Computer programs for modeling mammalian cell batch and fed-batch cultures using logistic equations

Cytotechnology

Volumn 64, Issue 4, 2012, Pages 465-475

  Goudar, Chetan T ^a  

^a Global Biological Development   (United States)

Author keywords

Cell culture; CHO; Fed batch; Logistic modeling; Metabolic flux analysis; Specific rates

Indexed keywords

AMMONIA; GLUCOSE; GLUTAMINE; LACTIC ACID;

ANIMAL CELL; ARTICLE; CELL DENSITY; CELL FUNCTION; CHO CELL; COMPUTER PROGRAM; FED BATCH CULTURE; LOGISTIC REGRESSION ANALYSIS; MAMMAL CELL; NONHUMAN; SENSITIVITY ANALYSIS;

MAMMALIA;

EID: 84865148683     PISSN: 09209069     EISSN: 15730778     Source Type: Journal    
DOI: 10.1007/s10616-011-9425-y     Document Type: Article

References (18)

1. Aggarwal S (2007) What's fueling the biotech engine? Nat Biotechnol 25:1097-1104 (Pubitemid 47538104)
2. Chu L, Robinson DK (2001) Industrial choices for protein production by large-scale cell culture. Curr Opin Biotechnol 12:180-187 (Pubitemid 32247406)
3. Chuppa S, Tsai SP, Yoon S, Shackelford S, Rozales C, Bhat R, Tsay G, Matanguihan R, Konstantinov K, Naveh D (1997) Fermentor temperature as a tool for control of high-density perfusion cultures of mammalian cells. Biotechnol Bioeng 55:328-338 (Pubitemid 27291201)
4. Combs RG, Yu E, Roe S, Piatchek MB, Jones HL, Mott J, Kennard ML, Goosney DL, Monteith D (2011) Fed-batch bioreactor performance and cell line stability evaluation of the artificial chromosome expression technology expressing an IgG1 in Chinese hamster ovary cells. Biotechnol Prog 27:201-208
5. Goudar CT, Joeris K, Konstantinov K, Piret JM (2005) Logistic equations effectively model mammalian cell batch and fedbatch kinetics by logically constraining the fit. Biotechnol Prog 21:1109-1118 (Pubitemid 41099582)
6. Goudar CT, Matanguihan R, Long E, Cruz C, Zhang C, Piret JM, Konstantinov KB (2007) Decreased pCO2 accumulation by eliminating bicarbonate addition to high cell-density cultures. Biotechnol Bioeng 96:1107-1117 (Pubitemid 46648671)
7. Goudar CT, Biener R, Konstantinov KB, Piret JM (2009) Error propagation from prime variables into specific rates and metabolic fluxes for mammalian cells in perfusion culture. Biotechnol Prog 25:986-998
8. Huang Y-M, Hu W, Rustandi E, Chang K, Yusuf-Makagiansar H, Ryll T (2010) Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment. Biotechnol Prog 26:1400-1410
9. Kozlowski S, Swann P (2006) Current and future issues in the manufacturing and development of monoclonal antibodies. Adv Drug Delivery Rev 58:707-722 (Pubitemid 44255854)
10. Linz M, Zeng AP, Wagner R, Deckwer WD (1997) Stoichiometry, kinetics and regulation of glucose and amino acid metabolism of a recombinant BHK cell line in batch and continuous culture. Biotechnol Prog 13:453-463 (Pubitemid 27335835)
11. Ljumggren J, Häggström L (1994) Catabolic control of hybridoma cells by glucose and glutamine limited fed batch cultures. Biotechnol Bioeng 44:808-818 (Pubitemid 24287963)
12. Nelder JA, Mead R (1965) A simplex method for function minimization. Comput J 7:308-313
13. Pörtner R, Schäfer T (1996) Modelling hybridoma cell growth and metabolism - a comparison of selected models and data. J Biotechnol 49:119-135 (Pubitemid 26316248)
14. Reichert JM (2009) Global antibody trends. mAbs 1:86-87
15. Robinson JA (1985) Determining microbial kinetic parameters using nonlinear regression analysis. Advantages and limitations in microbial ecology. Adv Microb Ecol 8:61-114
16. Stephanopoulos G (2002) Metabolic engineering: perspective of a chemical engineer. AIChE J 48:920-926 (Pubitemid 36173038)
17. Trampler F, Sonderhoff SA, Pui PW, Kilburn DG, Piret JM (1994) Acoustic cell filter for high density perfusion culture of hybridoma cells. Bio/Technology 12:281-284 (Pubitemid 24079488)
18. Tziampazis E, Sambanis A (1994) Modeling of cell culture processes. Cytotechnology 14:191-204 (Pubitemid 2164018)