords

Antigen Protection; Blood transfusion; Hyperbranched polyglycerol; Polyethylene glycol; Red blood cells; Topology architecture of polymers

Indexed keywords

ANTIBODY RECOGNITION; BLOOD TRANSFUSION; CELL STRUCTURE; CELL SURFACES; DEFORMATION PROPERTIES; DONOR CELLS; GRAFTED CHAINS; GRAFTED POLYMERS; HYDRODYNAMIC SIZE; HYDROXYL GROUPS; HYPERBRANCHED POLYGLYCEROL; MOLECULAR SIZE; POLYMER ARCHITECTURE; PULSED FIELD GRADIENT NMR; RED BLOOD CELL; STRUCTURE OF THE POLYMERS; SURFACE GRAFTED; THERAPEUTIC DELIVERY;

ANTIGENS; BLOOD; CELL MEMBRANES; DENDRIMERS; DIFFERENTIAL SCANNING CALORIMETRY; DIFFUSION; ELECTROPHORETIC MOBILITY; GRAFTING (CHEMICAL); HYDRODYNAMICS; POLYETHYLENE OXIDES;

POLYETHYLENE GLYCOLS;

CD47 ANTIGEN; HYDROXYL GROUP; MACROGOL; POLYGLYCEROL; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; CELL STRUCTURE; CELL SURFACE; CHEMICAL INTERACTION; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; COMPLEMENT ACTIVATION; CONCENTRATION (PARAMETERS); CONFORMATION; CONTROLLED STUDY; CYTOLYSIS; DIFFERENTIAL SCANNING CALORIMETRY; DIFFUSION COEFFICIENT; ENTHALPY; ERYTHROCYTE; ERYTHROCYTE TRANSFUSION; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; HYDRATION; HYDRODYNAMICS; IN VITRO STUDY; MEMBRANE STRUCTURE; MOLECULAR SIZE; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTIGENS, CD47; COMPLEMENT SYSTEM PROTEINS; CYTOPROTECTION; CYTOTOXICITY, IMMUNOLOGIC; ELECTROPHORESIS; ERYTHROCYTES; GLYCEROL; GLYCOCALYX; HUMANS; HYDRODYNAMICS; MOLECULAR WEIGHT; OSMOTIC FRAGILITY; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYMERS; RH-HR BLOOD-GROUP SYSTEM; SURFACE PROPERTIES;

EID: 84865158214     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.07.015     Document Type: Article

References (42)

1. Muzykantov V.R. Drug delivery by red blood cells: vascular carriers designed by mother nature. Expert Opin Drug Deliv 2010, 7(4):403-427.
2. Garratty G. Modulating the red cell membrane to produce universal/stealth donor red cells suitable for transfusion. Vox Sang 2008, 94(2):87-95.
3. Bradley A.J., Murad K.L., Regan K.L., Scott M.D. Biophysical consequences of linker chemistry and polymer size on stealth erythrocytes: size does matter. Biochim Biophys Acta 2002, 1561(2):147-158.
4. Chapanian R., Constantinescu I., Brooks D.E., Scott M.D., Kizhakkedathu J.N. In vivo circulation, clearance, and biodistribution of polyglycerol grafted functional red blood cells. Biomaterials 2012, 33(10):3047-3057.
5. Rossi N.A.A., Constantinescu I., Kainthan R.K., Brooks D.E., Scott M.D., Kizhakkedathu J.N. Red blood cell membrane grafting of multi-functional hyperbranched polyglycerols. Biomaterials 2010, 31(14):4167-4178.
6. Scott M.D., Murad K.L., Koumpouras F., Talbot M., Eaton J.W. Chemical camouflage of antigenic determinants: stealth erythrocytes. Proc Natl Acad Sci U S A 1997, 94(14):7566-7571.
7. Murad K.T., Mahany K.L., Brugnara C., Kuypers F.A., Eaton J.W., Scott M.D. Structural and functional consequences of antigenic modulation of red blood cells with methoxypoly(ethylene glycol). Blood 1999, 93(6):2121-2127.
8. Daniels G., Reid M.E. Blood groups: the past 50 years. Transfusion 2010, 50(2):281-289.
9. Garratty G. Progress in modulating the RBC membrane to produce transfusable universal/stealth donor RBCs. Transfus Med Rev 2004, 18(4):245-256.
10. Bradley A.J., Scott M.D. Immune complex binding by immunocamouflaged [poly(ethylene glycol)-grafted] erythrocytes. Am J Hematol 2007, 82(11):970-975.
11. Sofia S.J., Premnath V., Merrill E.W. Poly(ethylene oxide) grafted to silicon surfaces: grafting density and protein adsorption. Macromolecules 1998, 31(15):5059-5070.
12. Yeh P.Y.J., Kainthan R.K., Zou Y.Q., Chiao M., Kizhakkedathu J.N. Self-assembled monothiol-terminated hyperbranched polyglycerols on a gold surface: a comparative study on the structure, morphology, and protein adsorption characteristics with linear poly(ethylene glycol)s. Langmuir 2008, 24(9):4907-4916.
13. Pinholt C., Bukrinsky J.T., Hostrup S., Frokjaer S., Norde W., Jorgensen L. Influence of PEGylation with linear and branched PEG chains on the adsorption of glucagon to hydrophobic surfaces. Eur J Pharm Biopharm 2011, 77(1):139-147.
14. Bergstrom K., Osterberg E., Holmberg K., Hoffman A.S., Schuman T.P., Kozlowski A., et al. Effects of branching and molecular-weight of surface-bound poly(ethylene oxide) on protein rejection. J Biomater Sci Polym Ed 1994, 6(2):123-132.
15. Neu B., Armstrong J.K., Fisher T.C., Baumler H., Meiselman H.J. Electrophoretic mobility of human red blood cells coated with poly(ethylene glycol). Biorheology 2001, 38(5-6):389-403.
16. Neu B., Armstrong J.K., Fisher T.C., Meiselman H.J. Surface characterization of poly(ethylene glycol) coated human red blood cells by particle electrophoresis. Biorheology 2003, 40(4):477-487.
17. Kainthan R.K., Hester S.R., Levin E., Devine D.V., Brooks D.E. In vitro biological evaluation of high molecular weight hyperbranched polyglycerols. Biomaterials 2007, 28(31):4581-4590.
18. Kainthan R.K., Janzen J., Levin E., Devine D.V., Brooks D.E. Biocompatibility testing of branched and linear polyglycidol. Biomacromolecules 2006, 7(3):703-709.
19. Fox M.E., Szoka F.C., Frechet J.M.J. Soluble polymer carriers for the treatment of cancer: the importance of molecular architecture. Acc Chem Res 2009, 42(8):1141-1151.
20. Garamus V.M., Maksimova T.V., Kautz H., Barriau E., Frey H., Schlotterbeck U., et al. Hyperbranched polymers: structure of hyperbranched polyglycerol and amphiphilic poly(glycerol ester)s in dilute aqueous and nonaqueous solution. Macromolecules 2004, 37(22):8394-8399.
21. Kainthan R.K., Muliawan E.B., Hatzikiriakos S.G., Brooks D.E. Synthesis, characterization, and viscoelastic properties of high molecular weight hyperbranched polyglycerols. Macromolecules 2006, 39(22):7708-7717.
22. Squire P.G. Calculation of hydrodynamic parameters of random coil polymers from size exclusion chromatography and comparison with parameters by conventional methods. J Chromatogr 1981, 210(3):433-442.
23. Kainthan R.K., Brooks D.E. In vivo biological evaluation of high molecular weight hyperbranched polyglycerols. Biomaterials 2007, 28(32):4779-4787.
24. Sunder A., Hanselmann R., Frey H., Mulhaupt R. Controlled synthesis of hyperbranched polyglycerols by ring-opening multibranching polymerization. Macromolecules 1999, 32(13):4240-4246.
25. Rossi N.A.A., Constantinescu I., Brooks D.E., Scott M.D., Kizhakkedathu J.N. Enhanced cell surface polymer grafting in concentrated and nonreactive aqueous polymer solutions. J Am Chem Soc 2010, 132(10):3423-3430.
26. Price W.S. Pulsed-field gradient nuclear magnetic resonance as a tool for studying translational diffusion. 1. Basic theory. Concepts Magn Reson 1997, 9(5):299-336.
27. Zhang Y., Amsden B.G. Application of an obstruction-scaling model to diffusion of vitamin B-12 and proteins in semidilute alginate solutions. Macromolecules 2006, 39(3):1073-1078.
28. Tirosh O., Barenholz Y., Katzhendler J., Priev A. Hydration of polyethylene glycol-grafted liposomes. Biophys J 1998, 74(3):1371-1379.
29. Mohandas N., Gallagher P.G. Red cell membrane: past, present, and future. Blood 2008, 112(10):3939-3948.
30. Hochmuth R.M., Evans E.A., Wiles H.C., McCown J.T. Mechanical measurement of red cell membrane thickness. Science 1983, 220(4592):101-102.
31. Levine S., Levine M., Sharp K.A., Brooks D.E. Theory of the electrokinetic behavior of human erythrocytes. Biophys J 1983, 42(2):127-135.
32. Anniss A.M., Sparrow R.L. Expression of CD47 (integrin-associated protein) decreases on red blood cells during storage. Transfus Apher Sci 2002, 27(3):233-238.
33. Colsenet R., Soderman O., Mariette F.O. Pulsed field gradient NMR study of poly(ethylene glycol) diffusion in whey protein solutions and gels. Macromolecules 2006, 39(3):1053-1059.
34. Roovers J., Comanita B. Dendrimers and dendrimer-polymer hybrids. Adv Pol Sci 1999, 142:179-228.
35. Burchard W. Solution properties of branched macromolecules. Adv Pol Sci 1999, 143:113-194.
36. Lindberg F.P., Lublin D.M., Telen M.J., Veile R.A., Miller Y.E., Doniskeller H., et al. Rh-related antigen CD47 is the signal-transducer integrin-associated protein. J Biol Chem 1994, 269(3):1567-1570.
37. Oldenborg P.A., Zheleznyak A., Fang Y.F., Lagenaur C.F., Gresham H.D., Lindberg F.P. Role of CD47 as a marker of self on red blood cells. Science 2000, 288(5473):2051-2054.
38. Daniels G. Human blood groups 1995, Blackwell Science Ltd., Massachusetts, USA.
39. Bradley A.J., Test S.T., Murad K.L., Mitsuyoshi J., Scott M.D. Interactions of IgM ABO antibodies and complement with methoxy-PEG-modified human RBCs. Transfusion 2001, 41(10):1225-1233.
40. Arima Y., Kawagoe M., Toda M., Iwata H. Complement activation by polymers carrying hydroxyl groups. ACS Appl Mater Interfaces 2009, 1(10):2400-2407.
41. Gros P., Milder F.J., Janssen B.J.C. Complement driven by conformational changes. Nat Rev Immunol 2008, 8(1):48-58.
42. de Oliveira S., Saldanha C. An overview about erythrocyte membrane. Clin Hemorheol Microcirc 2010, 44(1):63-74.