The interaction between the yeast telomerase RNA and the Est1 protein requires three structural elements

RNA

Volumn 18, Issue 9, 2012, Pages 1597-1604

  Lubin, Johnathan W ^a   Tucey, Timothy M ^a,b   Lundblad, Victoria ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Est1; RNA structure; Telomerase; TLC1

Indexed keywords

EST1 PROTEIN; EST2 PROTEIN; PROTEIN; TELOMERASE; TLC1 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; GENE OVEREXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN RNA BINDING; RNA BINDING; RNA STRUCTURE; SACCHAROMYCES CEREVISIAE;

BASE SEQUENCE; CONSERVED SEQUENCE; GENE EXPRESSION; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; RNA; RNA, FUNGAL; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TELOMERASE;

EID: 84865148230     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.034447.112     Document Type: Article

References (28)

1. Armanios M. 2009. Syndromes of telomere shortening. Annu Rev Genomics Hum Genet 10: 45-61.
2. Bianchi A, Negrini S, Shore D. 2004. Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1. Mol Cell 16: 139-146. (Pubitemid 39330159)
3. Blackburn EH, Collins K. 2011. Telomerase: An RNP enzyme synthesizes DNA. Cold Spring Harb Perspect Biol 3: 1-9.
4. Chakrabarti K, Pearson M, Grate L, Sterne-Weiler T, Deans J, Donohue JP, Ares MJ. 2007. Structural RNAs of known and unknown function identified in malaria parasites by comparative genomics and RNA analysis. RNA 13: 1923-1939. (Pubitemid 350005218)
5. Chan A, Boule JB, Zakian VA. 2008. Two pathways recruit telomerase to Saccharomyces cerevisiae telomeres. PLoS Genet 4: e1000236. doi: 10.1371/journal.pgen.1000236.
6. Chappell AS, Lundblad V. 2004. Structural elements required for association of the Saccharomyces cerevisiae telomerase RNA with the Est2 reverse transcriptase. Mol Cell Biol 24: 7720-7736. (Pubitemid 39121496)
7. Dandjinou AT, Lévesque N, Larose S, Lucier JF, Abou Elela S, Wellinger RJ. 2004. A phylogenetically based secondary structure for the yeast telomerase RNA. Curr Biol 14: 1148-1158. (Pubitemid 38893977)
8. Evans SK, Lundblad V. 1999. Est1 and Cdc13 as comediators of telomerase access. Science 286: 117-120. (Pubitemid 29484489)
9. Evans SK, Lundblad V. 2002. The Est1 subunit of Saccharomyces cerevisiae telomerase makes multiple contributions to telomere length maintenance. Genetics 162: 1101-1115. (Pubitemid 35417505)
10. Gallardo F, Laterreur N, Cusanelli E, Ouenzar F, Querido E, Wellinger RJ, Chartrand P. 2011. Live cell imaging of telomerase RNA dynamics reveals cell cycle-dependent clustering of telomerase at elongating telomeres. Mol Cell 44: 819-827.
11. Garcia CK. 2011. Idiopathic pulmonary fibrosis: Update on genetic discoveries. Proc Am Thorac Soc 8: 158-162.
12. Gunisova S, Elboher E, Nosek J, Gorkovoy V, Brown Y, Lucier JF, Laterreur N, Wellinger RJ, Tzfati Y, Tomaska L. 2009. Identification and comparative analysis of telomerase RNAs from Candida species reveal conservation of functional elements. RNA 15: 546-559.
13. Guo N, Parry EM, Li LS, Kembou F, Lauder N, Hussain MA, Berggren PO, Armanios M. 2011. Short telomeres compromise b-cell signaling and survival. PLoS ONE 6: e17858. doi: 10.1371/journal. pone.0017858.
14. Kachouri-Lafond R, Dujon B, Gilson E, Westhof E, Fairhead C, Teixeira MT. 2009. Large telomerase RNA, telomere length heterogeneity and escape from senescence in Candida glabrata. FEBS Lett 583: 3605-3610.
15. Lee J, Mandell EK, Tucey TM, Morris DK, Lundblad V. 2008. The Est3 protein associates with yeast telomerase through an OB-fold domain. Nat Struct Mol Biol 15: 990-997.
16. Lendvay TS, Morris DK, Sah J, Balasubramanian B, Lundblad V. 1996. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics 144: 1399-1412. (Pubitemid 26427890)
17. Leonardi J, Box JA, Bunch JT, Baumann P. 2008. TER1, the RNA subunit of fission yeast telomerase. Nat Struct Mol Biol 15: 26-33.
18. Livengood AJ, Zaug AJ, Cech TR. 2002. Essential regions of Saccharomyces cerevisiae telomerase RNA: Separate elements for Est1p and Est2p interaction. Mol Cell Biol 22: 2366-2374. (Pubitemid 34224639)
19. Lundblad V, Blackburn EH. 1993. An alternative pathway for yeast telomere maintenance rescues est1- senescence. Cell 73: 347-360. (Pubitemid 23123312)
20. Mozdy AD, Cech TR. 2006. Low abundance of telomerase in yeast: Implications for telomerase haploinsufficiency. RNA 12: 1721-1737. (Pubitemid 44316036)
21. Pennock E, Buckley K, Lundblad V. 2001. Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell 104: 387-396. (Pubitemid 32206459)
22. Savage SA, Alter BP. 2008. The role of telomere biology in bone marrow failure and other disorders. Mech Ageing Dev 129: 35-47.
23. Seto AG, Livengood AJ, Tzfati Y, Blackburn EH, Cech TR. 2002. A bulged stem tethers Est1p to telomerase RNA in budding yeast. Genes Dev 16: 2800-2812. (Pubitemid 35253148)
24. Theimer CA, Feigon J. 2006. Structure and function of telomerase RNA. Curr Opin Struct Biol 16: 307-318. (Pubitemid 43831650)
25. von Figura G, Wagner M, Nalapareddy K, Hartmann D, Kleger A, Guachalla LM, Rolyan H, Adler G, Rudolph KL. 2011. Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice. PLoS ONE 6: e17122. doi: 10.1371/journal.pone.0017122.
26. Webb CJ, Zakian VA. 2008. Identification and characterization of the Schizosaccharomyces pombe TER1 telomerase RNA. Nat Struct Mol Biol 15: 34-42.
27. Ye AJ, Romero DP. 2002. Phylogenetic relationships amongst tetrahymenine ciliates inferred by a comparison of telomerase RNAs. Int J Syst Evol Microbiol 52: 2297-2302. (Pubitemid 36004211)
28. Zappulla DC, Cech TR. 2004. Yeast telomerase RNA: A flexible scaffold for protein subunits. Proc Natl Acad Sci 101: 10024-10029 (Pubitemid 38891188)