Metronidazole thiosalicylate conjugates: Synthesis, crystal structure, docking studies and antiamoebic activity

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 17, 2012, Pages 5694-5699

  Salahuddin, Attar ^a   Agarwal, Subhash M ^b   Avecilla, Fernando ^c   Azam, Amir ^a  

^a JAMIA MILLIA ISLAMIA CENTRAL UNIVERSITY   (India)

^b INSTITUTE OF CYTOLOGY AND PREVENTIVE ONCOLOGY   (India)

^c UNIVERSITY OF A CORUÑA   (Spain)

Author keywords

Amoebiasis; Entamoeba histolytica; Metronidazole; MTT assay; Thioredoxin reductase

Indexed keywords

1 (2 CHLOROETHYL) 2 METHYL 5 NITRO IMIDAZOLE; 2 [2 (2 METHYL 5 NITRO 1H IMIDAZOL 1 YL)ETHYLSULFINYL)BENZOATE; ANTIAMEBIC AGENT; IMIDAZOLE; METRONIDAZOLE THIOSALICYLATE CONJUGATE; SULFONE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG BINDING; DRUG MECHANISM; DRUG OXIDATION; ENTAMOEBA HISTOLYTICA; MOLECULAR DOCKING; NONHUMAN; SYNTHESIS;

AMINO ACID SEQUENCE; ANTIPARASITIC AGENTS; BENZOATES; CELL SURVIVAL; ENTAMOEBA HISTOLYTICA; ENTAMOEBIASIS; HUMANS; INHIBITORY CONCENTRATION 50; MCF-7 CELLS; METRONIDAZOLE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; SULFHYDRYL COMPOUNDS; THIMEROSAL; THIOREDOXIN-DISULFIDE REDUCTASE;

ENTAMOEBA HISTOLYTICA;

EID: 84865140704     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.06.083     Document Type: Article

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