Immunoselection in vivo: Independent loss of MHC class I and melanocyte differentiation antigen expression in metastatic melanoma

International Journal of Cancer

Volumn 71, Issue 2, 1997, Pages 142-147

  Jäger, Elke ^a   Ringhoffer, Mark ^a   Altmannsberger, Michael ^a   Arand, Michael ^b   Karbach, Julia ^a   Jäger, Dirk ^a   Oesch, Franz ^b   Knuth, Alexander ^a,c  

^a Nordwest Hospital   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c Medizinische Klinik I   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DIFFERENTIATION ANTIGEN; HLA A2 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MESSENGER RNA; MONOPHENOL MONOOXYGENASE;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; HUMAN; HUMAN TISSUE; MALE; MELANOCYTE; MELANOMA; METASTASIS; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, NEOPLASM; BIOPSY; DNA PRIMERS; FEMALE; GENES, MHC CLASS I; HLA-A2 ANTIGEN; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; LYMPHATIC METASTASIS; MALE; MELANOMA; MIDDLE AGED; MONOPHENOL MONOOXYGENASE; NEOPLASM PROTEINS; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SKIN NEOPLASMS;

EID: 1842372075     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970410)71:2<142::AID-IJC3>3.0.CO;2-0     Document Type: Article

References (30)

1. ANICHINI, A., MACCALLI, C., MORTARINI, R., SALVI, S., MAZZOCCHI, A., SQUARCINA, P., HERLYN, M. and PARMIANI, G., Melanoma cells and normal melanocytes share antigens recognized by HLA-A2-restricted cytotoxic T cell clones from melanoma patients. J. exp. Med., 177, 989-998 (1993).
2. BAKKER, A.B., SCHREURS, M.W.J., DEBOER, A.J., KAWAKAMI, Y., ROSENBERG, S.A., ADEMA, G.J. and FIGDOR, C.G., Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes. J. exp. Med., 179, 1005-1009 (1994).
3. BERNHARD, H., KARBACH, J., WÖLFEL, T., BUSCH, P., STÖRKEL, S., STÖCKLE, M., WÖLFEL, C., SELIGER, B., HUBER, C., MEYER ZUM BÜ SCHENFELDE, K.-H. and KNUTH, A., Cellular immune response to human renal cell carcinomas: definition of a common antigen recognized by HLA-A2-restricted cytotoxic T lymphocytes. Int. J. Cancer, 59, 1-6 (1994).
4. BRASSEUR, F. and 29 OTHERS, Expression of MAGE genes in primary and metastatic cutaneous melanoma. Int. J. Cancer, 63, 375-380 (1995).
5. BRICHARD, V., VAN PEL, A., WÖLFEL, T., WÖLFEL, C., DE PLAEN, E., LETHÉ, B., COULIE, P. and BOON, T., The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J. exp. Med., 178, 489-495 (1993).
6. BROWNING, M.J., KRAUSA, P., ROWAN, A., BICKNELL, D.C., BODMER, J.G. and BODMER, W.F., Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines. Proc. nat. Acad. Sci. (Wash.), 90, 2842-2845 (1993).
7. CHEN, Y.-T. STOCKERT, E., JUNGBLUTH, A., TSANG, S., COPLAN, C.A., SCANLAN, M.J. and OLD, L.J., Serological analysis of Melan A(MART-1), a melanocyte-specific protein homogenously expressed in human melanomas. Proc. nat. Acad. Sci. (Wash.), 93, 5915-5919 (1996).
8. CHEN, Y.T., STOCKERT, E., TSANG, S., COPLAN, K.A. and OLD, L.J., Immunophenotyping of melanomas for tyrosinase: implications for vaccine development. Proc. nat. Acad. Sci. (Wash.), 92, 8125-8129 (1995).
9. COULIE, P.G., BRICHARD, V., VAN PEL, A., WÖLFEL, T., SCHNEIDER, J., TRAVERSARI, C., MATTEL S., DE PLAEN, E., LURQUIN, C., SZIKORA, J.-P., RENAULD, J.-C. and BOON, T., A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J. exp. Med., 180, 35-42 (1994).
10. COULIE, P.G., LEHMANN, F., LETHÉ, B., HERMAN, J., LURQUIN, C., ANDRAWISS, M. and BOON, T., A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma. Proc. nat. Acad. Sci. (Wash.), 92, 7976-7980 (1995).
11. D'ALESSANDRO, G., ZARDAWI, I., GRACE, J., MCCARTHY, W.H. and MERSEY, P., Immunohistological evaluation of MHC class I and II antigen expression on nevi and melanoma: relation to biology of melanoma. Pathology, 19, 339-346 (1987).
12. DRANOFF, G., JAFFEE, E., LAZENBRY, A., GOLUMBEK, P., LEVITSKY, H., BROSE, K., JECKSON, V., HAMADA, H., PARDOLL, D. and MULLIGAN, R., Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. nat. Acad. Sci. (Wash.), 90, 3539-3543 (1993).
13. GAUGLER, B., VAN DEN EYNDE, B., VAN DER BRUGGEN, P., ROMERO, P., GAFORIO, J.J., DE PLAEN, E., LETHÉ, B., BRASSEUR, F. and BOON, T., Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. J. exp. Med., 179, 921-930 (1994).
14. JÄGER, E., BERNHARD, H., ROMERO, P., RINGHOFFER, M., ARAND, M., KARBACH, J., ILSEMANN, C., HAGEDORN, M. and KNUTH, A., Generation of cytotoxic T cell responses with synthetic melanoma associated peptides in vivo: implications for tumor vaccines with melanoma associated antigens. Int. J. Cancer. 66, 162-169 (1996a).
15. JÄGER, E., RINGHOFFER, M., DIENES, H.-P., ARAND, M., KARBACH, J., JÄGER, D., ILSEMANN, C., HAGEDORN, M., OESCH, F. and KNUTH, A., Granulocyte macrophage colony-stimulating factor enhances immune responses to melanoma associated peptides in vivo. Int. J. Cancer (1996b) (In press).
16. JÄGER, E., RINGHOFFER, M., KARBACH, J., ARAND, M., OESCH, F. and KNUTH, A., Inverse relationship of melanocyte differentiation antigen expression in melanoma: evidence for immunoselection of antigen-loss variants in vivo. Int. J. Cancer, 66, 470-476 (1996c).
17. KAWAKAMI, Y., ELIYAHU, S., DELGADO, C.H., ROBBINS, P.F., RIVOLTINI, L., TOPALIAN, S.L., MIKI, T. and ROSENBERG, S.A., Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. Proc. nat. Acad. Sci. (Wash.), 91, 3525-3529 (1994a).
18. KAWAKAMI, Y., ELIYAHU, S., DELGADO, C.H., ROBBINS, P.F., SAKAGUCHI, K., APPELLA, E., YANNELLI, J.R., ADEMA, G.J., MIKI, T. and ROSENBERG, S.A., Identification of a human melanoma antigen recognized by tumor- infiltrating lymphocytes associated with in vivo tumor rejection. Proc. nat. Acad. Sci. (Wash.), 91, 6458-6462 (1994b).
19. LEHMANN, P., MARCHAND, M., HAINAUT, P., POUILLART, P., SASTRE, X., IKEDA, H. and BOON, T., Differences in the antigens recognized by cytolytic T cells on two successive metastases of a melanoma patient are consistent with immune selection. Europ. J. Immunol., 25, 340-347 (1995).
20. LOPEZ NEVOT, M.A., ESTEBAN, F., FERRON, A., GUTIERREZ, J., OLIVA, M.R., ROMERO, C., HUELIN, C., RUIZ CABELLO, F. and GARRIDO, F., HLA class I gene expression on human primary tumours and autologous metastases: demonstration of selective losses of HLA antigens on colorectal, gastric and laryngeal carcinomas. Brit. J. Cancer, 59, 221-226 (1989).
21. MCMICHAEL, A.J., PARHAM, P., RUST, N. and BRODSKY, F.M., A monoclonal antibody that recognizes an antigenic determinant shared by HLA-A2 and B17. Hum. Immunol., 1, 121-123 (1980).
22. RESTIFO, N.P., MARINCOLA, F.M., KAWAKAMI, Y., TAUBENBERGER, J., YANNELLI, J.R. and ROSENBERG, S.A., Loss of functional beta2-microglobulin in metastatic melanomas from five patients receiving immunotherapy. J. nat. Cancer Inst., 88, 100-108 (1996).
23. RIVOLTINI, L., BARRACCHINI, K.C., VIGGIANO, V., KAWAKAMI, Y., SMITH, A., MIXON, A., RESTIFO, N.P., TOPALIAN, S.L., SIMONIS, T.B., ROSENBERG, S.A. and MARINCOLA, P.M., Quantitative correlation between HLA class I allele expression and recognition of melanoma cells by antigen-specific cytotoxic T lymphocytes. Cancer Res., 55, 3149-3157 (1995).
24. ROBBINS, P.F., EL-GAMIL, M., KAWAKAMI, Y. and ROSENBERG, S.A., Recognition of tyrosinase by tumor-infiltrating lymphocytes from a patient responding to immunotherapy. Cancer Res., 54, 3124-3126 (1994).
25. ROMAGNANI, S., Lymphokine production by human T cells in disease states. Ann. Rev. Immunol., 12, 227-257 (1994).
26. VAN DEN EYNDE, B., PEETERS, O., DR BACKER, O., GAUGLER, B., LUCAS, S. and BOON, T., A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. J. exp. Med., 182, 689-698 (1995).
27. VAN DER BRUGGEN, P., TRAVERSARI, C., CHOMEZ, P., LURQUIN, C., DE PLAEN, E., VAN DEN EYNDE, B., KNUTH, A. and BOON, T., A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science, 254, 1643-1647 (1991).
28. WANG, Z., CAO, Y., ALBINO, A.P., ZEFF, R.A., HOUGHTON, A. and FERRONE, S., Lack of HLA class I antigen expression by melanoma cells SK-MEL-33 caused by a reading frameshift in beta 2-microglobulin messenger RNA. J. clin. Invest., 91, 684-692 (1993).
29. WÖLFEL, T., HAUER, M., SCHNEIDER, J., SERKANO, M., WÖLFEL, C., KLEHMANN-HIEB, E., DE PLAEN, E., HANKELN, T., MEYER ZUM BÜSCHENFELDE, K.-H. and BEACH, D., A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science, 269, 1281-1284 (1995).
30. WOOD, G.S. and WARNKE, R., Suppression of endogenous avidin-binding activity in tissues and its relevance to biotin-avidin detection systems. J. Histochem. Cytochem., 29, 1196-1204 (1981).