Highly potent aminopyridines as Syk kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 17, 2012, Pages 5419-5423

  Castillo, Marcos ^a   Forns, Pilar ^a   Erra, Montse ^a   Mir, Marta ^a   López, Manel ^a   Maldonado, Mónica ^a   Orellana, Adelina ^a   Carreño, Cristina ^a   Ramis, Isabel ^a   Miralpeix, Montserrat ^a   Vidal, Bernat ^a  

^a Almirall Research Center Almirall ^*  (Spain)

Author keywords

Aminopyridines; Human mast cell line LAD2; Syk kinase

Indexed keywords

AMINOPYRIDINE DERIVATIVE; PROTEIN KINASE SYK INHIBITOR;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; HUMAN; HUMAN CELL; IC 50; MAST CELL; MAST CELL DEGRANULATION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

AMINOPYRIDINES; BINDING SITES; CELL DEGRANULATION; CELL LINE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAST CELLS; MOLECULAR DOCKING SIMULATION; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES;

EID: 84865145108     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.07.045     Document Type: Article

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