Pyrazine-based Syk kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 8, 2012, Pages 2784-2788

  Forns, Pilar ^a   Esteve, Cristina ^a   Taboada, Lorena ^a   Alonso, Juan Antonio ^a   Orellana, Adelina ^a   Maldonado, Mónica ^a   Carreño, Cristina ^a   Ramis, Isabel ^a   López, Manel ^a   Miralpeix, Montserrat ^a   Vidal, Bernat ^a  

^a Almirall ^*  (Spain)

Author keywords

2 Aminopyrazine; LAD2; Syk

Indexed keywords

ADAMANTANOL DERIVATIVE; PROTEIN KINASE SYK INHIBITOR; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CIS TRANS ISOMERISM; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION;

ADAMANTANE; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MOLECULAR STRUCTURE; PROTEIN-TYROSINE KINASES; PYRAZINES;

EID: 84859439113     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.087     Document Type: Article

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