Detection of the full-length transcript variant for neurokinin-1 receptor in human whole blood associated with enhanced reinforcement of clot by substance-P

Journal of Thrombosis and Thrombolysis

Volumn 33, Issue 4, 2012, Pages 329-337

  Azma, Toshiharu ^a   Sugimoto, Yuki ^b   Kinoshita, Hiroyuki ^c   Ito, Taishin ^a   Tsukamoto, Masanori ^a   Hoshijima, Hiroshi ^a   Nakao, Masakazu ^d   Kikuchi, Hirosato ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY HOSPITAL   (Japan)

^c WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^d Division of Dermatology   (Japan)

Author keywords

Clot formation; Leukocytes; Neurokinin 1 receptor; Splice isoform; Substance P; Transcript variant

Indexed keywords

CALCIUM; MESSENGER RNA; NEUROKININ 1 RECEPTOR; SPANTIDE; SUBSTANCE P; BIOLOGICAL MARKER;

ADULT; ARTICLE; BLOOD ANALYSIS; BLOOD CLOTTING; BLOOD LEVEL; CLINICAL ARTICLE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG TARGETING; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC VARIABILITY; HUMAN; MALE; NK1R GENE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TIME SERIES ANALYSIS; TRANSCRIPTION REGULATION; AGED; BLOOD; CLINICAL TRIAL; GENE EXPRESSION REGULATION; MIDDLE AGED; THROMBOSIS;

AGED; BIOLOGICAL MARKERS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; MIDDLE AGED; RECEPTORS, NEUROKININ-1; RNA, MESSENGER; SUBSTANCE P; THROMBOSIS;

EID: 84865152461     PISSN: 09295305     EISSN: 1573742X     Source Type: Journal    
DOI: 10.1007/s11239-011-0650-1     Document Type: Article

References (26)

1. Geerts WH, Bergqvist D, Pineo GF, Heit JA, Samama CM, Lassen MR, Colwell CW (2008) Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest 133: 381S-453S
2. Reed KL, Fruin AB, Gower AC, Stucchi AF, Leeman SE, Becker JM (2004) A neurokinin 1 receptor antagonist decreases postoperative peritoneal adhesion formation and increases peritoneal fibrinolytic activity. Proc Natl Acad Sci USA 101:9115-9120
3. Graham GJ, Stevens JM, Page NM, Grant AD, Brain SD, Lowry PJ, Gibbins JM (2004) Tachykinins regulate the function of platelets. Blood 104:1058-1065
4. Jones S, Tucker KL, Sage T, Kaiser WJ, Barrett NE, Lowry PJ, Zimmer A, Hunt SP, Emerson M, Gibbins JM (2008) Peripheral tachykinins and the neurokinin receptor NK1 are required for platelet thrombus formation. Blood 111:605-612
5. Harrison S, Geppetti P (2001) Substance P. Int J Biochem Cell Biol 33:555-576
6. Gerard NP, Garraway LA, Eddy RL Jr., Shows TB, Iijima H, Paquet JL, Gerard C (1991) Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones. Biochemistry 30:10640-10646
7. Gerard NP, Eddy RL Jr., Shows TB, Gerard C (1990) The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues. J Biol Chem 265:20455-20462
8. Huang RR, Cheung AH, Mazina KE, Strader CD, Fong TM (1992) cDNA sequence and heterologous expression of the human neurokinin-3 receptor. Biochem Biophys Res Commun 184:966-972
9. Tuluc F, Lai JP, Kilpatrick LE, Evans DL, Douglas SD (2009) Neurokinin 1 receptor isoforms and the control of innate immunity. Trends Immunol 30:271-276
10. Fong TM, Anderson SA, Yu H, Huang RR, Strader CD (1992) Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor. Mol Pharmacol 41:24-30
11. Lai JP, Ho WZ, Kilpatrick LE, Wang X, Tuluc F, Korchak HM, Douglas SD (2006) Full-length and truncated neurokinin-1receptor expression and function during monocyte/macrophage differentiation. Proc Natl Acad Sci USA 103:7771-7776
12. Azma T, Matsubara Y, Kinoshita H, Hidaka I, Shiraishi S, Nakao M, Kawamoto M, Yuge O, Hatano Y (2009) Prothrombotic roles of substance-P, neurokinin-1 receptors and leukocytes in the platelet-dependent clot formation in whole blood. J Thromb Thrombolysis 27:280-286
13. Benson DA, Karsch-Mizrachi I, Lipman DJ, Ostell J, Wheeler DL (2003) GenBank. Nucleic Acids Res 31:23-27
14. Saleem A, Blifeld C, Saleh SA, Yawn DH, Mace ML, Schwartz M, Crawford ES (1983) Viscoelastic measurement of clot formation: a new test of platelet function. Ann Clin Lab Sci 13: 115-124
15. Rozen S, Skaletsky H (2000) Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 132: 365-386
16. Ganter MT, Hofer CK (2008) Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices. Anesth Analg 106:1366-1375
17. Hett DA, Walker D, Pilkington SN, Smith DC (1995) Sonoclot analysis. Br J Anaesth 75:771-776
18. Cao YQ, Mantyh PW, Carlson EJ, Gillespie AM, Epstein CJ, Basbaum AI (1998) Primary afferent tachykinins are required to experience moderate to intense pain. Nature 392:390-393
19. Zimmer A, Zimmer Am, Baffi J, Usdin T, Reynolds K, Konig M, Palkovits M, Mezey E (1998) Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene. Proc Nat Acad Sci USA 95:2630-2635
20. De Felipe C, Herrero JF, O'Brien JA, Palmer JA, Doyle CA, Smith AJH, Laird JMA, Belmonte C, Cervero F, Hunt SP (1998) Altered nociception, analgesia and aggression in mice lacking the receptor for substance P. Nature 392:394-397
21. Eular US, Gaddum JH (1931) An unidentified depressor substance in certain tissue extracts. J Physiol 72:74-87
22. Gaddum JH, Shild H (1934) Depressor substances in extracts of intestine. J Physiol 83:1-14
23. Chernova I, Lai JP, Li H, Schwartz L, Tuluc F, Korchak HM, Douglas SD, Kilpatrick LE (2009) Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R). J Leukoc Biol 85:154-164
24. Manak MM, Moshkoff DA, Nguyen LT, Meshki J, Tebas P, Tuluc F, Douglas SD (2010) Anti-HIV-1 activity of the neurokinin-1 receptor antagonist aprepitant and synergisticinteractions with other antiretrovirals. AIDS 24:2789-2796
25. Monaco-Shawver L, Schwartz L, Tuluc F, Guo CJ, Lai JP, Gunnam SM, Kilpatrick LE, Banerjee PP, Douglas SD, Orange JS (2011) Substance P inhibits natural killer cell cytotoxicity through the neurokinin-1 receptor. J Leukoc Biol 89:113-125
26. Shantsila E, Lip GY (2009) The role of monocytes in thrombotic disorders. Insights from tissue factor, monocyte-platelet aggregates and novel mechanisms. Thromb Haemost 102:916-924