Prothrombotic roles of substance-P, neurokinin-1 receptors and leukocytes in the platelet-dependent clot formation in whole blood

Journal of Thrombosis and Thrombolysis

Volumn 27, Issue 3, 2009, Pages 280-286

  Azma, Toshiharu ^a   Matsubara, Yuki ^b   Kinoshita, Hiroyuki ^c   Hidaka, Ikuhiro ^d   Shiraishi, Seiji ^b   Nakao, Masakazu ^b   Kawamoto, Masashi ^d   Yuge, Osafumi ^d   Hatano, Yoshio ^c  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b JA HIROSHIMA GENERAL HOSPITAL   (Japan)

^c WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^d HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Clot formation; Leukocyte; Neurokinin 1 receptor; Platelet; Spantide; Substance P

Indexed keywords

LIPOCORTIN 5; NEUROKININ 1 RECEPTOR; SPANTIDE; SUBSTANCE P;

ARTICLE; BLOOD CLOTTING; BLOOD SAMPLING; CELL TYPE; CONTROLLED STUDY; FIBRIN FORMATION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LEUKOCYTE FUNCTION; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT; THROMBOCYTE FUNCTION; THROMBOGENESIS; VISCOELASTICITY;

BLOOD COAGULATION; BLOOD COAGULATION TESTS; BLOOD PLATELETS; CALCIUM; DIATOMACEOUS EARTH; HUMANS; LEUKOCYTES; RECEPTORS, NEUROKININ-1; SUBSTANCE P; THROMBOPHILIA;

EID: 64749096345     PISSN: 09295305     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11239-008-0215-0     Document Type: Article

References (25)

1. Cao YQ, Mantyh PW, Carlson EJ et al (1998) Primary afferent tachykinins are required to experience moderate to intense pain. Nature 392:390-394
2. Trevisani M, Smart D, Gunthorpe MJ et al (2002) Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1. Nat Neurosci 5:546-551
3. Gerard NP, Garraway LA, Eddy RL Jr et al (1991) Human substance P receptor (NK-1): Organization of the gene, chromosome localization, and functional expression of cDNA clones. Biochemistry 30:10640-10646
4. Bae SJ, Matsunaga Y, Takenaka M et al (2002) Substance P induced preprotachykinin-a mRNA, neutral endopeptidase mRNA and substance P in cultured normal fibroblasts. Int Arch Allergy Immunol 127:316-321
5. Bae S, Matsunaga Y, Tanaka Y et al (1999) Autocrine induction of substance P mRNA and peptide in cultured normal human keratinocytes. Biochem Biophys Res Commun 263:327-333
6. Lai JP, Douglas SD, Ho WZ (1998) Human lymphocytes express substance P and its receptor. J Neuroimmunol 86:80-86
7. Ho WZ, Lai JP, Zhu XH et al (1997) Human monocytes and macrophages express substance P and neurokinin-1 receptor. J Immunol 159:5654-5660
8. Lai JP, Ho WZ, Yang JH et al (2002) A non-peptide substance P antagonist down-regulates SP mRNA expression in human mononuclear phagocytes. J Neuroimmunol 128:101-108
9. Graham GJ, Stevens JM, Page NM et al (2004) Tachykinins regulate the function of platelets. Blood 104:1058-1065
10. Jones S, Tucker KL, Sage T et al (2007) Peripheral tachykinins and the neurokinin receptor NK1 are required for platelet thrombus formation. Blood 111:605-612
11. Rodgers A, Walker N, Schug S et al (2000) Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: Results from overview of randomised trials. BMJ 321:1-12
12. Reed KL, Fruin AB, Gower AC et al (2004) A neurokinin 1 receptor antagonist decreases postoperative peritoneal adhesion formation and increases peritoneal fibrinolytic activity. Proc Natl Acad Sci USA 101:9115-9120
13. Watando A, Ebihara S, Ebihara T et al (2004) Daily oral care and cough reflex sensitivity in elderly nursing home patients. Chest 126:1066-1070
14. Sakaida H, Tanemura H, Yoshikawa T et al (2005) Decreased serum substance P concentration in the acute phase of intracranial hemorrhage. J Am Geriatr Soc 53:734-735
15. Tedeschi A, Lorini M, Asero R (2005) No evidence of increased serum substance P levels in chronic urticaria patients with and without demonstrable circulating vasoactive factors. Clin Exp Dermatol 30:171-175
16. Alessandri M, Massanti L, Geppetti P et al (2006) Plasma changes of calcitonin gene-related peptide and substance P in patients with dialysis headache. Cephalalgia 26:1287-1293
17. Saleem A, Blifeld C, Saleh SA et al (1983) Viscoelastic measurement of clot formation: A new test of platelet function. Ann Clin Lab Sci 13:115-124
18. Oshita K, Az-ma T, Osawa Y et al (1999) Quantitative measurement of thromboelastography as a function of platelet count. Anesth Analg 89:296-299
19. Hett DA, Walker D, Pilkington SN et al (1995) Sonoclot analysis. Br J Anaesth 75:771-776
20. Zwaal RF, Schroit AJ (1997) Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood 89:1121-1132
21. Folkers K, Hakanson R, Horig J et al (1984) Biological evaluation of substance P antagonists. Br J Pharmacol 83:449-456
22. Römish J, Seiffge D, Reiner G et al (1990) Anticoagulant properties of placenta protein 4 (Annexin V) Thromb Res 60:355-366
23. Römish J, Seiffge D, Reiner G et al (1991) In-vivo antithrombotic potency of placenta protein 4 (Annexin V) Thromb Res 61:93-104
24. Mousa SA, Khurana S, Forsythe MS (2000) Comparative in vitro efficacy of different platelet glycoprotein IIb/IIIa antagonists on platelet-mediated clot strength induced by tissue factor with use of thromboelastography: Differentiation among glycoprotein IIb/IIIa antagonists. Arterioscler Thromb Vasc Biol 20:1162-1167
25. Lai JP, Ho WZ, Kilpatrick LE et al (2006) Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation. Proc Natl Acad Sci USA 103:7771-7776